Energy Expenditure. Role of Orexin.

Vitamins and Hormones

Volumn 89, Issue , 2012, Pages 91-109

  Teske, Jennifer A ^a,b   Mavanji, Vijayakumar ^c  

^a SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c VA MEDICAL CENTER   (United States)

Author keywords

Brain; Metabolism; Neuropeptide; Obesity; Spontaneous physical activity

Indexed keywords

EID: 84861464553     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394623-2.00006-8     Document Type: Chapter

References (147)

1. Adamantidis A.R., Zhang F., Aravanis A.M., Deisseroth K., de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 2007, 450:420-424.
2. Alam M.N., McGinty D., Szymusiak R. Neuronal discharge of preoptic/anterior hypothalamic thermosensitive neurons: Relation to NREM sleep. Am. J. Physiol. 1995, 269:R1240-R1249.
3. Alam M.N., McGinty D., Szymusiak R. Preoptic/anterior hypothalamic neurons: Thermosensitivity in wakefulness and non rapid eye movement sleep. Brain Res. 1996, 718:76-82.
4. Allard J.S., Tizabi Y., Shaffery J.P., Manaye K. Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression. Neuropeptides 2007, 41:329-337.
5. Ammoun S., Holmqvist T., Shariatmadari R., Oonk H.B., Detheux M., Parmentier M., Akerman K.E., Kukkonen J.P. Distinct recognition of OX1 and OX2 receptors by orexin peptides. J. Pharmacol. Exp. Ther. 2003, 305:507-514.
6. Ammoun S., Lindholm D., Wootz H., Akerman K.E., Kukkonen J.P. G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. J. Biol. Chem. 2006, 281:834-842.
7. Arch J.R., Hislop D., Wang S.J., Speakman J.R. Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals. Int. J. Obes. (Lond.) 2006, 30:1322-1331.
8. Asakawa A., Inui A., Goto K., Yuzuriha H., Takimoto Y., Inui T., Katsuura G., Fujino M.A., Meguid M.M., Kasuga M. Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. Int. J. Mol. Med. 2002, 10:523-525.
9. Bernard R., Lydic R., Baghdoyan H.A. Hypocretin (orexin) receptor subtypes differentially enhance acetylcholine release and activate g protein subtypes in rat pontine reticular formation. J. Pharmacol. Exp. Ther. 2006, 317:163-171.
10. Beuckmann C.T., Sinton C.M., Williams S.C., Richardson J.A., Hammer R.E., Sakurai T., Yanagisawa M. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J. Neurosci. 2004, 24:4469-4477.
11. Bourgin P., Huitron-Resendiz S., Spier A.D., Fabre V., Morte B., Criado J.R., Sutcliffe J.G., Henriksen S.J., de Lecea L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J. Neurosci. 2000, 20:7760-7765.
12. Brebbia D.R., Altshuler K.Z. Oxygen consumption rate and electroencephalographic stage of sleep. Science 1965, 150:1621-1623.
13. Brisbare-Roch C., Dingemanse J., Koberstein R., Hoever P., Aissaoui H., Flores S., Mueller C., Nayler O., van Gerven J., de Haas S.L., Hess P., Qiu C., et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat. Med. 2007, 13:150-155.
14. Burdakov D., Liss B., Ashcroft F.M. Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger. J. Neurosci. 2003, 23:4951-4957.
15. Burt J., Alberto C.O., Parsons M.P., Hirasawa M. Local network regulation of orexin neurons in the lateral hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 301:R572-R580.
16. Butler A.A., Kozak L.P. A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 2010, 59:323-329.
17. Carter M.E., Adamantidis A., Ohtsu H., Deisseroth K., de Lecea L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J. Neurosci. 2009, 29:10939-10949.
18. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., et al. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation. Cell 1999, 98:437-451.
19. Chen C.T., Dun S.L., Kwok E.H., Dun N.J., Chang J.K. Orexin A-like immunoreactivity in the rat brain. Neurosci. Lett. 1999, 260:161-164.
