-
1
-
-
67449150167
-
A Wnt survival guide: From flies to human disease
-
A.J. Chien, W.H. Conrad, R.T. Moon A Wnt survival guide: from flies to human disease J Invest Dermatol 129 2009 1614 1627
-
(2009)
J Invest Dermatol
, vol.129
, pp. 1614-1627
-
-
Chien, A.J.1
Conrad, W.H.2
Moon, R.T.3
-
2
-
-
34249814024
-
WNTS and WNT receptors as therapeutic tools and targets in human disease processes
-
A.J. Chien, R.T. Moon WNTS and WNT receptors as therapeutic tools and targets in human disease processes Front Biosci 12 2007 448 457
-
(2007)
Front Biosci
, vol.12
, pp. 448-457
-
-
Chien, A.J.1
Moon, R.T.2
-
3
-
-
4344584730
-
WNT and beta-catenin signalling: Diseases and therapies
-
R.T. Moon, A.D. Kohn, G.V. De Ferrari WNT and beta-catenin signalling: diseases and therapies Nat Rev Genet 5 2004 691 701
-
(2004)
Nat Rev Genet
, vol.5
, pp. 691-701
-
-
Moon, R.T.1
Kohn, A.D.2
De Ferrari, G.V.3
-
4
-
-
67650230896
-
Wnt/beta-catenin signaling: Components, mechanisms, and diseases
-
B.T. MacDonald, K. Tamai, X. He Wnt/beta-catenin signaling: components, mechanisms, and diseases Dev Cell 17 2009 9 26
-
(2009)
Dev Cell
, vol.17
, pp. 9-26
-
-
MacDonald, B.T.1
Tamai, K.2
He, X.3
-
5
-
-
67649470380
-
Proximal events in Wnt signal transduction
-
S. Angers, R.T. Moon Proximal events in Wnt signal transduction Nat Rev Mol Cell Biol 10 2009 468 477
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 468-477
-
-
Angers, S.1
Moon, R.T.2
-
6
-
-
18244377210
-
Wnt/beta-catenin pathway
-
R.T. Moon Wnt/beta-catenin pathway Sci STKE 2005 2005 cm1
-
(2005)
Sci STKE
, vol.2005
, pp. 1
-
-
Moon, R.T.1
-
7
-
-
33845351956
-
Beta-catenin destruction complex: Insights and questions from a structural perspective
-
D. Kimelman, W. Xu Beta-catenin destruction complex: insights and questions from a structural perspective Oncogene 25 2006 7482 7491
-
(2006)
Oncogene
, vol.25
, pp. 7482-7491
-
-
Kimelman, D.1
Xu, W.2
-
8
-
-
0023653232
-
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
-
F. Rijsewijk, M. Schuermann, E. Wagenaar The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless Cell 50 1987 649 657
-
(1987)
Cell
, vol.50
, pp. 649-657
-
-
Rijsewijk, F.1
Schuermann, M.2
Wagenaar, E.3
-
9
-
-
0029683606
-
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
-
C. Yost, M. Torres, J.R. Miller The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3 Genes Dev 10 1996 1443 1454
-
(1996)
Genes Dev
, vol.10
, pp. 1443-1454
-
-
Yost, C.1
Torres, M.2
Miller, J.R.3
-
10
-
-
67650594771
-
The opposing roles of Wnt-5a in cancer
-
S.L. McDonald, A. Silver The opposing roles of Wnt-5a in cancer Br J Cancer 101 2009 209 214
-
(2009)
Br J Cancer
, vol.101
, pp. 209-214
-
-
McDonald, S.L.1
Silver, A.2
-
11
-
-
77953539908
-
Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells
-
M. Nishita, M. Enomoto, K. Yamagata Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells Trends Cell Biol 20 2010 346 354
-
(2010)
Trends Cell Biol
, vol.20
, pp. 346-354
-
-
Nishita, M.1
Enomoto, M.2
Yamagata, K.3
-
12
-
-
34249061491
-
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
-
M.B. Major, N.D. Camp, J.D. Berndt Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling Science 316 2007 1043 1046
-
(2007)
Science
, vol.316
, pp. 1043-1046
-
-
Major, M.B.1
Camp, N.D.2
Berndt, J.D.3
-
13
-
-
58249087390
-
New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening
-
M.B. Major, B.S. Roberts, J.D. Berndt New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening Sci Signal 1 2008 ra12
-
(2008)
Sci Signal
, vol.1
, pp. 12
-
-
Major, M.B.1
Roberts, B.S.2
Berndt, J.D.3
-
15
-
-
58449088387
-
Gastrointestinal stem cells in development and cancer
-
S. Brabletz, O. Schmalhofer, T. Brabletz Gastrointestinal stem cells in development and cancer J Pathol 217 2009 307 317
-
(2009)
J Pathol
, vol.217
, pp. 307-317
-
-
Brabletz, S.1
Schmalhofer, O.2
Brabletz, T.3
-
16
-
-
17444423289
-
Wnt signaling in the intestinal epithelium: From endoderm to cancer
-
A. Gregorieff, H. Clevers Wnt signaling in the intestinal epithelium: from endoderm to cancer Genes Dev 19 2005 877 890
-
(2005)
Genes Dev
, vol.19
, pp. 877-890
-
-
Gregorieff, A.1
Clevers, H.2
-
17
-
-
15544381570
-
Self-renewal and cancer of the gut: Two sides of a coin
-
F. Radtke, H. Clevers Self-renewal and cancer of the gut: two sides of a coin Science 307 2005 1904 1909
-
(2005)
Science
, vol.307
, pp. 1904-1909
-
-
Radtke, F.1
Clevers, H.2
-
19
-
-
33847740988
-
Wnt/beta-catenin signaling in cancer stemness and malignant behavior
-
R. Fodde, T. Brabletz Wnt/beta-catenin signaling in cancer stemness and malignant behavior Curr Opin Cell Biol 19 2007 150 158
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 150-158
-
-
Fodde, R.1
Brabletz, T.2
-
20
-
-
33947733010
-
Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer
-
A. Mrtensson, A. Oberg, A. Jung Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer Oncol Rep 17 2007 447 452
