메뉴 건너뛰기




Volumn 14, Issue 3, 2009, Pages 505-521

Emerging drugs for the treatment of ulcerative colitis

Author keywords

Adhesion molecules; Biologic drugs; CD3; CTLA 4; IL 2 receptor; Inflammatory bowel disease; MMX; PPAR ; Probiotics; Therapy; TNF ; Treatment; Ulcerative colitis

Indexed keywords

ABATACEPT; ADALIMUMAB; ALICAFORSEN; AZATHIOPRINE; BASILIXIMAB; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CYCLOSPORIN A; DERSALAZINE; EPIDERMAL GROWTH FACTOR; GASTROINTESTINAL AGENT; GOLIMUMAB; INFLIXIMAB; KAPPAPROCT; MERCAPTOPURINE; MESALAZINE; MONOCLONAL ANTIBODY; NATALIZUMAB; PARNAPARIN; PHOSPHATIDYLCHOLINE; PLACEBO; PROBIOTIC AGENT; ROSIGLITAZONE; SALAZOSULFAPYRIDINE; STEROID; TRAFICET EN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEDOLIZUMAB; VISILIZUMAB; VSL3;

EID: 69949126456     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728210903146882     Document Type: Review
Times cited : (24)

References (119)
  • 3
    • 0028338424 scopus 로고
    • Course of ulcerative colitis: Analysis of changes in disease activity over years
    • Langholz E, Munkholm P, Davidsen M, Binder V. Course of ulcerative colitis: analysis of changes in disease activity over years. Gastroenterology 1994;107(1):3-11 (Pubitemid 24195339)
    • (1994) Gastroenterology , vol.107 , Issue.1 , pp. 3-11
    • Langholz, E.1    Munkholm, P.2    Davidsen, M.3    Binder, V.4
  • 4
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: A meta-analysis
    • DOI 10.1136/gut.48.4.526
    • Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001;48(4):526-535 (Pubitemid 32234798)
    • (2001) Gut , vol.48 , Issue.4 , pp. 526-535
    • Eaden, J.A.1    Abrams, K.R.2    Mayberry, J.F.3
  • 5
    • 53449086211 scopus 로고    scopus 로고
    • Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies
    • Lakatos PL, Lakatos L. Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies. World J Gastroenterol 2008;14(25):3937-3947
    • (2008) World J Gastroenterol , vol.14 , Issue.25 , pp. 3937-3947
    • Lakatos, P.L.1    Lakatos, L.2
  • 6
    • 42449094111 scopus 로고    scopus 로고
    • Quality of life of patients with ulcerative colitis: Past, present, and future
    • DOI 10.1002/ibd.20301
    • Irvine EJ. Quality of life of patients with ulcerative colitis: past, present, and future. Inflamm Bowel Dis 2008;14(4):554-565 (Pubitemid 351571837)
    • (2008) Inflammatory Bowel Diseases , vol.14 , Issue.4 , pp. 554-565
    • Irvine, E.J.1
  • 7
    • 0037732998 scopus 로고    scopus 로고
    • Work losses related to inflammatory bowel disease in the United States: Results from the National Health Interview Survey
    • DOI 10.1016/S0002-9270(02)06007-0
    • Longobardi T, Jacobs P, Bernstein CN. Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey. Am J Gastroenterol 2003;98(5):1064-1072 (Pubitemid 36733768)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.5 , pp. 1064-1072
    • Longobardi, T.1    Jacobs, P.2    Bernstein, C.N.3
  • 8
    • 6944250136 scopus 로고    scopus 로고
    • How effective are the usual treatments for ulcerative colitis?
