Small molecule bromodomain inhibitors: Extending the druggable genome

Progress in Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 1-55

  Chung, Chun Wa ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Bromodomain; Epigenetic; Fragment based drug design; Histone readers; Inflammation; Oncology; Protein protein inhibitors; Structure based drug design

Indexed keywords

ASH1L PROTEIN; ATAD2 PROTEIN; ATAD2B PROTEIN; BAZ1A PROTEIN; BAZ1B PROTEIN; BPTF PROTEIN; BRD1 PROTEIN; BRD2 PROTEIN; BRD3 PROTEIN; BRD4 PROTEIN; BRD7 PROTEIN; BRG1 PROTEIN; BROMODOMAIN INHIBITOR; BRWD1 PROTEIN; BRWD3 PROTEIN; CREBBP PROTEIN; DNA; E1A ASSOCIATED P300 PROTEIN; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE INHIBITOR; MIXED LINEAGE LEUKEMIA PROTEIN; PBRM1 PROTEIN; PRKCBP1 PROTEIN; PROTEIN; PROTEIN C; PROTEIN INHIBITOR; ROMIDEPSIN; SP110 PROTEIN; UNCLASSIFIED DRUG; VORINOSTAT;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; ASTHMA; B CELL LEUKEMIA; B CELL LYMPHOMA; BIPOLAR DISORDER; BRAIN TUMOR; BREAST CANCER; BREAST CARCINOMA; BROMODOMAIN; CANCER STEM CELL; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM TUMOR; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CROHN DISEASE; DISEASE ASSOCIATION; DNA BINDING; DRUG ACETYLATION; DRUG SYNTHESIS; DRUG TOLERABILITY; ENTERITIS; FLUOROMETRY; GENE EXPRESSION; GENETIC ASSOCIATION; GENOME; HEAD AND NECK CARCINOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFECTION; LIPID BLOOD LEVEL; LIVER CELL CARCINOMA; LUNG CANCER; LYMPHOMA; MACROCEPHALY; MENTAL DEFICIENCY; METABOLIC DISORDER; MORBIDITY; MORTALITY; MYOCLONUS EPILEPSY; NEUROBLASTOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OBESITY; OVARY CARCINOMA; PANCREAS CANCER; PARKINSONISM; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RHEUMATOID ARTHRITIS; RUBINSTEIN SYNDROME; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SQUAMOUS CELL CARCINOMA; STOMACH CANCER; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELL LYMPHOMA; UTERUS CANCER; VEIN THROMBOSIS; WILLIAMS BEUREN SYNDROME;

EID: 84859926557     PISSN: 00796468     EISSN: 18757863     Source Type: Book Series    
DOI: 10.1016/B978-0-12-396493-9.00001-7     Document Type: Chapter

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