NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of ibuprofen ((±)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues

Analytical Chemistry

Volumn 79, Issue 22, 2007, Pages 8720-8727

  Johnson, Caroline H ^a   Wilson, Ian D ^b   Harding, John R ^b   Stachulski, Andrew V ^c   Iddon, Lisa ^c   Nicholson, Jeremy K ^a   Lindon, John C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REARRANGEMENT; TRANSACYLATION;

BINDING SITES; CARBOXYLIC ACIDS; ISOMERS; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; REACTION KINETICS;

DRUG PRODUCTS;

1 BETA O ACYL GLUCURONIDE; ACYLTRANSFERASE; CARBOXYLIC ACID DERIVATIVE; GLUCURONIDE; IBUPROFEN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BIOSYNTHESIS; DEGRADATION; DRUG HALF LIFE; DRUG SYNTHESIS; HYDROLYSIS; METABOLITE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; URINE CULTURE;

ACYLATION; GLUCURONATES; HALF-LIFE; HUMANS; HYDROLYSIS; IBUPROFEN; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROPIONIC ACIDS;

EID: 36448976239     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac071368i     Document Type: Article

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