    • Bebb JR, Scott BB. How effective are the usual treatments for ulcerative colitis? Aliment Pharmacol Ther 2004;20(2):143-149
    • (2004) Aliment Pharmacol Ther , vol.20 , Issue.2 , pp. 143-149
    • Bebb, J.R.1    Scott, B.B.2
  • 11
    • 33745042439 scopus 로고    scopus 로고
    • Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis
    • CD000544
    • Sutherland L, Macdonald JK. Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2006;(2):CD000544
    • (2006) Cochrane Database Syst Rev , Issue.2
    • Sutherland, L.1    Macdonald, J.K.2
  • 12
    • 0028305575 scopus 로고
    • Risk factors for colorectal cancer in patients with ulcerative colitis: A case-control study
    • Pinczowski D, Ekbom A, Baron J, et al. Risk factors for colorectal cancer in patients with ulcerative colitis: a case-control study. Gastroenterology 1994;107(1):117-120 (Pubitemid 24195353)
    • (1994) Gastroenterology , vol.107 , Issue.1 , pp. 117-120
    • Pinczowski, D.1    Ekbom, A.2    Baron, J.3    Yuen, J.4    Adami, H.-O.5
  • 14
    • 0029803955 scopus 로고    scopus 로고
    • Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: A retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire
    • Moody GA, Jayanthi V, Probert CS, et al. Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire. Eur J Gastroenterol Hepatol 1996;8(12):1179-1183 (Pubitemid 26413548)
    • (1996) European Journal of Gastroenterology and Hepatology , vol.8 , Issue.12 , pp. 1179-1183
    • Moody, G.A.1    Jayanthi, V.2    Probert, C.S.J.3    Mac Kay, H.4    Mayberry, J.F.5
  • 15
    • 2942530847 scopus 로고    scopus 로고
    • Mesalamine derivatives in the treatment of Crohn's disease
    • ix-x
    • Harrell LE, Hanauer SB. Mesalamine derivatives in the treatment of Crohn's disease. Gastroenterol Clin North Am 2004;33(2):303-17, ix-x
    • (2004) Gastroenterol Clin North Am , vol.33 , Issue.2 , pp. 303-317
    • Harrell, L.E.1    Hanauer, S.B.2
  • 17
    • 0017898848 scopus 로고
    • Low dose steroids and clinical relapse in Crohn's disease: A controlled trial
    • Smith RC, Rhodes J, Heatley RV, et al. Low dose steroids and clinical relapse in Crohn's disease: a controlled trial. Gut 1978;19(7):606-610 (Pubitemid 8388152)
    • (1978) Gut , vol.19 , Issue.7 , pp. 606-610
    • Smith, R.C.1    Rhodes, J.2    Heatley, R.V.3
  • 18
    • 33644869450 scopus 로고    scopus 로고
    • American gastroenterological association institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease
    • DOI 10.1053/j.gastro.2006.01.048, PII S0016508506000746
    • Lichtenstein GR, Abreu MT, Cohen R, Tremaine W. American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease. Gastroenterology 2006;130(3):940-987 (Pubitemid 43374543)
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 940-987
    • Lichtenstein, G.R.1    Abreu, M.T.2    Cohen, R.3    Tremaine, W.4
  • 22
    • 0025219580 scopus 로고
    • Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone
    • Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
    • Modigliani R, Mary JY, Simon JF, et al. Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives. Gastroenterology 1990;98(4):811-818
    • (1990) Gastroenterology , vol.98 , Issue.4 , pp. 811-818
    • Modigliani, R.1    Mary, J.Y.2    Simon, J.F.3
  • 24
    • 49149112175 scopus 로고    scopus 로고
    • The use of thiopurines for the treatment of inflammatory bowel diseases in clinical practice
    • Saibeni S, Virgilio T, D'Inca R, et al. The use of thiopurines for the treatment of inflammatory bowel diseases in clinical practice. Dig Liver Dis 2008;40(10):814-820
    • (2008) Dig Liver Dis , vol.40 , Issue.10 , pp. 814-820
    • Saibeni, S.1    Virgilio, T.2    D'Inca, R.3
  • 25
    • 39149120115 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis
    • DOI 10.1002/14651858.CD000478.pub2
    • Timmer A, McDonald JW, Macdonald JK. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2007;(1):CD000478 (Pubitemid 351820399)
    • (2007) Cochrane Database of Systematic Reviews , Issue.1
    • Timmer, A.1    McDonald, J.W.D.2    MacDonald, J.K.3
  • 26
    • 35349027343 scopus 로고    scopus 로고
    • Lymphoma risk in inflammatory bowel disease: Is it the disease or its treatment?
    • Jones JL, Loftus EV. Lymphoma risk in inflammatory bowel disease: is it the disease or its treatment? Inflamm Bowel Dis 2007;13(10):1299-1307
    • (2007) Inflamm Bowel Dis , vol.13 , Issue.10 , pp. 1299-1307
    • Jones, J.L.1    Loftus, E.V.2
  • 27
    • 22644446331 scopus 로고    scopus 로고
    • Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine
    • DOI 10.1136/gut.2004.049460
    • Kandiel A, Fraser AG, Korelitz BI, et al. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut 2005;54(8):1121-1125 (Pubitemid 41025906)
    • (2005) Gut , vol.54 , Issue.8 , pp. 1121-1125
    • Kandiel, A.1    Fraser, A.G.2    Korelitz, B.I.3    Brensinger, C.4    Lewis, J.D.5
  • 29
    • 24144502521 scopus 로고    scopus 로고
    • Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: What is the cost?
