-
1
-
-
26444611245
-
Flavones and flavone synthases
-
Martens, S.; Mithofer, A. Flavones and flavone synthases. Phytochemistry 2005, 66, 2399-407.
-
(2005)
Phytochemistry
, vol.66
, pp. 2399-2407
-
-
Martens, S.1
Mithofer, A.2
-
2
-
-
84861753441
-
-
U. S Patent 7465569 (International Flower Developments Proprietary Limited, Australia)
-
Mizutani, M.; Tanaka, Y.; Kusumi, T.; Ayabe, S.; Akashi, T. Flavone synthases, methods of using flavone synthases, and plants expressing flavone synthases. U. S Patent 7465569 (International Flower Developments Proprietary Limited, Australia) 2008.
-
(2008)
Flavone synthases, methods of using flavone synthases, and plants expressing flavone synthases
-
-
Mizutani, M.1
Tanaka, Y.2
Kusumi, T.3
Ayabe, S.4
Akashi, T.5
-
3
-
-
0033779923
-
Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective
-
Pichersky, E.; Gang, D.R. Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective. Trends Plant Sci. 2000, 5, 439-45.
-
(2000)
Trends Plant Sci
, vol.5
, pp. 439-445
-
-
Pichersky, E.1
Gang, D.R.2
-
4
-
-
0029174805
-
The molecular basis of infection and nodulation by Rhizobia: The ins and outs of sympathogenesis
-
Spaink, H.P. The molecular basis of infection and nodulation by Rhizobia: The ins and outs of sympathogenesis. Annu. Rev. Phytopathol. 1995, 33, 345-68.
-
(1995)
Annu. Rev. Phytopathol
, vol.33
, pp. 345-368
-
-
Spaink, H.P.1
-
5
-
-
0034736046
-
Advances in flavonoid research since 1992
-
Harborne, J.B.; Williams, C.A. Advances in flavonoid research since 1992. Phytochemistry 2000, 55, 481-504.
-
(2000)
Phytochemistry
, vol.55
, pp. 481-504
-
-
Harborne, J.B.1
Williams, C.A.2
-
6
-
-
67349160050
-
Plant polyphenols: Structure, occurrence and bioactivity
-
In Elsevier
-
Pietta, P.; Minoggio, M.; Bramati, L.; Rahman, A.-U. Plant polyphenols: Structure, occurrence and bioactivity. In Studies in Natural Products Chemistry, Elsevier: 2003; Vol. 28, Part 9, pp 257-312.
-
(2003)
Studies in Natural Products Chemistry
, vol.28
, Issue.PART 9
, pp. 257-312
-
-
Pietta, P.1
Minoggio, M.2
Bramati, L.3
Rahman, A.-U.4
-
7
-
-
78049242972
-
The biological potential of flavones
-
Verma, A.K.; Pratap, R. The biological potential of flavones. Nat. Prod. Rep. 2010, 27, 1571-93.
-
(2010)
Nat. Prod. Rep
, vol.27
, pp. 1571-1593
-
-
Verma, A.K.1
Pratap, R.2
-
8
-
-
16344370794
-
Flavonoid compounds: A review of anticancer properties and interactions with cis-Diamminedichloroplatinum(II)
-
Kosmider, B.; Osiecka, R. Flavonoid compounds: A review of anticancer properties and interactions with cis-Diamminedichloroplatinum(II). Drug Dev. Res. 2004, 63, 200-11.
-
(2004)
Drug Dev. Res
, vol.63
, pp. 200-211
-
-
Kosmider, B.1
Osiecka, R.2
-
9
-
-
0038807711
-
Flavonoids: Promising anticancer agents
-
Ren, W.; Qiao, Z.; Wang, H.; Lei Zhu, L.Z. Flavonoids: Promising anticancer agents. Med. Res. Rev. 2003, 23, 519-34.
-
(2003)
Med. Res. Rev
, vol.23
, pp. 519-534
-
-
Ren, W.1
Qiao, Z.2
Wang, H.3
Lei Zhu, L.Z.4
-
10
-
-
50249085093
-
Flavonoids as RTK inhibitors and potential anticancer agents
-
Teillet, F.; Boumendjel, A.; Boutonnat, J.; Ronot, X. Flavonoids as RTK inhibitors and potential anticancer agents. Med. Res. Rev. 2008, 28, 715-45.
-
(2008)
Med. Res. Rev
, vol.28
, pp. 715-745
-
-
Teillet, F.1
Boumendjel, A.2
Boutonnat, J.3
Ronot, X.4
-
11
-
-
0033855919
-
The therapeutic potential of flavonoids
-
Wang, H.K. The therapeutic potential of flavonoids. Expert Opin. Investig. Drugs 2000, 9, 2103-19.
-
(2000)
Expert Opin. Investig. Drugs
, vol.9
, pp. 2103-2119
-
-
Wang, H.K.1
-
12
-
-
0031688155
-
Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents
-
Wang, H.K.; Xia, Y.; Yang, Z.Y.; Natschke, S.L.; Lee, K.H. Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents. Adv. Exp. Med. Biol. 1998, 439, 191-225.
-
(1998)
Adv. Exp. Med. Biol
, vol.439
, pp. 191-225
-
-
Wang, H.K.1
Xia, Y.2
Yang, Z.Y.3
Natschke, S.L.4
Lee, K.H.5
-
13
-
-
0036720280
-
Recent advances in the discovery of flavonoids and analogs with highaffinity binding to P-glycoprotein responsible for cancer cell multidrug resistance
-
Boumendjel, A.; Pietro, A.D.; Dumontet, C.; Barron, D. Recent advances in the discovery of flavonoids and analogs with highaffinity binding to P-glycoprotein responsible for cancer cell multidrug resistance. Med. Res. Rev. 2002, 22, 512-29.
-
(2002)
Med. Res. Rev
, vol.22
, pp. 512-529
-
-
Boumendjel, A.1
Pietro, A.D.2
Dumontet, C.3
Barron, D.4
-
14
-
-
0023751792
-
The nutritional incidence of flavonoids: Some physiological and metabolic considerations
-
Roger, C.R. The nutritional incidence of flavonoids: Some physiological and metabolic considerations. Experientia 1988, 44, 725-33.
-
(1988)
Experientia
, vol.44
, pp. 725-733
-
-
Roger, C.R.1
-
15
-
-
0026661473
-
Scavenger and antioxidant properties of ten synthetic flavones
-
Cotelle, N.; Bernier, J.L.; Henichart, J.P.; Catteau, J.P.; Gaydou, E.; Wallet, J.C. Scavenger and antioxidant properties of ten synthetic flavones. Free Radic. Biol. Med. 1992, 13, 211-9.
-
(1992)
Free Radic. Biol. Med
, vol.13
, pp. 211-219
-
-
Cotelle, N.1
Bernier, J.L.2
Henichart, J.P.3
Catteau, J.P.4
Gaydou, E.5
Wallet, J.C.6
-
16
-
-
0004580398
-
Flavonoids: Old and new aspects of a class of natural therapeutic drugs
-
DiCarlo, G.; Mascolo, N.; Izzo, A.A.; Capasso, F. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci. 1999, 65, 337-53.
-
(1999)
Life Sci
, vol.65
, pp. 337-353
-
-
DiCarlo, G.1
Mascolo, N.2
Izzo, A.A.3
Capasso, F.4
-
17
-
-
0032815147
-
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines
-
Kuntz, S.; Wenzel, U.; Daniel, H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur. J. Nutr. 1999, 38, 133-42.
