Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

Journal of Experimental Medicine

Volumn 200, Issue 5, 2004, Pages 659-669

  Barata, Joao T ^a   Silva, Ana ^a   Brandao, Joana G ^a   Nadler, Lee M ^b   Cardoso, Angelo A ^b   Boussiotis, Vassiliki A ^b,c  

^a UNIVERSITY OF LISBON   (Portugal)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Glut1; IL 7; MEK Erk; PI3K Akt; T cell acute lymphoblastic leukemia

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CD71 ANTIGEN; GLUCOSE TRANSPORTER 1; INTERLEUKIN 7; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P27; RUBIDIUM;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CELL SIZE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; LEUKEMIA CELL; METABOLIC ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; ENZYME INHIBITORS; FLAVONOIDS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOBLOTTING; IMMUNOPHENOTYPING; INTERLEUKIN-7; LEUKEMIA, LYMPHOCYTIC, ACUTE; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOSACCHARIDE TRANSPORT PROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 4544331713     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20040789     Document Type: Article

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