-
1
-
-
0242456105
-
Hypocretin-1 causes G protein activation and increases ACh release in rat pons
-
Bernard R, Lydic R, and Baghdoyan HA (2003) Hypocretin-1 causes G protein activation and increases ACh release in rat pons. Eur J Neurosci 18:1775-1785.
-
(2003)
Eur J Neurosci
, vol.18
, pp. 1775-1785
-
-
Bernard, R.1
Lydic, R.2
Baghdoyan, H.A.3
-
2
-
-
33645121613
-
35S]GTPγS autoradiography
-
Nishino S and Sakurai T eds Humana Press Inc., Totowa, NJ
-
35S]GTPγS autoradiography, in The Orexin/Hypocretin System: Physiology and Pathophysiology (Nishino S and Sakurai T eds) pp 83-96, Humana Press Inc., Totowa, NJ.
-
(2005)
The Orexin/Hypocretin System: Physiology and Pathophysiology
, pp. 83-96
-
-
Bernard, R.1
Lydic, R.2
Baghdoyan, H.A.3
-
4
-
-
0027978675
-
Pertussis toxin-catalyzed ADP-ribosylation of G proteins
-
Carty D (1994) Pertussis toxin-catalyzed ADP-ribosylation of G proteins. Methods Enzymol 237:63-70.
-
(1994)
Methods Enzymol
, vol.237
, pp. 63-70
-
-
Carty, D.1
-
5
-
-
0033588184
-
Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
-
Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.
-
(1999)
Cell
, vol.98
, pp. 437-451
-
-
Chemelli, R.M.1
Willie, J.T.2
Sinton, C.M.3
Elmquist, J.K.4
Scammell, T.5
Lee, C.6
Richardson, J.A.7
Williams, S.C.8
Xiong, Y.9
Kisanuki, Y.10
-
6
-
-
0008390266
-
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
-
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, et al. (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95:322-327.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 322-327
-
-
De Lecea, L.1
Kilduff, T.S.2
Peyron, C.3
Gao, X.4
Foye, P.E.5
Danielson, P.E.6
Fukuhara, C.7
Battenberg, E.L.8
Gautvik, V.T.9
Bartlett II, F.S.10
-
7
-
-
0035478438
-
Heterodimerization of G-protein-coupled receptors: Pharmacology, signaling and trafficking
-
Devi LA (2001) Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharm Sci 22:532-537.
-
(2001)
Trends Pharm Sci
, vol.22
, pp. 532-537
-
-
Devi, L.A.1
-
8
-
-
0035977981
-
Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats
-
Greco MA and Shiromani PJ (2001) Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats. Brain Res Mol Brain Res 88:176-182.
-
(2001)
Brain Res Mol Brain Res
, vol.88
, pp. 176-182
-
-
Greco, M.A.1
Shiromani, P.J.2
-
9
-
-
0032711428
-
Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons
-
Gronier B and Rasmussen K (1999) Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons. Neuropharmacology 38:1903-1912.
-
(1999)
Neuropharmacology
, vol.38
, pp. 1903-1912
-
-
Gronier, B.1
Rasmussen, K.2
-
10
-
-
0242552831
-
35S]GTPγS binding assay: Approaches and applications in pharmacology
-
35S]GTPγS binding assay: approaches and applications in pharmacology. Life Sci 74:489-508.
-
(2003)
Life Sci
, vol.74
, pp. 489-508
-
-
Harrison, C.1
Traynor, J.R.2
-
11
-
-
0035952657
-
G(z) signaling: Emerging divergence from G(i) signaling
-
Ho MK and Wong YK (2001) G(z) signaling: emerging divergence from G(i) signaling. Oncogene 20:1615-1625.
