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Volumn 2, Issue 4, 2011, Pages 492-516

Blood-Brain Barrier Pathophysiology in Traumatic Brain Injury

Author keywords

Blood brain barrier; Gliovascular unit; Traumatic brain injury

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ALBUMIN; ATP BINDING CASSETTE TRANSPORTER C8; CYTOKINE; FIBRINOGEN; GLUTAMIC ACID; MATRIX METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN; THROMBIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN A;

EID: 83355166774     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-011-0125-x     Document Type: Review
Times cited : (504)

References (245)
  • 2
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006; 7(1): 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 4
    • 0026073369 scopus 로고
    • Microglial cells are a component of the perivascular glia limitans
    • Lassmann H, Zimprich F, Vass K, Hickey WF. Microglial cells are a component of the perivascular glia limitans. J Neurosci Res. 1991; 28(2): 236-43.
    • (1991) J Neurosci Res , vol.28 , Issue.2 , pp. 236-243
    • Lassmann, H.1    Zimprich, F.2    Vass, K.3    Hickey, W.F.4
  • 6
    • 0027999170 scopus 로고
    • Animate models of human head injury
    • Gennarelli TA. Animate models of human head injury. J Neurotrauma. 1994; 11(4): 357-68.
    • (1994) J Neurotrauma , vol.11 , Issue.4 , pp. 357-368
    • Gennarelli, T.A.1
  • 8
    • 0027964581 scopus 로고
    • Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats
    • Dietrich WD, Alonso O, Halley M. Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J Neurotrauma. 1994; 11(3): 289-301.
    • (1994) J Neurotrauma , vol.11 , Issue.3 , pp. 289-301
    • Dietrich, W.D.1    Alonso, O.2    Halley, M.3
  • 9
    • 0036897373 scopus 로고    scopus 로고
    • Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury
    • Stein SC, Chen XH, Sinson GP, Smith DH. Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J Neurosurg. 2002; 97(6): 1373-7.
    • (2002) J Neurosurg , vol.97 , Issue.6 , pp. 1373-1377
    • Stein, S.C.1    Chen, X.H.2    Sinson, G.P.3    Smith, D.H.4
  • 10
    • 76349103537 scopus 로고    scopus 로고
    • Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice
    • Schwarzmaier SM, Kim SW, Trabold R, Plesnila N. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. J Neurotrauma. 2010; 27(1): 121-30.
    • (2010) J Neurotrauma , vol.27 , Issue.1 , pp. 121-130
    • Schwarzmaier, S.M.1    Kim, S.W.2    Trabold, R.3    Plesnila, N.4
  • 11
    • 0043071539 scopus 로고    scopus 로고
    • Cerebral microvessel responses to focal ischemia
    • del Zoppo GJ, Mabuchi T. Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab. 2003; 23(8): 879-94.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.8 , pp. 879-894
    • del Zoppo, G.J.1    Mabuchi, T.2
  • 12
    • 0345367905 scopus 로고    scopus 로고
    • Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia
    • discussion 1280-1
    • Schröder ML, Muizelaar JP, Fatouros PP, Kuta AJ, Choi SC. Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia. Neurosurgery. 1998; 42(6): 1276-80. discussion 1280-1.
    • (1998) Neurosurgery , vol.42 , Issue.6 , pp. 1276-1280
    • Schröder, M.L.1    Muizelaar, J.P.2    Fatouros, P.P.3    Kuta, A.J.4    Choi, S.C.5
  • 13
    • 0036556236 scopus 로고    scopus 로고
    • Blood flow and ischemia within traumatic cerebral contusions
    • discussion 788-90
    • von Oettingen G, Bergholt B, Gyldensted C, Astrup J. Blood flow and ischemia within traumatic cerebral contusions. Neurosurgery. 2002; 50(4): 781-8. discussion 788-90.
    • (2002) Neurosurgery , vol.50 , Issue.4 , pp. 781-788
    • von Oettingen, G.1    Bergholt, B.2    Gyldensted, C.3    Astrup, J.4
  • 14
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005; 308(5726): 1314-8.
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 15
    • 33947363967 scopus 로고    scopus 로고
    • 377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • 377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med. 2007; 204(3): 571-82.
