First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives

Biochemical and Biophysical Research Communications

Volumn 338, Issue 1, 2005, Pages 450-455

  Dansette, Patrick M ^a   Bertho, Gildas ^a   Mansuy, Daniel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

2 Phenylthiophene; Arene oxide; CYP1A1; Rat liver microsomes; Thiophene epoxide glutathione adduct; Thiophene S oxide dimers; Thiophene S oxide glutathione adduct

Indexed keywords

2 PHENYLTHIOPHENE; 2 PHENYLTHIOPHENE OXIDE; CYTOCHROME P450; CYTOCHROME P450 1A1; DIMER; GLUTATHIONE; GLUTATHIONE DERIVATIVE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIELS ALDER REACTION; DIMERIZATION; ENZYME ANALYSIS; ENZYME MECHANISM; EPOXIDATION; LIVER MICROSOME; MASS SPECTROMETRY; MICHAEL ADDITION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS;

ANIMALS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, CHEMICAL; OXIDATION-REDUCTION; RATS; THIOPHENES; TRITIUM;

ANIMALIA; BETULACEAE;

EID: 27544482086     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.091     Document Type: Article

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