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Volumn 10, Issue 4, 2012, Pages 243-254

Modulating immunity as a therapy for bacterial infections

Author keywords

[No Author keywords available]

Indexed keywords

AGATOLIMOD; ANTHRAX VACCINE; CADI 05; DIMS 0150; EA 230; ERITORAN; IC 31; IMIQUIMOD; IMMUNOLOGICAL ADJUVANT; IMMUNOMODULATING AGENT; IMX 942; LACTOFERRICIN[1-11]; LUIVAC; MIFAMURTIDE; MX 226; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OMIGANAN; OPEBACAN; PEXIGANAN; PHOSPHORYL LIPID A; PMX 30063; PMX 60063; POLYPEPTIDE ANTIBIOTIC AGENT; PROBIOTIC AGENT; RESATORVID; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; WART VIRUS VACCINE; XOMA 629;

EID: 84858381864     PISSN: 17401526     EISSN: 17401534     Source Type: Journal    
DOI: 10.1038/nrmicro2745     Document Type: Review
Times cited : (441)

References (123)
  • 1
    • 34249943678 scopus 로고    scopus 로고
    • The advent of the cytokine storm
    • DOI 10.1038/sj.icb.7100062, PII 7100062
    • Clark, I. A. The advent of the cytokine storm. Immunol. Cell Biol. 85, 271-273 (2007). (Pubitemid 46878938)
    • (2007) Immunology and Cell Biology , vol.85 , Issue.4 , pp. 271-273
    • Clark, I.A.1
  • 2
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Ulevitch, R. J. Therapeutics targeting the innate immune system. Nature Rev. Immunol. 4, 512-520 (2004). (Pubitemid 38931766)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.7 , pp. 512-520
    • Ulevitch, R.J.1
  • 4
    • 74849118783 scopus 로고    scopus 로고
    • Long-term efficacy of interferon α therapy on hepatitis B viral replication in patients with chronic hepatitis B: A meta-analysis
    • Yang, Y. F. et al. Long-term efficacy of interferon α therapy on hepatitis B viral replication in patients with chronic hepatitis B: a meta-analysis. Antiviral Res. 85, 361-365 (2010).
    • (2010) Antiviral Res. , vol.85 , pp. 361-365
    • Yang, Y.F.1
  • 5
    • 79551575923 scopus 로고    scopus 로고
    • Advances in the assessment and control of the effector functions of therapeutic antibodies
    • Jiang, X. R. et al. Advances in the assessment and control of the effector functions of therapeutic antibodies. Nature Rev. Drug Discov. 10, 101-111 (2011).
    • (2011) Nature Rev. Drug Discov. , vol.10 , pp. 101-111
    • Jiang, X.R.1
  • 6
    • 0036322883 scopus 로고    scopus 로고
    • Mathematical models of vaccination
    • DOI 10.1093/bmb/62.1.187
    • Scherer, A. & McLean, A. Mathematical models of vaccination. Br. Med. Bull. 62, 187-199 (2002). (Pubitemid 34832480)
    • (2002) British Medical Bulletin , vol.62 , pp. 187-199
    • Scherer, A.1    McLean, A.2
  • 7
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer
    • DOI 10.1016/j.cell.2006.02.016, PII S0092867406001917
    • Karin, M., Lawrence, T. & Nizet, V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 124, 823-835 (2006). (Pubitemid 43261455)
    • (2006) Cell , vol.124 , Issue.4 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 8
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • DOI 10.1038/415389a
    • Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395 (2002). (Pubitemid 34100944)
    • (2002) Nature , vol.415 , Issue.6870 , pp. 389-395
    • Zasloff, M.1
  • 10
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri, G. & Sher, A. Cooperation of Toll-like receptor signals in innate immune defence. Nature Rev. Immunol. 7, 179-190 (2007).