-
(1999)
Eur. J. Nutr
, vol.38
, pp. 133-142
-
-
Kuntz, S.1
Wenzel, U.2
Daniel, H.3
-
18
-
-
0033368232
-
Effects of flavonoids on the growth and cell cycle of cancer cells
-
Choi, S.U.; Ryu, S.Y.; Yoon, S.K.; Jung, N.P.; Park, S.H.; Kim, K.H.; Choi, E.J.; Lee, C.O. Effects of flavonoids on the growth and cell cycle of cancer cells. Anticancer Res. 1999, 19, 5229-33.
-
(1999)
Anticancer Res
, vol.19
, pp. 5229-5233
-
-
Choi, S.U.1
Ryu, S.Y.2
Yoon, S.K.3
Jung, N.P.4
Park, S.H.5
Kim, K.H.6
Choi, E.J.7
Lee, C.O.8
-
19
-
-
0038312107
-
Flavonoids-Novel lead compounds for the development of P2Y2 receptor antagonists
-
Kaulich, M.; Streicher, F.; Mayer, R.; Muller, I.; Muller, C.E. Flavonoids-Novel lead compounds for the development of P2Y2 receptor antagonists. Drug Dev. Res. 2003, 59, 72-81.
-
(2003)
Drug Dev. Res
, vol.59
, pp. 72-81
-
-
Kaulich, M.1
Streicher, F.2
Mayer, R.3
Muller, I.4
Muller, C.E.5
-
20
-
-
0027365576
-
Flavonoid inhibition of aromatase enzyme activity in human preadipocytes
-
Campbell, D.R.; Kurzer, M.S. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J. Steroid Biochem. Mol. Biol. 1993, 46, 381-8.
-
(1993)
J. Steroid Biochem. Mol. Biol
, vol.46
, pp. 381-388
-
-
Campbell, D.R.1
Kurzer, M.S.2
-
22
-
-
0025189757
-
Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol
-
Yamashita, Y.; Kawada, S.; Nakano, H. Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol. Biochem. Pharmacol. 1990, 39, 737-44.
-
(1990)
Biochem. Pharmacol
, vol.39
, pp. 737-744
-
-
Yamashita, Y.1
Kawada, S.2
Nakano, H.3
-
23
-
-
0024550507
-
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
-
Ferriola, P.C.; Cody, V.; Middleton, E. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem. Pharmacol. 1989, 38, 1617-24.
-
(1989)
Biochem. Pharmacol
, vol.38
, pp. 1617-1624
-
-
Ferriola, P.C.1
Cody, V.2
Middleton, E.3
-
24
-
-
51849133195
-
Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells
-
Lin, C.W.; Hou, W.C.; Shen, S.C.; Juan, S.H.; Ko, C.H.; Wang, L.M.; Chen, Y.C. Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 2008, 29, 1807-15.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1807-1815
-
-
Lin, C.W.1
Hou, W.C.2
Shen, S.C.3
Juan, S.H.4
Ko, C.H.5
Wang, L.M.6
Chen, Y.C.7
-
25
-
-
0035489192
-
Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin
-
Choi, J.A.; Kim, J.Y.; Lee, J.Y.; Kang, C.M.; Kwon, H.J.; Yoo, Y.D.; Kim, T.W.; Lee, Y.S.; Lee, S.J. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int. J. Oncol. 2001, 19, 837-44.
-
(2001)
Int. J. Oncol
, vol.19
, pp. 837-844
-
-
Choi, J.A.1
Kim, J.Y.2
Lee, J.Y.3
Kang, C.M.4
Kwon, H.J.5
Yoo, Y.D.6
Kim, T.W.7
Lee, Y.S.8
Lee, S.J.9
-
26
-
-
0031921546
-
Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an Increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclindependent kinases and associated cyclins
-
Zi, X.; Feyes, D.K.; Agarwal, R. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an Increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclindependent kinases and associated cyclins. Clin. Cancer Res. 1998, 4, 1055-64.
-
(1998)
Clin. Cancer Res
, vol.4
, pp. 1055-1064
-
-
Zi, X.1
Feyes, D.K.2
Agarwal, R.3
-
27
-
-
0028104631
-
Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src
-
Cushman, M.; Zhu, H.; Geahlen, R.L.; Kraker, A.J. Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J. Med. Chem. 1994, 37, 3353-62.
-
(1994)
J. Med. Chem
, vol.37
, pp. 3353-3362
-
-
Cushman, M.1
Zhu, H.2
Geahlen, R.L.3
Kraker, A.J.4
-
28
-
-
0035141075
-
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies
-
Senderowicz, A.M. Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. Leukemia 2001, 15, 1-9.
-
(2001)
Leukemia
, vol.15
, pp. 1-9
-
-
Senderowicz, A.M.1
-
29
-
-
0023945117
-
6-Dimethylaminopurine blocks starsh oocyte maturation by inhibiting a relevant protein kinase activity
-
Neant, I.; Guerrier, P. 6-Dimethylaminopurine blocks starsh oocyte maturation by inhibiting a relevant protein kinase activity. Exp. Cell Res. 1988, 176, 68-79.
-
(1988)
Exp. Cell Res
, vol.176
, pp. 68-79
-
-
Neant, I.1
Guerrier, P.2
-
30
-
-
0028093182
-
Inhibition of cyclin-dependent kinases by purine derivatives
-
Vesely, J.; Havlicek, L.; Strnad, M.; Blow, J.J.; Donella-Deana, A.; Pinna, L.; Letham, D.S.; Kato, J.Y.; DeÂtivaud, L.; Leclerc, J.; Meijer, L. Inhibition of cyclin-dependent kinases by purine derivatives. Eur. J. Biochem. 1994, 224, 771-9.
-
(1994)
Eur. J. Biochem
, vol.224
, pp. 771-779
-
-
Vesely, J.1
Havlicek, L.2
Strnad, M.3
Blow, J.J.4
Donella-Deana, A.5
Pinna, L.6
Letham, D.S.7
Kato, J.Y.8
DeÂtivaud, L.9
Leclerc, J.10
Meijer, L.11
-
31
-
-
0031037714
-
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
-
Meijer, L.; Borgne, A.; Mulner, O.; Chong, J.P.; Blow, J.J.; Inagaki, N.; Inagaki, M.; Delcros, J.G.; Moulinoux, J.P. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 1997, 243, 527-36.
-
(1997)
Eur. J. Biochem
, vol.243
, pp. 527-536
-
-
Meijer, L.1
Borgne, A.2
Mulner, O.3
Chong, J.P.4
Blow, J.J.5
Inagaki, N.6
Inagaki, M.7
Delcros, J.G.8
Moulinoux, J.P.9
-
32
-
-
0344809977
-
ATP-site directed inhibitors of cyclin-dependent kinases
-
Gray, N.; Detivaud, L.; Doerig, C.; Meijer, L. ATP-site directed inhibitors of cyclin-dependent kinases. Curr. Med. Chem. 1999, 6, 859-75.
-
(1999)
Curr. Med. Chem
, vol.6
, pp. 859-875
-
-
Gray, N.1
Detivaud, L.2
Doerig, C.3
Meijer, L.4
-
33
-
-
0032563315
-
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
-
Gray, N.S.; Wodicka, L.; Thunnissen, A.M.; Norman, T.C.; Kwon, S.; Espinoza, F.H.; Morgan, D.O.; Barnes, G.; LeClerc, S.; Meijer, L.; Kim, S.H.; Lockhart, D.J.; Schultz, P.G. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 1998, 281, 533-8.
-
(1998)
Science
, vol.281
, pp. 533-538
-
-
Gray, N.S.1
Wodicka, L.2
Thunnissen, A.M.3
Norman, T.C.4
Kwon, S.5
Espinoza, F.H.6
Morgan, D.O.7
Barnes, G.8
LeClerc, S.9
Meijer, L.10
Kim, S.H.11
Lockhart, D.J.12
Schultz, P.G.13
-
34
-
-
13444311605
-
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor fisetin
-
Lu, H.; Chang, D.J.; Baratte, B.; Meijer, L.; Schulze-Gahmen, U. Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor fisetin. J. Med. Chem. 2005, 48, 737-43.
