What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 375-381

  Goodman, Jay I ^a   Augustine, Karen A ^b   Cunnningham, Michael L ^c   Dixon, Darlene ^c   Dragan, Yvonne P ^d   Falls, James Greg ^e   Rasoulpour, Reza J ^f   Sills, Robert C ^c   Storer, Richard D ^g   Wolf, Douglas C ^h   Pettit, Syril D ⁱ  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d ASTRAZENECA   (United Kingdom)

^e GLAXOSMITHKLINE   (United States)

^f DOW CHEMICAL COMPANY   (United States)

^g MERCK RESEARCH LABORATORIES   (United States)

^h U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

ⁱ International Life Sciences Institute   (United States)

Author keywords

Epigenetics; Histone code; Methylation; Noncoding RNAs; Safety assessment

Indexed keywords

ARTICLE; DNA METHYLATION; EPIGENETICS; GENETIC MODEL; HUMAN; NONHUMAN; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; TERATOGENICITY; TOXICITY TESTING; ANIMAL; BIOASSAY; DRUG EFFECTS; GENETIC EPIGENESIS; PUBLIC HEALTH;

ANIMALS; DNA METHYLATION; ENDPOINT DETERMINATION; EPIGENESIS, GENETIC; HUMANS; PUBLIC HEALTH; RISK ASSESSMENT;

EID: 77955059818     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq133     Document Type: Article

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