    • (2007) Nature Rev. Immunol. , vol.7 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 11
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila toll protein signals activation of adaptive immunity
    • DOI 10.1038/41131
    • Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997). (Pubitemid 27334820)
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 16
    • 33845654330 scopus 로고    scopus 로고
    • CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine
    • DOI 10.1196/annals.1348.030, Oligonucleotide Therapeutics: First Annual Meeting of the Oligonucleotide Therapeutics Society
    • Klinman, D. M., Xie, H. & Ivins, B. E. CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine. Ann. NY Acad. Sci. 1082, 137-150 (2006). (Pubitemid 44955459)
    • (2006) Annals of the New York Academy of Sciences , vol.1082 , pp. 137-150
    • Klinman, D.M.1    Xie, H.2    Ivins, B.E.3
  • 18
    • 57049170370 scopus 로고    scopus 로고
    • Bacterial immunostimulants-mechanism of action and clinical application in respiratory diseases
    • Rozy, A. & Chorostowska-Wynimko, J. Bacterial immunostimulants- mechanism of action and clinical application in respiratory diseases. Pneumonol. Alergol. Pol. 76, 353-359 (2008).
    • (2008) Pneumonol. Alergol. Pol. , vol.76 , pp. 353-359
    • Rozy, A.1    Chorostowska-Wynimko, J.2
  • 19
    • 0034775973 scopus 로고    scopus 로고
    • Efficacy of a polyvalent bacterial lysate in children with recurrent respiratory tract infections
    • Ruah, S. B., Ruah, C., van Aubel, A., Abel, S. & Elsasser, U. Efficacy of a polyvalent bacterial lysate in children with recurrent respiratory tract infections. Adv. Ther. 18, 151-162 (2001). (Pubitemid 33010375)
    • (2001) Advances in Therapy , vol.18 , Issue.4 , pp. 151-162
    • Ruah, S.B.1    Ruah, C.2    Van Aubel, A.3    Abel, S.4    Elsasser, U.5
  • 20
    • 0242323599 scopus 로고    scopus 로고
    • Treatment of infectious diseases with immunostimulatory oligodeoxynucleotides containing CpG motifs
    • DOI 10.1016/j.mib.2003.09.007
    • Dittmer, U. & Olbrich, A. R. Treatment of infectious diseases with immunostimulatory oligodeoxynucleotides containing CpG motifs. Curr. Opin. Microbiol. 6, 472-477 (2003). (Pubitemid 37345412)
    • (2003) Current Opinion in Microbiology , vol.6 , Issue.5 , pp. 472-477
    • Dittmer, U.1    Olbrich, A.R.M.2
  • 21
    • 73949118392 scopus 로고    scopus 로고
    • Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi
    • Evans, S. E. et al. Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am. J. Respir. Cell Mol. Biol. 42, 40-50 (2009).
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.42 , pp. 40-50
    • Evans, S.E.1
  • 22
    • 77957728392 scopus 로고    scopus 로고
    • Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection
    • Munoz, N. et al. Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection. Infect. Immun. 78, 4226-4233 (2010).
    • (2010) Infect. Immun. , vol.78 , pp. 4226-4233
    • Munoz, N.1
  • 23
    • 77955494032 scopus 로고    scopus 로고
    • Flagellin stimulates protective lung mucosal immunity: Role of cathelicidin-related antimicrobial peptide
    • Yu, F. S. et al. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J. Immunol. 185, 1142-1149 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1142-1149
    • Yu, F.S.1
  • 24
    • 75749133608 scopus 로고    scopus 로고
    • Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection
    • Kinnebrew, M. A. et al. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J. Infect. Dis. 201, 534-543 (2010).
    • (2010) J. Infect. Dis. , vol.201 , pp. 534-543
    • Kinnebrew, M.A.1
  • 26
    • 77954052040 scopus 로고    scopus 로고
    • Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens
    • Ireland, R. et al. Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens. PLoS Pathog. 6, e1000921 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Ireland, R.1
  • 28
    • 79952198162 scopus 로고    scopus 로고
    • Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses
    • Shinya, K. et al. Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses. Virol. J. 8, 97 (2011).
    • (2011) Virol. J. , vol.8 , pp. 97
    • Shinya, K.1
  • 29
    • 77951782290 scopus 로고    scopus 로고
    • Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
    • Antonelli, L. R. et al. Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. J. Clin. Invest. 120, 1674-1682 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1674-1682
    • Antonelli, L.R.1
  • 30
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • DOI 10.1056/NEJMra021333
    • Hotchkiss, R. S. & Karl, I. E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348, 138-150 (2003). (Pubitemid 36056721)
    • (2003) New England Journal of Medicine , vol.348 , Issue.2 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 31
    • 77954953617 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    • Rice, T. W. et al. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit. Care Med. 38, 1685-1694 (2010).