-
(2005)
J. Med. Chem
, vol.48
, pp. 737-743
-
-
Lu, H.1
Chang, D.J.2
Baratte, B.3
Meijer, L.4
Schulze-Gahmen, U.5
-
35
-
-
48449094373
-
Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity
-
Zhang, S.; Ma, J.; Bao, Y.; Yang, P.; Zou, L.; Li, K.; Sun, X. Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity. Bioorg. Med. Chem. 2008, 16, 7128-33.
-
(2008)
Bioorg. Med. Chem
, vol.16
, pp. 7128-7133
-
-
Zhang, S.1
Ma, J.2
Bao, Y.3
Yang, P.4
Zou, L.5
Li, K.6
Sun, X.7
-
36
-
-
17444390875
-
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells
-
Lee, H.Z.; Leung, H.W.; Lai, M.Y.; Wu, C.H. Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res. 2005, 25, 959-64.
-
(2005)
Anticancer Res
, vol.25
, pp. 959-964
-
-
Lee, H.Z.1
Leung, H.W.2
Lai, M.Y.3
Wu, C.H.4
-
37
-
-
27644568638
-
Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression
-
Vijayababu, M.R.; Kanagaraj, P.; Arunkumar, A.; Ilangovan, R.; Aruldhas, M.M.; Arunakaran, J. Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression. J. Cancer Res. Clin. Oncol. 2005, 131, 765-71.
-
(2005)
J. Cancer Res. Clin. Oncol
, vol.131
, pp. 765-771
-
-
Vijayababu, M.R.1
Kanagaraj, P.2
Arunkumar, A.3
Ilangovan, R.4
Aruldhas, M.M.5
Arunakaran, J.6
-
38
-
-
84856171519
-
Chromone and flavonoid alkaloids: Occurrence and bioactivity
-
Khadem, S.; Marles, R.J. Chromone and flavonoid alkaloids: Occurrence and bioactivity. Molecules 2012, 17, 191-206.
-
(2012)
Molecules
, vol.17
, pp. 191-206
-
-
Khadem, S.1
Marles, R.J.2
-
39
-
-
0018396088
-
The structure of rohitukine, the main alkaloid of Amoora rohituka (syn Aphanamixis polystachya) (Meliaceae)
-
Harmon, A.D.; Weiss, U.; Silverton, J.V. The structure of rohitukine, the main alkaloid of Amoora rohituka (syn. Aphanamixis polystachya) (Meliaceae). Tetrahedron Lett. 1979, 8, 721-4.
-
(1979)
Tetrahedron Lett
, vol.8
, pp. 721-724
-
-
Harmon, A.D.1
Weiss, U.2
Silverton, J.V.3
-
40
-
-
0023924162
-
An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from Dysoxylum binectariferum: Isolation, structure and total synthesis
-
Naik, R.G.; Kattige, S.L.; Bhat, S.V.; Alreja, B.; de Souza, N.J.; Rupp, R.H. An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from Dysoxylum binectariferum: isolation, structure and total synthesis. Tetrahedron 1988, 44, 2081-6.
-
(1988)
Tetrahedron
, vol.44
, pp. 2081-2086
-
-
Naik, R.G.1
Kattige, S.L.2
Bhat, S.V.3
Alreja, B.4
de Souza, N.J.5
Rupp, R.H.6
-
41
-
-
77956637674
-
Flavopiridol, the first cyclin-dependent kinase inhibitor: Recent advances in combination chemotherapy
-
Wang, L.M.; Ren, D.M. Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy. Mini-Rev. Med. Chem. 2010, 10, 1058-70.
-
(2010)
Mini-Rev. Med. Chem
, vol.10
, pp. 1058-1070
-
-
Wang, L.M.1
Ren, D.M.2
-
42
-
-
0007231666
-
-
U. S, Patent 4,900,727, Feb 13
-
Kattige, S.L.; Naik, R.G.; Lakdawalla, A.D.; Alihussein, N.D.; Rupp, R.H.; Souza, N.J. 4H-Benzopyran-4-one Compounds Which Have Antiinflammatory or Immunomodulating Action. U.S. Patent 4,900,727, Feb 13, 1990.
-
(1990)
4H-Benzopyran-4-one Compounds Which Have Antiinflammatory or Immunomodulating Action
-
-
Kattige, S.L.1
Naik, R.G.2
Lakdawalla, A.D.3
Alihussein, N.D.4
Rupp, R.H.5
Souza, N.J.6
-
43
-
-
0041145892
-
Application of modified flavone closure for the preparation of racemic L86-8275
-
Tabaka, A.C.; Murthi, K.K.; Pal, K.; Teleha, C.A. Application of modified flavone closure for the preparation of racemic L86-8275. Org. Proc. Res. Dev. 1999, 3, 256-9.
-
(1999)
Org. Proc. Res. Dev
, vol.3
, pp. 256-259
-
-
Tabaka, A.C.1
Murthi, K.K.2
Pal, K.3
Teleha, C.A.4
-
44
-
-
0034597571
-
Thio-and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: Synthesis and biological effects
-
Kim, K.S.; Sack, J.S.; Tokarski, J.S.; Qian, L.; Chao, S.T.; Leith, L.; Kelly, Y.F.; Misra, R.N.; Hunt, J.T.; Kimball, S.D.; Humphreys, W.G.; Wautlet, B.S.; Mulheron, J.G.; Webster, K.R. Thio-and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J. Med. Chem. 2000, 43, 4126-34.
-
(2000)
J. Med. Chem
, vol.43
, pp. 4126-4134
-
-
Kim, K.S.1
Sack, J.S.2
Tokarski, J.S.3
Qian, L.4
Chao, S.T.5
Leith, L.6
Kelly, Y.F.7
Misra, R.N.8
Hunt, J.T.9
Kimball, S.D.10
Humphreys, W.G.11
Wautlet, B.S.12
Mulheron, J.G.13
Webster, K.R.14
-
45
-
-
0037171721
-
Structurebased design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics
-
Schoepfer, J.; Fretz, H.; Chaudhuri, B.; Muller, L.; Seeber, E.; Meijer, L.; Lozach, O.; Vangrevelinghe, E.; Furet, P. Structurebased design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics. J. Med. Chem. 2002, 45, 1741-7.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1741-1747
-
-
Schoepfer, J.1
Fretz, H.2
Chaudhuri, B.3
Muller, L.4
Seeber, E.5
Meijer, L.6
Lozach, O.7
Vangrevelinghe, E.8
Furet, P.9
-
46
-
-
84861738354
-
-
WO2008007169 (Piramal Life Science Ltd, India)
-
Sivakumar, M.; Shukla, M.; Jadhav, P.K.; Borhade, A. An enantioselective synthesis of pyrrolidine-substituted flavones. WO2008007169 (Piramal Life Science Ltd. India), 2008.
-
(2008)
An enantioselective synthesis of pyrrolidine-substituted flavones
-
-
Sivakumar, M.1
Shukla, M.2
Jadhav, P.K.3
Borhade, A.4
-
47
-
-
70349558526
-
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication
-
Ali, A.; Ghosh, A.; Nathans, R.S.; Sharova, N.; O'Brien, S.; Cao, H.; Stevenson, M.; Rana, T.M. Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. ChemBioChem 2009, 10, 2072-80.
-
(2009)
ChemBioChem
, vol.10
, pp. 2072-2080
-
-
Ali, A.1
Ghosh, A.2
Nathans, R.S.3
Sharova, N.4
O'Brien, S.5
Cao, H.6
Stevenson, M.7
Rana, T.M.8
-
48
-
-
0034657527
-
Structure-activity relationship studies of flavopiridol analogues
-
Murthi, K.K.; Dubay, M.; McClure, C.; Brizuela, L.; Boisclair, M.D.; Worland, P.J.; Mansuri, M.M.; Pal, K. Structure-activity relationship studies of flavopiridol analogues. Bioorg. Med. Chem. Lett. 2000, 10, 1037-41.