    • (2007) J Exp Med , vol.204 , Issue.3 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3    Sikorski, S.L.4    Nuriel, T.5    Lassmann, H.6
  • 18
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol. 2001; 167(5): 2887-94.
    • (2001) J Immunol , vol.167 , Issue.5 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 20
    • 34547415988 scopus 로고    scopus 로고
    • Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor
    • Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, et al. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci USA. 2007; 104(28): 11814-9.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.28 , pp. 11814-11819
    • Schachtrup, C.1    Lu, P.2    Jones, L.L.3    Lee, J.K.4    Lu, J.5    Sachs, B.D.6
  • 21
    • 77951664911 scopus 로고    scopus 로고
    • Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage
    • Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, et al. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. J Neurosci. 2010; 30(17): 5843-54.
    • (2010) J Neurosci , vol.30 , Issue.17 , pp. 5843-5854
    • Schachtrup, C.1    Ryu, J.K.2    Helmrick, M.J.3    Vagena, E.4    Galanakis, D.K.5    Degen, J.L.6
  • 22
    • 0025857712 scopus 로고
    • Prothrombin mRNA is expressed by cells of the nervous system
    • Dihanich M, Kaser M, Reinhard E, Cunningham D, Monard D. Prothrombin mRNA is expressed by cells of the nervous system. Neuron. 1991; 6(4): 575-81.
    • (1991) Neuron , vol.6 , Issue.4 , pp. 575-581
    • Dihanich, M.1    Kaser, M.2    Reinhard, E.3    Cunningham, D.4    Monard, D.5
  • 23
    • 0033435136 scopus 로고    scopus 로고
    • Expression of factor X in both the rat brain and cells of the central nervous system
    • Shikamoto Y, Morita T. Expression of factor X in both the rat brain and cells of the central nervous system. FEBS Lett. 1999; 463(3): 387-9.
    • (1999) FEBS Lett , vol.463 , Issue.3 , pp. 387-389
    • Shikamoto, Y.1    Morita, T.2
  • 24
    • 0033662889 scopus 로고    scopus 로고
    • Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury
    • Citron BA, Smirnova IV, Arnold PM, Festoff BW. Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury. J Neurotrauma. 2000; 17(12): 1191-203.
    • (2000) J Neurotrauma , vol.17 , Issue.12 , pp. 1191-1203
    • Citron, B.A.1    Smirnova, I.V.2    Arnold, P.M.3    Festoff, B.W.4
  • 25
    • 0037199664 scopus 로고    scopus 로고
    • Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors
    • Riek-Burchardt M, Striggow F, Henrich-Noack P, Reiser G, Reymann KG. Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors. Neurosci Lett. 2002; 329(2): 181-4.
    • (2002) Neurosci Lett , vol.329 , Issue.2 , pp. 181-184
    • Riek-Burchardt, M.1    Striggow, F.2    Henrich-Noack, P.3    Reiser, G.4    Reymann, K.G.5
  • 26
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000; 407(6801): 258-64.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 258-264
    • Coughlin, S.R.1
  • 27
    • 0036285822 scopus 로고    scopus 로고
    • Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia
    • Striggow F, Riek-Burchardt M, Kiesel A, Schmidt W, Henrich-Noack P, Breder J, et al. Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia. Eur J Neurosci. 2001; 14(4): 595-608.
    • (2001) Eur J Neurosci , vol.14 , Issue.4 , pp. 595-608
    • Striggow, F.1    Riek-Burchardt, M.2    Kiesel, A.3    Schmidt, W.4    Henrich-Noack, P.5    Breder, J.6
  • 28
    • 0037265689 scopus 로고    scopus 로고
    • The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?
    • Xi G, Reiser G, Keep RF. The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem. 2003; 84(1): 3-9.
    • (2003) J Neurochem , vol.84 , Issue.1 , pp. 3-9
    • Xi, G.1    Reiser, G.2    Keep, R.F.3
  • 29
    • 16944366731 scopus 로고    scopus 로고
    • Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities
    • Donovan FM, Pike CJ, Cotman CW, Cunningham DD. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci. 1997; 17(14): 5316-26.
