Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: Assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling

Journal of Immunological Methods

Volumn 273, Issue 1-2, 2003, Pages 29-41

  Curnock, Adam P ^a   Ward, Stephen G ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

Author keywords

Chemokine; PI3K; Tetracycline

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; PHOSPHATIDYLINOSITOL 3 KINASE; TETRACYCLINE;

ARTICLE; CELL CLONE; CELL LINE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOSKELETON; DEVELOPMENT; LEUKEMIA CELL; LEUKEMIA CELL LINE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CHEMOKINES; CHEMOKINES, CXC; CHEMOTAXIS; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; JURKAT CELLS; MUTATION; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; TETRACYCLINE; TRANSFECTION;

EID: 0037298561     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(02)00416-7     Document Type: Article

References (56)

1. Al-Aoukaty A., Rolstad B., Maghazachi A.A. Recruitment of pleckstrin and phosphoinositide 3-kinase-γ into the cell membranes, and their association with Gβγ after activation of NK cells with chemokines. J. Immunol. 162:1999;3249.
2. Amara A., LeGall S., Schwartz O., Salamero J., Montes M., Loetscher P., Baggiolini M., Virelizier J.L., Arenzana-Seisdedos F. HIV coreceptor downregulation as anti-viral principle: SDF-1α-dependent internalisation of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J. Exp. Med. 186:1997;139.
3. Arcaro A., Wymann M.P. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296:1993;297.
4. Bacon K.B., Premack B.A., Gardner P., Schall T.J. Activation of dual T cell signalling pathways by the chemokine RANTES. Science. 269:1995;1727.
5. Bleul C.C., Fuhlbrigge R.C., Casasnovas J.M., Aiuti A., Springer T.A. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor-1 (SDF-1). J. Exp. Med. 184:1996;1101.
6. Derman M.P., Toker A., Hartwig J.H., Spokes K., Falck J.R., Chen C.S., Cantley L.C. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J. Biol. Chem. 272:1997;6465.
7. Dhand R., Hiles I., Panayotou G., Roche S., Fry M.J., Gout I., Totty N.F., Truong O., Vicendo P., Yonezawa K., Kasuga M., Courtneidge S.A., Waterfield M.D. PI3K is a dual specificity enzyme: autoregulation by an intrinsic protein serine kinase. EMBO J. 13:1994;522.
8. Forster R., Kremmer E., Schubel A., Breitfeld D., Kleinschmidt A., Nerl C., Bernhardt G., Lipp M. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J. Immunol. 160:1998;1522.
9. Fruman D.A., Snapper S.B., Yballe C.M., Daiidson L., Yu J.Y., Alt F.W., Cantley L.C. Impaired B cell development and proliferation in the absence of phosphoinositide 3-kinase p85α Science. 283:1999;393.
10. Gaidarov I., Smith M.E.K., Domin J., Keen J.H. The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol. Cell. 7:2001;443.
11. Gerszten R.E., Friedrich E.B., Matsui T., Hung R.R., Li L., Force T., Rosenzweig A. Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions. J. Biol. Chem. 276:2001;26846.
12. Gossen M., Bujard H. Tight control of gene-expression in mammalian-cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U. S. A. 89:1992;5547.
13. Gossen M., Bonin A.L., Bujard H. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biotech. 12:1994;58.
14. Hannigan M., Zhan L., Li Z., Wu D., Huang C.-H. Neutrophils lacking phopshoinositide 3-kinase-γ show loss of directionality during N-formyl-met-Leu-Phe-induced chemotaxis. Proc. Natl. Acad. Sci. U. S. A. 99:2002;3603-3608.
15. Hara K., Yonezawa K., Sakaue H., Ando A., Kotani K., Kitamura T., Kitamura Y., Ueda H., Stephens L., Jackson T.R., Hawkins P.T., Dhand R., Clark A.E., Holman G.D., Waterfield M.D., Kasuga M. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose-transport but not for ras activation in CHO cells. Proc. Natl. Acad. Sci. U. S. A. 91:1994;7415.
