Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication

ChemBioChem

Volumn 10, Issue 12, 2009, Pages 2072-2080

  Ali, Akbar ^a   Ghosh, Animesh ^a   Nathans, Robins S ^a   Sharova, Natalia ^a   O'Brien, Siobhan ^a   Cao, Hong ^a   Stevenson, Mario ^a   Rana, Tariq M ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Antiviral agents; Cyclin dependent kinases; Enzymes; Inhibitors; P TEFb

Indexed keywords

2 CHLOROPHENYL DERIVATIVE; 2 FLUOROPHENYL DERIVATIVE; 3 CHLOROPHENYL DERIVATIVE; 3 PYRIDYL DERIVATIVE; 3 VINYLPHENYL DERIVATIVE; 4 BROMOPHENYL DERIVATIVE; 4 CHLORO 3 PYRIDYL DERIVATIVE; 4 CHLOROPHENYL DERIVATIVE; 4 FLUOROPHENYL DERIVATIVE; 4 HYDROXYPHENYL DERIVATIVE; 4 PYRIDYL DERIVATIVE; 4 TERT BUTYLPHENYL; 4 TRIFLUOROMETHYLPHENYL DERIVATIVE; 4 VINYLPHENYL DERIVATIVE; 5 METHYLISOXAZOLE DERIVATIVE; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; DESCHLOROFLAVOPIRIDOL; FLAVOPIRIDOL; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PYRID 2 YL DERIVATIVE; THIOFLAVOPIRIDOL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; HELA CELLS; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PIPERIDINES; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70349558526     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900303     Document Type: Article

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