3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6761-6770

  Hewings, David S ^a,b   Wang, Minghua ^a   Philpott, Martin ^a   Fedorov, Oleg ^a   Uttarkar, Sagar ^a   Filippakopoulos, Panagis ^a   Picaud, Sarah ^a   Vuppusetty, Chaitanya ^a   Marsden, Brian ^a   Knapp, Stefan ^a   Conway, Stuart J ^b   Heightman, Tom D ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (3,5 DIMETHYLISOXAZOL 4 YL) 5 ETHOXYPHENYL]ETHANOL; 1 [3 (3,5 DIMETHYLISOXAZOL 4 YL) 5 ETHOXYPHENYL]ETHANONE; 1 [3 (3,5 DIMETHYLISOXAZOL 4 YL)PHENYL]ETHANOL; 3 (3,5 DIMETHYLISOXAZOL 4 YL) 5 ETHOXYBENZOIC ACID; 3,5 DIMETHYL 4 PHENYLISOXAZOLE; 3,5 DIMETHYLISOXAZOLE DERIVATIVE; 4 (3 ETHOXYPHENYL) DIMETHYLISOXAZOLE; BROMODOMAIN 2 PROTEIN; BROMODOMAIN 4 PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOTOXIC AGENT; ETHYL 3 (3,5 DIMETHYLISOXAZOL 4 YL) 5 ETHOXYBENZOATE; HISTONE; ISOXAZOLE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; PHYLOGENY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CREB-BINDING PROTEIN; CRYSTALLOGRAPHY, X-RAY; CYTOTOXINS; HELA CELLS; HISTONES; HUMANS; ISOXAZOLES; LIGANDS; LYSINE; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PHENYLETHYL ALCOHOL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 80053924872     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200640v     Document Type: Article

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