-
(2007)
Oncol Rep
, vol.17
, pp. 447-452
-
-
Mrtensson, A.1
Oberg, A.2
Jung, A.3
-
21
-
-
59849089693
-
Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers
-
W. Wanitsuwan Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers World J Gastroenterol 14 2008 6052
-
(2008)
World J Gastroenterol
, vol.14
, pp. 6052
-
-
Wanitsuwan, W.1
-
22
-
-
54349109609
-
Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma
-
A. Elzagheid, A. Buhmeida, E. Korkeila Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma World J Gastroenterol 14 2008 3866 3871
-
(2008)
World J Gastroenterol
, vol.14
, pp. 3866-3871
-
-
Elzagheid, A.1
Buhmeida, A.2
Korkeila, E.3
-
23
-
-
0032521433
-
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
-
A.B. Sparks, P.J. Morin, B. Vogelstein Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer Cancer Res 58 1998 1130 1134
-
(1998)
Cancer Res
, vol.58
, pp. 1130-1134
-
-
Sparks, A.B.1
Morin, P.J.2
Vogelstein, B.3
-
24
-
-
0033119582
-
Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
-
W.S. Samowitz, M.D. Powers, L.N. Spirio Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas Cancer Res 59 1999 1442 1444
-
(1999)
Cancer Res
, vol.59
, pp. 1442-1444
-
-
Samowitz, W.S.1
Powers, M.D.2
Spirio, L.N.3
-
25
-
-
19944432960
-
Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome
-
V. Johnson, E. Volikos, S.E. Halford Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome Gut 54 2005 264 267
-
(2005)
Gut
, vol.54
, pp. 264-267
-
-
Johnson, V.1
Volikos, E.2
Halford, S.E.3
-
26
-
-
80054775320
-
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling
-
A. Scholer-Dahirel, M.R. Schlabach, A. Loo Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling Proc Natl Acad Sci U S A 108 2011 17135 17140
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17135-17140
-
-
Scholer-Dahirel, A.1
Schlabach, M.R.2
Loo, A.3
-
27
-
-
77956904030
-
Colorectal tumors are effectively eradicated by combined inhibition of β-catenin, KRAS, and the oncogenic transcription factor ITF2
-
L. Mologni, H. Dekhil, M. Ceccon Colorectal tumors are effectively eradicated by combined inhibition of β-catenin, KRAS, and the oncogenic transcription factor ITF2 Cancer Res 70 2010 7253 7263
-
(2010)
Cancer Res
, vol.70
, pp. 7253-7263
-
-
Mologni, L.1
Dekhil, H.2
Ceccon, M.3
-
28
-
-
27144552677
-
Non-traditional roles for the adenomatous polyposis coli (APC) tumor suppressor protein
-
C.A. Hanson, J.R. Miller Non-traditional roles for the adenomatous polyposis coli (APC) tumor suppressor protein Gene 361 2005 1 12
-
(2005)
Gene
, vol.361
, pp. 1-12
-
-
Hanson, C.A.1
Miller, J.R.2
-
29
-
-
0035070046
-
Mutations in the APC tumour suppressor gene cause chromosomal instability
-
R. Fodde, J. Kuipers, C. Rosenberg Mutations in the APC tumour suppressor gene cause chromosomal instability Nat Cell Biol 3 2001 433 438
-
(2001)
Nat Cell Biol
, vol.3
, pp. 433-438
-
-
Fodde, R.1
Kuipers, J.2
Rosenberg, C.3
-
30
-
-
0035067391
-
A role for the Adenomatous Polyposis Coli protein in chromosome segregation
-
K.B. Kaplan, A.A. Burds, J.R. Swedlow A role for the Adenomatous Polyposis Coli protein in chromosome segregation Nat Cell Biol 3 2001 429 432
-
(2001)
Nat Cell Biol
, vol.3
, pp. 429-432
-
-
Kaplan, K.B.1
Burds, A.A.2
Swedlow, J.R.3
-
31
-
-
0037096906
-
The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
-
C. Albuquerque, C. Breukel, R. van der Luijt The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade Hum Mol Genet 11 2002 1549 1560
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1549-1560
-
-
Albuquerque, C.1
Breukel, C.2
Van Der Luijt, R.3
-
32
-
-
5444233462
-
APC dosage effects in tumorigenesis and stem cell differentiation
-
C. Gaspar, R. Fodde APC dosage effects in tumorigenesis and stem cell differentiation Int J Dev Biol 48 2004 377 386
-
(2004)
Int J Dev Biol
, vol.48
, pp. 377-386
-
-
Gaspar, C.1
Fodde, R.2
-
33
-
-
68249083454
-
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
-
C. Gaspar, P. Franken, L. Molenaar A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis PLoS Genet 5 2009 e1000547
-
(2009)
PLoS Genet
, vol.5
, pp. 1000547
-
-
Gaspar, C.1
Franken, P.2
Molenaar, L.3
-
34
-
-
76749147440
-
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
-
M. Buchert, D. Athineos, H.E. Abud Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo PLoS Genet 6 2010 e1000816
-
(2010)
PLoS Genet
, vol.6
, pp. 1000816
-
-
Buchert, M.1
Athineos, D.2
Abud, H.E.3
-
36
-
-
33749320834
-
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
-
K.P. Janssen, P. Alberici, H. Fsihi APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression Gastroenterology 131 2006 1096 1109
-
(2006)
Gastroenterology
, vol.131
, pp. 1096-1109
-
-
Janssen, K.P.1
Alberici, P.2
Fsihi, H.3
-
37
-
-
27944442806
-
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: Inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms
-
