메뉴 건너뛰기




Volumn 1082, Issue , 2006, Pages 137-150

CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine

Author keywords

Adjuvant; Anthrax; CpG oligonucleotide; Protection; Vaccine

Indexed keywords

ANTHRAX VACCINE; CPG OLIGODEOXYNUCLEOTIDE;

EID: 33845654330     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1348.030     Document Type: Conference Paper
Times cited : (45)

References (48)
  • 1
    • 0030796341 scopus 로고    scopus 로고
    • Anthrax pathogenesis and host response
    • HANNA, P. 1998. Anthrax pathogenesis and host response. Curr. Top. Microbiol. Immunol. 225: 13-35.
    • (1998) Curr. Top. Microbiol. Immunol. , vol.225 , pp. 13-35
    • Hanna, P.1
  • 2
    • 3142531397 scopus 로고    scopus 로고
    • Anthrax
    • S.A. Plotkin & E.A. Mortimer, Eds.: W.B. Saunders. Philadelphia, PA
    • FRIEDLANDER, A.M. & P.S. BRACHMAN. 1998. Anthrax. In Vaccines. S.A. Plotkin & E.A. Mortimer, Eds.: 729-739. W.B. Saunders. Philadelphia, PA.
    • (1998) Vaccines , pp. 729-739
    • Friedlander, A.M.1    Brachman, P.S.2
  • 3
    • 0035664569 scopus 로고    scopus 로고
    • Bioterrorism: A clear and present danger
    • LANE, H.C., J.L. MONTAGNE & A.S. FAUCI. 2001. Bioterrorism: a clear and present danger. Nat. Med. 7: 1271-1273.
    • (2001) Nat. Med. , vol.7 , pp. 1271-1273
    • Lane, H.C.1    Montagne, J.L.2    Fauci, A.S.3
  • 4
    • 0023924122 scopus 로고
    • Recent advances in the development of an improved, human anthrax vaccine
    • IVINS, B.E. & S.L. WELKOS. 1988. Recent advances in the development of an improved, human anthrax vaccine. Eur. J. Epidemiol. 4: 12-19.
    • (1988) Eur. J. Epidemiol. , vol.4 , pp. 12-19
    • Ivins, B.E.1    Welkos, S.L.2
  • 5
    • 0026322202 scopus 로고
    • Immunization against anthrax with Bacilus anthracis protective antigen combined with adjuvants
    • IVINS, B.E., S.L. WELKOS, S.F. LITTLE, et al. 1992. Immunization against anthrax with Bacilus anthracis protective antigen combined with adjuvants. Infect. Immun. 60: 662-668.
    • (1992) Infect. Immun. , vol.60 , pp. 662-668
    • Ivins, B.E.1    Welkos, S.L.2    Little, S.F.3
  • 6
    • 0032760622 scopus 로고    scopus 로고
    • Molecular pathogenesis of Bacillus anthracis infection
    • LITTLE, S.F. & B.E. IVINS. 1999. Molecular pathogenesis of Bacillus anthracis infection. Microbes. Infect. 1: 131-139.
    • (1999) Microbes. Infect. , vol.1 , pp. 131-139
    • Little, S.F.1    Ivins, B.E.2
  • 7
    • 0034969908 scopus 로고    scopus 로고
    • The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores
    • WELKOS, S., S. LITTLE, A. FRIEDLANDER, et al. 2001. The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores. Microbiology 147: 1677-1685.
    • (2001) Microbiology , vol.147 , pp. 1677-1685
    • Welkos, S.1    Little, S.2    Friedlander, A.3
  • 8
    • 0023811218 scopus 로고
    • Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice
    • WELKOS, S.L. & A.M. FRIEDLANDER. 1988. Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice. Microb. Pathog. 5: 127-139.
    • (1988) Microb. Pathog. , vol.5 , pp. 127-139
    • Welkos, S.L.1    Friedlander, A.M.2
  • 9
    • 0035852337 scopus 로고    scopus 로고
    • Anthrax vaccine: Short-term safety experience in humans
    • PITTMAN, P.R., P.H. GIBBS, T.L. CANNON & A.M. FRIEDLANDER. 2001. Anthrax vaccine: short-term safety experience in humans. Vaccine 20: 972-978.
    • (2001) Vaccine , vol.20 , pp. 972-978
    • Pittman, P.R.1    Gibbs, P.H.2    Cannon, T.L.3    Friedlander, A.M.4
  • 10
    • 0037203927 scopus 로고    scopus 로고
    • Anthrax vaccine: Immunogenicity and safety of a dose-reduction, route-change comparison study in humans
    • PITTMAN, P.R., G. KIM-AHN, D.Y. PIFAT, et al. 2002. Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans. Vaccine 20: 1412-1420.
    • (2002) Vaccine , vol.20 , pp. 1412-1420
    • Pittman, P.R.1    Kim-Ahn, G.2    Pifat, D.Y.3
  • 11
    • 0035990186 scopus 로고    scopus 로고
    • Anthrax vaccination and joint related adverse reactions in light of biological warfare scenarios
    • GEIER, D.A. & M.R. GEIER. 2002. Anthrax vaccination and joint related adverse reactions in light of biological warfare scenarios. Clin. Exp. Rheumatol. 20: 217-220.
