Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 278, Issue 3 47-3, 2000, Pages

  Chen, Chiung Tong ^a   Hwang, Ling Ling ^a   Chang, Jaw Kang ^b   Dun, Nae J ^a  

^a East Tennessee State University   (United States)

^b PHOENIX PHARMACEUTICALS INC   (United States)

Author keywords

Blood pressure; Heart rate; Hypocretins; Obesity

Indexed keywords

OREXIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RESPONSE; HEART RATE; MALE; MEDULLA OBLONGATA; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; RAT;

EID: 0034062230     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2000.278.3.r692     Document Type: Article

References (27)

1. American Heart Association. 1998 Heart, and Stroke Statistical Update. Dallas, TX: Am. Heart Assoc., 1998.
2. Bernardis, L. L., and L. L. Bellinger. The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neurosci. Biobehav. Rev. 17: 141-193, 1993.
3. Bernardis, L. L., and L. L. Bellinger. The lateral hypothalamic area revisited: ingestive behavior. Neurosci. Biobehav. Rev. 20: 189-287, 1996.
4. Bhatnagar, T., V. C. Chitravanshi, and H. N. Sapru. Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat. Brain Res. 822: 192-199, 1999.
5. Chen, C.-T., S. L. Dun, E. H. Kwok, N. J. Dun, and J.-K. Chang. Orexin A-like immunoreactivity in the rat brain. Neurosci. Lett. 260: 161-164, 1999.
6. Chu, N. F., E. B. Rimm, D. J. Wang, H. S. Liou, and S. M. Shieh. Clustering of cardiovascular disease risk factors among obese schoolchildren: the Taipei Children Heart Study. Am. J. Clin. Nutr. 67: 1141-1146, 1998.
7. Date, Y., Y. Ueta, H. Yamashita, H. Yamaguchi, S. Matsukura, K. Kangawa, T. Sakurai, M. Yanagisawa, and M. Nakazato. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory system. Proc. Natl. Acad. Sci. USA 96: 748-753, 1999.
8. De Lean, A., P. J. Munson, and D. Rodbard. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. Endocrinol. Metab. Gastrointest. Physiol. 235: E97-E102, 1978.
9. de Lecea, L., T. S. Kilduff, C. Peyron, X. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. Battenberg, V. T. Gautvik, F. S. Bartlett II, W. N. Frankel, A. N. van den Pol, F. E. Bloom, K. M. Gautvik, and J. G. Sutcliffe. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95: 322-327, 1998.
10. Dun, N. J., S. L. Dun, E. Shen, H. Tang, R. Huang, and T. H. Chiu. c-fos expression as a marker of central cardiovascular neurons. Biol. Signals 4: 117-123, 1995.
11. Edwards, C. M., S. Abusnana, D. Sunter, K. G. Murphy, M. A. Ghatei, and S. R. Bloom. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 160: R7-R12, 1999.
12. Ferguson, A. V. The area postrema: a cardiovascular control centre at the blood-brain interface? Can. J. Physiol. Pharmacol. 69: 1026-1034, 1991.
13. Gillum, R. F., M. E. Mussolino, and J. H. Madans. Body fat distribution and hypertension incidence in women and men. The NHANES I epidemiologic follow-up study. Int. J. Obes. Relat. Metab. Disord. 22: 127-134, 1998.
14. Guyenet, P. G., N. Koshiya, D. Huangfu, S. C. Baraban, R. L. Stornetta, and Y.-W. Li. Role of medulla oblongata in generation of sympathetic and vagal outflows. Prog. Brain Res. 107: 127-144, 1996.
15. Ida, T., K. Nakahara, T. Katayama, N. Murakami, and M. Nakazato. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res. 821: 526-529, 1999.
16. Kwok, E. H., and N. J. Dun. Endomorphins decrease heart rate and blood pressure possibly by activating vagal afferents in anesthetized rats. Brain Res. 803: 204-207, 1998.
17. Lane, P. H., C. W. Belsha, J. Plummer, G. F. Steinhardt, R. E. Lynch, and E. G. Wood. Relationship of renal size, body size, and blood pressure in children. Pediatr. Nephrol. 12: 35-89, 1998.
18. Mondal, M. S., M. Nakazato, Y. Date, N. Murakami, M. Yanagisawa, and S. Matsukura. Widespread distribution of orexin in rat brain and its regulation upon fasting. Biochem. Biophys. Res. Commun. 256: 495-499, 1999.
19. Murphy, N. J., C. D. Schraer, M. C. Theile, E. J. Boyko, L. R. Bulkow, B. J. Doty, and A. P. Lanier. Hypertension in Alaska Natives: association with overweight, glucose intolerance, diet and mechanized activity. Ethn. Health 2: 267-275, 1997.
20. Peyron, C., D. K. Tighe, A. N. van den Pol, L. de Lecea, H. C. Heller, J. G. Sutcliffe, and T. S. Kilduff. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18: 9996-10015, 1998.
21. Qiao, Q., U. Rajala, and S. Keinanen-Kiukaanniemi. Hypertension, hyperinsulinaemia and obesity in middle-aged Finns with impaired glucose tolerance. J. Hum. Hypertens. 12: 265-269, 1998.
22. Ross, C. A., D. A. Ruggiero, T. H. Joh, D. H. Park, and D. J. Reis. Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons. J. Comp. Neurol. 228: 168-185, 1984.
23. Sakurai, T., A. Amemiya, M. Ishii, I. Matsuzaki, R. M. Chemelli, H. Tanaka, S. C. Williams, J. A. Richardson, G. P. Kozlowski, S. Wilson, J. R. Arch, R. E. Buckingham, A. C. Haynes, S. A. Carr, R. S. Annan, D. E. McNulty, W. S. Liu, J. A. Terrett, N. A. Elshourbagy, D. J. Bergsma, and M. Yanagisawa. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585, 1998.
24. Samson, W. K., T. C. Murphy, J. K. Chang, and B. A. Gosnell. Sympathostimulatory effects of orexin: doses which stimulate sucrose feeding elevate blood pressure in conscious rats (Abstract). Soc. Neurosci. Abstr. 24: 203, 1998.
25. Sayeed, M. A., A. Banu, M. A. Malek, and A. K. Khan. Blood pressure and coronary heart disease in NIDDM subjects at diagnosis: prevalence and risks in a Bangladeshi population. Diabetes Res. Clin. Pract. 39: 147-155, 1998.
26. Sowers, J. R. Obesity and cardiovascular disease. Clin. Chem. 44: 1821-1825, 1998.
27. Van den Pol, A. N., X. B. Gao, K. Obrietan, T. S. Kilduff, and A. B. Belousov. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 18: 7962-7971, 1998.