-
(2000)
Bioorg. Med. Chem. Lett
, vol.10
, pp. 1037-1041
-
-
Murthi, K.K.1
Dubay, M.2
McClure, C.3
Brizuela, L.4
Boisclair, M.D.5
Worland, P.J.6
Mansuri, M.M.7
Pal, K.8
-
49
-
-
33845425572
-
Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues
-
Ahn, Y.M.; Vogeti, L.; Liu, C.J.; Santhapuram, H.K.; White, J.M.; Vasandani, V.; Mitscher, L.A.; Lushington, G.H.; Hanson, P.R.; Powell, D.R.; Himes, R.H.; Roby, K.F.; Ye, Q.; Georg, G.I. Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues. Bioorg. Med. Chem. 2007, 15, 702-13.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 702-713
-
-
Ahn, Y.M.1
Vogeti, L.2
Liu, C.J.3
Santhapuram, H.K.4
White, J.M.5
Vasandani, V.6
Mitscher, L.A.7
Lushington, G.H.8
Hanson, P.R.9
Powell, D.R.10
Himes, R.H.11
Roby, K.F.12
Ye, Q.13
Georg, G.I.14
-
50
-
-
34147127727
-
In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor P276-00
-
Joshi, K.S.; Rathos, M.J.; Joshi, R.D.; Sivakumar, M.; Mascarenhas, M.; Kamble, S.; Lal, B.; Sharma, S. In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor P276-00. Mol. Cancer Ther. 2007, 6, 918-25.
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 918-925
-
-
Joshi, K.S.1
Rathos, M.J.2
Joshi, R.D.3
Sivakumar, M.4
Mascarenhas, M.5
Kamble, S.6
Lal, B.7
Sharma, S.8
-
51
-
-
67349099081
-
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
-
Raje, N.; Hideshima, T.; Mukherjee, S.; Raab, M.; Vallet, S.; Chhetri, S.; Cirstea, D.; Pozzi, S.; Mitsiades, C.; Rooney, M.; Kiziltepe, T.; Podar, K.; Okawa, Y.; Ikeda, H.; Carrasco, R.; Richardson, P.G.; Chauhan, D.; Munshi, N.C.; Sharma, S.; Parikh, H.; Chabner, B.; Scadden, D.; Anderson, K.C. Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma. Leukemia 2009, 23, 961-70.
-
(2009)
Leukemia
, vol.23
, pp. 961-970
-
-
Raje, N.1
Hideshima, T.2
Mukherjee, S.3
Raab, M.4
Vallet, S.5
Chhetri, S.6
Cirstea, D.7
Pozzi, S.8
Mitsiades, C.9
Rooney, M.10
Kiziltepe, T.11
Podar, K.12
Okawa, Y.13
Ikeda, H.14
Carrasco, R.15
Richardson, P.G.16
Chauhan, D.17
Munshi, N.C.18
Sharma, S.19
Parikh, H.20
Chabner, B.21
Scadden, D.22
Anderson, K.C.23
more..
-
52
-
-
0033375469
-
Flavopiridol: The first cyclin-dependent kinase inhibitor in human clinical trials
-
Senderowicz, A.M. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Invest. New Drugs 1999, 17, 313-20.
-
(1999)
Invest. New Drugs
, vol.17
, pp. 313-320
-
-
Senderowicz, A.M.1
-
53
-
-
0026452974
-
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
-
Kaur, G.; Stetler-Stevenson, M.; Sebers, S.; Worland, P.; Sedlacek, H.; Myers, C.; Czech, J.; Naik, R.; Sausville, E. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl. Cancer Inst. 1992, 84, 1736-40.
-
(1992)
J. Natl. Cancer Inst
, vol.84
, pp. 1736-1740
-
-
Kaur, G.1
Stetler-Stevenson, M.2
Sebers, S.3
Worland, P.4
Sedlacek, H.5
Myers, C.6
Czech, J.7
Naik, R.8
Sausville, E.9
-
54
-
-
0028176485
-
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275
-
Losiewicz, M.D.; Carlson, B.A.; Kaur, G.; Sausville, E.A.; Worland, P.J. Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. Biochem. Biophys. Res. Commun. 1994, 201, 589-95.
-
(1994)
Biochem. Biophys. Res. Commun
, vol.201
, pp. 589-595
-
-
Losiewicz, M.D.1
Carlson, B.A.2
Kaur, G.3
Sausville, E.A.4
Worland, P.J.5
-
55
-
-
0035055595
-
Mechanisms of action of flavopiridol
-
Sedlacek, H.H. Mechanisms of action of flavopiridol. Crit. Rev. Oncol. Hematol. 2001, 38, 139-70.
-
(2001)
Crit. Rev. Oncol. Hematol
, vol.38
, pp. 139-170
-
-
Sedlacek, H.H.1
-
56
-
-
0035808457
-
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
-
Leclerc, S.; Garnier, M.; Hoessel, R.; Marko, D.; Bibb, J.A.; Snyder, G.L.; Greengard, P.; Biernat, J.; Wu, Y.Z.; Mandelkow, E.M.; Eisenbrand, G.; Meijer, L. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J. Biol. Chem. 2001, 276, 251-60.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 251-260
-
-
Leclerc, S.1
Garnier, M.2
Hoessel, R.3
Marko, D.4
Bibb, J.A.5
Snyder, G.L.6
Greengard, P.7
Biernat, J.8
Wu, Y.Z.9
Mandelkow, E.M.10
Eisenbrand, G.11
Meijer, L.12
-
57
-
-
0029665778
-
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
-
Carlson, B.A.; Dubay, M.M.; Sausville, E.A.; Brizuela, L.; Worland, P.J. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res. 1996, 56, 2973-8.
-
(1996)
Cancer Res
, vol.56
, pp. 2973-2978
-
-
Carlson, B.A.1
Dubay, M.M.2
Sausville, E.A.3
Brizuela, L.4
Worland, P.J.5
-
58
-
-
0033646291
-
Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: Current status
-
Kelland, L.R. Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status. Expert Opin. Investig. Drugs 2000, 9, 2903-11.
-
(2000)
Expert Opin. Investig. Drugs
, vol.9
, pp. 2903-2911
-
-
Kelland, L.R.1
-
59
-
-
0027433237
-
Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity
-
Worland, P.J.; Kaur, G.; Stetler-Stevenson, M.; Sebers, S.; Sartor, O.; Sausville, E.A. Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochem. Pharmacol. 1993, 46, 1831-40.
-
(1993)
Biochem. Pharmacol
, vol.46
, pp. 1831-1840
-
-
Worland, P.J.1
Kaur, G.2
Stetler-Stevenson, M.3
Sebers, S.4
Sartor, O.5
Sausville, E.A.6
-
60
-
-
0037311226
-
Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-a or TNF-related apoptosis-inducing ligand in human cancer cell lines
-
Kim, D.M.; Koo, S.Y.; Jeon, K.; Kim, M.H.; Lee, J.; Hong, C.Y.; Jeong, S. Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-a or TNF-related apoptosis-inducing ligand in human cancer cell lines. Cancer Res. 2003, 63, 621-6.
-
(2003)
Cancer Res
, vol.63
, pp. 621-626
-
-
Kim, D.M.1
Koo, S.Y.2
Jeon, K.3
Kim, M.H.4
Lee, J.5
Hong, C.Y.6
Jeong, S.7
-
61
-
-
0037609180
-
Protein kinase C-dependent activation of the Tumor necrosis factor receptor-mediated extrinsic cell Death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol
-
Cartee, L.; Maggio, S.C.; Smith, R.; Sankala, H.M.; Dent, P.; Gran, S. Protein kinase C-dependent activation of the Tumor necrosis factor receptor-mediated extrinsic cell Death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol. Mol. Cancer Ther. 2003, 2, 83-93.
