The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3

Molecular and Cellular Biology

Volumn 31, Issue 13, 2011, Pages 2641-2652

  Rahman, Shaila ^a   Sowa, Mathew E ^a   Ottinger, Matthias ^a,b   Smith, Jennifer A ^a   Shi, Yang ^a,c   Harper, J Wade ^a   Howley, Peter M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMODOMAIN 2; BROMODOMAIN 3; BROMODOMAIN PROTEIN 4; CELL PROTEIN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROTEIN ATAD5; PROTEIN CHD4; PROTEIN GLTSCR1; PROTEIN JMJD6; PROTEIN NSD3; UNCLASSIFIED DRUG;

ARTICLE; HISTONE METHYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEOMICS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; CELL LINE; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 79959483607     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01341-10     Document Type: Article

References (60)

1. Abbate, E. A., C. Voitenleitner, and M. R. Botchan. 2006. Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates PV chromosomal association. Mol. Cell 24:877-889.
2. Barski, A., et al. 2007. High-resolution profiling of histone methylations in the human genome. Cell 129:823-837.
3. Baxter, M. K., M. G. McPhillips, K. Ozato, and A. A. McBride. 2005. The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J. Virol. 79:4806-4818.
4. Bisgrove, D. A., T. Mahmoudi, P. Henklein, and E. Verdin. 2007. Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc. atl. Acad. Sci. U. S. A. 104:13690-13695.
5. Carrozza, M. J., et al. 2005. Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123:581-592.
6. Chang, B., Y. Chen, Y. Zhao, and R. K. Bruick. 2007. JMJD6 is a histone arginine demethylase. Science 318:444-447.
7. Cho, W. K., et al. 2007. Modulation of the Brd4/P-TEFb interaction by the human T-lymphotropic virus type 1 tax protein. J. Virol. 81:11179-11186.
8. Crawford, N. P., et al. 2008. Bromodomain 4 activation predicts breast cancer survival. Proc. Natl. Acad. Sci. U. S. A. 105:6380-6385.
9. Crowley, T. E., E. M. Kaine, M. Yoshida, A. Nandi, and D. J. Wolgemuth. 2002. Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Mol. Endocrinol. 16:1727-1737.
10. Denis, G. V., et al. 2006. Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling achines. J. Proteome Res. 5:502-511.
11. Denis, G. V., C. Vaziri, N. Guo, and D. V. Faller. 2000. RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell rowth Differ. 11:417-424.
12. Denslow, S. A., and P. A. Wade. 2007. The human Mi-2/NuRD complex and gene regulation. Oncogene 26:5433-5438.
13. Digan, M. E., et al. 1986. Genetic and molecular analysis of fs(1)h, a maternal effect homeotic gene in Drosophila. Dev. Biol. 114:161-169.
14. Douglas, J., et al. 2005. Evaluation of NSD2 and NSD3 in overgrowth syndromes. Eur. J. Hum. Genet. 13:150-153.
15. French, C. A., et al. 2001. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am. J. Pathol. 159:1987-992.
16. French, C. A., et al. 2003. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 63:304-307.
17. French, C. A., et al. 2008. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the rowth of carcinoma cells. Oncogene 27:2237-2242.
18. Gyuris, A., et al. 2009. The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis. Biochim. Biophys. Acta 1789:413- 21.
19. Hargreaves, D. C., T. Horng, and R. Medzhitov. 2009. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138: 29-145.
20. Hong, X., et al. 2010. Interaction of JMJD6 with single-stranded RNA. Proc. Natl. Acad. Sci. U. S. A. 107:14568-14572.
21. Houzelstein, D., et al. 2002. Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol. Cell. Biol. 2:3794-3802.
22. Ilves, I., K. Maemets, T. Silla, K. Janikson, and M. Ustav. 2006. Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle. J. irol. 80:3660-3665.
23. Ishii, H., et al. 2005. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U. S. A. 102:9655-9660.
24. Jang, M. K., et al. 2005. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent ranscription. Mol. Cell 19:523-534.
25. Jiang, Y. W., et al. 1998. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc. atl. Acad. Sci. U. S. A. 95:8538-8543.
26. Keats, J. J., et al. 2005. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma atients. Blood 105:4060-4069.
27. Ladurner, A. G., C. Inouye, R. Jain, and R. Tjian. 2003. Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin oundaries. Mol. Cell 11:365-376.