-
(2001)
Oncogene
, vol.20
, pp. 1615-1625
-
-
Ho, M.K.1
Wong, Y.K.2
-
12
-
-
0042316832
-
Effects of orexin (hypocretin) on GIRK channels
-
Hoang QV, Bajic D, Yanagisawa M, Nakajima S, and Nakajima Y (2003) Effects of orexin (hypocretin) on GIRK channels. J Neurophysiol 90:693-702.
-
(2003)
J Neurophysiol
, vol.90
, pp. 693-702
-
-
Hoang, Q.V.1
Bajic, D.2
Yanagisawa, M.3
Nakajima, S.4
Nakajima, Y.5
-
13
-
-
14844332030
-
OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms
-
Holmqvist T, Johansson L, Ostman M, Ammoun S, Akerman KEO, and Kukkonen JP (2005) OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. J Biol Chem 280:6570-6579.
-
(2005)
J Biol Chem
, vol.280
, pp. 6570-6579
-
-
Holmqvist, T.1
Johansson, L.2
Ostman, M.3
Ammoun, S.4
Akerman, K.E.O.5
Kukkonen, J.P.6
-
14
-
-
0141920775
-
Orexin receptors and G-protein coupling: Evidence for another "promiscuous" seven transmembrane domain receptor
-
Karteris E and Randeva HS (2003) Orexin receptors and G-protein coupling: evidence for another "promiscuous" seven transmembrane domain receptor. J Pharmacol Sci 93:126-128.
-
(2003)
J Pharmacol Sci
, vol.93
, pp. 126-128
-
-
Karteris, E.1
Randeva, H.S.2
-
15
-
-
0034255401
-
The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders
-
Kilduff TS and Peyron C (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci 23:359-365.
-
(2000)
Trends Neurosci
, vol.23
, pp. 359-365
-
-
Kilduff, T.S.1
Peyron, C.2
-
18
-
-
3042742527
-
35S]GTPγS autoradiography: A powerful functional approach with expanding potential for neuropharmacological studies on receptors coupled to Gi family of G proteins
-
35S]GTPγS autoradiography: a powerful functional approach with expanding potential for neuropharmacological studies on receptors coupled to Gi family of G proteins. Curr Neuropharmacol 2:191-206.
-
(2004)
Curr Neuropharmacol
, vol.2
, pp. 191-206
-
-
Laitinen, J.T.1
-
19
-
-
22244443005
-
Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
-
Lee MG, Hassani OK, and Jones BE (2005) Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 25:6716-6720.
-
(2005)
J Neurosci
, vol.25
, pp. 6716-6720
-
-
Lee, M.G.1
Hassani, O.K.2
Jones, B.E.3
-
20
-
-
0033529520
-
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
-
Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, and Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98:365-376.
-
(1999)
Cell
, vol.98
, pp. 365-376
-
-
Lin, L.1
Faraco, J.2
Li, R.3
Kadotani, H.4
Rogers, W.5
Lin, X.6
Qiu, X.7
De Jong, P.J.8
Nishino, S.9
Mignot, E.10
-
21
-
-
28044444302
-
Sleep, anesthesiology and the neurobiology of arousal state control
-
Lydic R and Baghdoyan HA (2005) Sleep, anesthesiology and the neurobiology of arousal state control. Anesthesiology 103:1268-1295.
-
(2005)
Anesthesiology
, vol.103
, pp. 1268-1295
-
-
Lydic, R.1
Baghdoyan, H.A.2
-
22
-
-
19544376694
-
Behavioral correlates of activity in identified hypocretin/orexin neurons
-
Mileykovskiy BY, Kiyashchenko LI, and Siegel JM (2005) Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46:787-798.
-
(2005)
Neuron
, vol.46
, pp. 787-798
-
-
Mileykovskiy, B.Y.1
Kiyashchenko, L.I.2
Siegel, J.M.3
-
23
-
-
0033971611
-
Hypocretin (orexin) deficiency in human narcolepsy
-
Nishino S, Ripley B, Overeem S, Lammers GJ, and Mignot E (2000) Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355:39-40.