20. Chen C.T., Hwang L.L., Chang J.K., Dun N.J. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 278:R692-R697.
21. Chen L., Thakkar M.M., Winston S., Bolortuya Y., Basheer R., McCarley R.W. REM sleep changes in rats induced by siRNA-mediated orexin knockdown. Eur. J. Neurosci. 2006, 24:2039-2048.
22. Cluderay J.E., Harrison D.C., Hervieu G.J. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul. Pept. 2002, 104:131-144.
23. Cutler D.J., Morris R., Sheridhar V., Wattam T.A., Holmes S., Patel S., Arch J.R., Wilson S., Buckingham R.E., Evans M.L., Leslie R.A., Williams G. Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord. Peptides 1999, 20:1455-1470.
24. D'Alessio D.A., Kavle E.C., Mozzoli M.A., Smalley K.J., Polansky M., Kendrick Z.V., Owen L.R., Bushman M.C., Boden G., Owen O.E. Thermic effect of food in lean and obese men. J. Clin. Invest. 1988, 81:1781-1789.
25. Date Y., Mondal M.S., Matsukura S., Nakazato M. Distribution of orexin-A and orexin-B (hypocretins) in the rat spinal cord. Neurosci. Lett. 2000, 288:87-90.
26. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., et al. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:322-327.
27. de Oliveira C.V., Ciriello J. Cardiovascular responses to hypocretin-1 in nucleus ambiguus of the ovariectomized female rat. Brain Res. 2003, 986:148-156.
28. Dergacheva O., Wang X., Huang Z.G., Bouairi E., Stephens C., Gorini C., Mendelowitz D. Hypocretin-1 (orexin-A) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus. J. Pharmacol. Exp. Ther. 2005, 314:1322-1327.
29. Digby J.E., Chen J., Tang J.Y., Lehnert H., Matthews R.N., Randeva H.S. Orexin receptor expression in human adipose tissue: Effects of orexin-A and orexin-B. J. Endocrinol. 2006, 191:129-136.
30. Donahoo W.T., Levine J.A., Melanson E.L. Variability in energy expenditure and its components. Curr. Opin. Clin. Nutr. Metab. Care 2004, 7:599-605.
31. Eriksson K.S., Sergeeva O., Brown R.E., Haas H.L. Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J. Neurosci. 2001, 21:9273-9279.
32. Espana R.A., Baldo B.A., Kelley A.E., Berridge C.W. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): Basal forebrain sites of action. Neuroscience 2001, 106:699-715.
33. Estabrooke I.V., McCarthy M.T., Ko E., Chou T.C., Chemelli R.M., Yanagisawa M., Saper C.B., Scammell T.E. Fos expression in orexin neurons varies with behavioral state. J. Neurosci. 2001, 21:1656-1662.
34. Ferguson A.V., Samson W.K. The orexin/hypocretin system: A critical regulator of neuroendocrine and autonomic function. Front. Neuroendocrinol. 2003, 24:141-150.
35. Fujiki N., Yoshida Y., Ripley B., Honda K., Mignot E., Nishino S. Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. Neuroreport 2001, 12:993-997.
36. Gallopin T., Fort P., Eggermann E., Cauli B., Luppi P.H., Rossier J., Audinat E., Muhlethaler M., Serafin M. Identification of sleep-promoting neurons in vitro. Nature 2000, 404:992-995.
37. Gautvik K.M., de Lecea L., Gautvik V.T., Danielson P.E., Tranque P., Dopazo A., Bloom F.E., Sutcliffe J.G. Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:8733-8738.
38. Gerashchenko D., Kohls M.D., Greco M., Waleh N.S., Salin-Pascual R., Kilduff T.S., Lappi D.A., Shiromani P.J. Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat. J. Neurosci. 2001, 21:7273-7283.
39. Gerashchenko D., Blanco-Centurion C., Greco M.A., Shiromani P.J. Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Neuroscience 2003, 116:223-235.
40. Gilbert S.S., van den Heuvel C.J., Ferguson S.A., Dawson D. Thermoregulation as a sleep signalling system. Sleep Med. Rev. 2004, 8:81-93.