    • Poritz LS, Rowe WA, Swenson BR, et al. Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: what is the cost? Dis Colon Rectum 2005;48(9):1685-1690
    • (2005) Dis Colon Rectum , vol.48 , Issue.9 , pp. 1685-1690
    • Poritz, L.S.1    Rowe, W.A.2    Swenson, B.R.3
  • 30
    • 0041323231 scopus 로고    scopus 로고
    • Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis
    • DOI 10.1046/j.1365-2036.2003.01618.x
    • Rayner CK, McCormack G, Emmanuel AV, Kamm MA. Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis. Aliment Pharmacol Ther 2003;18(3):303-308 (Pubitemid 37046709)
    • (2003) Alimentary Pharmacology and Therapeutics , vol.18 , Issue.3 , pp. 303-308
    • Rayner, C.K.1    McCormack, G.2    Emmanuel, A.V.3    Kamm, M.A.4
  • 34
    • 0037379792 scopus 로고    scopus 로고
    • Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: A randomized controlled trial
    • DOI 10.1053/gast.2003.50145
    • Farrell RJ, Alsahli M, Jeen YT, et al. Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial. Gastroenterology 2003;124(4):917-924 (Pubitemid 36389794)
    • (2003) Gastroenterology , vol.124 , Issue.4 , pp. 917-924
    • Farrell, R.J.1    Alsahli, M.2    Jeen, Y.-T.3    Falchuk, K.R.4    Peppercorn, M.A.5    Michetti, P.6
  • 36
    • 21344464465 scopus 로고    scopus 로고
    • Leukocytapheresis in ulcerative colitis: Results of a multicenter double-blind prospective case-control study with sham apheresis as placebo treatment
    • DOI 10.1111/j.1572-0241.2005.41089.x
    • Sawada K, Kusugami K, Suzuki Y, et al. Leukocytapheresis in ulcerative colitis: results of a multicenter double-blind prospective case-control study with sham apheresis as placebo treatment. Am J Gastroenterol 2005;100(6):1362-1369 (Pubitemid 40904363)
    • (2005) American Journal of Gastroenterology , vol.100 , Issue.6 , pp. 1362-1369
    • Sawada, K.1    Kusugami, K.2    Suzuki, Y.3    Bamba, T.4    Munakata, A.5    Hibi, T.6    Shimoyama, T.7
  • 39
    • 48749099982 scopus 로고    scopus 로고
    • A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis
    • Sands BE, Sandborn WJ, Feagan B, et al. A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis. Gastroenterology 2008;135(2):400-409
    • (2008) Gastroenterology , vol.135 , Issue.2 , pp. 400-409
    • Sands, B.E.1    Sandborn, W.J.2    Feagan, B.3
  • 40
    • 40049097843 scopus 로고    scopus 로고
    • Role of the intestinal barrier in inflammatory bowel disease
    • DOI 10.3748/wjg.14.401
    • Laukoetter MG, Nava P, Nusrat A. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol 2008;14(3):401-407 (Pubitemid 351320848)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 401-407
    • Laukoetter, M.G.1    Nava, P.2    Nusrat, A.3
  • 41
    • 33646246756 scopus 로고    scopus 로고
    • Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease
    • D'Inca R, Annese V, di Leo V, et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease. Aliment Pharmacol Ther 2006;23(10):1455-1461
    • (2006) Aliment Pharmacol Ther , vol.23 , Issue.10 , pp. 1455-1461
    • D'Inca, R.1    Annese, V.2    Di Leo, V.3
  • 43
    • 54349114996 scopus 로고    scopus 로고
    • Molecular analysis of the intestinal microflora in IBD
    • Tannock GW. Molecular analysis of the intestinal microflora in IBD. Mucosal Immunol 2008;1(Suppl 1):S15-8
    • (2008) Mucosal Immunol , vol.1 , Issue.SUPPL. 1
    • Tannock, G.W.1
  • 44
    • 65449145198 scopus 로고    scopus 로고
    • Pathogenesis of and unifying hypothesis for idiopathic pouchitis
    • Coffey JC, Rowan F, Burke J, et al. Pathogenesis of and unifying hypothesis for idiopathic pouchitis. Am J Gastroenterol 2009;104(4):1013-1023