-
(2003)
Mol. Cancer Ther
, vol.2
, pp. 83-93
-
-
Cartee, L.1
Maggio, S.C.2
Smith, R.3
Sankala, H.M.4
Dent, P.5
Gran, S.6
-
62
-
-
0036632965
-
Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: Association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways
-
Wu, K.; Wang, C.; D'Amico, M.; Lee, R.J.; Albanese, C.; Pestell, R.G.; Mani, S. Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: Association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways. Mol. Cancer Ther. 2002, 1, 695-706.
-
(2002)
Mol. Cancer Ther
, vol.1
, pp. 695-706
-
-
Wu, K.1
Wang, C.2
D'Amico, M.3
Lee, R.J.4
Albanese, C.5
Pestell, R.G.6
Mani, S.7
-
63
-
-
0037089564
-
Rate-limiting effects of cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol
-
Nahta, R.; Iglehart, J.D.; Kempkes, B.; Schmidt, E.V. Rate-limiting effects of cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol. Cancer Res. 2002, 62, 2267-71.
-
(2002)
Cancer Res
, vol.62
, pp. 2267-2271
-
-
Nahta, R.1
Iglehart, J.D.2
Kempkes, B.3
Schmidt, E.V.4
-
64
-
-
0032055497
-
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts
-
Arguello, F.; Alexander, M.; Sterry, J.A.; Tudor, G.; Smith, E.M.; Kalavar, N.T.; Greene, J.F.; Koss, W.; Morgan, C.D.; Stinson, S.F.; Siford, T.J.; Alvord, W.G.; Klabansky, R.L.; Sausville, E.A. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts. Blood 1998, 91, 2482-90.
-
(1998)
Blood
, vol.91
, pp. 2482-2490
-
-
Arguello, F.1
Alexander, M.2
Sterry, J.A.3
Tudor, G.4
Smith, E.M.5
Kalavar, N.T.6
Greene, J.F.7
Koss, W.8
Morgan, C.D.9
Stinson, S.F.10
Siford, T.J.11
Alvord, W.G.12
Klabansky, R.L.13
Sausville, E.A.14
-
65
-
-
0036850211
-
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down regulation of Mcl-1
-
Gojo, I.; Zhang, B.; Fenton, R.G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down regulation of Mcl-1. Clin. Cancer Res. 2002, 8, 3527-38.
-
(2002)
Clin. Cancer Res
, vol.8
, pp. 3527-3538
-
-
Gojo, I.1
Zhang, B.2
Fenton, R.G.3
-
66
-
-
20244362748
-
Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis
-
Wittmann, S.; Bali, P.; Donapaty, S.; Nimmanapalli, R.; Guo, F.; Yamaguchi, H.; Huang, M.; Jove, R.; Wang, H.G.; Bhalla, K. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. Cancer Res. 2003, 63, 93-9.
-
(2003)
Cancer Res
, vol.63
, pp. 93-99
-
-
Wittmann, S.1
Bali, P.2
Donapaty, S.3
Nimmanapalli, R.4
Guo, F.5
Yamaguchi, H.6
Huang, M.7
Jove, R.8
Wang, H.G.9
Bhalla, K.10
-
67
-
-
0033568521
-
Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
-
Carlson, B.; Lahusen, T.; Singh, S.; Loaiza-Perez, A.; Worland, P.J.; Pestell, R.; Chris Albanese; Sausville, E.A.; Senderowicz, A.M. Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res. 1999, 59, 4634-41.
-
(1999)
Cancer Res
, vol.59
, pp. 4634-4641
-
-
Carlson, B.1
Lahusen, T.2
Singh, S.3
Loaiza-Perez, A.4
Worland, P.J.5
Pestell, R.6
Chris, A.7
Sausville, E.A.8
Senderowicz, A.M.9
-
68
-
-
0036101635
-
Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma
-
Rapella, A.; Negrioli, A.; Melillo, G.; Pastorino, S.; Varesio, L.; Bosco, M.C. Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. Int. J. Cancer 2002, 99, 658-64.
-
(2002)
Int. J. Cancer
, vol.99
, pp. 658-664
-
-
Rapella, A.1
Negrioli, A.2
Melillo, G.3
Pastorino, S.4
Varesio, L.5
Bosco, M.C.6
-
69
-
-
0033231301
-
Flavopiridol, a protein kinase inhibitor, downregulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
-
Melillo, G.; Sausville, E.A.; Cloud, K.; Lahusen, T.; Varesio, L.; Senderowicz, A.M. Flavopiridol, a protein kinase inhibitor, downregulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res. 1999, 59, 5433-7.
-
(1999)
Cancer Res
, vol.59
, pp. 5433-5437
-
-
Melillo, G.1
Sausville, E.A.2
Cloud, K.3
Lahusen, T.4
Varesio, L.5
Senderowicz, A.M.6
-
70
-
-
1042278138
-
Flavopiridol inhibits NF-kB activation induced by various carcinogens and inflammatory agents through inhibition of IkBa kinase and p65 phosphorylation
-
Takada, Y.; Aggarwal, B.B. Flavopiridol inhibits NF-kB activation induced by various carcinogens and inflammatory agents through inhibition of IkBa kinase and p65 phosphorylation. J. Biol. Chem. 2004, 279, 4750-9.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 4750-4759
-
-
Takada, Y.1
Aggarwal, B.B.2
-
71
-
-
0028953560
-
Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck
-
Michalides, R.; van Veelen, N.; Hart, A.; Loftus, B.; Wientjens, E.; Balm, A. Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res. 1995, 55, 975-8.
-
(1995)
Cancer Res
, vol.55
, pp. 975-978
-
-
Michalides, R.1
van Veelen, N.2
Hart, A.3
Loftus, B.4
Wientjens, E.5
Balm, A.6
-
72
-
-
0040379168
-
Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells
-
Brusselbach, S.; Nettelbeck, D.M.; Sedlacek, H.H.; Muller, R. Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells. Int. J. Cancer 1998, 77, 146-52.
-
(1998)
Int. J. Cancer
, vol.77
, pp. 146-152
-
-
Brusselbach, S.1
Nettelbeck, D.M.2
Sedlacek, H.H.3
Muller, R.4
-
73
-
-
0033065782
-
Novel small molecule alpha v integrin antagonists: Comparative anti-cancer efficacy with known angiogenesis inhibitors
-
Kerr, J.S.; Wexler, R.S.; Mousa, S.A.; Robinson, C.S.; Wexler, E.J.; Mohamed, S.; Voss, M.E.; Devenny, J.J.; Czerniak, P.M.; Gudzelak, A.; Slee, A.M. Novel small molecule alpha v integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors. Anticancer Res. 1999, 19, 959-68.
-
(1999)
Anticancer Res
, vol.19
, pp. 959-968
-
-
Kerr, J.S.1
Wexler, R.S.2
Mousa, S.A.3
Robinson, C.S.4
Wexler, E.J.5
Mohamed, S.6
Voss, M.E.7
Devenny, J.J.8
Czerniak, P.M.9
Gudzelak, A.10
Slee, A.M.11
-
74
-
-
0029807115
-
Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
-
Sedlacek, H.; Czech, J.; Naik, R.; Kaur, G.; Worland, P.; Losiewicz, M.; Parker, B.; Carlson, B.; Smith, A.; Senderowicz, A.; Sausville, E. Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int. J. Oncol. 1996, 9, 1143-68.
