Orexin A but not orexin B rapidly enters brain from blood by simple diffusion

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 1, 1999, Pages 219-223

  Kastin, Abba J ^a   Akerstrom, Victoria ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN TC 99M; APPETITE STIMULANT; IODINE 125; OREXIN A; OREXIN B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANOREXIA; APPETITE; ARTICLE; BLOOD BRAIN BARRIER; DIFFUSION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BUFFERS; CAPILLARIES; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; INJECTIONS, INTRAVENOUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IODINE RADIOISOTOPES; MALE; MICE; MICE, INBRED ICR; NEUROPEPTIDES; OCTANOLS; SOLUBILITY; TECHNETIUM TC 99M AGGREGATED ALBUMIN;

EID: 0032943465     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Banks WA, Fasold MB and Kastin AJ (1997) Measurement of efflux rates from brain to blood. Methods Mol Biol 73:353-360.
2. Banks WA, Jaspan JB and Kastin AJ (1997) Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin. Peptides 18:1577-1584.
3. Banks WA and Kastin AJ (1985) Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability. Brain Res Bull 15:287-292.
4. Banks WA and Kastin AJ (1989) Quantifying carrier-mediated transport of peptides from the brain to the blood. Methods Enzymol 168:652-660.
5. Banks WA and Kastin AJ (1993) Measurement of transport of cytokines across the blood-brain barrier. Neurobiol Cytokines A:67-77.
6. Banks WA, Kastin AJ and Huang W (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311.
7. Barinaga M (1998) New appetite-boosting peptides found. Science (Wash DC) 279: 1134.
8. Chikhale EG, Ng K-Y, Burton PS and Borchardt RT (1994) Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharm Res 11:412-419.
9. Pan W, Bank WA and Kastin AJ (1998) Permeability of the blood-brain/spinal cord barrier to neurotrophins. Brain Res 788:87-94.
10. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JRS, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu W-S, Terrett JA, Elshourbagy NA, Bergsma DJ and Yanagisawa M (1998) Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585.
11. Wolf G (1998) Orexins: A newly discovered family of hypothalamic regulators of food intake. Nutr Rev 56:172-173.
12. Zlokovic BV, Begley DJ, Djuricic BM and Mitrovic DM (1986) Measurement of solute transport across the blood-brain barrier in perfused guinea-pig brain: Method and application to N-methyl-α-aminoisobutyric acid. J Neurochem 46:1444-1451.