T. Tanaka, H. Kohno, R. Suzuki Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms Int J Cancer 118 2006 25 34
-
(2006)
Int J Cancer
, vol.118
, pp. 25-34
-
-
Tanaka, T.1
Kohno, H.2
Suzuki, R.3
-
38
-
-
77951975325
-
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
-
L. Vermeulen, F. De Sousa E Melo, M. van der Heijden Wnt activity defines colon cancer stem cells and is regulated by the microenvironment Nat Cell Biol 12 2010 468 476
-
(2010)
Nat Cell Biol
, vol.12
, pp. 468-476
-
-
Vermeulen, L.1
De Sousa Melo E, F.2
Van Der Heijden, M.3
-
39
-
-
0031727409
-
Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
-
T. Brabletz, A. Jung, K. Hermann Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front Pathol Res Pract 194 1998 701 704
-
(1998)
Pathol Res Pract
, vol.194
, pp. 701-704
-
-
Brabletz, T.1
Jung, A.2
Hermann, K.3
-
40
-
-
80051926611
-
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
-
W. de Lau, N. Barker, T.Y. Low Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling Nature 476 2011 293 297
-
(2011)
Nature
, vol.476
, pp. 293-297
-
-
De Lau, W.1
Barker, N.2
Low, T.Y.3
-
41
-
-
79960990066
-
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
-
K.S. Carmon, X. Gong, Q. Lin R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling Proc Natl Acad Sci U S A 108 2011 11452 11457
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 11452-11457
-
-
Carmon, K.S.1
Gong, X.2
Lin, Q.3
-
42
-
-
80053560465
-
LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling
-
A. Glinka, C. Dolde, N. Kirsch LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling EMBO Rep 12 2011 1055 1061
-
(2011)
EMBO Rep
, vol.12
, pp. 1055-1061
-
-
Glinka, A.1
Dolde, C.2
Kirsch, N.3
-
43
-
-
5044244757
-
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
-
O. Kazanskaya, A. Glinka, I. del Barco Barrantes R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis Dev Cell 7 2004 525 534
-
(2004)
Dev Cell
, vol.7
, pp. 525-534
-
-
Kazanskaya, O.1
Glinka, A.2
Del Barco Barrantes, I.3
-
44
-
-
23844455584
-
Mitogenic influence of human R-spondin1 on the intestinal epithelium
-
K.A. Kim, M. Kakitani, J. Zhao Mitogenic influence of human R-spondin1 on the intestinal epithelium Science 309 2005 1256 1259
-
(2005)
Science
, vol.309
, pp. 1256-1259
-
-
Kim, K.A.1
Kakitani, M.2
Zhao, J.3
-
45
-
-
79955681163
-
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
-
A. Merlos-Suarez, F.M. Barriga, P. Jung The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse Cell Stem Cell 8 2011 511 524
-
(2011)
Cell Stem Cell
, vol.8
, pp. 511-524
-
-
Merlos-Suarez, A.1
Barriga, F.M.2
Jung, P.3
-
46
-
-
79955800644
-
Significance of Lgr5(+ve) cancer stem cells in the colon and rectum
-
H. Takahashi, H. Ishii, N. Nishida Significance of Lgr5(+ve) cancer stem cells in the colon and rectum Ann Surg Oncol 18 2011 1166 1174
-
(2011)
Ann Surg Oncol
, vol.18
, pp. 1166-1174
-
-
Takahashi, H.1
Ishii, H.2
Nishida, N.3
-
47
-
-
0037369658
-
Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations
-
Y. Yamamoto, M. Sakamoto, G. Fujii Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations Hepatology 37 2003 528 533
-
(2003)
Hepatology
, vol.37
, pp. 528-533
-
-
Yamamoto, Y.1
Sakamoto, M.2
Fujii, G.3
-
48
-
-
80053568372
-
Notch post-translationally regulates β-catenin protein in stem and progenitor cells
-
C. Kwon, P. Cheng, I.N. King Notch post-translationally regulates β-catenin protein in stem and progenitor cells Nat Cell Biol 13 2011 1 9
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1-9
-
-
Kwon, C.1
Cheng, P.2
King, I.N.3
-
49
-
-
67650951418
-
Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling
-
S. Arimura, A. Matsunaga, T. Kitamura Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling Gastroenterology 137 2009 629 638
-
(2009)
Gastroenterology
, vol.137
, pp. 629-638
-
-
Arimura, S.1
Matsunaga, A.2
Kitamura, T.3
-
50
-
-
10744233571
-
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
-
G.R. van den Brink, Sa Bleuming, J.C.H. Hardwick Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation Nat Genet 36 2004 277 282
-
(2004)
Nat Genet
, vol.36
, pp. 277-282
-
-
Van Den Brink, G.R.1
Bleuming, S.2
Hardwick, J.C.H.3
-
51
-
-
77952528214
-
Cancer gene discovery in hepatocellular carcinoma
-
L. Zender, A. Villanueva, V. Tovar Cancer gene discovery in hepatocellular carcinoma J Hepatol 52 2010 921 929
-
(2010)
J Hepatol
, vol.52
, pp. 921-929
-
-
Zender, L.1
Villanueva, A.2
Tovar, V.3
-
52
-
-
0032525836
-
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
-
Y. Miyoshi, K. Iwao, Y. Nagasawa Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3 Cancer Res 58 1998 2524 2527
-
(1998)
Cancer Res
, vol.58
, pp. 2524-2527
-
-
Miyoshi, Y.1
Iwao, K.2
Nagasawa, Y.3
-
53
-
-
0345006147
-
Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
-
A. de La Coste, B. Romagnolo, P. Billuart Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas Proc Natl Acad Sci U S A 95 1998 8847 8851