    • (2010) Crit. Care Med. , vol.38 , pp. 1685-1694
    • Rice, T.W.1
  • 32
    • 74049125175 scopus 로고    scopus 로고
    • Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis
    • Tidswell, M. et al. Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis. Crit. Care Med. 38, 72-83 (2010).
    • (2010) Crit. Care Med. , vol.38 , pp. 72-83
    • Tidswell, M.1
  • 34
    • 67049095880 scopus 로고    scopus 로고
    • A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
    • Ungaro, R. et al. A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1167-G1179 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.296
    • Ungaro, R.1
  • 35
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • DOI 10.1016/j.cell.2004.07.002, PII S0092867404006610
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004). (Pubitemid 38962578)
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 36
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • Abreu, M. T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nature Rev. Immunol. 10, 131-144 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 37
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine, J. et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378 (2010).
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 39
    • 80052356829 scopus 로고    scopus 로고
    • Nod-like receptors in intestinal homeostasis, inflammation, and cancer
    • Werts, C., Rubino, S., Ling, A., Girardin, S. E. & Philpott, D. J. Nod-like receptors in intestinal homeostasis, inflammation, and cancer. J. Leukoc. Biol. 90, 471-482 (2011).
    • (2011) J. Leukoc. Biol. , vol.90 , pp. 471-482
    • Werts, C.1    Rubino, S.2    Ling, A.3    Girardin, S.E.4    Philpott, D.J.5
  • 40
    • 80052174103 scopus 로고    scopus 로고
    • Peptidoglycan: A critical activator of the mammalian immune system during infection and homeostasis
    • Sorbara, M. & Philpott, D. Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis. Immunol. Rev. 243, 40-60 (2011).
    • (2011) Immunol. Rev. , vol.243 , pp. 40-60
    • Sorbara, M.1    Philpott, D.2
  • 42
    • 77749245832 scopus 로고    scopus 로고
    • The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
    • Spreafico, R., Ricciardi-Castagnoli, P. & Mortellaro, A. The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants. Eur. J. Immunol. 40, 638-642 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 638-642
    • Spreafico, R.1    Ricciardi-Castagnoli, P.2    Mortellaro, A.3
  • 45
    • 0018196951 scopus 로고
    • Biological activities of muramyl dipeptide, a synthetic glycopeptide analogous to bacterial immunoregulating agents
    • Chedid, L., Audibert, F. & Johnson, A. G. Biological activities of muramyl dipeptide, a synthetic glycopeptide analogous to bacterial immunoregulating agents. Prog. Allergy 25, 63-105 (1978). (Pubitemid 9012043)
    • (1978) Progress in Allergy , vol.25 , pp. 63-105
    • Chedid, L.1    Audibert, F.2    Johnson, A.G.3
  • 47
    • 80052556040 scopus 로고    scopus 로고
    • Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation
    • Magalhaes, J. G. et al. Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc. Natl Acad. Sci. USA 108, 14896-14901 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14896-14901
    • Magalhaes, J.G.1
  • 48
    • 67349087922 scopus 로고    scopus 로고
    • The path to a successful vaccine adjuvant-'the long and winding road'
    • O'Hagan, D. T. & De Gregorio, E. The path to a successful vaccine adjuvant-'the long and winding road'. Drug Discov. Today 14, 541-551 (2009).
    • (2009) Drug Discov. Today , vol.14 , pp. 541-551
    • O'Hagan, D.T.1    De Gregorio, E.2
  • 49
    • 0037257192 scopus 로고    scopus 로고
    • Non-specific immunotherapy of HIV-1 infection: Potential use of the synthetic immunodulator murabutide
    • DOI 10.1093/jac/dkg063
    • Bahr, G. M. Non-specific immunotherapy of HIV-1 infection: potential use of the synthetic immunodulator murabutide. J. Antimicrob. Chemother. 51, 5-8 (2003). (Pubitemid 36163820)
    • (2003) Journal of Antimicrobial Chemotherapy , vol.51 , Issue.1 , pp. 5-8
    • Bahr, G.M.1
  • 50
    • 0020595380 scopus 로고
    • Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice
    • Mine, Y. et al. Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice. J. Antibiot. (Tokyo) 36, 1045-1050 (1983). (Pubitemid 13046930)
    • (1983) Journal of Antibiotics , vol.36 , Issue.8 , pp. 1045-1050
    • Mine, Y.1    Yokota, Y.2    Wakai, Y.3
  • 51
    • 57649184660 scopus 로고    scopus 로고
    • Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis
    • Wardowska, A. et al. Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis. Vaccine 27, 369-374 (2009).
