Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi

American Journal of Respiratory Cell and Molecular Biology

Volumn 42, Issue 1, 2010, Pages 40-50

  Evans, Scott E ^a,c   Scott, Brenton L ^a   Clement, Cecilia G ^a   Larson, Derek T ^a   Kontoyiannis, Dimitrios ^a   Lewis, Russell E ^a   Lasala, P Rocco ^a   Pawlik, Jennifer ^b   Peterson, Johnny W ^b   Chopra, Ashok K ^b   Klimpel, Gary ^b   Bowden, Gabriela ^c   Höök, Magnus ^c   Xu, Yi ^c   Tuvim, Michael J ^a,c   Dickey, Burton F ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Immunocompromised host; Innate immunity; Lung epithelium; Pneumonia

Indexed keywords

BACTERIUM LYSATE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 6; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN BCL 10; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACTERIAL IMMUNITY; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; FUNGAL VIRULENCE; FUNGUS IMMUNITY; GENE EXPRESSION PROFILING; IN VITRO STUDY; INFECTION RESISTANCE; INNATE IMMUNITY; LUNG ALVEOLUS EPITHELIUM; LUNG ASPERGILLOSIS; LUNG INFECTION; LUNG MYCOSIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PSEUDOMONAS AERUGINOSA; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; UPREGULATION; AEROSOL; ANIMAL; C57BL MOUSE; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; IMMUNOLOGY; INFLAMMATION; LUNG; MICROBIOLOGY; MYCOSIS; PATHOLOGY; PNEUMONIA; TIME;

ASPERGILLUS FUMIGATUS; BACTERIA (MICROORGANISMS); FUNGI; MUS; NEGIBACTERIA; POSIBACTERIA;

AEROSOLS; ANIMALS; BACTERIAL INFECTIONS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; IMMUNITY, INNATE; INFLAMMATION; LUNG; MALE; MICE; MICE, INBRED C57BL; MYCOSES; PNEUMONIA; TIME FACTORS;

EID: 73949118392     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0260OC     Document Type: Article

References (51)