    • (2009) Am J Gastroenterol , vol.104 , Issue.4 , pp. 1013-1023
    • Coffey, J.C.1    Rowan, F.2    Burke, J.3
  • 45
    • 0037242239 scopus 로고    scopus 로고
    • The effect of 5-aminosalicylic acid-containing drugs on sulfide production by sulfate-reducing and amino acid-fermenting bacteria
    • Edmond LM, Hopkins MJ, Magee EA, Cummings JH. The effect of 5-aminosalicylic acid-containing drugs on sulfide production by sulfate-reducing and amino acid-fermenting bacteria. Inflamm Bowel Dis 2003;9(1):10-17
    • (2003) Inflamm Bowel Dis , vol.9 , Issue.1 , pp. 10-17
    • Edmond, L.M.1    Hopkins, M.J.2    Magee, E.A.3    Cummings, J.H.4
  • 47
    • 34249857135 scopus 로고    scopus 로고
    • Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study
    • Peyrin-Biroulet L, Laclotte C, Roblin X, Bigard MA. Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: an open-label study. World J Gastroenterol 2007;13(16):2328-2332 (Pubitemid 46860734)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.16 , pp. 2328-2332
    • Peyrin-Biroulet, L.1    Laclotte, C.2    Roblin, X.3    Bigard, M.-A.4
  • 48
    • 52149104260 scopus 로고    scopus 로고
    • Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: A single-centre experience
    • Oussalah A, Laclotte C, Chevaux JB, et al. Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: a single-centre experience. Aliment Pharmacol Ther 2008;28(8):966-972
    • (2008) Aliment Pharmacol Ther , vol.28 , Issue.8 , pp. 966-972
    • Oussalah, A.1    Laclotte, C.2    Chevaux, J.B.3
  • 49
    • 68749118728 scopus 로고    scopus 로고
    • Efficacy of adalimumab for the management of inflammatory bowel disease in the clinical setting
    • Epub ahead of print
    • Trinder MW, Lawrance IC. Efficacy of adalimumab for the management of inflammatory bowel disease in the clinical setting. J Gastroenterol Hepatol 2009 [Epub ahead of print]
    • (2009) J Gastroenterol Hepatol
    • Trinder, M.W.1    Lawrance, I.C.2
  • 50
    • 67449133560 scopus 로고    scopus 로고
    • Golimumab, a human antibody to TNF-{alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate: The GO-FORWARD Study
    • Keystone EC, Genovese MC, Klareskog L, et al. Golimumab, a human antibody to TNF-{alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate: the GO-FORWARD Study. Ann Rheum Dis 2009;68(6):789-796
    • (2009) Ann Rheum Dis , vol.68 , Issue.6 , pp. 789-796
    • Keystone, E.C.1    Genovese, M.C.2    Klareskog, L.3
  • 51
    • 10744232542 scopus 로고    scopus 로고
    • Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
    • Creed TJ, Norman MR, Probert CS, et al. Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment Pharmacol Ther 2003;18(1):65-75
    • (2003) Aliment Pharmacol Ther , vol.18 , Issue.1 , pp. 65-75
    • Creed, T.J.1    Norman, M.R.2    Probert, C.S.3
  • 52
    • 33646232018 scopus 로고    scopus 로고
    • Basiliximab for the treatment of steroid-resistant ulcerative colitis: Further experience in moderate and severe disease
    • Creed TJ, Probert CS, Norman MN, et al. Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease. Aliment Pharmacol Ther 2006;23(10):1435-1442
    • (2006) Aliment Pharmacol Ther , vol.23 , Issue.10 , pp. 1435-1442
    • Creed, T.J.1    Probert, C.S.2    Norman, M.N.3
  • 55
    • 4644249955 scopus 로고    scopus 로고
    • NF-kappaB- And AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: A novel effect of a probiotic bacterium
    • Wehkamp J, Harder J, Wehkamp K, et al. NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun 2004;72(10):5750-5758