    • (2009) Vaccine , vol.27 , pp. 369-374
    • Wardowska, A.1
  • 52
  • 54
    • 0031154584 scopus 로고    scopus 로고
    • Protective effect of neoglycoprotein-Conjugated muramyl dipeptide against leishmania donovani infection: The role of cytokines
    • Sarkar, K. & Das, P. K. Protective effect of neoglycoprotein- conjugated muramyl dipeptide against Leishmania donovani infection: the role of cytokines. J. Immunol. 158, 5357-5365 (1997). (Pubitemid 127681242)
    • (1997) Journal of Immunology , vol.158 , Issue.11 , pp. 5357-5365
    • Sarkar, K.1    Das, P.K.2
  • 55
    • 70349433671 scopus 로고    scopus 로고
    • Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection
    • Le Bourhis, L. et al. Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection. Infect. Immun. 77, 4480-4486 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 4480-4486
    • Le Bourhis, L.1
  • 56
    • 0026578350 scopus 로고
    • Enhancement of the effectiveness of antimicrobial therapy by muramyl peptide immunomodulators
    • O'Reilly, T. & Zak, O. Enhancement of the effectiveness of antimicrobial therapy by muramyl peptide immunomodulators. Clin. Infect. Dis. 14, 1100-1109 (1992).
    • (1992) Clin. Infect. Dis. , vol.14 , pp. 1100-1109
    • O'Reilly, T.1    Zak, O.2
  • 57
    • 79958746242 scopus 로고    scopus 로고
    • Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections
    • Kim, Y. G. et al. Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe 9, 496-507 (2011).
    • (2011) Cell Host Microbe , vol.9 , pp. 496-507
    • Kim, Y.G.1
  • 58
    • 14244262138 scopus 로고    scopus 로고
    • Inhibition of RIP2/RICK/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK
    • DOI 10.1007/s11010-005-3701-0
    • Argast, G. M., Fausto, N. & Campbell, J. S. Inhibition of RIP2/RICK/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK. Mol. Cell. Biochem. 268, 129-140 (2005). (Pubitemid 40287835)
    • (2005) Molecular and Cellular Biochemistry , vol.268 , Issue.1-2 , pp. 129-140
    • Argast, G.M.1    Fausto, N.2    Campbell, J.S.3
  • 59
    • 33845699790 scopus 로고    scopus 로고
    • Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
    • DOI 10.1038/nbt1267, PII NBT1267
    • Hancock, R. E. & Sahl, H. G. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nature Biotech. 24, 1551-1557 (2006). (Pubitemid 44967479)
    • (2006) Nature Biotechnology , vol.24 , Issue.12 , pp. 1551-1557
    • Hancock, R.E.W.1    Sahl, H.-G.2
  • 61
    • 0037057645 scopus 로고    scopus 로고
    • Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    • Ong, P. Y. et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347, 1151-1160 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1151-1160
    • Ong, P.Y.1
  • 62
    • 77954143033 scopus 로고    scopus 로고
    • Human cathelicidin peptide LL-37 modulates the effects of IFN-γ on APCs
    • Nijnik, A., Pistolic, J., Wyatt, A., Tam, S. & Hancock, R. E. Human cathelicidin peptide LL-37 modulates the effects of IFN-γ on APCs. J. Immunol. 183, 5788-5798 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5788-5798
    • Nijnik, A.1    Pistolic, J.2    Wyatt, A.3    Tam, S.4    Hancock, R.E.5
  • 64
    • 51949104801 scopus 로고    scopus 로고
    • The human host defence peptide LL-37 prevents bacterial biofilm formation
    • Overhage, J. et al. The human host defence peptide LL-37 prevents bacterial biofilm formation. Infect Immun. 76, 4176-4182 (2008).
    • (2008) Infect Immun. , vol.76 , pp. 4176-4182
    • Overhage, J.1
  • 66
    • 65349178179 scopus 로고    scopus 로고
    • Human beta-defensin-3 promotes wound healing in infected diabetic wounds
    • Hirsch, T. et al. Human beta-defensin-3 promotes wound healing in infected diabetic wounds. J. Gene Med. 11, 220-228 (2009).