    • (2002) Clin. Exp. Rheumatol. , vol.20 , pp. 217-220
    • Geier, D.A.1    Geier, M.R.2
  • 12
    • 1942516827 scopus 로고    scopus 로고
    • US soldiers refuse to fall in line with anthrax vaccination scheme
    • READY, T. 2004. US soldiers refuse to fall in line with anthrax vaccination scheme. Nat. Med. 10: 112.
    • (2004) Nat. Med. , vol.10 , pp. 112
    • Ready, T.1
  • 13
    • 17944402906 scopus 로고    scopus 로고
    • CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
    • DAVIS, H.L., I.I. SUPARTO, R.R. WEERATNA, et al. 2000. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans. Vaccine 18: 1920-1924.
    • (2000) Vaccine , vol.18 , pp. 1920-1924
    • Davis, H.L.1    Suparto, I.I.2    Weeratna, R.R.3
  • 14
    • 0033529512 scopus 로고    scopus 로고
    • Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenic vaccine in Aotus monkeys
    • JONES, T.R., N. OBALDIA, R.A. GRAMZINSKI, et al. 1999. Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenic vaccine in Aotus monkeys. Vaccine 17: 3065-3071.
    • (1999) Vaccine , vol.17 , pp. 3065-3071
    • Jones, T.R.1    Obaldia, N.2    Gramzinski, R.A.3
  • 15
    • 0037083664 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides as vaccine adjuvants in primates
    • VERTHELYI, D., R.T. KENNEY, R.A. SEDER, et al. 2002. CpG oligodeoxynucleotides as vaccine adjuvants in primates. J. Immunol. 168: 1659-1663.
    • (2002) J. Immunol. , vol.168 , pp. 1659-1663
    • Verthelyi, D.1    Kenney, R.T.2    Seder, R.A.3
  • 16
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • KRIEG, A.M., A. YI, S. MATSON, et al. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-548.
    • (1995) Nature , vol.374 , pp. 546-548
    • Krieg, A.M.1    Yi, A.2    Matson, S.3
  • 17
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNg
    • KLINMAN, D.M., A. YI, S.L. BEAUCAGE, et al. 1996. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNg. Proc. Natl. Acad. Sci. USA 93: 2879-2883.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.2    Beaucage, S.L.3
  • 18
    • 0035477969 scopus 로고    scopus 로고
    • Cutting edge: Role of toll-like receptor 9 in CpG DNA-induced activation of human cells
    • TAKESHITA, F., C.A. LEIFER, I. GURSEL, et al. 2001. Cutting edge: role of toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167: 3555-3558.
    • (2001) J. Immunol. , vol.167 , pp. 3555-3558
    • Takeshita, F.1    Leifer, C.A.2    Gursel, I.3
  • 19
    • 0034619794 scopus 로고    scopus 로고
    • A toll-like receptor recognizes bacterial DNA
    • HEMMI, H., O. TAKEUCHI, T. KAWAI, et al. 2000. A toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 20
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • BALLAS, Z.D., W.L. RASMUSSEN & A.M. KRIEG. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157: 1840-1847.
    • (1996) J. Immunol. , vol.157 , pp. 1840-1847
    • Ballas, Z.D.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 21
    • 0030028722 scopus 로고    scopus 로고
    • Bacterial DNA induces murine interferon-gamma production by stimulation of IL-12 and tumor necrosis factor-alpha
    • HALPERN, M.D., R.J. KURLANDER & D.S. PISETSKY. 1996. Bacterial DNA induces murine interferon-gamma production by stimulation of IL-12 and tumor necrosis factor-alpha. Cell. Immunol. 167: 72-78.
    • (1996) Cell. Immunol. , vol.167 , pp. 72-78
    • Halpern, M.D.1    Kurlander, R.J.2    Pisetsky, D.S.3
  • 23
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • LIPFORD, G.B., M. BAUER, C. BLANK, et al. 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27: 2340-2344.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3
  • 24
    • 0033374028 scopus 로고    scopus 로고
    • Use of CpG DNA for enhancing specific immune responses
    • DAVIS, H.L. 2000. Use of CpG DNA for enhancing specific immune responses. Curr. Top. Microbiol. Immunol. 247: 171-184.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.247 , pp. 171-184
    • Davis, H.L.1
  • 25
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • MOLDOVEANU, Z., L. LOVE-HOMAN, W.Q. HUANG & A.M. KRIEG. 1998. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16: 1216-1224.
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 26