16. Hawkins P.T., Eguinoa A., Qiu R.G., Stokoe D., Cooke F.T., Walters R., Wennstrom S., Claesson-Welsh L., Evans T., Symons M., Stephens L. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5:1995;393.
17. Helgason C.D., Damen J.E., Rosten P., Grewal R., Sorensen P., Chappel S.M., Borowski A., Jirik F., Krystal G., Humphries R.K. Targeted disruption of SHIP leads to hemopoietic perturbations in lung pathology, and a shortened life span. Genes Dev. 12:1998;1610.
18. Hesselgesser J., Liang M., Hoxie J., Greenberg M., Brass L.F., Orsini M.J., Taub D., Horuk R. Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. J. Immunol. 160:1998;877.
19. Hirsch E., Katanaev V.L., Garlanda C., Azzolino O., Pirola L., Silengo L., Sozzani S., Mantovani A., Altruda F., Wymann M.P. Central role for G protein-coupled phosphoinositide 3-kinase-γ in inflammation. Science. 287:2000;1049.
20. Hooshmand-Rad R., Hajkova L., Klint P., Karlsson R., Vanhaesebroeck B., Claesson-Welsh L., Heldin C.H. The PI 3-kinase isoforms p110α and p110β have differential roles in PDGF- and insulin-mediated signaling. J. Cell Sci. 113:2000;207.
21. Knall C., Worthen G.S., Johnson G.L. Interleukin-8-stimulated phosphatidylinositol 3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc. Natl. Acad. Sci. U. S. A. 94:1997;3052.
22. Kuang Y.N., Wu Y.P., Jiang H.P., Wu D.Q. Selective G protein coupling by C-C chemokine receptors. J. Biol. Chem. 271:1996;3975.
23. Kundra V., Escobedo J.A., Kazlauskas A., Kim H.K., Rhee S.G., Williams L.T., Zetter B.R. Regulation of chemotaxis by the platelet-derived growth-factor receptor-β Nature. 367:1994;474.
24. Li Z., Jiang H., Zie W., Zhang Z., Smrcka A.V., Wu D. Roles of PLC-β2 and β-3 and PI3Kγ in chemoattractant-mediated signal transduction. Science. 287:2000;1046.
25. Matsuo T., Hazeki K., Hazeki O., Katada T., Ui M. Activation of phosphatidylinositol 3-kinase by concanavolin A through dual signalling pathways, G protein-coupled and phosphotyrosine-related, and an essential role of the G protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells. Biochem. J. 315:1996;505.
26. Reif K., Nobes C.D., Thomas G., Hall A., Cantrell D.A. PI3K signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6:1996;1445.
27. Rickert P., Weiner O.D., Wang F., Bourne H.R., Servant G. Leukocytes navigate by compass: roles of PI3Kγ and its lipid products. Trends Cell Biol. 10:2000;466.
28. Sanchez-Madrid F., Del Pozo M.A. Leukocyte polarisation in cell migration and immune interactions. EMBO J. 18:1999;501.
29. Sasaki T., Irie-Sasaki J., Jones R.G., Oliveira-dos-Santos A.J., Stanford W.L., Bolon B., Wakeham A., Itie A., Bouchard D., Kozieradzki I., Joza N., Mak T.W., Ohashi P.S., Suzuki A., Penninger J.M. Function of PI3Kγ in thymocyte development, T cell activation and neutrophil migration. Science. 287:2000;1040.
30. Servant G., Weiner O.R., Herzmark P., Balla T., Bourne H.R. Polarisation of chemoattractant receptor signaling during neutrophil chemotaxis. Science. 287:2000;1037.
31. Shimizu Y., Hunt S. Regulating integrin-mediated adhesion: one more function for PI3K? Immunol. Today. 17:1996;565-5.
32. Shyamala V., Khoja H. Interleukin-8 receptors R1 and R2 activate mitogen-activated protein kinases and induce c-fos independent of Ras and Raf-1 on Chinese hamster ovary cells. Biochemistry. 37:1998;15918.
33. Sotsios Y., Ward S.G. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in epsonse to chemokines. Immunol. Rev. 177:2000;217.
34. Sotsios Y., Whittaker G.C., Westwick J., Ward S.G. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163:1999;5954.
35. Stephens L., Eguinoa A., Corey S., Jackson T., Hawkins P.T. Receptor-stimulated accumulation of phosphatidylinositol-(3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J. 12:1993;2265.
36. Stephens L.R., Smrcka A.S., Cooke F.T., Jackson T.R., Sternweiss P.C., Hawkins P.T. A novel phosphoinositide 3 kinase activity in myeloid cells is activated by G protein βγ subunits. Cell. 77:1994;83-93.