    • (2009) J. Gene Med. , vol.11 , pp. 220-228
    • Hirsch, T.1
  • 67
    • 69949086979 scopus 로고    scopus 로고
    • Potential of immunomodulatory host defense peptides as novel anti-infectives
    • Easton, D. M., Nijnik, A., Mayer, M. L. & Hancock, R. E. Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol. 27, 582-590 (2009).
    • (2009) Trends Biotechnol. , vol.27 , pp. 582-590
    • Easton, D.M.1    Nijnik, A.2    Mayer, M.L.3    Hancock, R.E.4
  • 69
    • 23044502258 scopus 로고    scopus 로고
    • 3′,5′-cyclic diguanylic acid reduces the virulence of biofilm-forming Staphylococcus aureus strains in a mouse model of mastitis infection
    • DOI 10.1128/AAC.49.8.3109-3113.2005
    • Brouillette, E., Hyodo, M., Hayakawa, Y., Karaolis, D. K. & Malouin, F. 3′,5′-cyclic diguanylic acid reduces the virulence of biofilm-forming Staphylococcus aureus strains in a mouse model of mastitis infection. Antimicrob. Agents Chemother. 49, 3109-3113 (2005). (Pubitemid 41060547)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.8 , pp. 3109-3113
    • Brouillette, E.1    Hyodo, M.2    Hayakawa, Y.3    Karaolis, D.K.R.4    Malouin, F.5
  • 71
    • 77949655991 scopus 로고    scopus 로고
    • The potential of 3′5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
    • Chen, W., Kuolee, R. & Yan, H. The potential of 3′,5′- cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant. Vaccine 28, 3080-3085 (2010).
    • (2010) Vaccine , vol.28 , pp. 3080-3085
    • Chen, W.1    Kuolee, R.2    Yan, H.3
  • 72
    • 79960291542 scopus 로고    scopus 로고
    • Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant
    • Ebensen, T. et al. Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant. Vaccine 29, 5210-5220 (2011).
    • (2011) Vaccine , vol.29 , pp. 5210-5220
    • Ebensen, T.1
  • 73
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • Burdette, D. L. et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478, 515-518 (2011).
    • (2011) Nature , vol.478 , pp. 515-518
    • Burdette, D.L.1
  • 74
    • 79251506939 scopus 로고    scopus 로고
    • The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
    • Sauer, J. D. et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79, 688-694 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 688-694
    • Sauer, J.D.1
  • 75
    • 77954070545 scopus 로고    scopus 로고
    • C-di-AMP secreted by intracellular Listeria monocytogenes activates a host type i interferon response
    • Woodward, J. J., Iavarone, A. T. & Portnoy, D. A. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328, 1703-1705 (2010).
    • (2010) Science , vol.328 , pp. 1703-1705
    • Woodward, J.J.1    Iavarone, A.T.2    Portnoy, D.A.3
  • 76
    • 33644517930 scopus 로고    scopus 로고
    • Bacterial small-molecule signaling pathways
    • Camilli, A. & Bassler, B. L. Bacterial small-molecule signaling pathways. Science 311, 1113-1116 (2006).
    • (2006) Science , vol.311 , pp. 1113-1116
    • Camilli, A.1    Bassler, B.L.2
  • 77
    • 0036158178 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone contributes to virulence and induces inflammation in vivo
    • DOI 10.1128/jb.184.4.1132-1139.2002
    • Smith, R. S., Harris, S. G., Phipps, R. & Iglewski, B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J. Bacteriol. 184, 1132-1139 (2002). (Pubitemid 34113382)
    • (2002) Journal of Bacteriology , vol.184 , Issue.4 , pp. 1132-1139
    • Smith, R.S.1    Harris, S.G.2    Phipps, R.3    Iglewski, B.4
  • 78
    • 78651386518 scopus 로고    scopus 로고
    • Perception and degradation of N-acyl homoserine lactone quorum sensing signals by mammalian and plant cells
    • Teplitski, M., Mathesius, U. & Rumbaugh, K. P. Perception and degradation of N-acyl homoserine lactone quorum sensing signals by mammalian and plant cells. Chem. Rev. 111, 100-116 (2011).