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8847-8851
-
-
De La Coste, A.1
Romagnolo, B.2
Billuart, P.3
-
54
-
-
0037367866
-
Wnt signaling in hepatocellular carcinoma: Analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes
-
J. Cui, X. Zhou, Y. Liu Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes J Gastroenterol Hepatol 18 2003 280 287
-
(2003)
J Gastroenterol Hepatol
, vol.18
, pp. 280-287
-
-
Cui, J.1
Zhou, X.2
Liu, Y.3
-
55
-
-
0033054464
-
The oncogenic activation of beta-catenin
-
P. Polakis The oncogenic activation of beta-catenin Curr Opin Genet Dev 9 1999 15 21
-
(1999)
Curr Opin Genet Dev
, vol.9
, pp. 15-21
-
-
Polakis, P.1
-
56
-
-
0037130449
-
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
-
K. Taniguchi, L.R. Roberts, I.N. Aderca Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas Oncogene 21 2002 4863 4871
-
(2002)
Oncogene
, vol.21
, pp. 4863-4871
-
-
Taniguchi, K.1
Roberts, L.R.2
Aderca, I.N.3
-
57
-
-
37249092516
-
Genetic alterations of Wnt signaling pathway-associated genes in hepatocellular carcinoma
-
Y.-D. Kim, C.-H. Park, H.-S. Kim Genetic alterations of Wnt signaling pathway-associated genes in hepatocellular carcinoma J Gastroenterol Hepatol 23 2008 110 118
-
(2008)
J Gastroenterol Hepatol
, vol.23
, pp. 110-118
-
-
Kim, Y.-D.1
Park, C.-H.2
Kim, H.-S.3
-
58
-
-
0034088858
-
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
-
S. Satoh, Y. Daigo, Y. Furukawa AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 Nat Genet 24 2000 245 250
-
(2000)
Nat Genet
, vol.24
, pp. 245-250
-
-
Satoh, S.1
Daigo, Y.2
Furukawa, Y.3
-
59
-
-
33846846541
-
Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas
-
J. Zucman-Rossi, S. Benhamouche, C. Godard Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas Oncogene 26 2007 774 780
-
(2007)
Oncogene
, vol.26
, pp. 774-780
-
-
Zucman-Rossi, J.1
Benhamouche, S.2
Godard, C.3
-
60
-
-
70349739285
-
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
-
Y. Hoshida, S.M.B. Nijman, M. Kobayashi Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma Cancer Res 69 2009 7385 7392
-
(2009)
Cancer Res
, vol.69
, pp. 7385-7392
-
-
Hoshida, Y.1
Nijman, S.M.B.2
Kobayashi, M.3
-
61
-
-
0036699940
-
Molecular pathogenesis of human hepatocellular carcinoma
-
S.S. Thorgeirsson, J.W. Grisham Molecular pathogenesis of human hepatocellular carcinoma Nat Genet 31 2002 339 346
-
(2002)
Nat Genet
, vol.31
, pp. 339-346
-
-
Thorgeirsson, S.S.1
Grisham, J.W.2
-
62
-
-
17844372967
-
Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression
-
T. Fukutomi, Y. Zhou, S. Kawai Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression Hepatology 41 2005 1096 1105
-
(2005)
Hepatology
, vol.41
, pp. 1096-1105
-
-
Fukutomi, T.1
Zhou, Y.2
Kawai, S.3
-
63
-
-
77954168986
-
Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma
-
Y.-B. Deng, G. Nagae, Y. Midorikawa Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma Cancer Sci 101 2010 1501 1510
-
(2010)
Cancer Sci
, vol.101
, pp. 1501-1510
-
-
Deng, Y.-B.1
Nagae, G.2
Midorikawa, Y.3
-
64
-
-
78649636204
-
Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling
-
A. Hsieh, H.-S. Kim, S.-O. Lim Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling Cancer Lett 300 2011 162 172
-
(2011)
Cancer Lett
, vol.300
, pp. 162-172
-
-
Hsieh, A.1
Kim, H.-S.2
Lim, S.-O.3
-
65
-
-
0034995765
-
Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
-
P.L. Puig, P. Legoix, O. Bluteau Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis Gastroenterology 120 2001 1763 1773
-
(2001)
Gastroenterology
, vol.120
, pp. 1763-1773
-
-
Puig, P.L.1
Legoix, P.2
Bluteau, O.3
-
66
-
-
79952043062
-
Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad
-
K.N. Nejak-Bowen, S.P.S. Monga Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad Semin Cancer Biol 21 2011 44 58
-
(2011)
Semin Cancer Biol
, vol.21
, pp. 44-58
-
-
Nejak-Bowen, K.N.1
Monga, S.P.S.2
-
67
-
-
0035266134
-
Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: Relationship to phenotype and tumor grade
-
D.F. Calvisi, V.M. Factor, R. Loi Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade Cancer Res 61 2001 2085 2091
-
(2001)
Cancer Res
, vol.61
, pp. 2085-2091
-
-
Calvisi, D.F.1
Factor, V.M.2
Loi, R.3
-
68
-
-
2142812377
-
Disruption of β-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice
-
D.F. Calvisi, V.M. Factor, S. Ladu Disruption of β-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice Gastroenterology 126 2004 1374 1386
-
(2004)
Gastroenterology
, vol.126
, pp. 1374-1386
-
-
Calvisi, D.F.1
Factor, V.M.2
Ladu, S.3
-
69
-
-
18844402131
-
Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer
-
D.F. Calvisi, Ea Conner, S. Ladu Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer J Hepatol 42 2005 842 849
-
(2005)
J Hepatol
, vol.42
, pp. 842-849
-
-
Calvisi, D.F.1
Conner, E.2
Ladu, S.3
-
70
-
-
0035870293
-
