Brain melanocortin receptors: From cloning to function

Peptides

Volumn 18, Issue 8, 1997, Pages 1279-1287

  Adan, Roger A H ^a   Gispen, Willem Hendrik ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

ACTH; Grooming behavior; Melanocortin receptors; Melanocortins; Neuropeptides

Indexed keywords

CORTICOTROPIN; HORMONE RECEPTOR; INTERMEDIN; MELANOCORTIN; NEUROPEPTIDE;

ANIMAL BEHAVIOR; BLOOD PRESSURE REGULATION; BODY WEIGHT; FEEDING BEHAVIOR; GROOMING; HORMONE RECEPTOR INTERACTION; MOLECULAR CLONING; NEUROENDOCRINOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; THERMOREGULATION;

ANIMALIA;

EID: 0031471301     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00078-8     Document Type: Review

References (79)

1. Adan R. A. H., Cone R. D., Burbach J. P. H., Gispen W. H. Differential effects of melanocortin peptides on neural melanocortin receptors. Mol. Pharmacol. 46:1994;1182-1190.
2. 5 receptors. Eur. J. Pharmacol. 269:1994;331-337.
3. Aloyo V. J., Spruyt B., Zwiers H., Gispen W. H. Peptide induced excessive grooming behavior The role of opiate receptors . Peptides. 4:1983;833-836.
4. Alvaro J. S., Tatro J. B., Quillan J. M., Fogliano M., Eisenhard M., Lerner M. R., Nestler E. J., Duman R. S. Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol. Pharmacol. 50:1996;583-591.
5. Ashmarin J. P., Nezavibatko V. N., Levitskaya N. G., Koshelev V. B., Kamensky A. A. Design and investigation of an ACTH 4-10 analogue lacking D-amino acids and hydrophobic residues. Neurosci. Res. Comm. 16:1995;105-112.
6. Barrett P., MacDonald A., Helliwell R., Davidson G., Morgan P. Cloning and expression of a new member of the melanocyte-stimulating hormone receptor family. J. Mol. Endocrinol. 12:1994;203-213.
7. Bressers W. M. A., Kruk M. R., Van Erp H. H. M., Willekens-Bramer D. C., Haccou P., Meelis E. A time-structured analysis of hypothalamically induced increases in self-grooming and activity in the rat. Behav. Neurosci. 109:1995;1158-1171.
8. Castrucci A. M., Sherbrooke W. C., Sawyer T. K., Staples D. J., Tuma M. C. B., Hadley M. E. Discovery of an α-melanotropin antagonist effective in vivo. Peptides. 15:1994;527-632.
9. Catania A., Lipton J. M. α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr. Rev. 14:1993;564-576.
10. Ceriani G., Macalus A., Catania A., Lipton J. M. Central neurogenic antiinflammatory action of α-MSH. Neuroendocrinol. 59:1994;138-143.
11. 153N-6 at melanocortin receptor subtypes by radioligand binding. Peptides. 17:1996;349-351.
12. Chhajlani V., Muceniece R., Wikberg J. E. S. Molecular cloning of a novel human melanocortin receptor. Biochem. Biophys. Res. Commun. 195:1993;866-873.
13. Chhajlani V., Wikberg J. E. S. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 309:1992;417-420.
14. Chhajlani V., Xu X., Blauw J., Sudarshi S. Identification of ligand binding residues in extracellular loops of the Melanocortin 1 receptor. Biochem. Biophys. Res. Commun. 219:1996;521-525.
15. Contreras P. C., Takemori A. E. Antagonism of morphine-induced analgesia, tolerance and dependence by α-MSH. J. Pharmacol. Exp. Ther. 229:1984;21-26.
16. De Wied D. Influence of anterior pituitary on avoidance learning and escape behavior. Am. J. Physiol. 207:1964;255-259.
17. De Wied D. Inhibitory effects of ACTH and related peptides on extinction of conditioned avoidance behavior in rats. Proc. Soc. Exp. Biol. Med. 122:1966;28-32.
18. De Wildt D. J., Kasbergen C. M., Versteeg D. H. G. Effect of γ-melanocyte stimulating hormone on cerebral blood flow in rats. J. Cardiovasc. Pharmacol. 25:1995;898-905.
19. De Wildt D. J., Krugers H., Kasbergen.C. M.; De Lang H., Versteeg D. H. G. The hemodynamic effects of γ2-melanocyte-stimulating hormone and related melanotropins depend on the arousal potential of the rat. Eur. J. Pharmacol. 233:1993;157-164.