37. Stephens L.R., Eguinosa A., Erdjument-Bromage H., Lui M., Cooke F., Coadwell J., Smrcka A.S., Thelen M., Cadwallader K., Tempst P., Hawkins P.T. The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 89:1997;105.
38. Sullivan S.K., McGrath D.A., Liao F., Boehme S.A., Farber J.M., Bacon K.B. MIP-3α induces human eosinophil migration and activation of the mitogen-activated protein kinases (p42/p44 MAPK). J. Leukoc. Biol. 66:1999;674.
39. Suzuki H., Terauchi Y., Fujiwara M., Aizawa S., Yazaki Y., Kadowaki T., Koyasu Y. Xid-like immunodeficiency in mice with disruption of the p85 subunit of phosphoinositide 3-kinase. Science. 283:1999;390.
40. Takeda H., Matozaki T., Takada T., Noguchi T., Yamao T., Tsuda M., Ochi F., Fukunaga K., Inagaki K., Kasuga M. PI3Kγ and protein kinase C-ζ mediate Ras-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J. 18:1999;386.
41. Thelen M., Wymann M.P., Langen H. Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine-nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. Proc. Natl. Acad. Sci. U. S. A. 11:1994;4960.
42. Thelen M., Uguccioni M., Bosiger J. PI3K-dependent and independent chemotaxis of human neutrophil leukocytes. Biochem. Biophys. Res. Commun. 217:1995;1255.
43. Turner L., Ward S.G., Westwick J. RANTES-activated human T lymphocytes: a role for phosphoinositide 3-kinase. J. Immunol. 155:1995;2437.
44. Turner S.J., Domin J., Waterfield M.D., Ward S.G., Westwick J. The CC chemokine monocyte chemotactic peptide-1 activates both the class 1 p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α J. Biol. Chem. 73:1998;25987.
45. Ueki K., Yball C.M., Brachmann S.M., Vicent D., Watt J.M., Kahn C.R., Cantley L.C. Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. U. S. A. 99:2002;419.
46. Vanhaesebroeck B., Jones G.E., Allen W.E., Zicha D., Hooshmand-Rad R., Sawyer C., Wells C., Waterfield M.D., Ridley A.J. Distinct PI3Ks mediate mitogenic signalling and cell migration in macrophages. Nat. Cell Biol. 1:1999;69.
47. Vanhaesebroeck B., Higashi K., Raven C., Welham M., Anderson S., Brennan P., Ward S.G., Waterfield M.D. Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. EMBO J. 18:1999;1292.
48. Vanhaesebroeck B., Leevers S., Khatereh A., Timms J., Katso R., Driscoll P., Woscholski R., Parker P., Waterfield M. Synthesis and function of 3-phosphorylated inositol lipids. Ann. Rev. Biochem. 70:2001;535.
49. Vicente-Manzanares M., Rey M., Jones D.R., Sancho D., Mellado M., Rodriguez-Frade J.M., del Pozo M.A., Yanez-Mo M., de Ana A.M., Martinez C., Merida I., Sanchez-Madrid F. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1α-induced lymphocyte polarisation and chemotaxis. J. Immunol. 163:1999;4001.
50. Ward S.G., Westwick J. Chemokines: understanding their role in T lymphocyte biology. Biochem. J. 333:1998;457.
51. Ward S.G., Bacon K.B., Westwick J. Chemokines and T lymphocytes: more than an attraction. Immunity. 8:1998;1.
52. Wennstrom S., Hawkins P., Cooke F., Hara K., Yonezawa K., Kasuga M., Jackson T., Claesson-Welsh L., Stephens L. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4:1994;385.
53. Wennstrom S., Siegbahn A., Yokote K., Arvidsson A.K., Heldin C.H., Mori S., Claesson-Welsh L. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor requires the binding site for phosphatidylinositol 3-kinase. Oncogene. 9:1994;651.
54. Wu D.Q., LaRosa G.J., Simon M.I. G-protein-coupled signal-transduction pathways for interleukin-8. Science. 261:1993;101-103.
55. Yin D.X., Zhu L., Schimke R.T. Tetracycline-controlled gene expression system achieves high level and quantitative control of gene expression. Anal. Biochem. 235:1996;195.
56. Zhang J., Zhang J., Shattil S.J., Cunningham M.C., Rittenhouse S.E. Phosphoinositide 3-kinase-γ and p85/phosphoinositide 3-kinase in platelets: relative activation by thrombin receptor or β-phorbol myristate acetate and roles in promoting the ligand-binding function of αIIbβ3 integrin. J. Biol. Chem. 271:1996;6265.