Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression

Hepatology

Volumn 41, Issue 5, 2005, Pages 1096-1105

  Fukutomi, Takayoshi ^a   Zhou, Yonghong ^a   Kawai, Shigenobu ^a   Eguchi, Hidetoshi ^a   Wands, Jack R ^a   Li, Jisu ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; SMALL INTERFERING RNA; WNT1 PROTEIN;

ARTICLE; CELL COUNT; CELL CULTURE; CELL CYCLE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DNA MICROARRAY; DNA SYNTHESIS; DOWN REGULATION; GENE STRUCTURE; GENETIC TRANSFECTION; GROWTH REGULATION; GROWTH STIMULATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REPLICON; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; SUPERNATANT; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE; UPREGULATION; VIRUS GENE; VIRUS REPLICATION;

CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; HEPATITIS C; HEPATOCYTES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; REPLICON; TRANSCRIPTION, GENETIC; UP-REGULATION; VIRAL CORE PROTEINS; WNT PROTEINS; WNT1 PROTEIN;

EID: 17844372967     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20668     Document Type: Article

References (31)

1. Kiyosawa K, Sodeyama T, Tanaka E, et al. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. HEPATOLOGY 1990;12:671-675.
2. Saito I, Miyamura T, Ohbayashi A, et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A 1990;87:6547-6549.
3. Moriya K, Fuji H, Shintani Y, et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998;4: 1065-1067.
4. McLauchlan J. Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat 2000;7:2-14.
5. Ray RB, Ray R. Hepatitis C virus core protein: intriguing properties and functional relevance. FEMS Microbiol Lett 2002;202:149-156.
6. Ray RB, Meyer K, Ray R. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 2000;271:197-204.
7. Chang J, Yang SH, Cho YG, Hwang SB, Hahn YS, Sung YC. Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene. J Virol 1998;72:3060-3065.
8. Tsuchihara K, Hijikata M, Fukuda K, Kuroki T, Yamamoto N, Shimotohno K. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli. Virology 1999;258: 100-107.
9. Cho JW, Baek WK, Suh SI, Yang SH, Chang J, Sung YC, et al. Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels. Liver 2001;21:137-142.
10. Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 2002;196:641-653.
11. Moradpour D, Englert C, Wakita T, Wands JR. Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein. Virology 1996;222:51-63.
12. Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002;122: 366-375.
13. Erhardt A, Hassan M, Heintges T, Haussinger D. Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-off cell line. Virology 2002;292:272-284.
14. Blight KJ, McKeating JA, Rice CM. Highly permissive cell lines for sub-genomic and genomic hepatitis C virus RNA replication. J Virol 2002;76: 13001-13014.
15. Stubdal H, Zalvide J, Campbell KS, Schweitzer C, Roberts TM, DeCaprio JA. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol 1997;17:4979-4990.
16. Moradpour D, Wakita, T, Tokushige K, Carlson RI, Krawczynski K, Wands JR. Characterization of three novel monoclonal antibodies against hepatitis C virus core protein. J Med Virol 1996;48:234-241.
17. Tlsty T, Briot A, Poulose B. Analysis of cell cycle checkpoint status in mammalian cells. Methods Enzymol 1995;254:125-133.
18. Ali SH, DeCaprio J.A. Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 2001;11:15-23.
19. Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-1851.
20. Lerat H, Honda M, Beard MR, Loesch K, Sun J, Yang Y, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002;122:352-365.
21. Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 2000;287:1606-1609.
22. Koch A, Denkhaus D, Albrecht S, Leuschner I, von Schweinitz D, Pietsch T. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the β-catenin gene. Cancer Res 1999;59:269-273.
23. Terris B, Pineau P, Bregeaud L, Valla D, Belghiti J, Tiollais P, et al. Close correlation between β-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. Oncogene 1999;18: 6583-6588.
24. Jeng YM, Wu MZ, Mao TL, Chang MH, Hsu HC. Somatic mutations of β-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma. Cancer Lett 2000;152:45-51.
25. Xu L, Corcoran RB, Welsh JW, Pennica D, Levine AJ. WISP-1 is a Wnt-1 and β-catenin-responsive oncogene. Genes Dev 2000;14:585-595.
26. Tanaka S, Sugimachi K, Saeki H, Kinoshita J, Ohga T, Shimada M, et al. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. Oncogene 2001;20:5525-5532.
27. Tanaka S, Sugimachi K, Kameyama T, Maehara S, Shirabe K, Shimade M, et al. Human WISP-1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. HEPATOLOGY 2003;37:1122-1129.
28. th International Symposium on hepatitis C Virus and related Viruses, 2004; p. 235.
29. Kumar D, Farrell GC, Fung C, George J. Hepatitis C virus genotype 3 is cytopathic to hepatocytes: reversal of hepatic steatosis after sustained therapeutic response. HEPATOLOGY 2002;36:1266-1272.
30. Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y, et al. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 2001;61:2129-2137.
31. Iizuka N, Oka M, Yamada-Okabe H, et al. Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res 2002;62:3939-3944.