Stability and comparative metabolism of selected felbamate metabolites and postulated fluorofelbamate metabolites by postmitochondrial suspensions

Chemical Research in Toxicology

Volumn 18, Issue 12, 2005, Pages 1842-1848

  Parker, Robert J ^a   Hartman, Neil R ^a   Roecklein, Bryan A ^b   Mortko, Henry ^b   Kupferberg, Harvey J ^c   Stables, James ^a   Strong, John M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b MedPointe Pharmaceuticals   (United States)

^c National Institutes of Health ^*

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUORO 2 PHENYL 1,3 PROPANEDIOL DICARBAMATE; 2 FLUORO 2 PHENYL 1,3 PROPANEDIOL MONOCARBAMATE; 2 PHENYLPROPENAL; 3 CARBAMOYL 2 FLUORO 2 PHENYLPROPIONALDEHYDE; 3 CARBAMOYL 2 FLUORO 2 PHENYLPROPIONIC ACID; 3 CARBAMOYL 2 PHENYLPROPIONALDEHYDE; 3 CARBAMOYL 2 PHENYLPROPIONIC ACID; 4 HYDROXY 5 FLUORO 5 PHENYLTETRAHYDRO 1,3 OXAZIN 2 ONE; 4 HYDROXY 5 PHENYLTETRAHYDRO 1,3 OXAZIN 2 ONE; ANTICONVULSIVE AGENT; BUFFER; CARBAMIC ACID DERIVATIVE; DRUG METABOLITE; FELBAMATE; FLUORINE; FLUOROFELBAMATE; GLUTATHIONE; HYDROGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROPANE; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATE; DRUG SYNTHESIS; HALF LIFE TIME; HUMAN; IN VITRO STUDY; LIVER MITOCHONDRION; MITOCHONDRION; MOLECULAR STABILITY; OXIDATION; PHOSPHATE BUFFER; POSTMITOCHONDRIAL SUSPENSION; REDUCTION; SYNTHESIS; TOXICOKINETICS;

ALDEHYDES; ANTICONVULSANTS; AZA COMPOUNDS; CELLS, CULTURED; FLUORINE; HUMANS; MASS SPECTROMETRY; MITOCHONDRIA, LIVER; NAD; OXAZINES; OXIDATION-REDUCTION; PROPYLENE GLYCOLS; SIGNAL TRANSDUCTION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 29644434684     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050130r     Document Type: Article

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