41. Greene R., Siegel J. Sleep: A functional enigma. Neuromolecular Med. 2004, 5:59-68.
42. Hagan J.J., Leslie R.A., Patel S., Evans M.L., Wattam T.A., Holmes S., Benham C.D., Taylor S.G., Routledge C., Hemmati P., Munton R.P., Ashmeade T.E., et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:10911-10916.
43. Hara J., Beuckmann C.T., Nambu T., Willie J.T., Chemelli R.M., Sinton C.M., Sugiyama F., Yagami K., Goto K., Yanagisawa M., Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001, 30:345-354.
44. Harris G.C., Wimmer M., Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 2005, 437:556-559.
45. Haynes A.C., Jackson B., Overend P., Buckingham R.E., Wilson S., Tadayyon M., Arch J.R. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 1999, 20:1099-1105.
46. Hervieu G.J., Cluderay J.E., Harrison D.C., Roberts J.C., Leslie R.A. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience 2001, 103:777-797.
47. Hirota K., Kushikata T., Kudo M., Kudo T., Lambert D.G., Matsuki A. Orexin A and B evoke noradrenaline release from rat cerebrocortical slices. Br. J. Pharmacol. 2001, 134:1461-1466.
48. Hoang Q.V., Bajic D., Yanagisawa M., Nakajima S., Nakajima Y. Effects of orexin (hypocretin) on GIRK channels. J. Neurophysiol. 2003, 90:693-702.
49. Holmqvist T., Johansson L., Ostman M., Ammoun S., Akerman K.E., Kukkonen J.P. OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. J. Biol. Chem. 2005, 280:6570-6579.
50. Horvath T.L., Gao X.B. Input organization and plasticity of hypocretin neurons: Possible clues to obesity's association with insomnia. Cell Metab. 2005, 1:279-286.
51. Ida T., Nakahara K., Katayama T., Murakami N., Nakazato M. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res. 1999, 821:526-529.
52. Ivanov A., Aston-Jones G. Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. Neuroreport 2000, 11:1755-1758.
53. John J., Wu M.F., Siegel J.M. Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs. Sleep Res. Online 2000, 3:23-28.
54. Johren O., Neidert S.J., Kummer M., Dendorfer A., Dominiak P. Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology 2001, 142:3324-3331.
55. Joosen A.M., Westerterp K.R. Energy expenditure during overfeeding. Nutr. Metab. 2006, 3:25.
56. Karteris E., Randeva H.S., Grammatopoulos D.K., Jaffe R.B., Hillhouse E.W. Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. J. Clin. Endocrinol. Metab. 2001, 86:4512-4519.
57. Karteris E., Machado R.J., Chen J., Zervou S., Hillhouse E.W., Randeva H.S. Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E1089-E1100.
58. Kastin A.J., Akerstrom V. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. J. Pharmacol. Exp. Ther. 1999, 289:219-223.
59. Kiwaki K., Kotz C.M., Wang C., Lanningham-Foster L., Levine J.A. Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats. Am. J. Physiol. Endocrinol. Metab. 2004, 286:E551-E559.
60. Kiyashchenko L.I., Mileykovskiy B.Y., Lai Y.Y., Siegel J.M. Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area. J. Neurophysiol. 2001, 85:2008-2016.
61. Kohlmeier K.A., Inoue T., Leonard C.S. Hypocretin/orexin peptide signaling in the ascending arousal system: Elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. J. Neurophysiol. 2004, 92:221-235.
62. Kok S.W., Overeem S., Visscher T.L., Lammers G.J., Seidell J.C., Pijl H., Meinders A.E. Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity. Obes. Res. 2003, 11:1147-1154.
63. Kornum B.R., Faraco J., Mignot E. Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain. Curr. Opin. Neurobiol. 2011, 21:897-903.
64. Kotz C.M., Teske J.A., Levine J.A., Wang C. Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regul. Pept. 2002, 104:27-32.
65. Kotz C.M., Wang C., Teske J.A., Thorpe A.J., Novak C.M., Kiwaki K., Levine J.A. Orexin A mediation of time spent moving in rats: Neural mechanisms. Neuroscience 2006, 142:29-36.
66. Kotz C.M., Teske J.A., Billington C.J. Neuroregulation of nonexercise activity thermogenesis and obesity resistance. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 294:R699-R710.
