Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat

Neuroscience Letters

Volumn 341, Issue 3, 2003, Pages 256-258

  Smith, M I ^a   Piper, D C ^a   Duxon, M S ^a   Upton, N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Latency; Orexin 1 Receptor; Orexin A; Paradoxical Sleep; SB 334867 A

Indexed keywords

DRUG VEHICLE; ISOPROTEIN; OREXIN A; PROTEIN INHIBITOR; RECEPTOR; SB 334867 A;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; CANNULATION; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; LATENT PERIOD; LATERAL BRAIN VENTRICLE; MALE; NECK MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REM SLEEP;

ANIMALS; BENZOXAZOLES; CARRIER PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SLEEP, REM; UREA;

EID: 0037426563     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00066-1     Document Type: Article

References (11)

1. Bourgin P., Huitron-Resendiz S., Spier A.D., Fabre V., Morte B., Cirado J.R., Sutcliffe J.G., Henriksen S.J., deLecea L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J. Neurosci. 20:(20):2000;7760-7765.
2. Chemelli M.R., Willie J.T., Sinton C.M., Elmquist J.K., Scammel T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 98:1999;437-451.
3. de Lecea L., Kilduff T.S., Peyron C., Gao X.-B., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L.F., Gautvik V.T., Bartlett F.S. II, Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA. 95:1998;322-327.
4. 2C receptor involvement. Psychopharmacology. 153:2001;203-209.
5. Estabrooke I.V., McCarthy M.T., Ko E., Chou T.C., Chemelli R.M., Yanagisawa M., Saper B.B., Scammell T.E. Fos expression in orexin neurons varies with behavioral state. J. Neurosci. 21:(5):2001;1656-1662.
6. Fujiki N., Yoshida Y., Ripley B., Honda K., Mignot E., Nishino S. Changes in CSF hypocretin-1 (orexin-A) levels in rats across 24 hours and in response to food deprivation. NeuroReport. 12:(5):2001;993-997.
7. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qui X., deJong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:1999;365-376.
8. Nambu T., Sakurai T., Mizukami K., Hosoya Y., Yanagisawa M., Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res. 827:1999;243-260.
9. Paxinos G., Watson C. The Rat Brain in Stereotaxic Co-ordinates. 2nd Edition: 1986;Academic Press, New York.
10. Piper D.C., Upton N., Smith M.I., Hunter H. The novel neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. Eur. J. Neurosci. 12:2000;726-730.
11. Sakuri T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell. 92:1998;573-585.