    • (2011) Chem. Rev. , vol.111 , pp. 100-116
    • Teplitski, M.1    Mathesius, U.2    Rumbaugh, K.P.3
  • 79
    • 79551629639 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells
    • Mayer, M. L., Sheridan, J. A., Blohmke, C. J., Turvey, S. E. & Hancock, R. E. The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. PLoS ONE 6, e16246 (2011).
    • (2011) PLoS ONE , vol.6
    • Mayer, M.L.1    Sheridan, J.A.2    Blohmke, C.J.3    Turvey, S.E.4    Hancock, R.E.5
  • 80
    • 79959450318 scopus 로고    scopus 로고
    • Immunomodulatory and protective roles of quorum-sensing signaling molecules N-acyl homoserine lactones during infection of mice with Aeromonas hydrophila
    • Khajanchi, B. K., Kirtley, M. L., Brackman, S. M. & Chopra, A. K. Immunomodulatory and protective roles of quorum-sensing signaling molecules N-acyl homoserine lactones during infection of mice with Aeromonas hydrophila. Infect. Immun. 79, 2646-2657 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 2646-2657
    • Khajanchi, B.K.1    Kirtley, M.L.2    Brackman, S.M.3    Chopra, A.K.4
  • 81
    • 77957917687 scopus 로고    scopus 로고
    • Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa
    • Mattmann, M. E. & Blackwell, H. E. Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa. J. Org. Chem. 75, 6737-6746 (2010).
    • (2010) J. Org. Chem. , vol.75 , pp. 6737-6746
    • Mattmann, M.E.1    Blackwell, H.E.2
  • 84
    • 77950573969 scopus 로고    scopus 로고
    • Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis-a pilot randomized controlled trial
    • Smyth, A. R. et al. Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis-a pilot randomized controlled trial. Pediatr. Pulmonol. 45, 356-362 (2010).
    • (2010) Pediatr. Pulmonol. , vol.45 , pp. 356-362
    • Smyth, A.R.1
  • 85
    • 79956311555 scopus 로고    scopus 로고
    • Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo
    • Brackman, G., Cos, P., Maes, L., Nelis, H. J. & Coenye, T. Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo. Antimicrob. Agents Chemother. 55, 2655-2661 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 2655-2661
    • Brackman, G.1    Cos, P.2    Maes, L.3    Nelis, H.J.4    Coenye, T.5
  • 86
    • 66549083800 scopus 로고    scopus 로고
    • Enabling a systems biology approach to immunology: Focus on innate immunity
    • Gardy, J. L., Lynn, D. J., Brinkman, F. S. & Hancock, R. E. Enabling a systems biology approach to immunology: focus on innate immunity. Trends Immunol. 30, 249-262 (2009).
    • (2009) Trends Immunol. , vol.30 , pp. 249-262
    • Gardy, J.L.1    Lynn, D.J.2    Brinkman, F.S.3    Hancock, R.E.4
  • 87
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park, B. S. et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458, 1191-1195 (2009).
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1
  • 88
    • 34548608447 scopus 로고    scopus 로고
    • Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
    • DOI 10.1016/j.cell.2007.09.008, PII S009286740701152X
    • Jin, M. S. et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082 (2007). (Pubitemid 47410281)
    • (2007) Cell , vol.130 , Issue.6 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.-G.6    Lee, H.7    Lee, J.-O.8
  • 89
    • 23044445303 scopus 로고    scopus 로고
    • Structural biology: Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • DOI 10.1126/science.1115253
    • Choe, J., Kelker, M. S. & Wilson, I. A. Crystal structure of human Toll-like receptor 3 (TLR3) ectodomain. Science 309, 581-585 (2005). (Pubitemid 41033635)
    • (2005) Science , vol.309 , Issue.5734 , pp. 581-585
    • Choe, J.1    Kelker, M.S.2    Wilson, I.A.3
  • 90
    • 33845905223 scopus 로고    scopus 로고
    • Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling
    • DOI 10.1126/science.1135299
    • Gavin, A. L. et al. Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling. Science 314, 1936-1938 (2006). (Pubitemid 46026117)
    • (2006) Science , vol.314 , Issue.5807 , pp. 1936-1938
    • Gavin, A.L.1    Hoebe, K.2    Duong, B.3    Ota, T.4    Martin, C.5    Beutler, B.6    Nemazee, D.7
  • 91
    • 79952173864 scopus 로고    scopus 로고
    • Programming the magnitude and persistence of antibody responses with innate immunity
    • Kasturi, S. P. et al. Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470, 543-547 (2011).
