Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry

Drug Metabolism and Disposition

Volumn 25, Issue 3, 1997, Pages 275-280

  Maggs, J L ^b   Pirmohamed, M ^b   Kitteringham, N R ^b   Park, B K ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; DRUG METABOLITE;

ADULT; ARTICLE; BIOTRANSFORMATION; CASE REPORT; DIAGNOSTIC VALUE; DOSE TIME EFFECT RELATION; DRUG URINE LEVEL; EPILEPSY; FEMALE; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; LONG TERM EXPOSURE; MALE; PRIORITY JOURNAL;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; CHROMATOGRAPHY, LIQUID; EPILEPSY; FEMALE; GLUCURONATES; HUMANS; MALE; MASS SPECTROMETRY; OXIDATION-REDUCTION;

EID: 0030968046     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. R. K. Lynn, R. G. Smith, R. M. Thompson, M. L. Deinzer, D. Griffin, and N. Gerber: Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry. Drug Metab. Dispos. 6, 494-501 (1978).
2. K. Lertratanangkoon and M. G. Horning: Metabolism of carbamazepine. Drug Metab. Dispos. 10, 1-10 (1982).
3. A. Frigerio, R. Fanelli, P. Biandrate, G. Passerini, P. L. Morselli, and S. Garattini: Mass spectrometric characterization of carbamazepine-10,11-epoxide, a carbamazepine metabolite isolated from human urine. J. Pharm. Sci. 61, 1144-1147 (1972).
4. M. Eichelbaum, T. Tomson, G. Tybring, and L. Bertilsson: Carbamazepine metabolism in man: induction and pharmacogenetic aspects. Clin. Pharmacokinet. 10, 80-90 (1985).
5. M. Pirmohamed, R. Allott, V. J. Green, N. R. Kitteringham, D. Chadwick, and B. K. Park: Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy. Br. J. Clin. Pharmacol. 37, 577-581 (1994).
6. C. Beyer and G. Spiller: A new carbamazepine metabolite in uraemic filtrate. Xenobiotica 22, 1029-1035 (1992).
7. S. Madden, J. L. Maggs, and B. K. Park: Bioactivation of carbamazepine in the rat in vivo: evidence for the formation of reactive arene oxide(s). Drug Metab. Dispos. 24, 469-479 (1996).
8. D. Lindhout, R. J. Hoppener, and H. Meinardi: Teratogenicity of antiepileptic drug combinations with special emphasis on epoxidation (of carbamazepine). Epilepsia 25, 77-83 (1984).
9. M. Pirmohamed, N. R. Kitteringham, T. M. Guenthner, A. M. Breckenridge, and B. K. Park: Investigation into the formation of cytotoxic, protein reactive and stable metabolites from carbamazepine in vitro. Biochem. Pharmacol. 43, 1675-1682 (1992).
10. J. H. Lillibridge, B. M. Amore, J. T. Slattery, T. F. Kalhorn, S. D. Nelson, R. H. Finnell, and G. D. Bennett: Protein-reactive metabolites of carbamazepine in mouse liver microsomes. Drug Metab. Dispos. 24, 509-514 (1996).
11. C. Fenselau and L. Yellet: Glucuronic acid, sulfate ester, and glutathione xenobiotic conjugates: analysis by mass spectrometry. In "Xenobiotic Conjugation Chemistry" (G. D. Paulson, J. Caldwell, D. H. Hutson, and J. J. Menn, eds.), pp. 159-176. American Chemical Society, Washington, D.C., 1986.
12. 14C-oxcarbazepine in man. Xenobiotica 16, 769-778 (1986).
13. K. F. Feldmann, G. Dorhofer, J. W. Faigle, and P. Imhof: Pharmacokinetics and metabolism of GP47779, the main human metabolite of oxcarbazepine (GP47680) in animals and healthy volunteers. In "Advances in Epileptology XIIth Epilepsy International Symposium" (M. Dam, L. Gram, and J. K. Penry, eds.), pp. 89-96. Raven Press, New York, 1981.
14. W. J. Richter, P. Kriemler, and J. W. Faigle: Newer aspects of the biotransformation of carbamazepine: structural characterization of highly polar metabolites. In "Recent Developments in Mass Spectrometry in Biochemistry and Medicine" (A. Frigerio, ed.) vol. 1, pp. 1-14. Plenum Press, New York, 1978.
15. J. W. Faigle and K. F. Feldmann: Carbamazepine: chemistry and biotransformation. In "Antiepileptic Drugs" (R. H. Levy, R. H. Mattson, and B. S. Meldrum, eds.), pp. 499-513. Raven Press, New York, 1995.
16. T. P. Bleck: Convulsive disorders: the use of anticonvulsant drugs. Clin. Neuropharmacol. 13, 198-209 (1990).
17. T. B. Kudriakova, L. A. Sirota, G. I. Rozova, and V. A. Gorkov: Auto-induction and steady-state pharmacokinetics of carbamazepine and its major metabolites. Br. J. Clin. Pharmacol. 33, 611-615 (1992).
18. J. E. Bakke and K. L. Davidson: Metabolism of naphthalene in roosters. Xenobiotica 18, 1057-1062 (1988).
19. S. L. Iverson, L. Shen, N. Anlar, and J. L. Bolton: Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes. Chem. Res. Toxicol. 9, 492-499 (1996).