    • (1997) J Neurosci , vol.17 , Issue.14 , pp. 5316-5326
    • Donovan, F.M.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 30
    • 18244394288 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-1 triggers astrogliosis after brain injury
    • Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, et al. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci. 2005; 25(17): 4319-29.
    • (2005) J Neurosci , vol.25 , Issue.17 , pp. 4319-4329
    • Nicole, O.1    Goldshmidt, A.2    Hamill, C.E.3    Sorensen, S.D.4    Sastre, A.5    Lyuboslavsky, P.6
  • 31
    • 0033822556 scopus 로고    scopus 로고
    • Thrombin-induced activation of cultured rodent microglia
    • Möller T, Hanisch UK, Ransom BR. Thrombin-induced activation of cultured rodent microglia. J Neurochem. 2000; 75(4): 1539-47.
    • (2000) J Neurochem , vol.75 , Issue.4 , pp. 1539-1547
    • Möller, T.1    Hanisch, U.K.2    Ransom, B.R.3
  • 32
    • 0034730753 scopus 로고    scopus 로고
    • Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-κB
    • Ryu J, Pyo H, Jou I, Joe E. Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-κB. J Biol Chem. 2000; 275(39): 29955-9.
    • (2000) J Biol Chem , vol.275 , Issue.39 , pp. 29955-29959
    • Ryu, J.1    Pyo, H.2    Jou, I.3    Joe, E.4
  • 33
    • 0036326804 scopus 로고    scopus 로고
    • Participation of protease-activated receptor-1 in thrombin-induced microglial activation
    • Suo Z, Wu M, Ameenuddin S, Anderson HE, Zoloty JE, Citron BA, et al. Participation of protease-activated receptor-1 in thrombin-induced microglial activation. J Neurochem. 2002; 80(4): 655-66.
    • (2002) J Neurochem , vol.80 , Issue.4 , pp. 655-666
    • Suo, Z.1    Wu, M.2    Ameenuddin, S.3    Anderson, H.E.4    Zoloty, J.E.5    Citron, B.A.6
  • 34
    • 0028813087 scopus 로고
    • Contraction of human brain endothelial cells induced by thrombogenic and fibrinolytic factors. An in vitro cell culture model
    • Nagy Z, Kolev K, Csonka E, Pék M, Machovich R. Contraction of human brain endothelial cells induced by thrombogenic and fibrinolytic factors. An in vitro cell culture model. Stroke. 1995; 26(2): 265-70.
    • (1995) Stroke , vol.26 , Issue.2 , pp. 265-270
    • Nagy, Z.1    Kolev, K.2    Csonka, E.3    Pék, M.4    Machovich, R.5
  • 36
    • 0025500410 scopus 로고
    • Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases
    • Choi BH, Suzuki M, Kim T, Wagner SL, Cunningham DD. Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases. Am J Pathol. 1990; 137(4): 741-7.
    • (1990) Am J Pathol , vol.137 , Issue.4 , pp. 741-747
    • Choi, B.H.1    Suzuki, M.2    Kim, T.3    Wagner, S.L.4    Cunningham, D.D.5
  • 37
    • 15244356029 scopus 로고    scopus 로고
    • Pure albumin is a potent trigger of calcium signalling and proliferation in microglia but not macrophages or astrocytes
    • Hooper C, Taylor DL, Pocock JM. Pure albumin is a potent trigger of calcium signalling and proliferation in microglia but not macrophages or astrocytes. J Neurochem. 2005; 92(6): 1363-76.
    • (2005) J Neurochem , vol.92 , Issue.6 , pp. 1363-1376
    • Hooper, C.1    Taylor, D.L.2    Pocock, J.M.3
  • 38
    • 74149084554 scopus 로고    scopus 로고
    • Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways
    • Ralay Ranaivo H, Wainwright MS. Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways. Brain Res. 2010; 1313: 222-31.
    • (2010) Brain Res , vol.1313 , pp. 222-231
    • Ralay Ranaivo, H.1    Wainwright, M.S.2
  • 39
    • 67650739168 scopus 로고    scopus 로고
    • Transcriptome profiling reveals TGF-β signaling involvement in epileptogenesis
    • Cacheaux LP, Ivens S, David Y, Lakhter AJ, Bar-Klein G, Shapira M, et al. Transcriptome profiling reveals TGF-β signaling involvement in epileptogenesis. J Neurosci. 2009; 29(28): 8927-35.
