Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord

Peptides

Volumn 20, Issue 12, 1999, Pages 1455-1470

  Cutler, David J ^a   Morris, Richard ^a   Sheridhar, Vimal ^a   Wattam, Trevor A K ^b   Holmes, Stephen ^b   Patel, Sara ^b   Arch, Jonathan R S ^b   Wilson, Shelagh ^b   Buckingham, Robin E ^b   Evans, Martyn L ^b   Leslie, Ron A ^b   Williams, Gareth ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Feeding; Hypocretin; Hypothalamus; Immunohistochemistry; Lateral hypothalamic area; Orexin A; Orexin B; Spinal cord

Indexed keywords

OREXIN A; OREXIN B;

ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN VENTRICLE; HYPOTHALAMUS; IMMUNOREACTIVITY; LOCUS CERULEUS; MALE; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPINAL CORD; THALAMUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; BRAIN; CARRIER PROTEINS; EATING; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; RATS; RATS, WISTAR; SPINAL CORD; TISSUE DISTRIBUTION;

EID: 0033370580     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00157-6     Document Type: Article

References (39)

1. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited neuroanatomy, body weight regulation, neuroendocrinology and metabolism . Neurosci Biobehav Rev. 17:1993;141-193.
2. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited ingestive behavior . Neurosci Biobehav Rev. 20:1996;189-287.
3. Broberger C., de Lecea L., Sutcliffe J.G., Hökfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus relationship to the neuropeptide Y and agouti gene-related protein systems . J Comp Neurol. 402:1998;460-474.
4. Cai X., Tadayyon M., Buckingham R., Wilson S., Arch J.R.S., Widdowson P.S., Wilding J.P.H., Williams G. Changes in orexin mRNA during altered energy balance influences of leptin and insulin . Br J Pharmacol. 126:1999;4P.
5. Chen C.-T., Dun S.L., Kwok E.H., Dun N.J., Chang J-K. Orexin A-like immunoreactivity in the rat brain. Neurosci Lett. 260:1999;161-164.
6. 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography. Neurosci Lett. 70:1986;17-22.
7. Cutler D.J., Morris R., Sheridhar V., Wattam T.A., Arch J.R.S., Wilson S., Buckingham R.E., Williams G. Immunochemical investigation of a novel peptide, orexin-A anatomical distribution in rat brain and spinal cord and its relationship to other hypothalamic neurotransmitter systems . Br J Pharmacol. 126:1999;259P.
8. Dampney R.A.L. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev. 74:1994;323-364.
9. Date Y., Ueta Y., Yamashita H., Yamaguchi H., Matsukura S., Kangawa K., Sakurai T., Yanagisawa M., Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA. 96:1999;748-753.
10. de Lecea L., Kilduff T.S., Peyron C., Gao X.-B., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L.F., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins hypothalamus-specific peptides with neuroexcitatory activity . Proc Natl Acad Sci USA. 95:1998;322-327.
11. Edwards CMB, Abusnana S, Sunter D, Murphy KG, Ghatei MA, Bloom SR. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 1999;160:R7-12.
12. Feldman S.C., Kastin A.J. Localization of neurons containing immunoreactive delta sleep-inducing peptide in the rat brain an immunocytochemical study . Neuroscience. 11:1984;303-317.
13. Flier J.S., Maratos-Flier E. Obesity and the hypothalamus novel peptides for new pathways . Cell. 92:1998;437-440.
14. Griffond B., Deray A., Fellmann D., Ciofi P., Croix D., Bugnon C. Colocalization of prolactin- and dynorphin-like substances in a neuronal population of the rat lateral hypothalamus. Neurosci Lett. 156:1993;91-95.
15. Håkansson M.-L., Brown H., Ghilardi N., Skoda R.C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci. 18:1998;559-572.
16. Horvath T.L., Diano S., van den Pol A.N. Synaptic interaction between the hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus a novel circuit implicated in metabolic and endocrine regulations . J Neurosci. 19:1999;1072-1087.
17. Ida T., Nakahara K., Katayama T., Murakami N., Nakazato M. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res. 821:1999;526-529.
18. Leloup C., Arluison M., Lepetit N., Cartier N., Marfaing-Jallat P., Ferré P., Pénicaud L. Glucose transporter 2 (GLUT 2) expression in specific brain nuclei . Brain Res. 638:1994;221-226.
19. Le Magnen J. Body energy balance and food intake a neuroendocrine regulatory mechanism . Physiol Rev. 63:1983;314-386.
20. Moriguchi T., Sakurai T., Nambu T., Yanagisawa M., Goto K. Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci Lett. 264:1999;101-104.
21. Naito N., Kawazoe I., Nakai Y., Kawauchi H., Hirano T. Melanin-concentrating hormone-like immunoreactivity in the rat hypothalamus. Zool Sci. 2:1985;990.
22. Nambu T., Sakurai T., Mizukami K., Hosoya Y., Yanagisawa M., Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res. 827:1999;243-260.
23. Oomura Y., Ooyama H., Sugimori M., Nakamura T., Yamada Y. Glucose inhibition of the glucose-sensitive neurone in the rat lateral hypothalamus. Nature. 247:1974;284-286.
24. Oomura Y., Yoshimatsu H. Neural network of glucose monitoring system. J Autonom Nerv Syst. 10:1984;359-372.
25. Paxinos G., Watson C. The rat brain in stereotaxic coordinates, 4th Edition. 1998;Academic Press, San Diego.
26. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 18:1998;9996-10015.
27. Pu S., Jain M.R., Kalra P.S., Kalra S.P. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Reg Peptides. 78:1998;133-136.
28. Qu D., Ludwig D.S., Gammeltoft S., Piper M., Pelleymounter M.A., Cullen M.J., Mathes W.F., Przypek J., Kanarek R., Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 380:1996;243-247.
29. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior . Cell. 92:1998;573-585.
30. Shu S., Ju G., Fan L. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett. 85:1988;169-171.
31. Shughrue P.J., Lane M.V., Merchenthaler I. Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus. Endocrinology. 137:1996;5159-5162.
32. Smith O.A., DeVito J.L., Astley C.A. Neurons controlling cardiovascular responses to emotion are located in lateral hypothalamus-perifornical region. Am J Physiol. 259:1990;R943-R954.
33. Stanley B.G., Willett V.L., Donias H.W., Dee M.G., Duva M.A. Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. Am J Physiol. 270:1996;R443-R449.
34. Sweet D.C., Levine A.S., Billington C.J., Kotz C.M. Feeding response to central orexins. Brain Res. 821:1999;535-538.
35. Trivedi P., Yu H., MacNeil D.J., Van der Ploeg L.H.T., Guan X-M. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett. 438:1998;71-75.
36. van den Pol A.N. Hypothalamic hypocretin (orexin) robust innervation of the spinal cord . J Neurosci. 19:1999;3171-3182.
37. Wilding J., Widdowson P., Williams G. Neurobiology. Brit Med Bull. 53:1997;286-306.
38. Yamada K., Emson P., Hökfelt T. Immunohistochemical mapping of nitric oxide synthase in the rat hypothalamus and colocalization with neuropeptides. J Chem Neuroanat. 10:1996;295-316.
39. Zoli M., Torri C., Ferrari R., Jansson A., Zini I., Fuxe K., Agnati L.F. The emergence of the volume transmission concept. Brain Res Rev. 26:1998;136-147.