    • (2004) Infect Immun , vol.72 , Issue.10 , pp. 5750-5758
    • Wehkamp, J.1    Harder, J.2    Wehkamp, K.3
  • 59
    • 2342550172 scopus 로고    scopus 로고
    • Natalizumab: An 100226, anti-4α integrin monoclonal antibody
    • DOI 10.2165/00126839-200405020-00007
    • Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D 2004;5(2):102-107 (Pubitemid 38607632)
    • (2004) Drugs in R and D , vol.5 , Issue.2 , pp. 102-107
  • 63
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005;352(24):2499-2507
    • (2005) N Engl J Med , vol.352 , Issue.24 , pp. 2499-2507
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 64
    • 0036288638 scopus 로고    scopus 로고
    • Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
    • DOI 10.1136/gut.51.1.30
    • Yacyshyn BR, Chey WY, Goff J, et al. Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut 2002;51(1):30-36 (Pubitemid 34717740)
    • (2002) Gut , vol.51 , Issue.1 , pp. 30-36
    • Yacyshyn, B.R.1    Chey, W.Y.2    Goff, J.3    Salzberg, B.4    Baerg, R.5    Buchman, A.L.6    Tami, J.7    Yu, R.8    Gibiansky, E.9    Shanahan, W.R.10
  • 65
    • 7244252832 scopus 로고    scopus 로고
    • A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis
    • van Deventer SJ, Tami JA, Wedel MK. A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis. Gut 2004;53(11):1646-1651
    • (2004) Gut , vol.53 , Issue.11 , pp. 1646-1651
    • Van Deventer, S.J.1    Tami, J.A.2    Wedel, M.K.3
  • 66
    • 45249104849 scopus 로고    scopus 로고
    • Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways
    • Yu QT, Saruta M, Papadakis KA. Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways. Clin Immunol 2008;127(3):322-329
    • (2008) Clin Immunol , vol.127 , Issue.3 , pp. 322-329
    • Yu, Q.T.1    Saruta, M.2    Papadakis, K.A.3
  • 68
    • 69949138752 scopus 로고    scopus 로고
    • A Placebo-Controlled Trial of Visilizumab in Patients with Intravenous (IV) Steroid Refractory Ulcerative Colitis (UC)
    • Chicago; 2009
    • Sandborn W, Colombel JF, Frankel M, et al. A Placebo-Controlled Trial of Visilizumab in Patients with Intravenous (IV) Steroid Refractory Ulcerative Colitis (UC). Digestive Disease Week; 2009; Chicago; 2009
    • (2009) Digestive Disease Week
    • Sandborn, W.1    Colombel, J.F.2    Frankel, M.3
  • 69
    • 2942733370 scopus 로고    scopus 로고
    • CTLA4Ig: A novel inhibitor of costimulation
    • Dall'Era M, Davis J. CTLA4Ig: a novel inhibitor of costimulation. Lupus 2004;13(5):372-376
    • (2004) Lupus , vol.13 , Issue.5 , pp. 372-376
    • Dall'Era, M.1    Davis, J.2
  • 70
    • 65349176911 scopus 로고    scopus 로고
    • Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors
    • Epub ahead of print
    • Westhovens R, Robles M, Ximenes AC, et al. Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis 2009 [Epub ahead of print]
    • (2009) Ann Rheum Dis
    • Westhovens, R.1    Robles, M.2    Ximenes, A.C.3
  • 71
    • 64249129595 scopus 로고    scopus 로고
    • The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-TNF therapy or were directly switched to abatacept: The ARRIVE trial
    • Epub ahead of print
    • Schiff MH, Pritchard C, Huffstutter JE, et al. The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-TNF therapy or were directly switched to abatacept: the ARRIVE trial. Ann Rheum Dis 2008 [Epub ahead of print]
    • (2008) Ann Rheum Dis
    • Schiff, M.H.1    Pritchard, C.2    Huffstutter, J.E.3
  • 73
    • 0032540013 scopus 로고    scopus 로고
    • PPARgamma in monocytes: Less pain, any gain?