    • 0035112910 scopus 로고    scopus 로고
    • Enhancing vaccines with immune stimulatory CpG DNA
    • KRIEG, A.M. & H.L. DAVIS. 2001. Enhancing vaccines with immune stimulatory CpG DNA. Curr. Opin. Mol. Ther. 3: 15-24.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 15-24
    • Krieg, A.M.1    Davis, H.L.2
  • 27
    • 0032810718 scopus 로고    scopus 로고
    • DNA activates human immune cells through a CpG sequence-dependent manner
    • BAUER, M., K. HEEG, H. WAGNER & G.B. LIPFORD. 1999. DNA activates human immune cells through a CpG sequence-dependent manner. Immunology 97: 699-705.
    • (1999) Immunology , vol.97 , pp. 699-705
    • Bauer, M.1    Heeg, K.2    Wagner, H.3    Lipford, G.B.4
  • 28
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • HARTMANN, G. & A.M. KRIEG. 2000. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164: 944-952.
    • (2000) J. Immunol. , vol.164 , pp. 944-952
    • Hartmann, G.1    Krieg, A.M.2
  • 29
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
    • VERTHELYI, D., K.J. ISHII, M. GURSEL, et al. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166: 2372-2377.
    • (2001) J. Immunol. , vol.166 , pp. 2372-2377
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3
  • 30
    • 9144238063 scopus 로고    scopus 로고
    • Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
    • VOLLMER, J., R. WEERATNA, P. PAYETTE, et al. 2004. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur. J. Immunol. 34: 251-262.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 251-262
    • Vollmer, J.1    Weeratna, R.2    Payette, P.3
  • 31
    • 0035885126 scopus 로고    scopus 로고
    • Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
    • GURSEL, I., M. GURSEL, K.J. ISHII & D.M. KLINMAN. 2001. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J. Immunol. 167: 3324-3328.
    • (2001) J. Immunol. , vol.167 , pp. 3324-3328
    • Gursel, I.1    Gursel, M.2    Ishii, K.J.3    Klinman, D.M.4
  • 32
    • 3142602923 scopus 로고    scopus 로고
    • CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques
    • KLINMAN, D.M., H. XIE, S.F. LITTLE, et al. 2004. CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques. Vaccine 22: 2881-2886.
    • (2004) Vaccine , vol.22 , pp. 2881-2886
    • Klinman, D.M.1    Xie, H.2    Little, S.F.3
  • 33
    • 0029815056 scopus 로고    scopus 로고
    • Order-restricted tests for stratified comparisons of binomial proportions
    • AGRESTI, A. & B.A. COULL. 1996. Order-restricted tests for stratified comparisons of binomial proportions. Biometrics 52: 1103-1111.
    • (1996) Biometrics , vol.52 , pp. 1103-1111
    • Agresti, A.1    Coull, B.A.2
  • 34
    • 0035865228 scopus 로고    scopus 로고
    • Distinct CpG DNA and polyinosinic-polycytidylic acid ds RNA, respectively stimulate CD11c- type II dendritic precursor and CD11c+ dendritic cells to produce type I interferon
    • KADOWAKI, N., S. ANTONENKO & Y.J. LIU. 2001. Distinct CpG DNA and polyinosinic-polycytidylic acid ds RNA, respectively stimulate CD11c- type II dendritic precursor and CD11c+ dendritic cells to produce type I interferon. J. Immunol. 166: 2291-2295.
    • (2001) J. Immunol. , vol.166 , pp. 2291-2295
    • Kadowaki, N.1    Antonenko, S.2    Liu, Y.J.3
  • 35
    • 0037829434 scopus 로고    scopus 로고
    • Human response to immunostimulatory CpG oligondeoxynucleotides
    • LEIFER, C., D. VERTHELYI & D.M. KLINMAN. 2003. Human response to immunostimulatory CpG oligondeoxynucleotides. J. Immunotherapy 26: 313-318.
    • (2003) J. Immunotherapy , vol.26 , pp. 313-318
    • Leifer, C.1    Verthelyi, D.2    Klinman, D.M.3
  • 36
    • 0031942366 scopus 로고    scopus 로고
    • Estimation of the avidity of immunoglobulin G for routine diagnosis of chronic Toxoplasma gondii infection in pregnant women
    • COZON, G.J., J. FERRANDIZ, H. NEBHI, et al. 1998. Estimation of the avidity of immunoglobulin G for routine diagnosis of chronic Toxoplasma gondii infection in pregnant women. Eur. J. Clin. Microbiol. Infect. Dis. 17: 32-36.
    • (1998) Eur. J. Clin. Microbiol. Infect. Dis. , vol.17 , pp. 32-36
    • Cozon, G.J.1    Ferrandiz, J.2    Nebhi, H.3
  • 37
    • 0342948846 scopus 로고    scopus 로고
