In vitro studies on the metabolic activation of the furanopyridine L- 754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4

Chemical Research in Toxicology

Volumn 9, Issue 6, 1996, Pages 1007-1012

  Sahali Sahly, Yousif ^a   Balani, Suresh K ^a   Lin, Jiunn H ^a   Baillie, Thomas A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYL 5 [2 TERT BUTYLAMINOCARBONYL 4 [(FURO[2,3 B]PYRIDIN 5 YL)METHYL] 1 PIPERAZINYL] 4 HYDROXY N (2 HYDROXY 1 INDANYL)PENTANAMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYTOCHROME P450; L 754394; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVATION; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIVER MICROSOME; MONKEY; NONHUMAN;

ANIMALS; BINDING SITES; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; ENZYME INHIBITORS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYLAMINES; INDANS; MACACA MULATTA; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NADP; OXIDATION-REDUCTION; PIPERAZINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TRICHLOROEPOXYPROPANE;

EID: 0029741202     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960060b     Document Type: Article

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