    • Spiegelman BM. PPARgamma in monocytes: less pain, any gain? Cell 1998;93(2):153-155
    • (1998) Cell , vol.93 , Issue.2 , pp. 153-155
    • Spiegelman, B.M.1
  • 74
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • DOI 10.1016/S0092-8674(00)81575-5
    • Tontonoz P, Nagy L, Alvarez JG, et al. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93(2):241-252 (Pubitemid 28180857)
    • (1998) Cell , vol.93 , Issue.2 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.A.3    Thomazy, V.A.4    Evans, R.M.5
  • 78
    • 20344363144 scopus 로고    scopus 로고
    • Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats
    • DOI 10.1016/j.bcp.2005.03.024, PII S0006295205001760
    • Sanchez-Hidalgo M, Martin AR, Villegas I, et al. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats. Biochem Pharmacol 2005;69(12):1733-1744 (Pubitemid 40780073)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.12 , pp. 1733-1744
    • Sanchez-Hidalgo, M.1    Martin, A.R.2    Villegas, I.3    Alarcon De La Lastra, C.4
  • 79
    • 34147176714 scopus 로고    scopus 로고
    • Rosiglitazone, a PPARγ ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats
    • DOI 10.1016/j.ejphar.2007.01.047, PII S0014299907000957
    • Sanchez-Hidalgo M, Martin AR, Villegas I, et al. Rosiglitazone, a PPARgamma ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats. Eur J Pharmacol 2007;562(3):247-258 (Pubitemid 46560498)
    • (2007) European Journal of Pharmacology , vol.562 , Issue.3 , pp. 247-258
    • Sanchez-Hidalgo, M.1    Martin, A.R.2    Villegas, I.3    Alarcon De La Lastra, C.4
  • 81
    • 39849093143 scopus 로고    scopus 로고
    • A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis
    • DOI 10.3748/wjg.14.114
    • Liang HL, Ouyang Q. A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis. World J Gastroenterol 2008;14(1):114-119 (Pubitemid 351314337)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.1 , pp. 114-119
    • Liang, H.-L.1    Ouyang, Q.2
  • 82
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • DOI 10.1001/jama.298.10.1189
    • Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 2007;298(10):1189-1195 (Pubitemid 47403105)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.10 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 83
    • 4143054569 scopus 로고    scopus 로고
    • Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoelectrospray-tandem mass spectrometry
    • DOI 10.1080/00365520410006233
    • Ehehalt R, Wagenblast J, Erben G, et al. Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoElectrospray-tandem mass spectrometry. Scand J Gastroenterol 2004;39(8):737-742 (Pubitemid 39093247)
    • (2004) Scandinavian Journal of Gastroenterology , vol.39 , Issue.8 , pp. 737-742
    • Ehehalt, R.1    Wagenblast, J.2    Erben, G.3    Lehmann, W.-D.4    Hinz, U.5    Merle, U.6    Stremmel, W.7
  • 84
    • 21044457089 scopus 로고    scopus 로고
    • Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis
    • DOI 10.1136/gut.2004.052316
    • Stremmel W, Merle U, Zahn A, et al. Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis. Gut 2005;54(7):966-971 (Pubitemid 40873911)
    • (2005) Gut , vol.54 , Issue.7 , pp. 966-971
    • Stremmel, W.1    Merle, U.2    Zahn, A.3    Autschbach, F.4    Hinz, U.5    Ehehalt, R.6
  • 85
    • 38449107095 scopus 로고    scopus 로고
    • Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: A randomized trial
    • Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med 2007;147(9):603-610 (Pubitemid 351664479)
    • (2007) Annals of Internal Medicine , vol.147 , Issue.9 , pp. 603-610
    • Stremmel, W.1    Ehehalt, R.2    Autschbach, F.3    Karner, M.4
  • 86
    • 0037483705 scopus 로고    scopus 로고
    • Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis
    • DOI 10.1056/NEJMoa013136
    • Sinha A, Nightingale J, West KP, et al. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis. N Engl J Med 2003;349(4):350-357 (Pubitemid 36886241)
    • (2003) New England Journal of Medicine , vol.349 , Issue.4 , pp. 350-357
    • Sinha, A.1    Nightingale, J.2    West, K.P.3    Berlanga-Acosta, J.4    Playford, R.J.5
  • 87
    • 33846420200 scopus 로고    scopus 로고
    • Probiotics in experimental and human inflammatory bowel disease: Discussion points
    • DOI 10.1016/S1590-8658(07)60008-5, PII S1590865807600085