67. Kumar V.M. Why the medial preoptic area is important for sleep regulation. Indian J. Physiol. Pharmacol. 2004, 48:137-149.
68. Kuo T.B., Shaw F.Z., Lai C.J., Yang C.C. Asymmetry in sympathetic and vagal activities during sleep-wake transitions. Sleep 2008, 31:311-320.
69. 2+ entry: Evidence for involvement of trpc channels and protein kinase C regulation. J. Biol. Chem. 2005, 280:1771-1781.
70. Lee M.G., Hassani O.K., Jones B.E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J. Neurosci. 2005, 25:6716-6720.
71. Levine J.A., Eberhardt N.L., Jensen M.D. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 1999, 283:212-214.
72. Li Y., Gao X.B., Sakurai T., van den Pol A.N. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 2002, 36:1169-1181.
73. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999, 98:365-376.
74. Liu Z.W., Gan G., Suyama S., Gao X.B. Intracellular energy status regulates activity in hypocretin/orexin neurones: A link between energy and behavioural states. J. Physiol. 2011, 589:4157-4166.
75. Llewellyn-Smith I.J., Martin C.L., Marcus J.N., Yanagisawa M., Minson J.B., Scammell T.E. Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons. Neurosci. Lett. 2003, 351:115-119.
76. Lubkin M., Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem. Biophys. Res. Commun. 1998, 253:241-245.
77. Lushington K., Dawson D., Lack L. Core body temperature is elevated during constant wakefulness in elderly poor sleepers. Sleep 2000, 23:504-510.
78. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 2001, 435:6-25.
79. Matsumura K., Tsuchihashi T., Abe I. Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension 2001, 37:1382-1387.
80. McGinty D., Szymusiak R. Brain structures and mechanisms involved in the generation of NREM sleep: Focus on the preoptic hypothalamus. Sleep Med. Rev. 2001, 5:323-342.
81. Methippara M.M., Alam M.N., Szymusiak R., McGinty D. Effects of lateral preoptic area application of orexin-A on sleep-wakefulness. Neuroreport 2000, 11:3423-3426.
82. Mieda M., Willie J.T., Hara J., Sinton C.M., Sakurai T., Yanagisawa M. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:4649-4654.
83. Mileykovskiy B.Y., Kiyashchenko L.I., Siegel J.M. Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medulla. J. Neurophysiol. 2002, 87:2480-2489.
84. Mileykovskiy B.Y., Kiyashchenko L.I., Siegel J.M. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 2005, 46:787-798.
85. Mochizuki T., Crocker A., McCormack S., Yanagisawa M., Sakurai T., Scammell T.E. Behavioral state instability in orexin knock-out mice. J. Neurosci. 2004, 24:6291-6300.
86. Mochizuki T., Klerman E.B., Sakurai T., Scammell T.E. Elevated body temperature during sleep in orexin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 291:R533-R540.
87. Monda M., Viggiano A., Mondola P., De Luca V. Inhibition of prostaglandin synthesis reduces hyperthermic reactions induced by hypocretin-1/orexin A. Brain Res. 2001, 909:68-74.
88. Monda M., Viggiano A., De Luca V. Paradoxical [correction of parodoxical] effect of orexin A: Hypophagia induced by hyperthermia. Brain Res. 2003, 961:220-228.
89. Monda M., Viggiano A., Viggiano A., Fuccio F., De Luca V. Injection of orexin A into the diagonal band of Broca induces sympathetic and hyperthermic reactions. Brain Res. 2004, 1018:265-271.
90. Morrison S.F., Nakamura K. Central neural pathways for thermoregulation. Front. Biosci. 2011, 16:74-104.
91. Nambu T., Sakurai T., Mizukami K., Hosoya Y., Yanagisawa M., Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res. 1999, 827:243-260.
92. Nishino S., Ripley B., Overeem S., Lammers G.J., Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
93. Novak C.M., Levine J.A. Daily intraparaventricular orexin-A treatment induces weight loss in rats. Obesity (Silver Spring) 2009, 17:1493-1498.
94. Novak C.M., Kotz C.M., Levine J.A. Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant rats. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E396-E403.
