Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 13, 2004, Pages 4649-4654

  Mieda, Michihiro ^a   Willie, Jon T ^a   Hara, Junko ^b,c   Sinton, Christopher M ^a   Sakurai, Takeshi ^b,c   Yanagisawa, Masashi ^a,c,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN; OREXIN A; OREXIN RECEPTOR; OREXIN RECEPTOR STIMULATING AGENT; PREPROOREXIN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATAPLEXY; CELL LOSS; CONTROLLED STUDY; DISEASE MODEL; GENE EXPRESSION; GENETIC TRANSFECTION; MALE; MOUSE; NARCOLEPSY; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REM SLEEP; SYMPTOM; TRANSGENE; WAKEFULNESS;

ANIMALS; CARRIER PROTEINS; CATAPLEXY; CATHETER ABLATION; DISEASE MODELS, ANIMAL; GENE THERAPY; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NARCOLEPSY; NEURONS; NEUROPEPTIDES; PROTEIN PRECURSORS; RATS; WAKEFULNESS;

ANIMALIA;

EID: 1842584959     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400590101     Document Type: Article

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