    • Pagnini C, Cominelli F. Probiotics in experimental and human inflammatory bowel disease: discussion points. Dig Liver Dis 2006;38(Suppl 2):S270-3 (Pubitemid 46140767)
    • (2006) Digestive and Liver Disease , vol.38 , Issue.SUPPL. 2
    • Pagnini, C.1    Cominelli, F.2
  • 88
    • 59249100550 scopus 로고    scopus 로고
    • Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases
    • Vanderpool C, Yan F, Polk DB. Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis 2008;14(11):1585-1596
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.11 , pp. 1585-1596
    • Vanderpool, C.1    Yan, F.2    Polk, D.B.3
  • 89
    • 60549106052 scopus 로고    scopus 로고
    • Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans
    • Mondel M, Schroeder BO, Zimmermann K, et al. Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Mucosal Immunol 2009;2(2):166-172
    • (2009) Mucosal Immunol , vol.2 , Issue.2 , pp. 166-172
    • Mondel, M.1    Schroeder, B.O.2    Zimmermann, K.3
  • 90
    • 0030611915 scopus 로고    scopus 로고
    • Double-blind comparison of an oral Escherichia coli prepration and mesalazine in maintaining remission of ulcerative colitis
    • Kruis W, Schutz E, Fric P, et al. Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 1997;11(5):853-858 (Pubitemid 27445670)
    • (1997) Alimentary Pharmacology and Therapeutics , vol.11 , Issue.5 , pp. 853-858
    • Kruis, W.1    Schutz, E.2    Fric, P.3    Fixa, B.4    Judmaier, G.5    Stolte, M.6
  • 91
    • 4644239296 scopus 로고    scopus 로고
    • Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    • Kruis W, Fric P, Pokrotnieks J, et al. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 2004;53(11):1617-1623
    • Gut 2004 , vol.53 , Issue.11 , pp. 1617-1623
    • Kruis, W.1    Fric, P.2    Pokrotnieks, J.3
  • 92
    • 0033592203 scopus 로고    scopus 로고
    • Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: A randomised trial
    • DOI 10.1016/S0140-6736(98)06343-0
    • Rembacken BJ, Snelling AM, Hawkey PM, et al. Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet 1999;354(9179):635-639 (Pubitemid 29391428)
    • (1999) Lancet , vol.354 , Issue.9179 , pp. 635-639
    • Rembacken, B.J.1    Snelling, A.M.2    Hawkey, P.M.3    Chalmers, D.M.4    Axon, A.T.R.5
  • 95
    • 67650311571 scopus 로고    scopus 로고
    • Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: A pilot study
    • Huynh HQ, Debruyn J, Guan L, et al. Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: a pilot study. Inflamm Bowel Dis 2009;15(5):760-768
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.5 , pp. 760-768
    • Huynh, H.Q.1    Debruyn, J.2    Guan, L.3
  • 96
    • 59749088586 scopus 로고    scopus 로고
    • Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis
    • Miele E, Pascarella F, Giannetti E, et al. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol 2009;104(2):437-443
    • (2009) Am J Gastroenterol , vol.104 , Issue.2 , pp. 437-443
    • Miele, E.1    Pascarella, F.2    Giannetti, E.3
  • 100
    • 33947125482 scopus 로고    scopus 로고
    • Helminths as governors of immune-mediated inflammation
    • Elliott DE, Summers RW, Weinstock JV. Helminths as governors of immune-mediated inflammation. Int J Parasitol 2007;37(5):457-464
    • (2007) Int J Parasitol , vol.37 , Issue.5 , pp. 457-464
    • Elliott, D.E.1    Summers, R.W.2    Weinstock, J.V.3
  • 102
    • 17144402166 scopus 로고    scopus 로고
    • Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial
    • DOI 10.1053/j.gastro.2005.01.005
    • Summers RW, Elliott DE, Urban JF, et al. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology 2005;128(4):825-832 (Pubitemid 40523535)
    • (2005) Gastroenterology , vol.128 , Issue.4 , pp. 825-832
    • Summers, R.W.1    Elliott, D.E.2    Urban Jr., J.F.3    Thompson, R.A.4    Weinstock, J.V.5
  • 108
    • 46349099233 scopus 로고    scopus 로고
    • Randomised trial of once- or twice-daily MMX mesalazine for maintenance of remission in ulcerative colitis
    • Kamm MA, Lichtenstein GR, Sandborn WJ, et al. Randomised trial of once- or twice-daily MMX mesalazine for maintenance of remission in ulcerative colitis. Gut 2008;57(7):893-902
    • (2008) Gut , vol.57 , Issue.7 , pp. 893-902
    • Kamm, M.A.1    Lichtenstein, G.R.2    Sandborn, W.J.3
  • 109
    • 50849090436 scopus 로고    scopus 로고
