Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma

International Journal of Cancer

Volumn 99, Issue 5, 2002, Pages 658-664

  Rapella, Annamaria ^a   Negrioli, Anna ^a   Melillo, Giovanni ^b   Pastorino, Sandra ^a   Varesio, Luigi ^a   Bosco, Maria Carla ^a  

^a G GASLINI INSTITUTE   (Italy)

^b SAIC FREDERICK INC   (United States)

Author keywords

Flavopiridol; Hypoxia; Neuroblastoma; Picolinic acid; Vascular endothelial growth factor

Indexed keywords

DEFEROXAMINE; FERROUS SULFATE; FLAVOPIRIDOL; PICOLINIC ACID; TRYPTOPHAN; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HYPOXIA; IRON CHELATION; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; CELL HYPOXIA; DEFEROXAMINE; ENDOTHELIAL GROWTH FACTORS; FERROUS COMPOUNDS; FLAVONOIDS; GENE EXPRESSION; HUMANS; IRON CHELATING AGENTS; LYMPHOKINES; NEUROBLASTOMA; PICOLINIC ACIDS; PIPERIDINES; RNA, MESSENGER; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036101635     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10392     Document Type: Article

References (47)

1. Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts
2. Disseminated neuroblastoma (stage IV and IV-S) in the first year of life. Outcome related to age and stage
3. Biology and genetics of human neuroblastomas
4. Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients
5. Localized but unresectable neuroblastoma: Treatment and outcome of 145 cases
6. Angiogenesis in cancer and other diseases
7. Patterns and emerging mechanisms of the angiogenic switch during angiogenesis
8. High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas
9. Human neuroblastoma cells produce extracellular matrix-degrading enzymes, induce endothelial cell proliferation and are angiogenic in vivo
10. Tumour progression of human neuroblastoma cells tagged with a lacZ marker gene: Earliest events at ectopic injection sites
11. Tumor angiogenesis correlates with metastatic disease, N-myc anplification, and poor outcome in human neuroblastoma
12. Angiostatic treatment of neuroblastoma
13. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
14. Hypoxia-inducible factor I and the molecular physiology of oxygen homeostasis
15. Upregulation of interleukin 8 by oxygendeprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis
16. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
17. Vascular-specific growth factors and blood vessel formation
18. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
19. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
20. Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis
21. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
22. Immunobiology of picolinic acid
23. New high-performance liquid chromatography method for the detection of picolinic acid in biological fluids
24. A hypoxiaresponsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
25. The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1α and -1β in macrophages
26. Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
27. 1 arrest with inhibition of cyclin-depedent kinase CDK2 and CDK4 in human breast carcinoma cells
28. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
29. Flavopiridol (L86-8275): Selective antitumor activity in vitro and in vivo for prostate carcinoma cells
30. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
31. Phase I trial of continuous infusion of flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
32. Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A University of Chicago phase II consortium study
33. N-myc amplification at chromosome band 1p32 in neuroblastoma cells as investigated by in situ hybridization
34. Definition of a Thy-1 determinant of human neuroblastoma, glioma, sarcoma and teratoma cells with a monoclonal antibody
35. Epidermal growth factor responsiveness of a new neuroblastoma cell line
36. Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation
37. Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine
38. Vascular endothelial growth factor expression in human neuroblastoma: Up-regulation by hypoxia
39. In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells
40. Expression of vascular endothelial growth factor (VEGF) and its receptors in human neuroblastoma
41. Deferoxamine in children with recurrent neuroblastoma
42. Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
43. p27Kip1: A key mediator of retinoic acid-induced growth arrest in the SMS-KCNR human neuroblastoma cell line
44. Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: Apoptosis versus differentiation
45. Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma
46. TNP-470 antiangiogenic therapy for advanced murine neuroblastoma