The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the β-catenin signaling cascade

Human Molecular Genetics

Volumn 11, Issue 13, 2002, Pages 1549-1560

  Albuquerque, Cristina ^a   Breukel, Cor ^b   Van Der Luijt, Rob ^b,d   Fidalgo, Paulo ^a   Lage, Pedro ^a   Slors, Frederik J M ^c   Nobre Leitao C ^a   Fodde, Riccardo ^b   Smits, Ron ^b  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN;

ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COLON POLYPOSIS; COLORECTAL TUMOR; CONTROLLED STUDY; DOWN REGULATION; FAMILIAL DISEASE; GENE ACTIVATION; GENE DELETION; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; HYPOTHESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SOMATIC MUTATION;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ALLELES; BETA CATENIN; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 5; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GERM-LINE MUTATION; HUMANS; KARYOTYPING; LOSS OF HETEROZYGOSITY; MUTATION; POINT MUTATION; REPETITIVE SEQUENCES, AMINO ACID; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSLOCATION, GENETIC;

EID: 0037096906     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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