20. De Wildt D. J., Van Der Ven J. C., Van Bergen P., De Lang H., Versteeg D. H. G. A hypotensive and bradycardic action of γ2-MSH microinjected into the nucleus tractus solitarii of the rat. Arch. Pharmacol. 349:1994;50-56.
21. Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M. Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. Biochem. J. 299:1994;367-373.
22. Drouin J., Goodman H. M. Most of the coding region of rat ACTH//β-LPH precursor gene lacks intervening sequences. Nature. 288:1980;610-613.
23. Dunn A. J., Green E. J., Isaacson R. L. Intracerebral adreno-corticotrope hormone mediates novelty-induced grooming in the rat. Science. 203:1979;281-283.
24. Fathi Z., Iben L. G., Parker E. M. Cloning, expression and tissue distribution of a fifth melanocortin receptor subtype. Neurochem. Res. 20:1995;107-113.
25. Ferrari W. Behavioural changes in animals after intracisternal injection with adrenocorticotropic hormone and melanocyte-stimulating hormone. Nature. 181:1958;925-926.
26. Florijn W. J., Holtmaat J. G. D., De Lang H., Spierenburg H., Gispen W. H., Versteeg D. H. G. Peptide induced grooming behavior and caudate nucleus dopamine release. Brain Res. 625:1993;169-172.
27. Gantz I., Konda T., Tashiro T., Shimoto Y., Miwa H., Munzert G., Watson S. J., DelValle J., Yamada T. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268:1993;8246-8250.
28. Gantz I., Miwa H., Konda Y., Shimoto Y., Tashiro T., Watson S. J., DelValle J., Yamada T. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268:1993;15174-15179.
29. Gantz I., Shimoto Y., Konda Y., Miwa H., Dickinson C. J., Yamada T. Molecular cloning, expression, and characterization of a fifth melanocortin receptor. Biochem. Biophys. Res. Commun. 200:1994;1214-1220.
30. Gee C. E., Chen C. L. C., Roberts J. L., Thompson R., Watson S. J. Identification of proopiomelanocortin neurons in the rat hypothalamus by in situ cDNA-mRNA hybridization. Nature. 306:1983;374-375.
31. Gispen, W. H.; Isaacson, R. L. Excessive grooming in response to ACTH. In: De Wied, D.; Gispen, W. H.; Van Wimersma Greidanus, T. B., Eds. Neuropeptides and Behavior, vol. 1. Oxford: Pergamon Press; 1986:273-312.
32. Gispen W. H., Wiegant V. M. Opiate antagonists suppress ACTH 1-24 induced excessive grooming in the rat. Neurosci. Lett. 2:1976;159-164.
33. Gispen W. H., Wiegant V. M., Greven H. M., De Wied D. The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH Structure-activity studies . Life Sci. 17:1975;645-652.
34. Griffon N., Mignon V., Facchinetti P., Diaz J., Schwartz J., Sokoloff P. Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochem. Biophys. Res. Commun. 200:1994;1007-1014.
35. Gruber K. A., Callahan M. F. ACTH 4-10 through γ-MSH Evidence for a new class of central autonomic nervous system-regulating peptides . Am. J. Physiol. 257:1989;R681-R694.
36. Hirsch M. D., O'Donohue T. L., Wilson R., Sawyer T. K., Hruby V. J., Hadley M. E., Cody W. L., Knittel J. J., Crawley J. N. Structural and conformational modifications of αMSH/ACTH 4-10 provide melanotrpin analogues with high potent behavioral activities. Peptides. 5:1984;1197-1201.
37. 2 with bulkyaromatic amino acids at position 7 show high potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38:1995;3454-3460.
38. Huszar D., Lynch C. A., Fairchild-Huntress V., Dunmore J. H., Fang Q., Berkemeier L. R., Gu W., Kesterson R. A., Boston B. A., Cone R. D., Smith F. J., Campfield L. A., Burn P., Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.