1. World Health Organization. The World Health report 2004 - changing history. Geneva: World Health Organization; 2004.
2. File TM. Community-acquired pneumonia. Lancet 2003;362:1991-2001.
3. Joos L, Tamm M. Breakdown of pulmonary host defense in the immunocompromised host: cancer chemotherapy. Proc Am Thorac Soc 2005;2:445-448.
4. Flanders SA, Collard HR, Saint S. Nosocomial pneumonia: state of the science. Am J Infect Control 2006;34:84-93.
5. Kuderer NM, Dale DC, Crawford J, Cosler LE, Lyman GH. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer 2006;106:2258-2266.
6. Norgaard M, Larsson H, Pedersen G, Schonheyder HC, Sorensen HT. Risk of bacteraemia and mortality in patients with haematological malignancies. Clin Microbiol Infect 2006;12:217-223.
7. Wadhwa PD, Morrison VA. Infectious complications of chronic lymphocytic leukemia. Semin Oncol 2006;33:240-249.
8. Cheng VC, Lau SK, Woo PC, Yuen KY. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev 2007;20:660-694.
9. Johnson NP, Mueller J. Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic. Bull Hist Med 2002;76:105-115.
10. Hilleman MR. Overview: cause and prevention in biowarfare and bioterrorism. Vaccine 2002;20:3055-3067.
11. Wilkening DA. Sverdlovsk revisited: modeling human inhalation anthrax. Proc Natl Acad Sci USA 2006;103:7589-7594.
12. Bals R, Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 2004;23:327-333.
13. Evans CM, Williams OW, Tuvim MJ, Nigam R, Mixides GP, Blackburn MR, DeMayo FJ, Burns AR, Smith C, Reynolds SD, et al. Mucin is produced by Clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol 2004;31:382-394.
14. Evans SE, Hahn PY, McCann F, Kottom TJ, Pavlovic ZV, Limper AH. Pneumocystis cell wall β-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-κB-dependent mechanisms. Am J Respir Cell Mol Biol 2005;32:490-497.
15. Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc 2005;2:403-411.
16. Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, et al. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med 2008;177:1322-1330.
17. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003;300:1524-1525.
18. Boldrick JC, Alizadeh AA, Diehn M, Dudoit S, Liu CL, Belcher CE, Botstein D, Staudt LM, Brown PO, Relman DA. Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc Natl Acad Sci USA 2002;99:972-977.
19. Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 2003;15:396-401.
20. Agusti C, Rano A, Rovira M, Filella X, Benito N, Moreno A, Torres A. Inflammatory response associated with pulmonary complications in non-HIV immunocompromised patients. Thorax 2004;59:1081-1088.
21. Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF. Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype. Am J Respir Cell Mol Biol 2008;38:629-638.
22. Bielinska AU, Janczak KW, Landers JJ, Makidon P, Sower LE, Peterson JW, Baker JR Jr. Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge. Infect Immun 2007;75:4020-4029.
23. Comer JE, Noffsinger DM, McHenry DJ, Weisbaum DM, Chatuev BM, Chopra AK, Peterson JW. Evaluation of the protective effects of quinacrine against Bacillus anthracis Ames. J Toxicol Environ Health A 2006;69:1083-1095.
24. Wiederhold NP, Kontoyiannis DP, Chi J, Prince RA, Tam VH, Lewis RE. Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity. J Infect Dis 2004;190:1464-1471.
25. Labandeira-Rey M, Couzon F, Boisset S, Brown EL, Bes M, Benito Y, Barbu EM, Vazquez V, Hook M, Etienne J, et al. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 2007;315:1130-1133.
26. Tuvim MJ, Evans SE, Clement CG, Dickey BF, Gilbert BE. Augmented lung inflammation protects against influenza A pneumonia. PLoS One 2009;4:e4176.
27. Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006;442:651-656.
28. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007;449:819-826.
29. Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Kohler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994;368:339-342.
30. Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J. MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol 2007;178:1164-1171.
31. Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007;7:179-190.
32. Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007;447:972-978.
33. Raberg L, Sim D, Read AF. Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science 2007;318:812-814.
34. +-thalassemia and the sickle cell trait. Nat Genet 2005;37:1253-1257.
35. Cluff CW, Baldridge JR, Stover AG, Evans JT, Johnson DA, Lacy MJ, Clawson VG, Yorgensen VM, Johnson CL, Livesay MT, et al. Synthetic Toll-like receptor 4 agonists stimulate innate resistance to infectious challenge. Infect Immun 2005;73:3044-3052.
36. Deng JC, Moore TA, Newstead MW, Zeng X, Krieg AM, Standiford TJ. CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection. J Immunol 2004;173:5148-5155.
37. Lee JS, Frevert CW, Matute-Bello G, Wurfel MM, Wong VA, Lin SM, Ruzinski J, Mongovin S, Goodman RB, Martin TR. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 2005;289:L731-L738.
38. Agusti C, Rano A, Sibila O, Torres A. Nosocomial pneumonia in immunosuppressed patients. Infect Dis Clin North Am 2003;17:785-800.
39. Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf R, Loeffler J, Aepinus C, Bock T, Jahn G, Hebart H. Infectious pulmonary complications after stem cell transplantation or chemotherapy: diagnostic yield of bronchoalveolar lavage. Diagn Microbiol Infect Dis 2005;52:275-280.
40. Schmitt B, Dobrez D, Parada JP, Kyriacou DN, Golub RM, Sharma R, Bennett C. Responding to a small-scale bioterrorist anthrax attack: cost-effectiveness analysis comparing preattack vaccination with postattack antibiotic treatment and vaccination. Arch Intern Med 2007;167:655-662.
41. Bouzianas DG. Potential biological targets of Bacillus anthracis in antiinfective approaches against the threat of bioterrorism. Expert Rev Anti Infect Ther 2007;5:665-684.
42. Hassani M, Patel MC, Pirofski LA. Vaccines for the prevention of diseases caused by potential bioweapons. Clin Immunol 2004;111:1-15.
43. Thorn CF, Whitehead AS. Differential transcription of the mouse acute phase serum amyloid A genes in response to pro-inflammatory cytokines. Amyloid 2002;9:229-236.
44. Christenson K, Bjorkman L, Tangemo C, Bylund J. Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1. J Leukoc Biol 2008;83:139-148.
45. Sandri S, Rodriguez D, Gomes E, Monteiro HP, Russo M, Campa A. Is serum amyloid A an endogenous TLR4 agonist? J Leukoc Biol 2008;83:1174-1180.
46. Vallon R, Freuler F, Desta-Tsedu N, Robeva A, Dawson J, Wenner P, Engelhardt P, Boes L, Schnyder J, Tschopp C, et al. Serum amyloid A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases. J Immunol 2001;166:2801-2807.
47. Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, et al. IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia. Nat Med 2008;14:275-281.
48. Berger T, Togawa A, Duncan GS, Elia AJ, You-Ten A, Wakeham A, Fong HE, Cheung CC, Mak TW. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci USA 2006;103:1834-1839.
49. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004;432:917-921.
50. Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity 2004;21:241-254.
51. Iwasaki A. Mucosal dendritic cells. Annu Rev Immunol 2007;25:381-418.