Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro

Drug Metabolism and Disposition

Volumn 30, Issue 1, 2002, Pages 55-62

  Grillo, Mark P ^a,b   Benet, Leslie Z ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(4 CHLOROPHENOXYISOBUTYRYL)GLUTATHIONE; 2,3 DICHLOROPHENOXYACETIC ACID; 2,4 CHLOROPHENOXYACETIC ACID; 4 CHLOROPHENOXYACETIC ACID; ACYL COENZYME A; CARPROFEN; CLOFIBRIC ACID; CLOFIBRIC ACID DERIVATIVE; DICLOFENAC; FENOPROFEN; GEMFIBROZIL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; NAPROXEN; THIOESTER; TOLMETIN; UNCLASSIFIED DRUG; ZOMEPIRAC;

ACYLATION; ARTICLE; CHEMICAL REACTION KINETICS; DOSE TIME EFFECT RELATION; DRUG CROSS REACTIVITY; DRUG METABOLISM; DRUG PROTEIN BINDING; GLUTATHIONE METABOLISM; HUMAN; HYDROLYSIS; INCUBATION TIME; LIVER METABOLISM; MOLECULAR STABILITY; PH; PRIORITY JOURNAL; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIDE EFFECT; TANDEM MASS SPECTROMETRY;

ACETYLCYSTEINE; ACYL COENZYME A; ACYLATION; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOFIBRIC ACID; DITHIOTHREITOL; GLUTATHIONE; HYDROGEN-ION CONCENTRATION; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; XENOBIOTICS;

EID: 0036136379     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.1.55     Document Type: Article

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