-
(2000)
Lancet
, vol.355
, pp. 39-40
-
-
Nishino, S.1
Ripley, B.2
Overeem, S.3
Lammers, G.J.4
Mignot, E.5
-
25
-
-
0032402181
-
Neurons containing hypocretin (orexin) project to multiple neuronal systems
-
Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, and Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015.
-
(1998)
J Neurosci
, vol.18
, pp. 9996-10015
-
-
Peyron, C.1
Tighe, D.K.2
Van Den Pol, A.N.3
De Lecea, L.4
Heller, H.C.5
Sutcliffe, J.G.6
Kilduff, T.S.7
-
26
-
-
0036973951
-
Adenosine receptors in the nervous system: Pathophysiological implications
-
Ribeiro JA, Sebastiao AM, and de Mendonca A (2003) Adenosine receptors in the nervous system: pathophysiological implications. Prog Neurobiol 68:377-392.
-
(2003)
Prog Neurobiol
, vol.68
, pp. 377-392
-
-
Ribeiro, J.A.1
Sebastiao, A.M.2
De Mendonca, A.3
-
27
-
-
0032489093
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585.
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
-
29
-
-
0036016118
-
The physiology and pharmacology of the orexins
-
Smart D and Jerman JC (2002) The physiology and pharmacology of the orexins. Pharmacol Ther 94:51-61.
-
(2002)
Pharmacol Ther
, vol.94
, pp. 51-61
-
-
Smart, D.1
Jerman, J.C.2
-
30
-
-
0002131765
-
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
-
Smart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F, Elshourbagy NA, Ellis CE, Middlemiss DN, and Brown F (1999) Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br J Pharmacol 128:1-3.
-
(1999)
Br J Pharmacol
, vol.128
, pp. 1-3
-
-
Smart, D.1
Jerman, J.C.2
Brough, S.J.3
Rushton, S.L.4
Murdock, P.R.5
Jewitt, F.6
Elshourbagy, N.A.7
Ellis, C.E.8
Middlemiss, D.N.9
Brown, F.10
-
31
-
-
0035084442
-
SB-334867-A: The first selective orexin-1 receptor antagonist
-
Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA, and Jerman JC (2001) SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132:1179-1182.
-
(2001)
Br J Pharmacol
, vol.132
, pp. 1179-1182
-
-
Smart, D.1
Sabido-David, C.2
Brough, S.J.3
Jewitt, F.4
Johns, A.5
Porter, R.A.6
Jerman, J.C.7
-
32
-
-
33751357411
-
GABA levels are increased in the pontine reticular nucleus, oral part (PnO) of anesthetized rat by dialysis administration of hypocretin-1 (orexin A)
-
Soto-Calderon H, Lydic R, and Baghdoyan HA (2005) GABA levels are increased in the pontine reticular nucleus, oral part (PnO) of anesthetized rat by dialysis administration of hypocretin-1 (orexin A). Sleep 28 (Abstr Suppl):0036.
-
(2005)
Sleep
, vol.28
, Issue.ABSTR SUPPL.
, pp. 0036
-
-
Soto-Calderon, H.1
Lydic, R.2
Baghdoyan, H.A.3
-
34
-
-
0037379551
-
Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time
-
Tanase D, Baghdoyan HA, and Lydic R (2003) Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time. Anesthesiology 98:912-920.
-
(2003)
Anesthesiology
, vol.98
, pp. 912-920
-
-
Tanase, D.1
Baghdoyan, H.A.2
Lydic, R.3
-
35
-
-
0033710848
-
Reduced number of hypocretin neurons in human narcolepsy
-
Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Comford M, and Siegel JM (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27:469-474.
-
(2000)
Neuron
, vol.27
, pp. 469-474
-
-
Thannickal, T.C.1
Moore, R.Y.2
Nienhuis, R.3
Ramanathan, L.4
Gulyani, S.5
Aldrich, M.6
Comford, M.7
Siegel, J.M.8
-
36
-
-
0142157610
-
Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: Site and mechanism of action
-
Tzavara ET, Wade M, and Nomikos GG (2003) Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action. J Neurosci 23:9374-9384.
