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Volumn 450, Issue 7168, 2007, Pages 420-424

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

Author keywords

[No Author keywords available]

Indexed keywords

CHANNELRHODOPSIN 2; OREXIN; RHODOPSIN; UNCLASSIFIED DRUG;

EID: 36248996490     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06310     Document Type: Article
Times cited : (1053)

References (29)
  • 1
    • 0036674614 scopus 로고    scopus 로고
    • The neurobiology of sleep: Genetics, cellular physiology and subcortical networks
    • Pace-Schott, E. F. & Hobson, J. A. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nature Rev. Neurosci. 3, 591-605 (2002).
    • (2002) Nature Rev. Neurosci , vol.3 , pp. 591-605
    • Pace-Schott, E.F.1    Hobson, J.A.2
  • 2
    • 0035576935 scopus 로고    scopus 로고
    • The sleep switch: Hypothalamic control of sleep and wakefulness
    • Saper, C. B., Chou, T. C. & Scammell, T. E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 24, 726-731 (2001).
    • (2001) Trends Neurosci , vol.24 , pp. 726-731
    • Saper, C.B.1    Chou, T.C.2    Scammell, T.E.3
  • 3
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea, L. et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA 95, 322-327 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 322-327
    • de Lecea, L.1
  • 4
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585 (1998).
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1
  • 5
    • 0032402181 scopus 로고    scopus 로고
    • Neurons containing hypocretin (orexin) project to multiple neuronal systems
    • Peyron, C. et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18, 9996-10015 (1998).
    • (1998) J. Neurosci , vol.18 , pp. 9996-10015
    • Peyron, C.1
  • 6
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
    • Chemelli, R. M. et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437-451 (1999).
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1
  • 7
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • Lin, L. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365-376 (1999).
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1
  • 8
    • 0033826856 scopus 로고    scopus 로고
    • A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    • Peyron, C. et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nature Med. 6, 991-997 (2000).
    • (2000) Nature Med , vol.6 , pp. 991-997
    • Peyron, C.1
  • 9
    • 0033710848 scopus 로고    scopus 로고
    • Reduced number of hypocretin neurons in human narcolepsy
    • Thannickal, T. C. et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27, 469-474 (2000).
    • (2000) Neuron , vol.27 , pp. 469-474
    • Thannickal, T.C.1
  • 10
    • 26444621497 scopus 로고    scopus 로고
    • Millisecondtimescale, genetically targeted optical control of neural activity
    • Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecondtimescale, genetically targeted optical control of neural activity. Nature Neurosci. 8, 1263-1268 (2005).
    • (2005) Nature Neurosci , vol.8 , pp. 1263-1268
    • Boyden, E.S.1    Zhang, F.2    Bamberg, E.3    Nagel, G.4    Deisseroth, K.5
  • 11
    • 29044433616 scopus 로고    scopus 로고
    • Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    • Nagel, G. et al. Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Curr. Biol. 15, 2279-2284 (2005).
    • (2005) Curr. Biol , vol.15 , pp. 2279-2284
    • Nagel, G.1
  • 12
    • 33749020262 scopus 로고    scopus 로고
    • Channelrhodopsin-2 and optical control of excitable cells
    • Zhang, F., Wang, L. P., Boyden, E. S. & Deisseroth, K. Channelrhodopsin-2 and optical control of excitable cells. Nature Methods 3, 785-792 (2006).
    • (2006) Nature Methods , vol.3 , pp. 785-792
    • Zhang, F.1    Wang, L.P.2    Boyden, E.S.3    Deisseroth, K.4
  • 13
    • 17044431846 scopus 로고    scopus 로고
    • Remote control of behavior through genetically targeted photostimulation of neurons
    • Lima, S. Q. & Miesenbock, G. Remote control of behavior through genetically targeted photostimulation of neurons. Cell 121, 141-152 (2005).
    • (2005) Cell , vol.121 , pp. 141-152
    • Lima, S.Q.1    Miesenbock, G.2
  • 14
    • 34547133175 scopus 로고    scopus 로고
    • An optical neural interface: In vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology
    • Aravanis, A. M. et al. An optical neural interface: In vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J. Neural Eng. 4, S143-S156 (2007).
    • (2007) J. Neural Eng , vol.4
    • Aravanis, A.M.1
  • 15
    • 34247548430 scopus 로고    scopus 로고
    • Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
    • Petreanu, L., Huber, D., Sobczyk, A. & Svoboda, K. Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nature Neurosci. 10, 663-668 (2007).
    • (2007) Nature Neurosci , vol.10 , pp. 663-668
    • Petreanu, L.1    Huber, D.2    Sobczyk, A.3    Svoboda, K.4
  • 16
    • 34147126914 scopus 로고    scopus 로고
    • In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
    • Arenkiel, B. R. et al. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron 54, 205-218 (2007).
    • (2007) Neuron , vol.54 , pp. 205-218
    • Arenkiel, B.R.1
  • 17
    • 34147162254 scopus 로고    scopus 로고
    • High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice
    • Wang, H. et al. High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc. Natl Acad. Sci. USA 104, 8143-8148 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 8143-8148
    • Wang, H.1
  • 18
    • 33645974269 scopus 로고    scopus 로고
    • Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration
    • Bi, A. et al. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50, 23-33 (2006).
    • (2006) Neuron , vol.50 , pp. 23-33
    • Bi, A.1
  • 19
    • 33750681712 scopus 로고    scopus 로고
    • Transgenic mice with a reduced core body temperature have an increased life span
    • Conti, B. et al. Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006).
    • (2006) Science , vol.314 , pp. 825-828
    • Conti, B.1
  • 20
    • 0033580910 scopus 로고    scopus 로고
    • Structure and function of human prepro-orexin gene
    • Sakurai, T. et al. Structure and function of human prepro-orexin gene. J. Biol. Chem. 274, 17771-17776 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 17771-17776
    • Sakurai, T.1
  • 21
    • 0037137682 scopus 로고    scopus 로고
    • Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system
    • Li, Y., Gao, X. B., Sakurai, T. & van den Pol, A. N. Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36, 1169-1181 (2002).
    • (2002) Neuron , vol.36 , pp. 1169-1181
    • Li, Y.1    Gao, X.B.2    Sakurai, T.3    van den Pol, A.N.4
  • 22
    • 22244443005 scopus 로고    scopus 로고
    • Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    • Lee, M. G., Hassani, O. K. & Jones, B. E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J. Neurosci. 25, 6716-6720 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 6716-6720
    • Lee, M.G.1    Hassani, O.K.2    Jones, B.E.3
  • 23
    • 19544376694 scopus 로고    scopus 로고
    • Behavioral correlates of activity in identified hypocretin/orexin neurons
    • Mileykovskiy, B. Y., Kiyashchenko, L. I. & Siegel, J. M. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46, 787-798 (2005).
    • (2005) Neuron , vol.46 , pp. 787-798
    • Mileykovskiy, B.Y.1    Kiyashchenko, L.I.2    Siegel, J.M.3
  • 24
    • 0035084442 scopus 로고    scopus 로고
    • SB-334867-A: The first selective orexin-1 receptor antagonist
    • Smart, D. et al. SB-334867-A: the first selective orexin-1 receptor antagonist. Br. J. Pharmacol. 132, 1179-1182 (2001).
    • (2001) Br. J. Pharmacol , vol.132 , pp. 1179-1182
    • Smart, D.1
  • 25
    • 34247222730 scopus 로고    scopus 로고
    • Multimodal fast optical interrogation of neural circuitry
    • Zhang, F. et al. Multimodal fast optical interrogation of neural circuitry. Nature 446, 633-639 (2007).
    • (2007) Nature , vol.446 , pp. 633-639
    • Zhang, F.1
  • 28
    • 0034667702 scopus 로고    scopus 로고
    • Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
    • Bourgin, P. et al. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J. Neurosci. 20, 7760-7765 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 7760-7765
    • Bourgin, P.1
  • 29
    • 0037336785 scopus 로고    scopus 로고
    • The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization
    • Eggermann, E. et al. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J. Neurosci. 23, 1557-1562 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 1557-1562
    • Eggermann, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.