Thiophene sulfoxides as reactive metabolites: Formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo

Chemical Research in Toxicology

Volumn 9, Issue 8, 1996, Pages 1403-1413

  Valadon, Philippe ^a   Dansette, Patrick M ^a   Girault, Jean Pierre ^a   Amar, Claudine ^a   Mansuy, Daniel ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b URA 400   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOETHANOL; REACTIVE OXYGEN METABOLITE; SULFOXIDE; THIOPHENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; COVALENT BOND; DIASTEREOISOMER; DRUG OXIDATION; HEPATITIS; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION; RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MERCAPTOETHANOL; MICROSOMES, LIVER; OXIDATION-REDUCTION; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFOXIDES; THIOPHENES;

ANIMALIA;

EID: 0029852501     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9601622     Document Type: Article

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