Hepatomegaly in transgenic mice expressing an oncogenic form of β-catenin
-
A. Cadoret, C. Ovejero, S. Saadi-Kheddouci Hepatomegaly in transgenic mice expressing an oncogenic form of β-catenin Cancer 61 2001 3245 3249
-
(2001)
Cancer
, vol.61
, pp. 3245-3249
-
-
Cadoret, A.1
Ovejero, C.2
Saadi-Kheddouci, S.3
-
71
-
-
0036531817
-
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of β-catenin
-
N. Harada, H. Miyoshi, N. Murai Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of β-catenin Cancer 62 2002 1971 1977
-
(2002)
Cancer
, vol.62
, pp. 1971-1977
-
-
Harada, N.1
Miyoshi, H.2
Murai, N.3
-
72
-
-
22344435816
-
Epidermal growth factor receptor: A novel target of the wnt/β-catenin pathway in liver
-
X. Tan, U. Apte, A. Micsenyi Epidermal growth factor receptor: a novel target of the wnt/β-catenin pathway in liver Gastroenterology 129 2005 285 302
-
(2005)
Gastroenterology
, vol.129
, pp. 285-302
-
-
Tan, X.1
Apte, U.2
Micsenyi, A.3
-
73
-
-
10344254872
-
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
-
S. Colnot, T. Decaens, M. Niwa-Kawakita Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas Proc Natl Acad Sci U S A 101 2004 17216 17221
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17216-17221
-
-
Colnot, S.1
Decaens, T.2
Niwa-Kawakita, M.3
-
74
-
-
0037340399
-
The multiple functions of tumour suppressors: It's all in APC
-
R. Fodde The multiple functions of tumour suppressors: it's all in APC Nat Cell Biol 5 2003 190 192
-
(2003)
Nat Cell Biol
, vol.5
, pp. 190-192
-
-
Fodde, R.1
-
75
-
-
1642535593
-
Hepatocarcinogenesis in mice with β-catenin and Ha-ras gene mutations
-
N. Harada Hepatocarcinogenesis in mice with β-catenin and Ha-ras gene mutations Cancer Res 64 2004 48 54
-
(2004)
Cancer Res
, vol.64
, pp. 48-54
-
-
Harada, N.1
-
76
-
-
71049143563
-
Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice
-
H. Miyoshi, A. Deguchi, M. Nakau Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice Cancer Sci 100 2009 2046 2053
-
(2009)
Cancer Sci
, vol.100
, pp. 2046-2053
-
-
Miyoshi, H.1
Deguchi, A.2
Nakau, M.3
-
77
-
-
77951487860
-
Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin
-
K.N. Nejak-Bowen, M.D. Thompson, S. Singh Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin Hepatology 51 2010 1603 1613
-
(2010)
Hepatology
, vol.51
, pp. 1603-1613
-
-
Nejak-Bowen, K.N.1
Thompson, M.D.2
Singh, S.3
-
78
-
-
33846463379
-
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
-
S. Boyault, D.S. Rickman, A. de Reynis Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets Hepatology 45 2007 42 52
-
(2007)
Hepatology
, vol.45
, pp. 42-52
-
-
Boyault, S.1
Rickman, D.S.2
De Reynis, A.3
-
79
-
-
53049086329
-
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
-
D.Y. Chiang, A. Villanueva, Y. Hoshida Focal gains of VEGFA and molecular classification of hepatocellular carcinoma Cancer Res 68 2008 6779 6788
-
(2008)
Cancer Res
, vol.68
, pp. 6779-6788
-
-
Chiang, D.Y.1
Villanueva, A.2
Hoshida, Y.3
-
80
-
-
5144226941
-
Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma
-
P. Merle, S. de la Monte, M. Kim Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma Gastroenterology 127 2004 1110 1122
-
(2004)
Gastroenterology
, vol.127
, pp. 1110-1122
-
-
Merle, P.1
De La Monte, S.2
Kim, M.3
-
81
-
-
77249169899
-
Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration
-
T. Toyama, H.C. Lee, H. Koga Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration Mol Cancer Res 8 2010 254 265
-
(2010)
Mol Cancer Res
, vol.8
, pp. 254-265
-
-
Toyama, T.1
Lee, H.C.2
Koga, H.3
-
82
-
-
33847177201
-
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
-
C.L. Stoick-Cooper, G. Weidinger, K.J. Riehle Distinct Wnt signaling pathways have opposing roles in appendage regeneration Development 134 2007 479 489
-
(2007)
Development
, vol.134
, pp. 479-489
-
-
Stoick-Cooper, C.L.1
Weidinger, G.2
Riehle, K.J.3
-
83
-
-
73949099275
-
Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence
-
G. Zulehner, M. Mikula, D. Schneller Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence Am J Pathol 176 2010 472 481
-
(2010)
Am J Pathol
, vol.176
, pp. 472-481
-
-
Zulehner, G.1
Mikula, M.2
Schneller, D.3
-
84
-
-
34249028607
-
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression
-
A.N. Fischer, E. Fuchs, M. Mikula PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression Oncogene 26 2007 3395 3405
-
(2007)
Oncogene
, vol.26
, pp. 3395-3405
-
-
Fischer, A.N.1
Fuchs, E.2
Mikula, M.3
-
85
-
-
33645007189
-
Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells
-
H. Jian, X. Shen, I. Liu Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells Genes Dev 20 2006 666 674
-
(2006)
Genes Dev
, vol.20
, pp. 666-674
-
-
Jian, H.1
Shen, X.2
Liu, I.3
-
86
-
-
80255131066
-
Interferon-α2b and transforming growth factor-β1 treatments on HCC cell lines: Are Wnt/β-catenin pathway and Smads signaling connected in hepatocellular carcinoma?
