Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

Peptides

Volumn 20, Issue 9, 1999, Pages 1099-1105

  Haynes, Andrea C ^a   Jackson, Brian ^a   Overend, Phil ^a   Buckingham, Robin E ^a   Wilson, Shelagh ^a   Tadayyon, Mohammad ^a   Arch, Jonathan R S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Feeding; i.c.v. administration; Light dark cycle; Orexins

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; NEUROPEPTIDE; OREXIN A; OREXIN B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIET RESTRICTION; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032858014     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00105-9     Document Type: Article

References (41)

1. Beck B., Jhanwar-Uniyal M., Burlet A., Chapleur-Chateau M., Leibowitz S.F., Burlet C. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528:1990;245-249.
2. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited neuroanatomy, body weight regulation, neuroendocrinology and metabolism . Neurosci Biobehav Rev. 17:1993;141-193.
3. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited ingestive behaviour . Neurosci Biobehav Rev. 20:1996;189-287.
4. Broberger C., de Lecea L., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus relationship to the neuropeptide Y and agouti gene-related protein systems . J Comp Neurol. 402:1998;460-474.
5. Cai XJ, Widdowson PS, Harrold JA, Wilding J, Buckingham R, Wilson S, Arch JRS, Williams G. Hypothalamic orexin neurones: a role in the integration of feeding behaviour. Int J Obes Relat Metab Disord 1999, in press.
6. Cochran W.G., Cox G.M. Experimental designs. 1957;John Wiley & Sons, New York.
7. de Lecea L., Kilduff T.S., Peyron C., Gao X.-B., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L.F., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins hypothalamus-specific peptides with neuroexcitatory activity . Proc Natl Acad Sci USA. 95:1998;322-327.
8. Diano S., van den Pol A.N., Horvath T.L. Hypocretin (orexin)-containing neuronal network in the primate hypothalamus and its relationship to fasting-induced c-fos expressing cells. Soc Neurosci. 24:1998;12.
9. Dube M.G., Kalra S.P., Kalra P.S. Food intake elicited by central administration of orexins Identification of hypothalamic sites of action . Soc Neurosci. 24:1998;448.
10. Elias C.F., Saper C.B., Maratos-Flier E., Tritos N.A., Lee C., Kelly J., Tatro J.B., Hoffman G.E., Ollmann M.M., Barsh G.S., Sakurai T., Yanagisawa M., Elmquist J.K. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamus. J Comp Neurol. 402:1998;442-459.
11. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (Lond). 381:1996;415-421.
12. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature (Lond). 385:1997;165-168.
13. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DNC, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N. Orexin-A activates locus coeruleus cell firing and increases arousal in the rat. In press, 1999.
14. Haynes, AC, Arch JRS, Wilson S, McClue S, Buckingham RE. Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor? Regul Pept 1998;75-76:355-61.
15. Horvath T.L., Diano S., van den Pol A.N. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus a novel circuit implicated in metabolic and endocrine regulators . J Neurosci. 19:1999;1072-1087.
16. Ida T., Nakahara K., Katayama T., Murakami N., Nakazato M. Effects of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioural activities of rats. Brain Res. 821:1999;526-529.
17. Jain M.R., Pu S., Kalra S.P. Orexin-B. A novel neuropeptide activates hypothalamic axes regulating appetite and reproduction. Soc Neurosci. 24:1998;269.
18. Kalra S.P., Dube M.G., Sahu A., Phelps C.P., Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA. 88:1991;10931-10935.
19. Kyrkouli S.E., Stanley B.G., Leibowitz S.F. Galanin. Stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur J Pharmacol. 122:1986;159-160.
20. Leibowitz S.F. Paraventricular nucleus a primary site mediating adrenergic stimulation of feeding and drinking . Pharmacol Biochem Behav. 8:1977;163-175.
21. Levine A.S., Morley J.E. Neuropeptide Y a potent inducer of consumatory behaviour in rats . Peptides. 5:1984;1025-1029.
22. Lubkin M., Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun. 253:1998;241-245.
23. McKay L.D., Kenney N.J., Edens N.K., Williams R.H., Woods S.C. Intracerebroventricular β-endorphin increases food intake of rats. Life Sci. 29:1981;1429-1434.
24. McKibbin P.E., Rogers P., Williams G. Increased neuropeptide Y concentrations in the lateral hypothalamic area of the rat after the onset of darkness Possible relevance to the circadian periodicity of feeding behaviour . Life Sci. 48:1991;2527-2533.
25. Moore R.Y., Speh J.C., van den Pol A.N. Hypocretin localization in the human hypothalamus. Soc Neurosci. 24:1998;1918.
26. Morley J.E., Levine A.S., Grace M., Kneip J. Peptide YY (PYY) a potent orexigenic agent. Brain Res. 341:1985;200-203.
27. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.G., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 18:1998;9996-10015.
28. Qu D., Ludwig D.S., Gammeltoft S., Piper M., Pelleymounter M.A., Cullen M.J., Mathes W.F., Przypek J., Kanarek R., Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature (Lond). 380:1996;243-247.
29. Rossi M., Choi S.J., O'Shea D., Miyoshi T., Ghatei M.A., Bloom S.R. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology. 138:1997;351-355.
30. Rossi M., Kim M.S., Morgan D.G., Small C.J., Edwards C.M., Sunter D., Abusnana S., Goldstone A.P., Russell S.H., Stanley S.A., Smith D.M., Yagaloff K., Ghatei M.A., Bloom S.R. A c-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo. Endocrinology. 139:1998;4428-4431.
31. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors a family of hypothalamic neuropeptides and G-protein-coupled receptors that regulate feeding behaviour . Cell. 92:1998;573-585.
32. Samson W.K., Murphy T.C., Chang J.K., Gosneil B.A. Sympathostimulatory effects of orexin doses which stimulate sucrose feeding elevate blood pressure in conscious rats. Soc Neurosci. 24:1998;203.
33. Sanchez M., Baker B.I., Celis M. Melanin-concentrating hormone (MCH) antagonizes the effects of a-MSH and neuropeptide E-I on grooming and locomotor activities in the rat. Peptides. 18:1997;393-396.
34. Schick R.R., Schusdziarra V., Nussbaumer C., Meinhard C. Neuropeptide Y and food intake in fasted rats Effect of naloxone and site of action . Brain Res. 552:1991;232-239.
35. Shimada M., Tritos N.A., Lowell B.B., Flier J.S., Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (Lond). 396:1998;670-674.
36. Smith B.K., York D.A., Bray G.A. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides. 15:1994;1267-1272.
37. Stanley B.G., Kyrkouli S.E., Lampert S., Leibowitz S.F. Neuropeptide Y chronically injected into the hypothalamus a powerful neurochemical inducer of hyperphagia and obesity . Peptides. 7:1986;1189-1192.
38. Stanley B.G., Thomas W.J. Feeding responses to preifornical hypothalamic injection of neuropeptide Y in relation to circadian rhythms of eating behaviour. Peptides. 14:1993;475-481.
39. Tatemoto K. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci. 79:1982;2514-2518.
40. Tempel D.L., Leibowitz S.F. Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN. Brain Res Bull. 25:1990;821-825.
41. Trivedi P., Yu H., MacNeil D.J., van der Ploeg L.H.T., Guan X. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett. 438:1998;71-75.