95. Nunez A., Moreno-Balandran M.E., Rodrigo-Angulo M.L., Garzon M., De Andres I. Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep. Eur. J. Neurosci. 2006, 24:2834-2842.
96. Ohno K., Sakurai T. Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness. Front. Neuroendocrinol. 2008, 29:70-87.
97. Overton J.M. Phenotyping small animals as models for the human metabolic syndrome: Thermoneutrality matters. Int. J. Obes. (Lond.) 2010, 34(Suppl. 2):S53-S58.
98. Parsons M.P., Hirasawa M. ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: Implications for brain energetics during arousal. J. Neurosci. 2010, 30:8061-8070.
99. Pedrazzoli M., D'Almeida V., Martins P.J., Machado R.B., Ling L., Nishino S., Tufik S., Mignot E. Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation. Brain Res. 2004, 995:1-6.
100. Peever J.H., Lai Y.Y., Siegel J.M. Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism. J. Neurophysiol. 2003, 89:2591-2600.
101. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 1998, 18:9996-10015.
102. Pierangeli G., Provini F., Maltoni P., Barletta G., Contin M., Lugaresi E., Montagna P., Cortelli P. Nocturnal body core temperature falls in Parkinson's disease but not in Multiple-System Atrophy. Mov. Disord. 2001, 16:226-232.
103. Piper D.C., Upton N., Smith M.I., Hunter A.J. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. Eur. J. Neurosci. 2000, 12:726-730.
104. Randeva H.S., Karteris E., Grammatopoulos D., Hillhouse E.W. Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: Implications for adrenal function and energy homeostasis. J. Clin. Endocrinol. Metab. 2001, 86:4808-4813.
105. Rauh R.A., Senior D.G., Miller W.P. Delayed complete heart block complicating percutaneous transluminal coronary angioplasty. Am. Heart J. 1990, 120:972-975.
106. Ravussin E., Bogardus C. A brief overview of human energy metabolism and its relationship to essential obesity. Am. J. Clin. Nutr. 1992, 55:242S-245S.
107. Ravussin E., Lillioja S., Anderson T.E., Christin L., Bogardus C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J. Clin. Invest. 1986, 78:1568-1578.
108. Rodgers R.J., Ishii Y., Halford J.C., Blundell J.E. Orexins and appetite regulation. Neuropeptides 2002, 36:303-325.
109. Sakurai T. Reverse pharmacology of orexin: From an orphan GPCR to integrative physiology. Regul. Pept. 2005, 126:3-10.
110. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., et al. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
111. Samson W.K., Gosnell B., Chang J.K., Resch Z.T., Murphy T.C. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res. 1999, 831:248-253.
112. Samson W.K., Taylor M.M., Ferguson A.V. Non-sleep effects of hypocretin/orexin. Sleep Med. Rev. 2005, 9:243-252.
113. Saper C.B., Fuller P.M., Pedersen N.P., Lu J., Scammell T.E. Sleep state switching. Neuron 2010, 68:1023-1042.
114. Sato-Suzuki I., Kita I., Seki Y., Oguri M., Arita H. Cortical arousal induced by microinjection of orexins into the paraventricular nucleus of the rat. Behav. Brain Res. 2002, 128:169-177.
115. Sellayah D., Bharaj P., Sikder D. Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab. 2011, 14:478-490.
116. Semjonous N.M., Smith K.L., Parkinson J.R., Gunner D.J., Liu Y.L., Murphy K.G., Ghatei M.A., Bloom S.R., Small C.J. Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance. Int. J. Obes. (Lond.) 2009, 33:775-785.
117. Shirasaka T., Nakazato M., Matsukura S., Takasaki M., Kannan H. Sympathetic and cardiovascular actions of orexins in conscious rats. Am. J. Physiol. 1999, 277:R1780-R1785.
118. Shirasaka T., Kunitake T., Takasaki M., Kannan H. Neuronal effects of orexins: Relevant to sympathetic and cardiovascular functions. Regul. Pept. 2002, 104:91-95.
119. Siegel J.M. Narcolepsy: A key role for hypocretins (orexins). Cell 1999, 98:409-412.
120. Smith P.M., Connolly B.C., Ferguson A.V. Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressure. Brain Res. 2002, 950:261-267.