-
(2003)
J Neurosci
, vol.23
, pp. 9374-9384
-
-
Tzavara, E.T.1
Wade, M.2
Nomikos, G.G.3
-
37
-
-
0032189780
-
Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
-
van den Pol AN, Gao XB, Obrietan K, Kilduff TS, and Belousov AB (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 18:7962-7971.
-
(1998)
J Neurosci
, vol.18
, pp. 7962-7971
-
-
Van Den Pol, A.N.1
Gao, X.B.2
Obrietan, K.3
Kilduff, T.S.4
Belousov, A.B.5
-
38
-
-
0038380613
-
Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones
-
549.3
-
van den Top M, Nolan MF, Lee K, Richardson PJ, Buijs RM, Davies CH, and Spanswick D (2003) Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones. J Physiol 549.3:809-821.
-
(2003)
J Physiol
, pp. 809-821
-
-
Van Den Top, M.1
Nolan, M.F.2
Lee, K.3
Richardson, P.J.4
Buijs, R.M.5
Davies, C.H.6
Spanswick, D.7
-
39
-
-
0025860813
-
Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles
-
van der Ploeg I, Cintra A, Altiok N, Askeloef P, Fuxe K, and Fredholm BB (1991) Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles. Neuroscience 44:205-214.
-
(1991)
Neuroscience
, vol.44
, pp. 205-214
-
-
Van Der Ploeg, I.1
Cintra, A.2
Altiok, N.3
Askeloef, P.4
Fuxe, K.5
Fredholm, B.B.6
-
40
-
-
0037409367
-
G protein-coupled receptor cross talk: Pivotal roles of protein phosphorylation and protein-protein interaction
-
Vazquez-Prado J, Casas-Gonzalez P, and Garcia-Sainz JA (2003) G protein-coupled receptor cross talk: pivotal roles of protein phosphorylation and protein-protein interaction. Cell Signal 15:549-557.
-
(2003)
Cell Signal
, vol.15
, pp. 549-557
-
-
Vazquez-Prado, J.1
Casas-Gonzalez, P.2
Garcia-Sainz, J.A.3
-
41
-
-
0036086471
-
Induction of active (REM) sleep by microinjection of hypocretin into the nucleus pontis oralis of the cat
-
Xi M-C, Fung SJ, Yamuy J, Morales FR, and Chase MH (2002) Induction of active (REM) sleep by microinjection of hypocretin into the nucleus pontis oralis of the cat. J Neurophysiol 87:2880-2888.
-
(2002)
J Neurophysiol
, vol.87
, pp. 2880-2888
-
-
Xi, M.-C.1
Fung, S.J.2
Yamuy, J.3
Morales, F.R.4
Chase, M.H.5
-
42
-
-
9344265788
-
Interactions between GABAergic and cholinergic processes in the nucleus pontis oralis: Neuronal mechanisms controlling active (rapid eye movement) sleep and wakefulness
-
Xi M-C, Morales FR, and Chase MH (2004) Interactions between GABAergic and cholinergic processes in the nucleus pontis oralis: neuronal mechanisms controlling active (rapid eye movement) sleep and wakefulness. J Neurosci 24:10670-10678.
-
(2004)
J Neurosci
, vol.24
, pp. 10670-10678
-
-
Xi, M.-C.1
Morales, F.R.2
Chase, M.H.3
-
43
-
-
0042565939
-
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
-
Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, and Goto K (2003) Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci 92:259-266.
-
(2003)
J Pharmacol Sci
, vol.92
, pp. 259-266
-
-
Zhu, Y.1
Miwa, Y.2
Yamanaka, A.3
Yada, T.4
Shibahara, M.5
Abe, Y.6
Sakurai, T.7
Goto, K.8
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