39. Jacobowitz D. M., O'Donohue T. L. α-melanocyte stimulating hormone immunohistochemical identification and mapping in neurons of the rat brain . Proc. Natl. Acad. Sci. USA. 75:1978;6300-6304.
40. Jap Tjoen San E. R., van Rozen A. J., Nielander H. B., Oestreicher A. B., Gispen W. H., Schotman P. Expression levels of B-50/GAP-43 in PC12 cells are decisive for the complexity of their neurites and growth cones. J. Mol. Neurosci. 6:1995;185-200.
41. Jayawickcreme C. K., Quillan J. M., Graminski G. F., Lerner M. R. Discovery and structure-function analysis of α-MSH antagonists. J. Biol. Chem. 47:1994;29846-29854.
42. Klein M. C., Hutchins P. M., Lymangrover J. R., Gruber K. A. Pressor and cardioaccelerator effects of γ MSH and related peptides. Life Sci. 36:1985;769-775.
43. Labbe O., Desarnaud F., Eggerickx D., Vassart G., Parmentier M. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry. 33:1994;4543-4549.
44. Li S. J., Varga K., Archer P., Hruby V. J., Sharma S. D., Kesterson R. A., Cone R. D., Kunos G. Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and γ-melanocyte-stimulating hormones. J. Neurosci,. 16:1996;5182-5188.
45. Low, M. J.; Simerly, R. B.; Cone, R. D. Receptors for melanocortin peptides in the central nervous system. Curr. Opin. in Endocrinol. Diabet. 79-88; 1994.
46. Lu D., Willard D., Patel I. R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R. P., Wilkison W. O., Cone R. D. Agouti protein is an antagonist of the melanocortin-stimulating-hormone receptor. Nature. 371:1994;799-802.
47. Mastrianni L. A., Palkovits M., Kunos G. Activation of brainstem endorphinergic neurons causes cardiovascular depression and facilitates baroreflex bradycardia. Neuroscience. 33:1989;559-566.
48. Miwa H., Gantz I., Konda Y., Shimoto Y., Yamada T. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J. Biol. Chem. 273:1995;367-372.
49. Motta M., Mangili G., Martini L. A "short" feedback loop in the control of ACTH secretion. Endocrinology,. 77:1965;392-395.
50. 4-R) localized in neuroendocrine and autonomic circuitry in the brain. Mol. Endocrinol. 8:1994;1298-1308.
51. Mountjoy K. G., Robbins L. S., Mortrud M. T., Cone R. D. The cloning of a family of genes that encode the melanocortin receptors. Science. 257:1992;1248-1251.
52. 2. Life Sci. 31:1982;2555-2561.
53. Nakanishi S., Teranishi Y., Watanabe Y., Notake M., Noda M., Kakidani H., Jingami H., Numa S. Isolation and characterization of the bovine corticotropin/β-lipotropin precursor gene. Eur. J. Biochem. 115:1981;429-438.
54. Prusis P., Frandberg P. A., Muceniece R., Kalvinsh I., Wikberg J. E. S. A three dimensional model for the interaction of MSH with the Melanocortin 1 receptor. Biochem. Biophys. Res. Commun. 210:1995;205-210.
55. Rehfuss-Roselli L., Mountjoy K. G., Robbins L. S., Mortrud M. T., Low M. J., Tatro J. B., Entwistle M. L., Simerly R. B., Cone R. D. Identification of a receptor for melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl. Acad. Sci. USA. 90:1993;8856-8860.
56. Robbins L. S., Nadeau J. H., Johnson K. R., Kelly M. A., Roselli-Rehfuss L., Baack E., Mountjoy K. G., Cone R. D. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell. 72:1993;827-834.
57. Robertson B., Dostal K., Daynes R. A. Neuropeptide regulation of inflammatory and immunologic responses. J. Immunol. 140:1988;4300-4307.
58. Sawyer T. K., Sanfilippo P. J., Hruby V. J., Engel M. H., Heward C. B., Burnett J. B., Hadley M. E. 4-Norleucine,7-D-phenylalanine-α-melanocyte-stimulating hormone A highly potent α-melanotropin with ultralong biological activity . Proc. Natl. Acad. Sci. USA. 77:1980;5754-5758.
59. Schioth H. B., Muceniece R., Wikberg J. E. S., Chhajlani V. Characterisation of melanocortin receptor subtypes by radioligand binding analysis. Eur. J. Pharmacol. 288:1995;311-317.