    • (2011) Nature , vol.470 , pp. 543-547
    • Kasturi, S.P.1
  • 92
    • 34250331531 scopus 로고    scopus 로고
    • The perfect mix: Recent progress in adjuvant research
    • DOI 10.1038/nrmicro1681, PII NRMICRO1681
    • Guy, B. The perfect mix: recent progress in adjuvant research. Nature Rev. Microbiol. 5, 505-517 (2007). (Pubitemid 46925379)
    • (2007) Nature Reviews Microbiology , vol.5 , Issue.7 , pp. 505-517
    • Guy, B.1
  • 93
    • 70349559403 scopus 로고    scopus 로고
    • Endotoxin tolerance: New mechanisms, molecules and clinical significance
    • Biswas, S. K. & Lopez-Collazo, E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 30, 475-487 (2009).
    • (2009) Trends Immunol. , vol.30 , pp. 475-487
    • Biswas, S.K.1    Lopez-Collazo, E.2
  • 95
    • 79951811069 scopus 로고    scopus 로고
    • Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection
    • van Dissel, J. T. et al. Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection. Vaccine 29, 2100-2109 (2011).
    • (2011) Vaccine , vol.29 , pp. 2100-2109
    • Van Dissel, J.T.1
  • 96
    • 23444451770 scopus 로고    scopus 로고
    • High-throughput generation of small antibacterial peptides with improved activity
    • DOI 10.1038/nbt1113
    • Hilpert, K., Volkmer-Engert, R., Walter, T. & Hancock, R. E. High-throughput generation of small antibacterial peptides with improved activity. Nature Biotech. 23, 1008-1012 (2005). (Pubitemid 41114036)
    • (2005) Nature Biotechnology , vol.23 , Issue.8 , pp. 1008-1012
    • Hilpert, K.1    Volkmer-Engert, R.2    Walter, T.3    Hancock, R.E.W.4
  • 97
    • 38849155828 scopus 로고    scopus 로고
    • QSAR modeling and computer-aided design of antimicrobial peptides
    • DOI 10.1002/psc.908
    • Jenssen, H., Fjell, C. D., Cherkasov, A. & Hancock, R. E. QSAR modeling and computer-aided design of antimicrobial peptides. J. Pept. Sci. 14, 110-114 (2008). (Pubitemid 351188097)
    • (2008) Journal of Peptide Science , vol.14 , Issue.1 , pp. 110-114
    • Jenssen, H.1    Fjell, C.D.2    Cherkasov, A.3    Hancock, R.E.W.4
  • 98
    • 33750304297 scopus 로고    scopus 로고
    • A linguistic model for the rational design of antimicrobial peptides
    • DOI 10.1038/nature05233, PII NATURE05233
    • Loose, C., Jensen, K., Rigoutsos, I. & Stephanopoulos, G. A linguistic model for the rational design of antimicrobial peptides. Nature 443, 867-869 (2006). (Pubitemid 44622698)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 867-869
    • Loose, C.1    Jensen, K.2    Rigoutsos, I.3    Stephanopoulos, G.4
  • 100
    • 77951908013 scopus 로고    scopus 로고
    • Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment
    • Nijnik, A. et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J. Immunol. 184, 2539-2550 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 2539-2550
    • Nijnik, A.1
  • 101
    • 0141988798 scopus 로고    scopus 로고
    • The design, synthesis and application of stereochemical and directional peptide isomers: A critical review
    • DOI 10.2174/1389203033487054
    • Fischer, P. M. The design, synthesis and application of stereochemical and directional peptide isomers: a critical review. Curr. Protein Pept. Sci. 4, 339-356 (2003). (Pubitemid 37236348)
    • (2003) Current Protein and Peptide Science , vol.4 , Issue.5 , pp. 339-356
    • Fischer, P.M.1
  • 103
    • 67649494271 scopus 로고    scopus 로고
    • A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity
    • Kindrachuk, J. et al. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine 27, 4662-4671 (2009).
    • (2009) Vaccine , vol.27 , pp. 4662-4671
    • Kindrachuk, J.1
  • 104
    • 78651427507 scopus 로고    scopus 로고
    • High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: A double-blind randomised controlled trial
    • Martineau, A. R. et al. High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 377, 242-250 (2011).
