Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7127-7132

  Zhang, Shixuan ^a   Ma, Jigang ^a   Bao, Yongming ^a   Yang, Puwen ^a   Zou, Liang ^a   Li, Kangjian ^a   Sun, Xiaodan ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Baicalein; CDK1 Cyclin B inhibitor; Flavonoid analogues; SAR

Indexed keywords

1 (2 HYDROXY 4 METHOXYPHENYL) 3 PHENYLPROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (4 METHYLPIPERAZIN 1 YLMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (MORPHOLINOMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (PIPERIDIN 1 YLMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (PYRROLIDIN 1 YLMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [2 HYDROXY 4 METHOXY 5 (THIOMORPHOLINOMETHYL)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [5 [(DIMETHYLAMINO)METHYL] 2 HYDROXY 4 METHOXYPHENYL] 3 PHENYLPROP 2 EN 1 ONE; 2 (3,4 DIHYDROXYPHENYL) 3,5,7 TRIHYDROXY 8 (DIMETHYL AMINOMETHYL) 4H CHROMEN 4 ONE; 2 (3,4 DIHYDROXYPHENYL) 3,5,7 TRIHYDROXY 8 (MORPHOLINOMETHYL) 4H CHROMEN 4 ONE; 2 (3,4 DIHYDROXYPHENYL) 3,5,7 TRIHYDROXY 8 (PIPERIDIN 1 YLMETHYL) 4H CHROMEN 4 ONE; 2 (3,4 DIHYDROXYPHENYL) 3,5,7 TRIHYDROXY 8 [(4METHYL PIPERAZIN 1 YL)METHYL] 4H CHROMEN 4 ONE; 5,6,7 TRIHYDROXY 8 (DIMETHYLAMINO) 2 PHENYL 4H CHROMEN 4 ONE; 5,6,7 TRIHYDROXY 8 (MORPHOLINOMETHYL) 2 PHENYL 4H CHROMEN 4 ONE; 5,6,7 TRIHYDROXY 8 (PIPERIDIN 1 YLMETHYL) 2 PHENYL 4H CHROMEN 4 ONE; 5,6,7 TRIHYDROXY 8 (PYRROLIDIN 1 YLMETHYL) 2 PHENYL 4H CHROMEN 4 ONE; 5,6,7 TRIHYDROXY 8 (THIOMORPHOLINOMETHYL) 2 PHENYL 4H CHROMEN 4 ONE; 5,6,7 TRIHYDROXY 8 [(4 METHYLPIPERAZIN 1 YL)METHYL] 2 PHENYL 4H CHROMEN 4 ONE; CHROMENE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 1; FLAVONOID; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL ANALYSIS; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MANNICH REACTION; STRUCTURE ACTIVITY RELATION;

EID: 48449094373     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.055     Document Type: Article

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