    • (2009) J Neurosci , vol.29 , Issue.28 , pp. 8927-8935
    • Cacheaux, L.P.1    Ivens, S.2    David, Y.3    Lakhter, A.J.4    Bar-Klein, G.5    Shapira, M.6
  • 40
    • 77958492335 scopus 로고    scopus 로고
    • Albumin activates the canonical TGF receptor-smad signaling pathway but this is not required for activation of astrocytes
    • Ralay Ranaivo H, Patel F, Wainwright MS. Albumin activates the canonical TGF receptor-smad signaling pathway but this is not required for activation of astrocytes. Exp Neurol. 2010; 226(2): 310-9.
    • (2010) Exp Neurol , vol.226 , Issue.2 , pp. 310-319
    • Ralay Ranaivo, H.1    Patel, F.2    Wainwright, M.S.3
  • 41
    • 33846623307 scopus 로고    scopus 로고
    • TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis
    • Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, et al. TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain. 2007; 130(2): 535-47.
    • (2007) Brain , vol.130 , Issue.2 , pp. 535-547
    • Ivens, S.1    Kaufer, D.2    Flores, L.P.3    Bechmann, I.4    Zumsteg, D.5    Tomkins, O.6
  • 42
    • 69449102409 scopus 로고    scopus 로고
    • Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?
    • David Y, Cacheaux LP, Ivens S, Lapilover E, Heinemann U, Kaufer D, et al. Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? J Neurosci. 2009; 29(34): 10588-99.
    • (2009) J Neurosci , vol.29 , Issue.34 , pp. 10588-10599
    • David, Y.1    Cacheaux, L.P.2    Ivens, S.3    Lapilover, E.4    Heinemann, U.5    Kaufer, D.6
  • 43
    • 70349652273 scopus 로고    scopus 로고
    • Bovine serum albumin promotes IL-1β and TNF-α secretion by N9 microglial cells
    • Zhao TZ, Xia YZ, Li L, Li J, Zhu G, Chen S, et al. Bovine serum albumin promotes IL-1β and TNF-α secretion by N9 microglial cells. Neurol Sci. 2009; 30(5): 379-83.
    • (2009) Neurol Sci , vol.30 , Issue.5 , pp. 379-383
    • Zhao, T.Z.1    Xia, Y.Z.2    Li, L.3    Li, J.4    Zhu, G.5    Chen, S.6
  • 44
    • 64149114105 scopus 로고    scopus 로고
    • Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage
    • Hooper C, Pinteaux-Jones F, Fry VA, Sevastou IG, Baker D, Heales SJ, et al. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. J Neurochem. 2009; 109(3): 694-705.
    • (2009) J Neurochem , vol.109 , Issue.3 , pp. 694-705
    • Hooper, C.1    Pinteaux-Jones, F.2    Fry, V.A.3    Sevastou, I.G.4    Baker, D.5    Heales, S.J.6
  • 45
    • 0033769139 scopus 로고    scopus 로고
    • Identification of a peptide sequence in albumin that potentiates superoxide production by microglia
    • Nakamura Y, Si QS, Takaku T, Kataoka K. Identification of a peptide sequence in albumin that potentiates superoxide production by microglia. J Neurochem. 2000; 75(6): 2309-15.
    • (2000) J Neurochem , vol.75 , Issue.6 , pp. 2309-2315
    • Nakamura, Y.1    Si, Q.S.2    Takaku, T.3    Kataoka, K.4
  • 46
    • 0027213179 scopus 로고
    • Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats
    • Shapira Y, Setton D, Artru AA, Shohami E. Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats. Anesth Analg. 1993; 77(1): 141-8.
    • (1993) Anesth Analg , vol.77 , Issue.1 , pp. 141-148
    • Shapira, Y.1    Setton, D.2    Artru, A.A.3    Shohami, E.4
  • 47
  • 48
    • 0031471178 scopus 로고    scopus 로고
    • Serum extravasation and cytoskeletal alterations following traumatic brain injury in rats. Comparison of lateral fluid percussion and cortical impact models
    • Hicks RR, Baldwin SA, Scheff SW. Serum extravasation and cytoskeletal alterations following traumatic brain injury in rats. Comparison of lateral fluid percussion and cortical impact models. Mol Chem Neuropathol. 1997; 32(1-3): 1-16.
