PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

Nature

Volumn 450, Issue 7166, 2007, Pages 106-109

  Batterham, Rachel L ^a   Ffytche, Dominic H ^b   Rosenthal, J Miranda ^a   Zelaya, Fernando O ^b   Barker, Gareth J ^b   Withers, Dominic J ^a   Williams, Steven C R ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE YY; PEPTIDE YY[3-36]; UNCLASSIFIED DRUG;

BRAIN; FEEDING BEHAVIOR; FOOD INTAKE; HOMINID; NEUROLOGY;

ADULT; APPARATUS; ARTICLE; BRAIN CORTEX; BRAIN MAPPING; BRAIN STEM; COGNITION; CONTROLLED STUDY; EMOTION; EXPERIENCE; FEEDING BEHAVIOR; FOOD DEPRIVATION; FOOD INTAKE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; IMAGE ANALYSIS; LIMBIC CORTEX; MALE; NERVE CELL NETWORK; NEUROBIOLOGY; NORMAL HUMAN; OBESITY; POSTPRANDIAL STATE; PREDICTION; PRIORITY JOURNAL; REWARD; SATIETY; SIGNAL TRANSDUCTION; SURVIVAL;

MAMMALIA;

EID: 35948998870     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06212     Document Type: Article

References (38)

1. Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S. & Schwartz, M. W. Central nervous system control of food intake and body weight. Nature 443, 289-295 (2006).
2. Schwartz, M. W. & Porte, D. Jr. Diabetes, obesity, and the brain. Science 307, 375-379 (2005).
3. Berthoud, H. R. Neural control of appetite: cross-talk between homeostatic and non-homeostatic systems. Appetite 43, 315-317 (2004).
4. Fulton, S., Woodside, B. & Shizgal, P. Modulation of brain reward circuitry by leptin. Science 287, 125-128 (2000).
5. Saper, C. B., Chou, T. C. & Elmquist, J. K. The need to feed: homeostatic and hedonic control of eating. Neuron 36, 199-211 (2002).
6. Liu, Y., Gao, J. H., Liu, H. L. & Fox, P. T. The temporal response of the brain after eating revealed by functional MRI. Nature 405, 1058-1062 (2000).
7. Small, D. M., Zatorre, R. J., Dagher, A., Evans, A. C. & Jones-Gotman, M. Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 124, 1720-1733 (2001).
8. Tataranni, P. A. et al. Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc. Natl Acad. Sci. USA 96, 4569-4574 (1999).
9. Smeets, P. A. et al. Effect of satiety on brain activation during chocolate tasting in men and women. Am. J. Clin. Nutr. 83, 1297-1305 (2006).
10. DelParigi, A. et al. Persistence of abnormal neural responses to a meal in postobese individuals. Int. J. Obes. Relat. Metab. Disord. 28, 370-377 (2004).
11. Cummings, D. E. & Overduin, J. Gastrointestinal regulation of food intake. J. Clin. Invest. 117, 13-23 (2007).
12. Badman, M. K. & Flier, J. S. The gut and energy balance: visceral allies in the obesity wars. Science 307, 1909-1914 (2005).
13. 3-36 physiologically inhibits food intake. Nature 418, 650-654 (2002).
14. Batterham, R. L. et al. Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 349, 941-948 (2003).
15. Wren, A. M. et al. Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86, 5992-5995 (2001).
16. Chan, J. L., Stoyneva, V., Kelesidis, T., Raciti, P. & Mantzoros, C. S. Peptide YY levels are decreased by fasting and elevated following caloric intake but are not regulated by leptin. Diabetologia 49, 169-173 (2006).
17. le Roux, C. W. et al. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147, 3-8 (2006).
18. Batterham, R. L. et al. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab. 4, 223-233 (2006).
19. 3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res. 1044, 127-131 (2005).
20. Abizaid, A. et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116, 3229-3239 (2006).
21. Fulton, S. et al. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51, 811-822 (2006).
22. Kringelbach, M. L. Food for thought: hedonic experience beyond homeostasis in the human brain. Neuroscience 126, 807-819 (2004).
23. Kringelbach, M. L. The human orbitofrontal cortex: linking reward to hedonic experience. Nature Rev. Neurosci. 6, 691-702 (2005).
24. Kringelbach, M. L., O'Doherty, J., Rolls, E. T. & Andrews, C. Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness. Cereb. Cortex 13, 1064-1071 (2003).
25. Wang, G. J. et al. Exposure to appetitive food stimuli markedly activates the human brain. Neuroimage 21, 1790-1797 (2004).
26. Gautier, J. F. et al. Effect of satiation on brain activity in obese and lean women. Obes. Res. 9, 676-684 (2001).
27. Hinton, E. C. et al. Neural contributions to the motivational control of appetite in humans. Eur. J. Neurosci. 20, 1411-1418 (2004).
28. Rolls, E. T. The functions of the orbitofrontal cortex. Brain Cogn. 55, 11-29 (2004).
29. Delparigi, A. et al. Successful dieters have increased neural activity in cortical areas involved in the control of behavior. Int. J. Obes. (Lond.) 31, 440-448 (2006).
30. Whitwell, J. L. et al. VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration. Neuroimage 35, 207-213 (2007).
31. Flint, A., Raben, A., Blundell, J. E. & Astrup, A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int. J. Obes. Relat. Metab. Disord. 24, 38-48 (2000).
32. Batterham, R. L. et al. Pancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 88, 3989-3992 (2003).
33. Rosenthal, J. M. et al. The effect of acute hypoglycemia on brain function and activation: a functional magnetic resonance imaging study. Diabetes 50, 1618-1626 (2001).
34. Rosenthal, M. J. et al. Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers. Diabet. Med. 24, 720-727 (2007).
35. Deichmann, R., Gottfried, J. A., Hutton, C. & Turner, R. Optimized EPI for fMRI studies of the orbitofrontal cortex. Neuroimage 19, 430-441 (2003).
36. Friston, K. J., Holmes, A., Poline, J. B., Price, C. J. & Frith, C. D. Detecting activations in PET and fMRI: levels of inference and power. Neuroimage 4, 223-235 (1996).
37. Talairach, J. & Tournoux, P. Co-planar Stereotaxic Atlas of the Human Brain (Thieme, Stuttgart, 1988).
38. Paxinos, G. & Huang, X. Atlas of the Human Brainstem (Academic Press, San Diego, 1995).