-
(1996)
Int. J. Oncol
, vol.9
, pp. 1143-1168
-
-
Sedlacek, H.1
Czech, J.2
Naik, R.3
Kaur, G.4
Worland, P.5
Losiewicz, M.6
Parker, B.7
Carlson, B.8
Smith, A.9
Senderowicz, A.10
Sausville, E.11
-
75
-
-
0033646291
-
Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: Current status
-
Kelland, L.R. Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status. Expert Opin. Investig. Drugs 2000, 9, 2903-11.
-
(2000)
Expert Opin. Investig. Drugs
, vol.9
, pp. 2903-2911
-
-
Kelland, L.R.1
-
76
-
-
0031019034
-
Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells
-
Drees, M.; Dengler, W.A.; Roth, T.; Labonte, H.; Mayo, J.; Malspeis, L.; Grever, M.; Sausville, E.A.; Fiebig, H.H. Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin. Cancer Res. 1997, 3, 273-9.
-
(1997)
Clin. Cancer Res
, vol.3
, pp. 273-279
-
-
Drees, M.1
Dengler, W.A.2
Roth, T.3
Labonte, H.4
Mayo, J.5
Malspeis, L.6
Grever, M.7
Sausville, E.A.8
Fiebig, H.H.9
-
77
-
-
0032533599
-
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
-
Byrd, J.C.; Shinn, C.; Waselenko, J.K.; Fuchs, E.J.; Lehman, T.A.; Nguyen, P.L. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood 1998, 92, 3804-16.
-
(1998)
Blood
, vol.92
, pp. 3804-3816
-
-
Byrd, J.C.1
Shinn, C.2
Waselenko, J.K.3
Fuchs, E.J.4
Lehman, T.A.5
Nguyen, P.L.6
-
78
-
-
0036450831
-
Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol
-
Thomas, J.P.; Tutsch, K.D.; Cleary, J.F.; Bailey, H.H.; Arzoomanian, R.; Alberti, D. Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. Cancer Chemother. Pharmacol. 2002, 50, 465-72.
-
(2002)
Cancer Chemother. Pharmacol
, vol.50
, pp. 465-472
-
-
Thomas, J.P.1
Tutsch, K.D.2
Cleary, J.F.3
Bailey, H.H.4
Arzoomanian, R.5
Alberti, D.6
-
79
-
-
0031963058
-
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
-
Parker, B.W.; Kaur, G.; Nieves-Neira, W.; Taimi, M.; Kohlhagen, G.; Shimizu, T.; Losiewicz, M.D.; Pommier, Y.; Sausville, E.A.; Senderowicz, A.M. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 1998, 91, 458-65.
-
(1998)
Blood
, vol.91
, pp. 458-465
-
-
Parker, B.W.1
Kaur, G.2
Nieves-Neira, W.3
Taimi, M.4
Kohlhagen, G.5
Shimizu, T.6
Losiewicz, M.D.7
Pommier, Y.8
Sausville, E.A.9
Senderowicz, A.M.10
-
80
-
-
0032055497
-
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts
-
Arguello, F.; Alexander, M.; Sterry, J.A.; Tudor, G.; Smith, E.M.; Kalavar, N.T.; Greene, J.F., Jr.; Koss, W.; Morgan, C.D.; Stinson, S.F.; Siford, T.J.; Alvord, W.G.; Klabansky, R.L.; Sausville, E.A. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts. Blood 1998, 91, 2482-90.
-
(1998)
Blood
, vol.91
, pp. 2482-2490
-
-
Arguello, F.1
Alexander, M.2
Sterry, J.A.3
Tudor, G.4
Smith, E.M.5
Kalavar, N.T.6
Greene Jr., J.F.7
Koss, W.8
Morgan, C.D.9
Stinson, S.F.10
Siford, T.J.11
Alvord, W.G.12
Klabansky, R.L.13
Sausville, E.A.14
-
81
-
-
85017360144
-
Kinase inhibitors: Approved drugs and clinical candidates
-
In 7th ed.; Abraham, D.J.; Rotella, D.P., Eds. John Wiley & Sons, Inc
-
Bradbury, R.H. Kinase inhibitors: Approved drugs and clinical candidates. In Burger's medicinal chemistry, drug discovery, and development, 7th ed.; Abraham, D.J.; Rotella, D.P., Eds. John Wiley & Sons, Inc.: 2010.
-
(2010)
Burger's medicinal chemistry, drug discovery, and development
-
-
Bradbury, R.H.1
-
82
-
-
70450280886
-
Cyclin-dependent kinase inhibitors as potential targeted anticancer agents
-
Diaz-Padilla, I.; Siu, L.L.; Duran, I. Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest. New Drugs 2009, 27, 586-94.
-
(2009)
Invest. New Drugs
, vol.27
, pp. 586-594
-
-
Diaz-Padilla, I.1
Siu, L.L.2
Duran, I.3
-
83
-
-
3542996265
-
Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor in untreated metastatic malignant melanoma
-
Burdette-Radoux, S.; Tozer, R.G.; Lohmann, R.C.; Quirt, I.; Ernst, D.S.; Walsh, W. Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor in untreated metastatic malignant melanoma. Invest. New Drugs 2004, 22, 315-22.
-
(2004)
Invest. New Drugs
, vol.22
, pp. 315-322
-
-
Burdette-Radoux, S.1
Tozer, R.G.2
Lohmann, R.C.3
Quirt, I.4
Ernst, D.S.5
Walsh, W.6
-
84
-
-
10744230675
-
A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer
-
Liu, G.; Gandara, D.R.; Lara, P.; Raghavan, D.; Doroshow, J.H.; Twardowski, P. A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer. Clin. Cancer Res. 2004, 10, 924-8.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 924-928
-
-
Liu, G.1
Gandara, D.R.2
Lara, P.3
Raghavan, D.4
Doroshow, J.H.5
Twardowski, P.6
-
85
-
-
0033955395
-
Flavopiridol, a novel cyclin-dependent kinase inhibitor in metastatic renal cancer: A University of Chicago Phase II consortium study
-
Stadler, W.M.; Vogelzang, N.J.; Amato, R.; Sosman, J.; Taber, D.; Liebowitz, D.; Vokes, E.E. Flavopiridol, a novel cyclin-dependent kinase inhibitor in metastatic renal cancer: A University of Chicago Phase II consortium study. J. Clin. Oncol. 2000, 18, 371-5.
-
(2000)
J. Clin. Oncol
, vol.18
, pp. 371-375
-
-
Stadler, W.M.1
Vogelzang, N.J.2
Amato, R.3
Sosman, J.4
Taber, D.5
Liebowitz, D.6
Vokes, E.E.7
-
86
-
-
20344387478
-
Chronic lymphocytic leukemia: A niche for flavopiridol?
-
Brown, J.R. Chronic lymphocytic leukemia: a niche for flavopiridol? Clin. Cancer Res. 2005, 11, 3971-3.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 3971-3973
-
-
Brown, J.R.1
-
87
-
-
34848818485
-
Flavopiridol in the treatment of chronic lymphocytic leukemia
-
Christian, B.A.; Grever, M.R.; Byrd, J.C.; Lin, T.S. Flavopiridol in the treatment of chronic lymphocytic leukemia. Curr. Opin. Oncol. 2007, 19, 573-8.
-
(2007)
Curr. Opin. Oncol
, vol.19
, pp. 573-578
-
-
Christian, B.A.1
Grever, M.R.2
Byrd, J.C.3
Lin, T.S.4
-
88
-
-
33645542538
-
Clinical progress of selective cyclin dependent kinase (CDK) inhibitors
-
Misra, R.N. Clinical progress of selective cyclin dependent kinase (CDK) inhibitors. Drugs Future 2006, 31, 43-52.