    • (1997) Mol Chem Neuropathol , vol.32 , Issue.1-3 , pp. 1-16
    • Hicks, R.R.1    Baldwin, S.A.2    Scheff, S.W.3
  • 49
    • 0343247794 scopus 로고    scopus 로고
    • The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats
    • Bas{comma below}kaya MK, Rao AM, Doǧan A, Donaldson D, Dempsey RJ. The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci Lett. 1997; 226(1): 33-6.
    • (1997) Neurosci Lett , vol.226 , Issue.1 , pp. 33-36
    • Baskaya, M.K.1    Rao, A.M.2    Doǧan, A.3    Donaldson, D.4    Dempsey, R.J.5
  • 50
    • 0021137454 scopus 로고
    • Formation of transendothelial channels in traumatic human brain edema
    • Castejón OJ. Formation of transendothelial channels in traumatic human brain edema. Pathol Res Pract. 1984; 179(1): 7-12.
    • (1984) Pathol Res Pract , vol.179 , Issue.1 , pp. 7-12
    • Castejón, O.J.1
  • 51
    • 0030971953 scopus 로고    scopus 로고
    • Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions
    • Vaz R, Sarmento A, Borges N, Cruz C, Azevedo I. Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions. Acta Neurochir (Wien). 1997; 139(3): 215-20.
    • (1997) Acta Neurochir (Wien) , vol.139 , Issue.3 , pp. 215-220
    • Vaz, R.1    Sarmento, A.2    Borges, N.3    Cruz, C.4    Azevedo, I.5
  • 52
    • 0036942704 scopus 로고    scopus 로고
    • 3H]inulin across rat blood-brain barrier after cerebral ischemia
    • 3H]inulin across rat blood-brain barrier after cerebral ischemia. Acta Neuropathol. 2002; 103(3): 237-42.
    • (2002) Acta Neuropathol. , vol.103 , Issue.3 , pp. 237-242
    • Preston, E.1    Webster, J.2
  • 53
    • 0034889456 scopus 로고    scopus 로고
    • Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia
    • Liu KF, Li F, Tatlisumak T, Garcia JH, Sotak CH, Fisher M, et al. Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia. Stroke. 2001; 32(8): 1897-905.
    • (2001) Stroke , vol.32 , Issue.8 , pp. 1897-1905
    • Liu, K.F.1    Li, F.2    Tatlisumak, T.3    Garcia, J.H.4    Sotak, C.H.5    Fisher, M.6
  • 54
    • 35848967588 scopus 로고    scopus 로고
    • Neuroinflammatory responses after experimental diffuse traumatic brain injury
    • Kelley BJ, Lifshitz J, Povlishock JT. Neuroinflammatory responses after experimental diffuse traumatic brain injury. J Neuropathol Exp Neurol. 2007; 66(11): 989-1001.
    • (2007) J Neuropathol Exp Neurol , vol.66 , Issue.11 , pp. 989-1001
    • Kelley, B.J.1    Lifshitz, J.2    Povlishock, J.T.3
  • 55
    • 33646470272 scopus 로고    scopus 로고
    • Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries
    • Marmarou A, Signoretti S, Fatouros PP, Portella G, Aygok GA, Bullock MR. Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries. J Neurosurg. 2006; 104(5): 720-30.
    • (2006) J Neurosurg , vol.104 , Issue.5 , pp. 720-730
    • Marmarou, A.1    Signoretti, S.2    Fatouros, P.P.3    Portella, G.4    Aygok, G.A.5    Bullock, M.R.6
  • 57
    • 80051782344 scopus 로고    scopus 로고
    • Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system
    • Liu W, Tang Y, Feng J. Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system. Life Sci. 2011; 89(5-6): 141-6.
    • (2011) Life Sci , vol.89 , Issue.5-6 , pp. 141-146
    • Liu, W.1    Tang, Y.2    Feng, J.3
  • 58
    • 37549027570 scopus 로고    scopus 로고
    • Transforming growth factor-β activation in the lung: focus on fibrosis and reactive oxygen species
    • Koli K, Myllärniemi M, Keski-Oja J, Kinnula VL. Transforming growth factor-β activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal. 2008; 10(2): 333-42.