121. Smith M.I., Piper D.C., Duxon M.S., Upton N. Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat. Neurosci. Lett. 2003, 341:256-258.
122. Smith P.M., Samson W.K., Ferguson A.V. Cardiovascular actions of orexin-A in the rat subfornical organ. J. Neuroendocrinol. 2007, 19:7-13.
123. Sutcliffe J.G., de Lecea L. The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J. Neurosci. Res. 2000, 62:161-168.
124. Szekely M., Petervari E., Balasko M., Hernadi I., Uzsoki B. Effects of orexins on energy balance and thermoregulation. Regul. Pept. 2002, 104:47-53.
125. Takahashi K., Lin J.S., Sakai K. Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse. Neuroscience 2008, 153:860-870.
126. Tang J., Chen J., Ramanjaneya M., Punn A., Conner A.C., Randeva H.S. The signalling profile of recombinant human orexin-2 receptor. Cell. Signal. 2008, 20:1651-1661.
127. Teske J.A., Levine A.S., Kuskowski M., Levine J.A., Kotz C.M. Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 291:R889-R899.
128. Teske J.A., Billington C.J., Kotz C.M. Hypocretin/orexin and energy expenditure. Acta Physiol. (Oxf.) 2010, 198:303-312.
129. Thakkar M.M., Ramesh V., Cape E.G., Winston S., Strecker R.E., McCarley R.W. REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation. Sleep Res. Online 1999, 2:112-120.
130. Thorpe A.J., Kotz C.M. Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Brain Res. 2005, 1050:156-162.
131. Trivedi P., Yu H., MacNeil D.J., Van der Ploeg L.H., Guan X.M. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett. 1998, 438:71-75.
132. Tsunematsu T., Kilduff T.S., Boyden E.S., Takahashi S., Tominaga M., Yamanaka A. Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J. Neurosci. 2011, 31:10529-10539.
133. Tupone D., Madden C.J., Cano G., Morrison S.F. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J. Neurosci. 2011, 31:15944-15955.
134. van den Pol A.N., Gao X.B., Obrietan K., Kilduff T.S., Belousov A.B. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 1998, 18:7962-7971.
135. Vijgen G.H., Bouvy N.D., Teule G.J., Brans B., Schrauwen P., van Marken Lichtenbelt W.D. Brown adipose tissue in morbidly obese subjects. PLoS One 2011, 6:e17247.
136. Wang J., Osaka T., Inoue S. Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats. Neurosci. Lett. 2001, 315:49-52.
137. Wang J., Osaka T., Inoue S. Orexin-A-sensitive site for energy expenditure localized in the arcuate nucleus of the hypothalamus. Brain Res. 2003, 971:128-134.
138. Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu. Rev. Neurosci. 2001, 24:429-458.
139. Willie J.T., Chemelli R.M., Sinton C.M., Tokita S., Williams S.C., Kisanuki Y.Y., Marcus J.N., Lee C., Elmquist J.K., Kohlmeier K.A., Leonard C.S., Richardson J.A., et al. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 2003, 38:715-730.
140. Wu M.F., John J., Maidment N., Lam H.A., Siegel J.M. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002, 283:R1079-R1086.
141. Xi M.C., Morales F.R., Chase M.H. Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat. Brain Res. 2001, 901:259-264.
142. Yamanaka A., Muraki Y., Tsujino N., Goto K., Sakurai T. Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem. Biophys. Res. Commun. 2003, 303:120-129.
143. Yang B., Ferguson A.V. Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductances. J. Neurophysiol. 2003, 89:2167-2175.
144. Yoshida Y., Fujiki N., Nakajima T., Ripley B., Matsumura H., Yoneda H., Mignot E., Nishino S. Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur. J. Neurosci. 2001, 14:1075-1081.
145. Zepelin H., McDonald C.S. Age differences in autonomic variables during sleep. J. Gerontol. 1987, 42:142-146.
146. 2+ channel-activated slow after hyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons. J. Neurophysiol. 2009, 101:2741-2750.
147. Zheng H., Patterson L.M., Berthoud H.R. Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function. J. Comp. Neurol. 2005, 485:127-142.