Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat

Journal of Neuroscience

Volumn 24, Issue 18, 2004, Pages 4469-4477

  Beuckmann, Carsten T ^a,b,e   Sinton, Christopher M ^b   Williams, S Clay ^a,b   Richardson, James A ^b   Hammer, Robert E ^a,b   Sakurai, Takeshi ^c,d   Yanagisawa, Masashi ^a,b,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e Elsal Company   (Japan)

Author keywords

Cataplexy; Electroencephalography; Electromyography; Lateral hypothalamus; REM; Sleep

Indexed keywords

OREXIN;

ALERTNESS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY POSTURE; CATAPLEXY; CONTROLLED STUDY; DARK ADAPTATION; ELECTROENCEPHALOGRAM; ELECTROMYOGRAPHY; GENE; GENE EXPRESSION; HUMAN ATAXIN 3 GENE; HYPOTHALAMUS; MUSCLE ATONIA; NARCOLEPSY; NERVE CELL; NERVE PROJECTION; NONHUMAN; NONREM SLEEP; OREXIN GENE; OREXIN RECEPTOR GENE; PHENOTYPE; PHOTOPERIODICITY; POLYGLUTAMINE ATAXIN 3 GENE; PREPROOREXIN GENE; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP; SLEEP DISORDER; SLEEP TIME; TRANSGENE; TRANSGENIC ANIMAL; WAKEFULNESS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AROUSAL; BEHAVIOR, ANIMAL; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NARCOLEPSY; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; NUCLEAR PROTEINS; PHENOTYPE; PHOTOPERIOD; PROMOTER REGIONS (GENETICS); RATS; RATS, WISTAR; REPRESSOR PROTEINS; SLEEP, REM; TRANSGENES; WAKEFULNESS;

EID: 2342602218     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5560-03.2004     Document Type: Article

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