-
M.P. Ceballos, J.P. Parody, M.D.L. Alvarez Interferon-α2b and transforming growth factor-β1 treatments on HCC cell lines: are Wnt/β-catenin pathway and Smads signaling connected in hepatocellular carcinoma? Biochem Pharmacol 82 2011 1682 1691
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 1682-1691
-
-
Ceballos, M.P.1
Parody, J.P.2
Alvarez, M.D.L.3
-
87
-
-
78649420006
-
MET signalling: Principles and functions in development, organ regeneration and cancer
-
L. Trusolino, A. Bertotti, P.M. Comoglio MET signalling: principles and functions in development, organ regeneration and cancer Nat Rev Mol Cell Biol 11 2010 834 848
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 834-848
-
-
Trusolino, L.1
Bertotti, A.2
Comoglio, P.M.3
-
88
-
-
0036531819
-
Hepatocyte growth factor induces Wnt-independent nuclear translocation of β-catenin after Met-β-catenin dissociation in hepatocytes
-
S.P. Monga, W.M. Mars, P. Pediaditakis Hepatocyte growth factor induces Wnt-independent nuclear translocation of β-catenin after Met-β-catenin dissociation in hepatocytes Cancer Res 62 2002 2064 2071
-
(2002)
Cancer Res
, vol.62
, pp. 2064-2071
-
-
Monga, S.P.1
Mars, W.M.2
Pediaditakis, P.3
-
89
-
-
0030951358
-
Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma
-
T. Ueki, J. Fujimoto, T. Suzuki Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma Hepatology 25 1997 862 866
-
(1997)
Hepatology
, vol.25
, pp. 862-866
-
-
Ueki, T.1
Fujimoto, J.2
Suzuki, T.3
-
90
-
-
33745220780
-
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
-
P. Kaposi-Novak, J.S. Lee, L. Gmez-Quiroz Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype J Clin Invest 116 2006 1582 1595
-
(2006)
J Clin Invest
, vol.116
, pp. 1582-1595
-
-
Kaposi-Novak, P.1
Lee, J.S.2
Gmez-Quiroz, L.3
-
91
-
-
0035395236
-
Beta-catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance
-
C.M. Wong, S.T. Fan, I.O. Ng Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance Cancer 92 2001 136 145
-
(2001)
Cancer
, vol.92
, pp. 136-145
-
-
Wong, C.M.1
Fan, S.T.2
Ng, I.O.3
-
92
-
-
0036190930
-
Expression and prognostic roles of β-catenin in hepatocellular carcinoma: Correlation with tumor progression and postoperative survival
-
S. Inagawa, M. Itabashi, S. Adachi Expression and prognostic roles of β-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival Clin Cancer Res 8 2002 450 456
-
(2002)
Clin Cancer Res
, vol.8
, pp. 450-456
-
-
Inagawa, S.1
Itabashi, M.2
Adachi, S.3
-
93
-
-
18744416578
-
Expression of β-catenin in hepatocellular carcinoma
-
L.T. Tien, M. Ito, M. Nakao Expression of β-catenin in hepatocellular carcinoma J Gastroenterol 11 2005 2398 2401
-
(2005)
J Gastroenterol
, vol.11
, pp. 2398-2401
-
-
Tien, L.T.1
Ito, M.2
Nakao, M.3
-
94
-
-
0032885751
-
Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
-
J.T. Nhieu, C.A. Renard, Y. Wei Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation Am J Pathol 155 1999 703 710
-
(1999)
Am J Pathol
, vol.155
, pp. 703-710
-
-
Nhieu, J.T.1
Renard, C.A.2
Wei, Y.3
-
95
-
-
0034746832
-
Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis
-
T.L. Mao, J.S. Chu, Y.M. Jeng Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis J Pathol 193 2001 95 101
-
(2001)
J Pathol
, vol.193
, pp. 95-101
-
-
Mao, T.L.1
Chu, J.S.2
Jeng, Y.M.3
-
96
-
-
0034495080
-
Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
-
H.C. Hsu, Y.M. Jeng, T.L. Mao Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis Am J Pathol 157 2000 763 770
-
(2000)
Am J Pathol
, vol.157
, pp. 763-770
-
-
Hsu, H.C.1
Jeng, Y.M.2
Mao, T.L.3
-
97
-
-
79958189588
-
Beta-catenin plays a key role in metastasis of human hepatocellular carcinoma
-
T.Y. Lai, C.C. Su, W.W. Kuo Beta-catenin plays a key role in metastasis of human hepatocellular carcinoma Oncol Rep 26 2011 415 422
-
(2011)
Oncol Rep
, vol.26
, pp. 415-422
-
-
Lai, T.Y.1
Su, C.C.2
Kuo, W.W.3
-
98
-
-
80052864015
-
Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes
-
H. Wege, D. Heim, M. Ltgehetmann Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes Mol Cancer Res 9 2011 1222 1231
-
(2011)
Mol Cancer Res
, vol.9
, pp. 1222-1231
-
-
Wege, H.1
Heim, D.2
Ltgehetmann, M.3
-
99
-
-
70449366626
-
Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells
-
W. Wei, M.-S. Chua, S. Grepper Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells Mol Cancer 8 2009 76
-
(2009)
Mol Cancer
, vol.8
, pp. 76
-
-
Wei, W.1
Chua, M.-S.2
Grepper, S.3
-
100
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
S. Jones, X. Zhang, D.W. Parsons Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 2008 1801 1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
102
-
-
33646425568
-
Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma
-
G. Zeng, M. Germinaro, A. Micsenyi Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma Neoplasia 8 2006 279 289
-
(2006)
Neoplasia
, vol.8
, pp. 279-289
-
-
Zeng, G.1
Germinaro, M.2
Micsenyi, A.3
-
103
-
-
0032700298
-
Analysis of beta-catenin gene mutations in pancreatic tumors
-