    • Safety and efficacy of a novel extended release budesonide formulation in patients with active left sided ulcerative colitis
    • D'Haens GR, Kovács á, Vergauwe P, et al. Safety and efficacy of a novel extended release budesonide formulation in patients with active left sided ulcerative colitis. Gastroenterology 2007;132(Suppl 2):T1276
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 2
    • D'Haens, G.R.1    Kovács, Á.2    Vergauwe, P.3
  • 110
    • 12344250990 scopus 로고    scopus 로고
    • TARGIT technology: Coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract
    • DOI 10.1517/17425247.2.1.159
    • Watts P, Smith A. TARGIT technology: coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract. Expert Opin Drug Deliv 2005;2(1):159-167 (Pubitemid 40123890)
    • (2005) Expert Opinion on Drug Delivery , vol.2 , Issue.1 , pp. 159-167
    • Watts, P.1    Smith, A.2
  • 111
    • 34547094356 scopus 로고    scopus 로고
    • Heparin, low molecular weight heparin, and derivatives in thrombosis, angiogenesis, and inflammation: Emerging links
    • Mousa SA. Heparin, low molecular weight heparin, and derivatives in thrombosis, angiogenesis, and inflammation: emerging links. Semin Thromb Hemost 2007;33(5):524-533
    • (2007) Semin Thromb Hemost , vol.33 , Issue.5 , pp. 524-533
    • Mousa, S.A.1
  • 112
    • 55949135189 scopus 로고    scopus 로고
    • Efficacy of intracolonic administration of low-molecular-weight heparin CB-01-05, compared to other low-molecular-weight heparins and unfractionated heparin, in experimentally induced colitis in rat
    • Celasco G, Moro L, Bozzella R, et al. Efficacy of intracolonic administration of low-molecular-weight heparin CB-01-05, compared to other low-molecular-weight heparins and unfractionated heparin, in experimentally induced colitis in rat. Dig Dis Sci 2008;53(12):3170-3175
    • (2008) Dig Dis Sci , vol.53 , Issue.12 , pp. 3170-3175
    • Celasco, G.1    Moro, L.2    Bozzella, R.3
  • 113
    • 48449091370 scopus 로고    scopus 로고
    • Oral, colonic-release low-molecular-weight heparin: An initial open study of Parnaparin-MMX for the treatment of mild-to-moderate left-sided ulcerative colitis
    • Pastorelli L, Saibeni S, Spina L, et al. Oral, colonic-release low-molecular-weight heparin: an initial open study of Parnaparin-MMX for the treatment of mild-to-moderate left-sided ulcerative colitis. Aliment Pharmacol Ther 2008;28(5):581-588
    • (2008) Aliment Pharmacol Ther , vol.28 , Issue.5 , pp. 581-588
    • Pastorelli, L.1    Saibeni, S.2    Spina, L.3
  • 117
    • 53149124013 scopus 로고    scopus 로고
    • Erythrocyte-mediated delivery of dexamethasone in patients with mild-to-moderate ulcerative colitis, refractory to mesalamine: A randomized, controlled study
    • Bossa F, Latiano A, Rossi L, et al. Erythrocyte-mediated delivery of dexamethasone in patients with mild-to-moderate ulcerative colitis, refractory to mesalamine: a randomized, controlled study. Am J Gastroenterol 2008;103(10):2509-2516
    • (2008) Am J Gastroenterol , vol.103 , Issue.10 , pp. 2509-2516
    • Bossa, F.1    Latiano, A.2    Rossi, L.3
  • 118
    • 0344466539 scopus 로고    scopus 로고
    • The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production
    • DOI 10.1097/00054725-200311000-00004
    • Galvez J, Garrido M, Rodriguez-Cabezas ME, et al. The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. Inflamm Bowel Dis 2003;9(6):363-371 (Pubitemid 37461447)
    • (2003) Inflammatory Bowel Diseases , vol.9 , Issue.6 , pp. 363-371
    • Galvez, J.1    Garrido, M.2    Rodriguez-Cabezas, M.E.3    Ramis, I.4    Sanchez De Medina, F.5    Merlos, M.6    Zarzuelo, A.7
  • 119
    • 35748933207 scopus 로고    scopus 로고
    • A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: Androstene hormones as regulators of regulatory T cells
    • DOI 10.1196/annals.1423.066, Autoimmunity, Part B Novel Applications of Basic Research
    • Auci D, Kaler L, Subramanian S, et al. A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: androstene hormones as regulators of regulatory T cells. Ann NY Acad Sci 2007;1110:630-640 (Pubitemid 350043052)
    • (2007) Annals of the New York Academy of Sciences , vol.1110 , pp. 630-640
    • Auci, D.L.1    Kaler, L.2    Subramanian, S.3    Huang, Y.4    Frincke, J.5    Reading, C.6    Offner, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.