Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressure

Brain Research

Volumn 950, Issue 1-2, 2002, Pages 261-267

  Smith, Pauline M ^a   Connolly, Barbara C ^a   Ferguson, Alastair V ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Autonomic control; Cardiovascular regulation; Hypocretin

Indexed keywords

NEUROPEPTIDE RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; UNCLASSIFIED DRUG; URETHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; HEART RATE; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS;

ANIMALS; BLOOD PRESSURE; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROINJECTIONS; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SOLITARY NUCLEUS;

EID: 0037144189     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03048-2     Document Type: Article

References (29)

1. Allen M.A., Smith P.M., Ferguson A.V. Adrenomedullin microinjection into the area postrema increases blood pressure. Am. J. Physiol. 272:1997;R1698-R1703.
2. Antunes V.R., Brailoiu G.C., Kwok E.H., Scruggs P., Dun N.J. Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:2001;R1801-R1807.
3. Chen C.T., Hwang L.L., Chang J.K., Dun N.J. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278:2000;R692-R697.
4. Date Y., Ueta Y., Yamashita H., Yamaguchi H., Matsukura S., Kangawa K., Sakurai T., Yanagisawa M., Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. USA. 96:1999;748-753.
5. Dube M.G., Kalra S.P., Kalra P.S. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res. 842:1999;473-477.
6. Ferguson A.V., Marcus P. Area postrema stimulation induced cardiovascular changes in the rat. Am. J. Physiol. 255:1988;R855-R860.
7. Ferguson A.V., Wall K.M. Central actions of angiotensin in cardiovascular control: multiple roles for a single peptide. Can. J. Physiol. Pharmacol. 70:1992;779-785.
8. Furchgott R.F. Role of endothelium in responses of vascular smooth muscle. Circ. Res. 53:1983;557-573.
9. Hagan J.J., Leslie R.A., Patel S., Evans M.L., Wattam T.A., Holmes S., Benham C.D., Taylor S.G., Routledge C., Hemmati P., Munton R.P., Ashmeade T.E., Shah A.S., Hatcher J.P., Hatcher P.D., Jones D.N., Smith M.I., Piper D.C., Hunter A.J., Porter R.A., Upton N. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl. Acad. Sci. USA. 96:1999;10911-10916.
10. Hegarty A.A., Hayward L.F., Felder R.B. Influence of circulating angiotensin II and vasopressin on neurons of the nucleus of the solitary tract. Am. J. Physiol. 270:1996;R675-R681.
11. Kunii K., Yamanaka A., Nambu T., Matsuzaki I., Goto K., Sakurai T. Orexins/hypocretins regulate drinking behaviour. Brain Res. 842:1999;256-261.
12. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:1999;365-376.
13. Malendowicz L.K., Hochol A., Ziolkowska A., Nowak M., Gottardo L., Nussdorfer G.G. Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal gland. Int. J. Mol. Med. 7:2001;401-404.
14. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435:2001;6-25.
15. Matsumura K., Tsuchihashi T., Abe I. Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension. 37:2001;1382-1387.
16. Nowak K.W., Mackowiak P., Switonska M.M., Fabis M., Malendowicz L.K. Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies. Life Sci. 66:2000;449-454.
17. Papas S., Smith P., Ferguson A.V. Electrophysiological evidence that systemic angiotensin influences rat area postrema neurons. Am. J. Physiol. 258:1990;R70-R76.
18. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18:1998;9996-10015.
19. Pu S., Jain M.R., Kalra P.S., Kalra S.P. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Regul. Pept. 78:1998;133-136.
20. Qu L., Mcqueeney A.J., Barnes K.L. Presynaptic or postsynaptic location of receptors for angiotensin II and substance P in the medial solitary tract nucleus. J. Neurophysiol. 75:1996;2220-2228.
21. Russell S.H., Kim M.S., Small C.J., Abbott C.R., Morgan D.G., Taheri S., Murphy K.G., Todd J.F., Ghatei M.A., Bloom S.R. Central administration of orexin A suppresses basal and domperidone stimulated plasma prolactin. J. Neuroendocrinol. 12:2000;1213-1218.
22. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [see comments]. Cell. 92:1998;573-585.
23. Samson W.K., Gosnell B., Chang J.K., Resch Z.T., Murphy T.C. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res. 831:1999;248-253.
24. Shirasaka T., Nakazato M., Matsukura S., Takasaki M., Kannan H. Sympathetic and cardiovascular actions of orexins in conscious rats. Am. J. Physiol. 277:1999;R1780-R1785.
25. Siegel J.M. Narcolepsy: a key role for hypocretins (orexins) [comment]. Cell. 98:1999;409-412.
26. Smith P.M., Ferguson A.V. Adrenomedullin acts in the rat paraventricular nucleus to decrease blood pressure. J. Neuroendocrinol. 13:2001;467-471.
27. Takahashi N., Okumura T., Yamada H., Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem. Biophys. Res. Commun. 254:1999;623-627.
28. Takeda K., Nakata T., Takesako T., Itoh H., Hirata M., Kawasaki S., Hayashi J., Oguro M., Sasaki S., Nakagawa M. Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats. Brain Res. 543:1991;296-300.
29. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA. 95:1998;322-327.