60. Shih S. T., Khorram O., Lipton J. M., McCann S. M. Central administration of α-MSH antiserum augments fever in the rabbit. Am. J. Physiol. 250:1986;R803-R806.
61. Spampinato S., Canossa M., Carboni L., Campana G., Leanza G., Ferri S. Inhibition of proopiomelanocortin expression by an oligonucleotide complementary to β-endorphin mRNA. Proc. Natl. Acad. Sci. USA. 91:1994;8072-8076.
62. Spruijt B. M., Van Hooff J. A. R. A. M., Gispen W. H. Ethology and neurobiology of grooming behavior. Physiol. Rev. 72:1992;825-852.
63. Suda T., Yajima F., Tomori N., Sumitomo T., Nakagami Y., Ushiyama T., Demura H., Shizume K. Inhibitory effect of adrenocorticotropin on corticotropin-releasing factor release from rat hypothalamus in vitro. Endocrinology. 118:1986;459-461.
64. Szekely J. I., Miglecz E., Dunai-Kovacs Z., Tarnawa I., Ronai A. Z., Graf L., Bajusz S. Attenuation of morphine tolerance and dependence by α-MSH. Life Sci. 24:1979;1931-1938.
65. Tatro J. B. Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and α-melnocyte stimulating hormone. Brain Res. 536:1990;124-132.
66. Tatro J. B., Entwistle M. L. Identification of a specific mammalian melanocortin receptor antagonist. Ann. NY Acad. Sci. 680:1993;315-319.
67. Tatro J. B., Entwistle M. L. Distribution of melanocortin receptors in the lower brainstem of the rat. Ann. NY Acad. Sci. 680:1993;315-319.
68. Tatro J. B., Entwistle M. L. Heterogeneity of brain melanocortin receptors suggested by differential ligand binding in situ. Brain Res. 635:1994;148-158.
69. Tatro J. B., Reichlin S. Specific receptors for α-MSH are widely distributed in tissues of rodents. Endocrinology. 121:1987;1900-1907.
70. Traber J., Klein H. R., Gispen W. H. Actions of antidepressant and neuroleptic drugs on ACTH- and novelty-induced behavior in the rat. Eur. J. Pharmacol. 80:1982;407-414.
71. Van Bergen P., Janssen P. M., Hoogerhout P., De Wildt D. J., Versteeg D. H. Cardiovascular effects of γ-MSH/ACTH-like peptides structure-activity relationship . Eur. J. Pharmacol. 294:1995;795-803.
72. Van Bergen P. ;Van Der Vaart, J. G.;Kasbergen, C.M.; Versteeg, D. H.; De Wildt, D.J. Structure-activity analysis for the effects of γ-MSH/ACTH-like peptides on cerebral hemodynamics in rats. Eur. J. Pharmacol. 318:1995;357-368.
73. Van Nispen, J. W.; Greven, H. M. 1986 Structure-activity relationships of peptides derived from ACTH, β-LPH and MSH with regard to avoidance behavior in rats. In: De Wied, D.; Gispen, W. H.; Van Wimersma Greidanus, T. B., Eds. Neuropeptides and Behavior, Vol.1. Oxford: Pergamon; 1986:349-384.
74. Vanetti M., Schonrock C., Meyerhof W., Hollt V. Molecular cloning of a bovine MSH receptor which is highly expressed in the testis. FEBS Lett. 348:1994;268-272.
75. Watanabe T., Hiltz M. E., Catania A., Lipton J. M. Inhibition of interleukin-1-induced peripheral inflammation by peripheral and central administration of analogs of the neuropeptide αγ-MSH. Brain Res. Bull. 32:1993;311-314.
76. Watson S. J., Richard-III C. W., Barchas J. D. Adrenocorticotropin in rat brain immunocytochemical localization in cells and axons . Science. 200:1978;1180-1182.
77. Wiegant V. M., Jolles J., Colbern D. L., Zimmerman E., Gispen W. H. ntracerebroventricular ACTH activates the pituitary-adrenal system:dissociation from a behavioral response. Life Sci. 25:1979;1791-1796.
78. Xia Y., Wikberg J. E., Chhajlani V. Expression of melanocortin 1 receptor in periaqueductal gray matter. Neuroreport. 6:1995;2193-2196.
79. Zhou W., Flanagan C., Ballesteros J. A., Konvicka K., Davidson J. S., Weinstein H., Millar R. P., Sealfon S. C. A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol. Pharmacol. 45:1994;165-170.