    • (2011) Lancet , vol.377 , pp. 242-250
    • Martineau, A.R.1
  • 105
    • 33645224419 scopus 로고    scopus 로고
    • Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    • Liu, P. T. et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311, 1770-1773 (2006).
    • (2006) Science , vol.311 , pp. 1770-1773
    • Liu, P.T.1
  • 107
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • DOI 10.1038/nature06246, PII NATURE06246
    • Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature 449, 819-826 (2007). (Pubitemid 47598622)
    • (2007) Nature , vol.449 , Issue.7164 , pp. 819-826
    • Medzhitov, R.1
  • 108
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar, H., Kawai, T. & Akira, S. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30, 16-34 (2009).
    • (2009) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 110
    • 78650375715 scopus 로고    scopus 로고
    • Immunomodulators as adjuvants for vaccines and antimicrobial therapy
    • Nicholls, E. F., Madera, L. & Hancock, R. E. Immunomodulators as adjuvants for vaccines and antimicrobial therapy. Ann. NY Acad. Sci. 1213, 46-61 (2011).
    • (2011) Ann. NY Acad. Sci. , vol.1213 , pp. 46-61
    • Nicholls, E.F.1    Madera, L.2    Hancock, R.E.3
  • 111
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round, J. L. & Mazmanian, S. K. The gut microbiota shapes intestinal immune responses during health and disease. Nature Rev. Immunol. 9, 313-323 (2009).
    • (2009) Nature Rev. Immunol. , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 112
    • 79952768866 scopus 로고    scopus 로고
    • Shifting the balance: Antibiotic effects on host-microbiota mutualism
    • Willing, B. P., Russell, S. L. & Finlay, B. B. Shifting the balance: antibiotic effects on host-microbiota mutualism. Nature Rev. Microbiol. 9, 233-243 (2011).
    • (2011) Nature Rev. Microbiol. , vol.9 , pp. 233-243
    • Willing, B.P.1    Russell, S.L.2    Finlay, B.B.3
  • 113
    • 76949107790 scopus 로고    scopus 로고
    • Host interactions of probiotic bacterial surface molecules: Comparison with commensals and pathogens
    • Lebeer, S., Vanderleyden, J. & De Keersmaecker, S. C. Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nature Rev. Microbiol. 8, 171-184 (2010).
    • (2010) Nature Rev. Microbiol. , vol.8 , pp. 171-184
    • Lebeer, S.1    Vanderleyden, J.2    De Keersmaecker, S.C.3
  • 116
    • 51949091201 scopus 로고    scopus 로고
    • The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis
    • Cosseau, C. et al. The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect. Immun. 76, 4163-4175 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 4163-4175
    • Cosseau, C.1
  • 117
    • 67650066587 scopus 로고    scopus 로고
    • The K5 capsule of Escherichia coli strain Nissle 1917 is important in mediating interactions with intestinal epithelial cells and chemokine induction
    • Hafez, M. et al. The K5 capsule of Escherichia coli strain Nissle 1917 is important in mediating interactions with intestinal epithelial cells and chemokine induction. Infect. Immun. 77, 2995-3003 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 2995-3003
    • Hafez, M.1
  • 120
    • 42349105761 scopus 로고    scopus 로고
    • Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
    • DOI 10.1038/nrmicro1840, PII NRMICRO1840
    • Wells, J. M. & Mercenier, A. Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Nature Rev. Microbiol. 6, 349-362 (2008). (Pubitemid 351552656)
    • (2008) Nature Reviews Microbiology , vol.6 , Issue.5 , pp. 349-362
    • Wells, J.M.1    Mercenier, A.2
  • 121
    • 67649884707 scopus 로고    scopus 로고
    • Beyond a decade of 5% imiquimod topical therapy
    • Gaspari, A., Tyring, S. K. & Rosen, T. Beyond a decade of 5% imiquimod topical therapy. J. Drugs Dermatol. 8, 467-474 (2009).
    • (2009) J. Drugs Dermatol. , vol.8 , pp. 467-474
    • Gaspari, A.1    Tyring, S.K.2    Rosen, T.3
  • 122
    • 33646058566 scopus 로고    scopus 로고
    • Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: Follow-up from a randomised control trial
    • Harper, D. M. et al. Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial. Lancet 367, 1247-1255 (2006).
    • (2006) Lancet , vol.367 , pp. 1247-1255
    • Harper, D.M.1


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