Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities

European Journal of Neuroscience

Volumn 14, Issue 7, 2001, Pages 1075-1081

  Yoshida, Y ^a,b   Fujiki, N ^a   Nakajima, T ^b   Ripley, B ^a   Matsumura, H ^b   Yoneda, H ^b   Mignot, E ^a   Nishino, Seiji ^a  

^a STANFORD UNIVERSITY   (United States)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Circadian; Homeostasis; Microdialysis; Narcolepsy; Sleep propensity

Indexed keywords

OREXIN A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORRELATION ANALYSIS; HYPOTHALAMUS; LIGHT DARK CYCLE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SLEEP; SLEEP DEPRIVATION; SLEEP WAKING CYCLE; THALAMUS; WAKEFULNESS;

ANIMALS; CARRIER PROTEINS; CIRCADIAN RHYTHM; DIENCEPHALON; DOWN-REGULATION; EXTRACELLULAR SPACE; HYPOTHALAMIC AREA, LATERAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICRODIALYSIS; MIDLINE THALAMIC NUCLEI; NEURONS; NEUROPEPTIDES; PHOTIC STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SLEEP; SLEEP DEPRIVATION; SLEEP, REM; UP-REGULATION; WAKEFULNESS;

EID: 0035783672     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01725.x     Document Type: Article

References (44)