28. Lambert, P. F., B. A. Spalholz, and P. M. Howley. 1987. A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain ith the E2 transactivator. Cell 50:69-78.
29. LeRoy, G., B. Rickards, and S. J. Flint. 2008. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol. Cell 0:51-60.
30. Li, Y., et al. 2009. The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J. Biol. Chem. 284: 34283-4295.
31. Lin, A., S. Wang, T. Nguyen, K. Shire, and L. Frappier. 2008. The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4. J. Virol. 82: 2009-12019.
32. Lygerou, Z., et al. 1994. The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs. ucleic Acids Res. 22:5332-5340.
33. Mantri, M., et al. 2010. Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. J. Mol. Biol. 401:211-222.
34. Matangkasombut, O., R. M. Buratowski, N. W. Swilling, and S. Buratowski. 2000. Bromodomain factor 1 corresponds to a missing piece of yeast FIID. Genes Dev. 14:951-962.
35. McPhillips, M. G., J. G. Oliveira, J. E. Spindler, R. Mitra, and A. A. McBride. 2006. Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J. Virol. 80:9530-9543.
36. Nimura, K., et al. 2009. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 460:287-291.
37. Ottinger, M., et al. 2009. The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle romoters. J. Virol. 83:4423-4434.
38. Reynoird, N., et al. 2010. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 29: 943-2952.
39. Rosati, R., et al. 2002. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Blood 99:3857-3860.
40. Schweiger, M. R., M. Ottinger, J. You, and P. M. Howley. 2007. Brd4-independent transcriptional repression function of the papillomavirus e2 roteins. J. Virol. 81:9612-9622.
41. Schweiger, M. R., J. You, and P. M. Howley. 2006. Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J. Virol. 0:4276-4285.
42. Senechal, H., G. G. Poirier, B. Coulombe, L. A. Laimins, and J. Archambault. 2007. Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4. Virology 358:10-17.
43. Sillibourne, J. E., B. Delaval, S. Redick, M. Sinha, and S. J. Doxsey. 2007. Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Mol. Biol. Cell 18:3667-3680.
44. Sinha, A., D. V. Faller, and G. V. Denis. 2005. Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem. J. 387:257- 69.
45. Smith, J. A., et al. 2010. Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc. Natl. Acad. Sci. U. S. A. 107:3752-3757.
46. Sowa, M. E., E. J. Bennett, S. P. Gygi, and J. W. Harper. 2009. Defining the human deubiquitinating enzyme interaction landscape. Cell 138:389-403.
47. Tatton-Brown, K., et al. 2005. Genotype-phenotype associations in Sotos syndrome: an analysis of 266 individuals with NSD1 aberrations. Am. J. um. Genet. 77:193-204.
48. Tompa, R., and H. D. Madhani. 2007. Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics 175:585-593.
49. Tonon, G., et al. 2005. High-resolution genomic profiles of human lung cancer. Proc. Natl. Acad. Sci. U. S. A. 102:9625-9630.
50. Webby, C. J., et al. 2009. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science 325:90-93.
51. Weidner-Glunde, M., M. Ottinger, and T. F. Schulz. 2010. WHAT do viruses BET on? Front. Biosci. 15:537-549.
52. Wu, S. Y., et al. 2006. Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev. 20:2383-2396.
53. Xiao, T., et al. 2003. Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev. 17:654-663.
54. Xue, Y., et al. 1998. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol. Cell 2:851- 61.
55. Yang, P., et al. 2005. Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas. Cancer 103:2363-2372.
56. Yang, Z., et al. 2005. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 19:535-545.
57. You, J., J. L. Croyle, A. Nishimura, K. Ozato, and P. M. Howley. 2004. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral NA to host mitotic chromosomes. Cell 117:349-360.
58. You, J., et al. 2009. Regulation of aurora B expression by the bromodomain protein Brd4. Mol. Cell. Biol. 29:5094-5103.
59. You, J., M. R. Schweiger, and P. M. Howley. 2005. Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine apillomavirus-transformed cells. J. Virol. 79:14956-14961.
60. You, J., et al. 2006. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host itotic chromosomes. J. Virol. 80:8909-8919.