Stabilization of β-Catenin Induces Pancreas Tumor Formation

Gastroenterology

Volumn 135, Issue 4, 2008, Pages 1288-1300

  Heiser, Patrick W ^a   Cano, David A ^a   Landsman, Limor ^a   Kim, Grace E ^b   Kench, James G ^c,d   Klimstra, David S ^e   Taketo, Maketo M ^f   Biankin, Andrew V ^g   Hebrok, Matthias ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d WESTMEAD HOSPITAL   (Australia)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f KYOTO UNIVERSITY   (Japan)

^g BANKSTOWN LIDCOMBE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; GENE MUTATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MORPHOLOGY; MOUSE; NONHUMAN; ONCOGENE K RAS; PANCREAS TUMOR; PANCREAS TUMORIGENESIS; PANCREATIC INTRAEPITHELIAL NEOPLASIA; PRIORITY JOURNAL; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

EID: 53049110158     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.06.089     Document Type: Article

References (46)

1. Gregorieff A., and Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 19 (2005) 877-890
2. Fodde R., and Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 19 (2007) 150-158
3. Polakis P. The many ways of Wnt in cancer. Curr Opin Gene Dev 17 (2007) 45-51
4. Reya T., and Clevers H. Wnt signalling in stem cells and cancer. Nature 434 (2005) 843-850
5. Widelitz R. Wnt signaling through canonical and non-canonical pathways: recent progress. Growth Factors 23 (2005) 111-116
6. Murtaugh L.C., Law A.C., Dor Y., et al. Beta-catenin is essential for pancreatic acinar but not islet development. Development 132 (2005) 4663-4674
7. Papadopoulou S., and Edlund H. Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54 (2005) 2844-2851
8. Dessimoz J., Bonnard C., Huelsken J., et al. Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol 15 (2005) 1677-1683
9. Wells J.M., Esni F., Boivin G.P., et al. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol 7 (2007) 4
10. Heller R.S., Dichmann D.S., Jensen J., et al. Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn 225 (2002) 260-270
11. Koesters R., and von Knebel Doeberitz M. The Wnt signaling pathway in solid childhood tumors. Cancer Lett 198 (2003) 123-138
12. Abraham S.C., Wu T.T., Hruban R.H., et al. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol 160 (2002) 953-962
13. Al-Aynati M.M., Radulovich N., Riddell R.H., et al. Epithelial-cadherin and beta-catenin expression changes in pancreatic intraepithelial neoplasia. Clin Cancer Res 10 (2004) 1235-1240
14. Lowy A.M., Fenoglio-Preiser C., Kim O.J., et al. Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma. Ann Surg Oncol 10 (2003) 284-290
15. Zeng G., Germinaro M., Micsenyi A., et al. Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia 8 (2006) 279-289
16. Nishimori I., Kohsaki T., Tochika N., et al. Non-cystic solid-pseudopapillary tumor of the pancreas showing nuclear accumulation and activating gene mutation of beta-catenin. Pathol Int 56 (2006) 707-711
17. Min Kim S., Sun C.D., Park K.C., et al. Accumulation of beta-catenin protein, mutations in exon-3 of the beta-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas. J Surg Oncol 94 (2006) 418-425
18. Abraham S.C., Klimstra D.S., Wilentz R.E., et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol 160 (2002) 1361-1369
19. Cao D., Maitra A., Saavedra J.A., et al. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. Mod Pathol 18 (2005) 752-761
20. Harada N., Tamai Y., Ishikawa T., et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18 (1999) 5931-5942
21. Hingorani S.R., Petricoin E.F., Maitra A., et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4 (2003) 437-450
22. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21 (1999) 70-71
23. Lobe C.G., Koop K.E., Kreppner W., et al. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208 (1999) 281-292
24. Kawaguchi Y., Cooper B., Gannon M., et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32 (2002) 128-134
25. Gu G., Dubauskaite J., and Melton D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129 (2002) 2447-2457
26. Kawahira H., Ma N.H., Tzanakakis E.S., et al. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 130 (2003) 4871-4879
27. Kim S.K., Hebrok M., and Melton D.A. Notochord to endoderm signaling is required for pancreas development. Development 124 (1997) 4243-4252
28. Heiser P.W., Lau J., Taketo M.M., et al. Stabilization of beta-catenin impacts pancreas growth. Development 133 (2006) 2023-2032
29. Jaffee E.M., Hruban R.H., Canto M., et al. Focus on pancreas cancer. Cancer Cell 2 (2002) 25-28
30. Tuveson D.A., and Hingorani S.R. Ductal pancreatic cancer in humans and mice. Cold Spring Harb Symp Quant Biol 70 (2005) 65-72
31. Hezel A.F., Kimmelman A.C., Stanger B.Z., et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 20 (2006) 1218-1249
32. Zhu L., Shi G., Schmidt C.M., et al. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 171 (2007) 263-273
33. Aguirre A.J., Bardeesy N., Sinha M., et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17 (2003) 3112-3126
34. Hingorani S.R., Wang L., Multani A.S., Combs C., et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005) 469-483
35. Tajiri T., Tate G., Inagaki T., Kunimura T., et al. Intraductal tubular neoplasms of the pancreas: histogenesis and differentiation. Pancreas 30 (2005) 115-121
36. Albores-Saavedra J., Sheahan K., O'Riain C., et al. Intraductal tubular adenoma, pyloric type, of the pancreas: additional observations on a new type of pancreatic neoplasm. Am J Surg Pathol 28 (2004) 233-238
37. Tajiri T., Tate G., Kunimura T., et al. Histologic and immunohistochemical comparison of intraductal tubular carcinoma, intraductal papillary-mucinous carcinoma, and ductal adenocarcinoma of the pancreas. Pancreas 29 (2004) 116-122
38. Pasca di Magliano M., Sekine S., Ermilov A., et al. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev 20 (2006) 3161-3173
39. Thayer S.P., di Magliano M.P., Heiser P.W., et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425 (2003) 851-856
40. Miyamoto Y., Maitra A., Ghosh B., et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3 (2003) 565-576
41. Klimstra D.S., Wenig B.M., and Heffess C.S. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol 17 (2000) 66-80
42. Tanaka Y., Kato K., Notohara K., et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res 61 (2001) 8401-8404
43. Strom A., Bonal C., Ashery-Padan R., et al. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134 (2007) 2719-2725
44. Bardeesy N., Aguirre A.J., Chu G.C., et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 103 (2006) 5947-5952
45. Bardeesy N., Cheng K.H., Berger J.H., et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 20 (2006) 3130-3146
46. Izeradjene K., Combs C., Best M., et al. Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11 (2007) 229-243