1. Abrahamson, E.E., Leak, R.K. & Moore, R.Y. (2001) The suprachiasmatic nucleus projects to posterior hypothalamus arousal system. Neuroreport, 12, 435-440.
2. Bassetti, C. & Aldrich, M. (1996) Narcolepsy. Neurol. Clinics, 14, 545-571.
3. Bernardis, L.L. & Bellinger, L.L. (1993) The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neurosci. Bio. Behav. Rev., 17, 141-193.
4. Borbely, A.A., Baumann, F., Brandeis, D., Strauch, I. & Lehmann, D. (1981) Sleep deprivation: Effect on sleep stages and EEG power density in man. Electroencephalogr. Clin. Neurophysiol., 51, 483-495.
5. Broughton, R., Krupa, S., Boucher, B., Rivers, M. & Mulligan, J. (1998) Impaired circadian waking arousal in narcolepsy-cataplexy. Sleep Res. Online, 1, 159-165.
6. Brown, R.E., Sergeeva, O., Eriksson, K.S. & Haas, H.L. (2001) Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology, 40, 457-459.
7. Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B. & Yanagisawa, M. (1999) Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation. Cell, 98, 437-451.
8. Daan, S., Beersma, D.G. & Borbely, A.A. (1984) Timing of human sleep: Recovery process gated by a circadian pacemaker. Am. J. Physiol., 246, R161-R183.
9. Dantz, B., Edgar, D.M. & Dement, W.C. (1994) Circadian rhythms in narcolepsy: Studies on a 90 minute day. Electroencephalogr. Clin. Neurophysiol., 90, 24-35.
10. Date, Y., Ueta. Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. & Nakazato, M. (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. USA, 96, 748-753.
11. Dijk, D.J. & Czeisler, C.A. (1994) Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci. Lett., 166, 63-68.
12. Edgar, . D.M., Dement, W.C. & Fuller, C.A. (1993) Effect of SCN-lesions on sleep in squirrel monkeys: Evidence for opponent processes in sleep-wake regulation. J. Neurosci., 13, 1065-1079.
13. Franken, P., Tobler, I. & Borbely, A.A. (1991) Sleep homeostasis in the rat: Simulation of the time course of EEG slow-wave activity. Neurosci. Lett., 130, 141-144.
14. Fujiki, N., Yoshida, Y., Ripley, B., Honda, K., Mignot, E. & Nishino, S. (2001) Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. Neuroreport, 12, 993-997.
15. Hagan, J.J., Leslie, R.A., Patel, S., Evans, M.L., Wattam, T.A., Holmes, S., Benham, C.D., Taylor, S.G., Routledge, C., Hemmati, P., Munton. R.P., Ashmeade, T.E., Shah, A.S., Hatcher, J.P., Hatcher, P.D., Jones, D.N., Smith, M.I., Piper, D.C., Hunter, A.J., Porter, R.A. & Upton, N. (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl. Acad. Sci. USA, 96, 10911-10916.
16. Hara, J., Beuckmann, C.T., Nambu, T., Willie, J.T., Chemelli, R.M., Sinton, C.M., Sugiyama, F., Yagami, K., Goto, K., Yanagisawa, M. & Sakurai, T. (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron, 30, 345-354.
17. Hishikawa, Y., Wakamatsu, H., Furuya, E., Sugita, Y., Masaoka, S., Kaneda, H., Sato, M., Nan'no, H. & Kaneko, Z. (1976) Sleep satiation in narcoleptic patients. Electroencephalogr. Clin. Neurophysiol., 41, 1-18.
18. Jones, B.E. (1994) Basic mechanism of sleep-wake states. In Kryger, M.H., Roth, T. & Dement, W.C., (eds), Principles and Practice of Sleep Medicine. W.B. Saunders Co., Philadelphia, pp. 145-162.
19. Kilduff, T.S. & Peyron, C. (2000) The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders. Trends Neurosci., 23, 359-365.
20. de Lecea, L., Kilduff, T., Peyron, C., Gao, X.-B., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L.F., Gautvik, V.T., Bartlett, F.S., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. & Sutcliffe, J.G. (1998) The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA, 95, 322-327.
21. Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S. & Mignot, E. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell, 98, 365-376.
22. Marcus, J.N., Aschkenasi, C.J., Lee, C.E., Chemelli, R.M., Saper, C.B., Yanagisawa, M. & Elmquist, J.K. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol., 435, 6-25.
23. Matsumura, H., Kinoshita, G., Satoh, S., Osaka, T. & Hayaishi, O. (1995) A novel apparatus that permits multiple routes for infusions and body-fluid collections in a freely-moving animal. J. Neurosci. Meth., 57, 145-149.
24. 2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. Proc. Natl. Acad. Sci. USA, 91, 11998-12002.
25. Mitler, M.M., Gujavarty, K.S. & Browman, C.P. (1982) Maintenance of wakefulness test: A polysomnographic technique for evaluation treatment efficacy in patients with excessive somnolence. Electroencephalogr. Clin. Neurophysiol., 53, 658-661.
26. Montplaisir, J. (1976) Disturbed nocturnal sleep. In Guilleminault, C., Dement, W.C. & Passouant, P., (eds), Narcolepsy, Spectrum, New York, pp. 43-56.
27. Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T. (2000) Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res., 873, 181-187.
28. Nishino, S., Honda, K., Fujiki, N., Wurts, S.W., Sakurai, E., Kato, M., Watanabe, T., Mignot, E. & Yanai, K. (2001). The role of histamine in a hypocretin (orexin)-deficient sleep disorder, narcolepsy. In Yanai, K. (ed.), International Sendai Histamine Symposium, Sendai, Japan, Elsevier; pp. 247-252.
29. Nishino, S., Okura, M. & Mignot, M. (2000a) Narcolepsy: Genetic predisposition and neuropharmacological mechanisms. Sleep Med. Rev., 4, 57-99.
30. Nishino, S., Riehl, J., Hong, J., Kwan, M., Reid, M. & Mignot, E. (2000c) Is narcolepsy REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans. Neurosci. Res., 38, 437-446.
31. Nishino, S., Ripley, B., Overeem, S., Lammers, G.L. & Mignot, E. (2000b) Hypocretin (orexin) deficiency in human narcolepsy. Lancet, 355, 39-40.
32. Paxinos, G. & Watson, C. (1986). The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
33. Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., Li, R., Hungs, M., Pedrazzoli, M., Padigaru, M., Kucherlapati, M., Fan, J., Maki, R., Lammers, G.J., Bouras, C., Kucherlapati, R., Nishino, S. & Mignot, E. (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nature Med., 6, 991-997.
34. Peyron, C., Tighe, D.K., van den Pol. A.N., Lecea, L., Heller, H.C., Sutcliffe, J.G. & Kilduff, T.S. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci., 18, 9996-10015.
35. Pittendrigh, C.S. & Daan, S. (1976) A functional analysis of circadian pacemakers in nocturnal rodents, IV: Entrainment, pacemaker as a clock. J. Comp. Physiol., 106, 291-331.
36. Ripley, B., Fujiki, N., Okura, M., Mignot, E. & Nishino, S. (2001) Hypocretin levels in sporadic and familial cases of canine narcolepsy. Neurobiol. Dis., 8, 525-534.
37. Sakurai, T., Amemiya, A., Ishil, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch., J.R.S., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.-S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. & Yanagisawa, M. (1998) Orexins and orexin receptors: A family of hypothalamic neuropeptides and G-protein-coupled receptors that regulate feeding behavior. Cell, 92, 573-585.
38. Strand, F.L. (1999). Neuropeptide: Regulators of Physiological Processes, The MIT press, Massachusetts.
39. Tafti, M., Rondouin, G., Basset, A. & Billiard, M. (1992a) Sleep deprevation in narcoleptic subjects: Effect on sleep stages and EEG power density. Electroencephalogr. Clin. Neurophysiol., 83, 339-349.
40. Tafti, M., Villemin, E., Carlander, B., Besset, A. & Billiard, M. (1992b) Sleep in human narcolepsy revisited with special reference to prior wakefulness duration. Sleep, 15, 344-351.
41. Taheri, S., Sunter, D., Dakin, C., Moyes, S., Seal, L., Gardiner, J., Rossi, M., Ghatei, M. & Bloom, S. (2000) Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system. Neurosci. Lett., 279, 109-112.
42. Terao, A., Peyron, C., Ding, J., Wurts, S.W., Edgar, D.M., Heller, H.C. & Kilduff, T.S. (2000) Preprohypocretin (prepro-orexin) expression is unaffected by short-term sleep deprivation in rats and mice. Sleep, 23, 867-874.
43. Thannickal, T.C., Moore, R.Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M. & Siegel, J.M. (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron, 27, 469-474.
44. Xi, M., Morales, F.R. & Chase, M.H. (2001) Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat. Brain Res., 901, 259-264.