-
(2006)
Drugs Future
, vol.31
, pp. 43-52
-
-
Misra, R.N.1
-
89
-
-
17144391819
-
Flavopiridol, an inhibitor of transcription. Implications, problems and solutions
-
Blagosklonny, M.V. Flavopiridol, an inhibitor of transcription. Implications, problems and solutions. Cell Cycle 2004, 3, 1537-42.
-
(2004)
Cell Cycle
, vol.3
, pp. 1537-1542
-
-
Blagosklonny, M.V.1
-
90
-
-
84861755934
-
Molecular targets of flavopiridol, a promising new antineoplastic agent
-
Getman, C.R.; Bible, K.C. Molecular targets of flavopiridol, a promising new antineoplastic agent. Recent Res. Dev. Cancer 2004, 6, 37-56.
-
(2004)
Recent Res. Dev. Cancer
, vol.6
, pp. 37-56
-
-
Getman, C.R.1
Bible, K.C.2
-
91
-
-
63849246351
-
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
-
Phelps, M.A.; Lin, T.S.; Johnson, A.J.; Hurh, E.; Rozewski, D.M.; Farley, K.L.; Wu, D.; Blum, K.A.; Fischer, B.; Mitchell, S.M.; Moran, M.E.; Brooker-McEldowney, M.; Heerema, N.A.; Jarjoura, D.; Schaaf, L.J.; Byrd, J.C.; Grever, M.R.; Dalton, J.T. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood 2009, 113, 2637-45.
-
(2009)
Blood
, vol.113
, pp. 2637-2645
-
-
Phelps, M.A.1
Lin, T.S.2
Johnson, A.J.3
Hurh, E.4
Rozewski, D.M.5
Farley, K.L.6
Wu, D.7
Blum, K.A.8
Fischer, B.9
Mitchell, S.M.10
Moran, M.E.11
Brooker-McEldowney, M.12
Heerema, N.A.13
Jarjoura, D.14
Schaaf, L.J.15
Byrd, J.C.16
Grever, M.R.17
Dalton, J.T.18
-
92
-
-
33645393211
-
Flavopiridol in patients with relapsed or refractory multiple myeloma: A phase 2 trial with clinical and pharmacodynamic end-points
-
Dispenzieri, A.; Gertz, M.A.; Lacy, M.Q.; Geyer, S.M.; Fitch, T.R.; Fenton, R.G.; Fonseca, R.; Isham, C.R.; Ziesmer, S.C.; Erlichman, C.; Bible, K.C. Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points. Haematologica 2006, 91, 390-3.
-
(2006)
Haematologica
, vol.91
, pp. 390-393
-
-
Dispenzieri, A.1
Gertz, M.A.2
Lacy, M.Q.3
Geyer, S.M.4
Fitch, T.R.5
Fenton, R.G.6
Fonseca, R.7
Isham, C.R.8
Ziesmer, S.C.9
Erlichman, C.10
Bible, K.C.11
-
93
-
-
33846219417
-
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
-
Byrd, J.C.; Lin, T.S.; Dalton, J.T.; Wu, D.; Phelps, M.A.; Fischer, B.; Moran, M.; Blum, K.A.; Rovin, B.; Brooker-McEldowney, M.; Broering, S.; Schaaf, L.J.; Johnson, A.J.; Lucas, D.M.; Heerema, N.A.; Lozanski, G.; Young, D.C.; Suarez, J.-R.; Colevas, A.D.; Grever, M.R. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007, 109, 399-404.
-
(2007)
Blood
, vol.109
, pp. 399-404
-
-
Byrd, J.C.1
Lin, T.S.2
Dalton, J.T.3
Wu, D.4
Phelps, M.A.5
Fischer, B.6
Moran, M.7
Blum, K.A.8
Rovin, B.9
Brooker-McEldowney, M.10
Broering, S.11
Schaaf, L.J.12
Johnson, A.J.13
Lucas, D.M.14
Heerema, N.A.15
Lozanski, G.16
Young, D.C.17
Suarez, J.-R.18
Colevas, A.D.19
Grever, M.R.20
more..
-
94
-
-
0035679234
-
Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts
-
Motwani, M.; Jung, C.; Sirotnak, F.M.; She, Y.; Shah, M.A.; Gonen, M.; Schwartz, G.K. Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. Clin. Cancer Res. 2001, 7, 4209-19.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 4209-4219
-
-
Motwani, M.1
Jung, C.2
Sirotnak, F.M.3
She, Y.4
Shah, M.A.5
Gonen, M.6
Schwartz, G.K.7
-
95
-
-
0034887884
-
Cell cycle-mediated drug resistance: An emerging concept in cancer therapy
-
Shah, M.A.; Schwartz, G.K. Cell cycle-mediated drug resistance: an emerging concept in cancer therapy. Clin. Cancer Res. 2001, 7, 2168-81.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 2168-2181
-
-
Shah, M.A.1
Schwartz, G.K.2
-
96
-
-
0030812207
-
Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
-
Bible, K.C.; Kaufmann, S.H. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration. Cancer Res. 1997, 57, 3375-80.
-
(1997)
Cancer Res
, vol.57
, pp. 3375-3380
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
97
-
-
0035866782
-
The cyclindependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells
-
Cartee, L.; Wang, Z.; Decker, R.H.; Chellappan, S.P.; Fusaro, G.; Hirsch, K.G.; Sankala, H.M.; Dent, P.; Grant, S. The cyclindependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells. Cancer Res. 2001, 61, 2583-91.
-
(2001)
Cancer Res
, vol.61
, pp. 2583-2591
-
-
Cartee, L.1
Wang, Z.2
Decker, R.H.3
Chellappan, S.P.4
Fusaro, G.5
Hirsch, K.G.6
Sankala, H.M.7
Dent, P.8
Grant, S.9
-
98
-
-
0348075994
-
Flavopiridol enhances the effects of docetaxel in vitro and in vivo in human gastric cancer cells
-
Motwani, M.; Rizzo, C.; Sirotnak, F.; She, Y.; Schwartz, G.K. Flavopiridol enhances the effects of docetaxel in vitro and in vivo in human gastric cancer cells. Mol. Cancer Ther. 2003, 2, 549-55.
-
(2003)
Mol. Cancer Ther
, vol.2
, pp. 549-555
-
-
Motwani, M.1
Rizzo, C.2
Sirotnak, F.3
She, Y.4
Schwartz, G.K.5
-
99
-
-
0032804733
-
Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells
-
Motwani, M.; Delohery, T.M.; Schwartz, G.K. Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. Clin. Cancer Res. 1999, 5, 1876-83.
-
(1999)
Clin. Cancer Res
, vol.5
, pp. 1876-1883
-
-
Motwani, M.1
Delohery, T.M.2
Schwartz, G.K.3
-
100
-
-
33646497497
-
A phase I study of flavopiridol and docetaxel
-
El-Rayes, B.F.; Gadgeel, S.; Parchment, R.; Lorusso, P.; Philip, P.A. A phase I study of flavopiridol and docetaxel. Invest. New Drugs 2006, 24, 305-10.
-
(2006)
Invest. New Drugs
, vol.24
, pp. 305-310
-
-
El-Rayes, B.F.1
Gadgeel, S.2
Parchment, R.3
Lorusso, P.4
Philip, P.A.5
-
101
-
-
21044432331
-
A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol
-
Shah, M.A.; Kortmansky, J.; Motwani, M.; Drobnjak, M.; Gonen, M.; Yi, S. A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. Clin. Cancer Res. 2005, 11, 3836-45.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 3836-3845
-
-
Shah, M.A.1
Kortmansky, J.2
Motwani, M.3
Drobnjak, M.4
Gonen, M.5
Yi, S.6
-
102
-
-
35348859609
-
Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors
-
Fornier, M.N.; Rathkopf, D.; Shah, M.A.; Patil, S.; O'Reilly, E.; Tse, A.N. Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors. Clin. Cancer Res. 2007, 13, 5841-6.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 5841-5846
-
-
Fornier, M.N.1
Rathkopf, D.2
Shah, M.A.3
Patil, S.4
O'Reilly, E.5
Tse, A.N.6
-
103
-
-
70449725806
-
A phase II study of docetaxel followed by flavopiridol in advanced, gemcitabine-refractory pancreatic cancer
-
Carvajal, R.D.; Shah, M.A.; Tse, R. A phase II study of docetaxel followed by flavopiridol in advanced, gemcitabine-refractory pancreatic cancer. Proc. Am. Soc. Clin Oncol. abstr. 2008, 15558.