B. Gerdes, A. Ramaswamy, B. Simon Analysis of beta-catenin gene mutations in pancreatic tumors Digestion 60 1999 544 548
-
(1999)
Digestion
, vol.60
, pp. 544-548
-
-
Gerdes, B.1
Ramaswamy, A.2
Simon, B.3
-
106
-
-
77957150824
-
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
-
I.V. Morris JP, S.C. Wang, M. Hebrok KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma Nat Rev Cancer 10 2010 683 695
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 683-695
-
-
Morris Jp, I.V.1
Wang, S.C.2
Hebrok, M.3
-
107
-
-
33745084564
-
Stabilization of beta-catenin impacts pancreas growth
-
P.W. Heiser, J. Lau, M.M. Taketo Stabilization of beta-catenin impacts pancreas growth Development 133 2006 2023 2032
-
(2006)
Development
, vol.133
, pp. 2023-2032
-
-
Heiser, P.W.1
Lau, J.2
Taketo, M.M.3
-
108
-
-
34548167006
-
Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
-
A. Strom, C. Bonal, R. Ashery-Padan Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas Development 134 2007 2719 2725
-
(2007)
Development
, vol.134
, pp. 2719-2725
-
-
Strom, A.1
Bonal, C.2
Ashery-Padan, R.3
-
109
-
-
53049110158
-
Stabilization of beta-catenin induces pancreas tumor formation
-
P.W. Heiser, D.A. Cano, L. Landsman Stabilization of beta-catenin induces pancreas tumor formation Gastroenterology 135 2008 1288 1300
-
(2008)
Gastroenterology
, vol.135
, pp. 1288-1300
-
-
Heiser, P.W.1
Cano, D.A.2
Landsman, L.3
-
110
-
-
76649105065
-
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
-
J.P. Morris IV, D.A. Cano, S. Sekine Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice J Clin Invest 120 2010 508 520
-
(2010)
J Clin Invest
, vol.120
, pp. 508-520
-
-
Morris, I.V.J.P.1
Cano, D.A.2
Sekine, S.3
-
111
-
-
79960309513
-
Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma
-
A. Vincent, N. Omura, S.M. Hong Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma Clin Cancer Res 17 2011 4341 4354
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4341-4354
-
-
Vincent, A.1
Omura, N.2
Hong, S.M.3
-
112
-
-
78649272579
-
Molecular biology of pancreatic ductal adenocarcinoma progression: Aberrant activation of developmental pathways
-
A.D. Rhim, B.Z. Stanger Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways Prog Mol Biol Transl Sci 97 2010 41 78
-
(2010)
Prog Mol Biol Transl Sci
, vol.97
, pp. 41-78
-
-
Rhim, A.D.1
Stanger, B.Z.2
-
113
-
-
42649138943
-
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
-
M. Pasca di Magliano, A.V. Biankin, P.W. Heiser Common activation of canonical Wnt signaling in pancreatic adenocarcinoma PLoS ONE 2 2007 e1155
-
(2007)
PLoS ONE
, vol.2
, pp. 1155
-
-
Pasca Di Magliano, M.1
Biankin, A.V.2
Heiser, P.W.3
-
114
-
-
77953158971
-
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
-
L. Hanlon, J.L. Avila, R.M. Demarest Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma Cancer Res 70 2010 4280 4286
-
(2010)
Cancer Res
, vol.70
, pp. 4280-4286
-
-
Hanlon, L.1
Avila, J.L.2
Demarest, R.M.3
-
115
-
-
47249108568
-
Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells
-
D. Romero, M. Iglesias, C.P. Vary Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells Carcinogenesis 29 2008 1070 1076
-
(2008)
Carcinogenesis
, vol.29
, pp. 1070-1076
-
-
Romero, D.1
Iglesias, M.2
Vary, C.P.3
-
116
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
A. Blackford, O.K. Serrano, C.L. Wolfgang SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer Clin Cancer Res 15 2009 4674 4679
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4674-4679
-
-
Blackford, A.1
Serrano, O.K.2
Wolfgang, C.L.3
-
117
-
-
40749106656
-
Gene expression patterns in pancreatic tumors, cells and tissues
-
A.W. Lowe, M. Olsen, Y. Hao Gene expression patterns in pancreatic tumors, cells and tissues PLoS ONE 2 2007 e323
-
(2007)
PLoS ONE
, vol.2
, pp. 323
-
-
Lowe, A.W.1
Olsen, M.2
Hao, Y.3
-
118
-
-
20344379938
-
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: Additional evidence of different genetic pathways
-
D. Cao, A. Maitra, J.A. Saavedra Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways Mod Pathol 18 2005 752 761
-
(2005)
Mod Pathol
, vol.18
, pp. 752-761
-
-
Cao, D.1
Maitra, A.2
Saavedra, J.A.3
-
119
-
-
0038133109
-
Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma
-
A.M. Lowy, C. Fenoglio-Preiser, O.J. Kim Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma Ann Surg Oncol 10 2003 284 290
-
(2003)
Ann Surg Oncol
, vol.10
, pp. 284-290
-
-
Lowy, A.M.1
Fenoglio-Preiser, C.2
Kim, O.J.3
-
120
-
-
68449096481
-
Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells
-
F.E. Froeling, T.A. Mirza, R.M. Feakins Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells Am J Pathol 175 2009 636 648
-
(2009)
Am J Pathol
, vol.175
, pp. 636-648
-
-
Froeling, F.E.1
Mirza, T.A.2
Feakins, R.M.3
-
121
-
-
60649114313
-
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization
-
L. Wang, D.G. Heidt, C.J. Lee Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization Cancer Cell 15 2009 207 219
-
(2009)
Cancer Cell
, vol.15