    • Combination of microneutralization and avidity assays: Improved diagnosis of recent primary human cytomegalovirus infection in single serum sample of second trimester pregnancy
    • EGGERS, M., U. BADER & G. ENDERS. 2000. Combination of microneutralization and avidity assays: improved diagnosis of recent primary human cytomegalovirus infection in single serum sample of second trimester pregnancy. J. Med. Virol. 60: 324-330.
    • (2000) J. Med. Virol. , vol.60 , pp. 324-330
    • Eggers, M.1    Bader, U.2    Enders, G.3
  • 38
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • SPARWASSER, T., E. KOCH, R.M. VABULAS, et al. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28: 2045-2054.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.2    Vabulas, R.M.3
  • 39
    • 0030764558 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants
    • ROMAN, M., E. MARTIN-OROZCO, J.S. GOODMAN, et al. 1997. Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants. Nat. Med. 3: 849-854.
    • (1997) Nat. Med. , vol.3 , pp. 849-854
    • Roman, M.1    Martin-Orozco, E.2    Goodman, J.S.3
  • 40
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • BRAZOLOT MILLAN, C.L., R. WEERATNA, A.M. KRIEG, et al. 1998. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc. Natl. Acad. Sci. USA 95: 15553-15558.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15553-15558
    • Brazolot Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3
  • 41
    • 0032209286 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    • MCCLUSKIE, M.J. & H.L. DAVIS. 1998. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J. Immunol. 161: 4463-4466.
    • (1998) J. Immunol. , vol.161 , pp. 4463-4466
    • Mccluskie, M.J.1    Davis, H.L.2
  • 42
    • 0030231262 scopus 로고    scopus 로고
    • Amplification of antibody production by phosphorothioate oligodeoxynucleotides
    • BRANDA, R.F., A.L. MOORE, A.R. LAFAYETTE, et al. 1996. Amplification of antibody production by phosphorothioate oligodeoxynucleotides. J. Lab. Clin. Med. 128: 329-338.
    • (1996) J. Lab. Clin. Med. , vol.128 , pp. 329-338
    • Branda, R.F.1    Moore, A.L.2    Lafayette, A.R.3
  • 43
    • 0033082499 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    • KOVARIK, J., P. BOZZOTTI, L. LOVE-HOMAN, et al. 1999. CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming. J. Immunol. 162: 1611-1617.
    • (1999) J. Immunol. , vol.162 , pp. 1611-1617
    • Kovarik, J.1    Bozzotti, P.2    Love-Homan, L.3
  • 44
    • 0031964257 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    • DAVIS, H.L., R. WEERANTA, T.J. WALDSCHMIDT, et al. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160: 870-876.
    • (1998) J. Immunol. , vol.160 , pp. 870-876
    • Davis, H.L.1    Weeranta, R.2    Waldschmidt, T.J.3
  • 45
    • 12844272901 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine
    • XIE, H., I. GURSEL, B.E. IVINS, et al. 2005. CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine. Infect. Immun. 73: 828-833.
    • (2005) Infect. Immun. , vol.73 , pp. 828-833
    • Xie, H.1    Gursel, I.2    Ivins, B.E.3
  • 46
    • 0345096575 scopus 로고    scopus 로고
    • Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine
    • LITTLE, S.F., B.E. IVINS, P.F. FELLOWS, et al. 2004. Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine. Vaccine 22: 422-430.
    • (2004) Vaccine , vol.22 , pp. 422-430
    • Little, S.F.1    Ivins, B.E.2    Fellows, P.F.3
  • 47
    • 0036587573 scopus 로고    scopus 로고
    • Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides
    • GURSEL, M., D. VERTHELYI, I. GURSEL, et al. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides. J. Leukocyte Bio. 71: 813-820.
    • (2002) J. Leukocyte Bio. , vol.71 , pp. 813-820
    • Gursel, M.1    Verthelyi, D.2    Gursel, I.3
  • 48
    • 0032706198 scopus 로고    scopus 로고
    • Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection
    • KLINMAN, D.M., J. CONOVER & C. COBAN. 1999. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect. Immun. 67: 5658-5663.
    • (1999) Infect. Immun. , vol.67 , pp. 5658-5663
    • Klinman, D.M.1    Conover, J.2    Coban, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.