-
(2008)
Proc. Am. Soc. Clin Oncol. abstr
, pp. 15558
-
-
Carvajal, R.D.1
Shah, M.A.2
Tse, R.3
-
104
-
-
45849087334
-
Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with nonsmall-cell lung cancer
-
George, S.; Kasimis, B.S.; Cogswell, J.; Schwarzenberger, P.; Shapiro, G.I.; Fidias, P. Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with nonsmall-cell lung cancer. Clin. Lung Cancer 2008, 9, 160-5.
-
(2008)
Clin. Lung Cancer
, vol.9
, pp. 160-165
-
-
George, S.1
Kasimis, B.S.2
Cogswell, J.3
Schwarzenberger, P.4
Shapiro, G.I.5
Fidias, P.6
-
105
-
-
78149416790
-
A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol
-
Dickson, M.A.; Shah, M.A.; Rathkopf, D.; Tse, A.; Carvajal, R.D.; Wu, N.; Lefkowitz, R.A.; Gonen, M.; Cane, L.M.; Dials, H.J.; Schwartz, G.K. A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol. Cancer Chemother. Pharmacol. 2010, 66, 1113-21.
-
(2010)
Cancer Chemother. Pharmacol
, vol.66
, pp. 1113-1121
-
-
Dickson, M.A.1
Shah, M.A.2
Rathkopf, D.3
Tse, A.4
Carvajal, R.D.5
Wu, N.6
Lefkowitz, R.A.7
Gonen, M.8
Cane, L.M.9
Dials, H.J.10
Schwartz, G.K.11
-
106
-
-
79956036001
-
Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms
-
Holkova, B.; Perkins, E.B.; Ramakrishnan, V.; Tombes, M.B.; Shrader, E.; Talreja, N.; Wellons, M.D.; Hogan, K.T.; Roodman, G.D.; Coppola, D.; Kang, L.; Dawson, J.; Stuart, R.K.; Peer, C.; Figg, W.D.; Kolla, S.; Doyle, A.; Wright, J.; Sullivan, D.M.; Roberts, J.D.; Grant, S. Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms. Clin. Cancer Res. 2011, 17, 3388-97.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 3388-3397
-
-
Holkova, B.1
Perkins, E.B.2
Ramakrishnan, V.3
Tombes, M.B.4
Shrader, E.5
Talreja, N.6
Wellons, M.D.7
Hogan, K.T.8
Roodman, G.D.9
Coppola, D.10
Kang, L.11
Dawson, J.12
Stuart, R.K.13
Peer, C.14
Figg, W.D.15
Kolla, S.16
Doyle, A.17
Wright, J.18
Sullivan, D.M.19
Roberts, J.D.20
Grant, S.21
more..
-
107
-
-
44549087881
-
A phase 1 study of the selective cyclin dependent kinase inhibitor P276-00 in patients with advanced refractory neoplasms
-
Hirte, H.W.; Raghunadharao, D.; Baetz, T.; Hotte, S.; Rajappa, S.; Iacobucci, A.; Sharma, S.; Parikh, H.; Kulkarni, S.; Patil, S.; Gaston, S. A phase 1 study of the selective cyclin dependent kinase inhibitor P276-00 in patients with advanced refractory neoplasms. J. Clin. Oncol. (Abstract: ASCO Annual Meeting Proceedings) 2007, 25, 14117.
-
(2007)
J. Clin. Oncol. (Abstract: ASCO Annual Meeting Proceedings)
, vol.25
, pp. 14117
-
-
Hirte, H.W.1
Raghunadharao, D.2
Baetz, T.3
Hotte, S.4
Rajappa, S.5
Iacobucci, A.6
Sharma, S.7
Parikh, H.8
Kulkarni, S.9
Patil, S.10
Gaston, S.11
-
108
-
-
34147167723
-
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models
-
Joshi, K.S.; Rathos, M.J.; Mahajan, P.; Wagh, V.; Shenoy, S.; Bhatia, D.; Chile, S.; Sivakumar, M.; Maier, A.; Fiebig, H.H.; Sharma, S. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol. Cancer Ther. 2007, 6, 926-34.
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 926-934
-
-
Joshi, K.S.1
Rathos, M.J.2
Mahajan, P.3
Wagh, V.4
Shenoy, S.5
Bhatia, D.6
Chile, S.7
Sivakumar, M.8
Maier, A.9
Fiebig, H.H.10
Sharma, S.11
-
109
-
-
84861760028
-
-
US2010/0152129 (Piramal Life Science Ltd, India)
-
Giridharan, P.; Chakrabarti, D.; Khanna, A.; Ved, U.; Almeida, A.; Sharma, S.; Padigaru, M.; Balakrishnan, A. Novel syngergistic combination of gemcitabine with P-276-00 or PI446A in treatment of cancer. US2010/0152129 (Piramal Life Science Ltd. India), 2010.
-
(2010)
Novel syngergistic combination of gemcitabine with P-276-00 or PI446A in treatment of cancer
-
-
Giridharan, P.1
Chakrabarti, D.2
Khanna, A.3
Ved, U.4
Almeida, A.5
Sharma, S.6
Padigaru, M.7
Balakrishnan, A.8
-
110
-
-
84861733335
-
-
WO2008/139271 (Piramal Life Sciences Ltd, India)
-
Rathos, M.; Joshi, K.; Khanwalkar, H.; Sharma, S. A synergistic pharmaceutical combination for the treatment of cancer. WO2008/139271 (Piramal Life Sciences Ltd. India), 2008.
-
(2008)
A synergistic pharmaceutical combination for the treatment of cancer
-
-
Rathos, M.1
Joshi, K.2
Khanwalkar, H.3
Sharma, S.4
-
111
-
-
0029993339
-
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
-
De Azevedo, W.F., Jr.; Mueller-Dieckmann, H.J.; Schulze-Gahmen, U.; Worland, P.J.; Sausville, E.; Kim, S.H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA 1996, 93, 2735-40.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2735-2740
-
-
de Azevedo Jr., W.F.1
Mueller-Dieckmann, H.J.2
Schulze-Gahmen, U.3
Worland, P.J.4
Sausville, E.5
Kim, S.H.6
-
112
-
-
0038245253
-
Small molecules as inhibitors of cyclin-dependent kinases
-
Huwe, A.; Mazitschek, R.; Giannis, A. Small molecules as inhibitors of cyclin-dependent kinases. Angew. Chem. Int. Ed. 2003, 42, 2122-38.
-
(2003)
Angew. Chem. Int. Ed
, vol.42
, pp. 2122-2138
-
-
Huwe, A.1
Mazitschek, R.2
Giannis, A.3
-
113
-
-
77649144556
-
Cyclin-dependent kinase inhibitors: A survey of recent patent literature
-
Galons, H.; Oumata, N.; Meijer, L. Cyclin-dependent kinase inhibitors: a survey of recent patent literature. Expert Opin. Ther. Patents 2010, 20, 377-404.
-
(2010)
Expert Opin. Ther. Patents
, vol.20
, pp. 377-404
-
-
Galons, H.1
Oumata, N.2
Meijer, L.3
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