, pp. 207-219
-
-
Wang, L.1
Heidt, D.G.2
Lee, C.J.3
-
122
-
-
30744441863
-
Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: A tissue microarray analysis
-
R. Chetty, S. Serra, S. Salahshor Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis Hum Pathol 37 2006 212 217
-
(2006)
Hum Pathol
, vol.37
, pp. 212-217
-
-
Chetty, R.1
Serra, S.2
Salahshor, S.3
-
123
-
-
0036284906
-
Expression of E-cadherin, alpha- and beta-catenins in patients with pancreatic adenocarcinoma
-
Y.E. Joo, J.S. Rew, C.S. Park Expression of E-cadherin, alpha- and beta-catenins in patients with pancreatic adenocarcinoma Pancreatology 2 2002 129 137
-
(2002)
Pancreatology
, vol.2
, pp. 129-137
-
-
Joo, Y.E.1
Rew, J.S.2
Park, C.S.3
-
124
-
-
0035572340
-
Expression patterns of alpha-, beta- and gamma-catenin in pancreatic cancer: Correlation with E-cadherin expression, pathological features and prognosis
-
A.J. Karayiannakis, K.N. Syrigos, A. Polychronidis Expression patterns of alpha-, beta- and gamma-catenin in pancreatic cancer: correlation with E-cadherin expression, pathological features and prognosis Anticancer Res 21 2001 4127 4134
-
(2001)
Anticancer Res
, vol.21
, pp. 4127-4134
-
-
Karayiannakis, A.J.1
Syrigos, K.N.2
Polychronidis, A.3
-
125
-
-
17444408560
-
Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis
-
Y.J. Li, Z.M. Wei, Y.X. Meng Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis World J Gastroenterol 11 2005 2117 2123
-
(2005)
World J Gastroenterol
, vol.11
, pp. 2117-2123
-
-
Li, Y.J.1
Wei, Z.M.2
Meng, Y.X.3
-
126
-
-
0035918538
-
Reduced membranous and ectopic cytoplasmic expression of beta -catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer
-
Q. Qiao, M. Ramadani, S. Gansauge Reduced membranous and ectopic cytoplasmic expression of beta -catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer Int J Cancer 95 2001 194 197
-
(2001)
Int J Cancer
, vol.95
, pp. 194-197
-
-
Qiao, Q.1
Ramadani, M.2
Gansauge, S.3
-
127
-
-
55349119506
-
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
-
R. Nawroth, A. van Zante, S. Cervantes Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells PLoS ONE 2 2007 e392
-
(2007)
PLoS ONE
, vol.2
, pp. 392
-
-
Nawroth, R.1
Van Zante, A.2
Cervantes, S.3
-
128
-
-
78049502871
-
The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation
-
J.-P. Lai, A.M. Oseini, C.D. Moser The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation Hepatology 52 2010 1680 1689
-
(2010)
Hepatology
, vol.52
, pp. 1680-1689
-
-
Lai, J.-P.1
Oseini, A.M.2
Moser, C.D.3
-
129
-
-
79960470568
-
GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1
-
Y. Zhong, Z. Wang, B. Fu GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1 PLoS ONE 6 2011 e22129
-
(2011)
PLoS ONE
, vol.6
, pp. 22129
-
-
Zhong, Y.1
Wang, Z.2
Fu, B.3
-
130
-
-
33646428351
-
Collagen type i induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells
-
A. Koenig, C. Mueller, C. Hasel Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells Cancer Res 66 2006 4662 4671
-
(2006)
Cancer Res
, vol.66
, pp. 4662-4671
-
-
Koenig, A.1
Mueller, C.2
Hasel, C.3
-
131
-
-
80053577336
-
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression
-
F.E. Froeling, C. Feig, C. Chelala Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression Gastroenterology 141 2011 1486 1497
-
(2011)
Gastroenterology
, vol.141
, pp. 1486-1497
-
-
Froeling, F.E.1
Feig, C.2
Chelala, C.3
-
132
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
-
S.M. Huang, Y.M. Mishina, S. Liu Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Nature 461 2009 614 620
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
-
133
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
B. Chen, M.E. Dodge, W. Tang Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer Nat Chem Biol 5 2009 100 107
-
(2009)
Nat Chem Biol
, vol.5
, pp. 100-107
-
-
Chen, B.1
Dodge, M.E.2
Tang, W.3
-
134
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]
-
K.H. Emami, C. Nguyen, H. Ma A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected] Proc Natl Acad Sci U S A 101 2004 12682 12687
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
-
135
-
-
82355186665
-
Wnt/beta-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming
-
T. Miki, S.Y. Yasuda, M. Kahn Wnt/beta-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming Stem Cell Rev 7 2011 836 846
-
(2011)
Stem Cell Rev
, vol.7
, pp. 836-846
-
-
Miki, T.1
Yasuda, S.Y.2
Kahn, M.3
-
136
-
-
77956266718
-
A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers
-
O.M. Lucero, D.W. Dawson, R.T. Moon A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers Curr Oncol Rep 12 2010 314 318
-
(2010)
Curr Oncol Rep
, vol.12
, pp. 314-318
-
-
Lucero, O.M.1
Dawson, D.W.2
Moon, R.T.3
-
137
-
-
78649381826
-
Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma
-
T. Biechele, N. Camp, D. Fass Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma Chem Biol 17 2010 1177 1182
-
(2010)
Chem Biol
, vol.17
, pp. 1177-1182
-
-
Biechele, T.1
Camp, N.2
Fass, D.3
|