    • (2008) Antioxid Redox Signal. , vol.10 , Issue.2 , pp. 333-342
    • Koli, K.1    Myllärniemi, M.2    Keski-Oja, J.3    Kinnula, V.L.4
  • 59
    • 0022477623 scopus 로고
    • β-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex
    • Pircher R, Jullien P, Lawrence DA. β-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex. Biochem Biophys Res Commun. 1986; 136(1): 30-7.
    • (1986) Biochem Biophys Res Commun , vol.136 , Issue.1 , pp. 30-37
    • Pircher, R.1    Jullien, P.2    Lawrence, D.A.3
  • 60
    • 0026541255 scopus 로고
    • Differential expression of transforming growth factor-β1, -β2, and -β3 by glioblastoma cells, astrocytes, and microglia
    • Constam DB, Philipp J, Malipiero UV, ten Dijke P, Schachner M, Fontana A. Differential expression of transforming growth factor-β1, -β2, and -β3 by glioblastoma cells, astrocytes, and microglia. J Immunol. 1992; 148(5): 1404-10.
    • (1992) J Immunol , vol.148 , Issue.5 , pp. 1404-1410
    • Constam, D.B.1    Philipp, J.2    Malipiero, U.V.3    Ten Dijke, P.4    Schachner, M.5    Fontana, A.6
  • 63
    • 79951676935 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium
    • Shen W, Li S, Chung SH, Zhu L, Stayt J, Su T, et al. Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. Eur J Cell Biol. 2011; 90(4): 323-32.
    • (2011) Eur J Cell Biol. , vol.90 , Issue.4 , pp. 323-332
    • Shen, W.1    Li, S.2    Chung, S.H.3    Zhu, L.4    Stayt, J.5    Su, T.6
  • 64
    • 3342950478 scopus 로고    scopus 로고
    • Endothelial cell-astrocyte interactions and TGFβ are required for induction of blood-neural barrier properties
    • Garcia CM, Darland DC, Massingham LJ, D'Amore PA. Endothelial cell-astrocyte interactions and TGFβ are required for induction of blood-neural barrier properties. Dev Brain Res. 2004; 152(1): 25-38.
    • (2004) Dev Brain Res. , vol.152 , Issue.1 , pp. 25-38
    • Garcia, C.M.1    Darland, D.C.2    Massingham, L.J.3    D'Amore, P.A.4
  • 65
    • 20044387390 scopus 로고    scopus 로고
    • Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-β production
    • Dohgu S, Takata F, Yamauchi A, Nakagawa S, Egawa T, Naito M, et al. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-β production. Brain Res. 2005; 1038(2): 208-15.
    • (2005) Brain Res. , vol.1038 , Issue.2 , pp. 208-215
    • Dohgu, S.1    Takata, F.2    Yamauchi, A.3    Nakagawa, S.4    Egawa, T.5    Naito, M.6
  • 66
    • 79952525332 scopus 로고    scopus 로고
    • Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch
    • Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, et al. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell. 2011; 20(3): 291-302.
    • (2011) Dev Cell. , vol.20 , Issue.3 , pp. 291-302
    • Li, F.1    Lan, Y.2    Wang, Y.3    Wang, J.4    Yang, G.5    Meng, F.6
  • 67
    • 5444245546 scopus 로고    scopus 로고
    • Critical appraisal of neuroprotection trials in head injury: what have we learned?
    • Tolias CM, Bullock MR. Critical appraisal of neuroprotection trials in head injury: what have we learned? NeuroRx. 2004; 1(1): 71-9.
    • (2004) NeuroRx , vol.1 , Issue.1 , pp. 71-79
    • Tolias, C.M.1    Bullock, M.R.2
  • 68
    • 33646516853 scopus 로고    scopus 로고
    • Evaluation of pharmacological treatment strategies in traumatic brain injury
    • Marklund N, Bakshi A, Castelbuono DJ, Conte V, McIntosh TK. Evaluation of pharmacological treatment strategies in traumatic brain injury. Curr Pharm Des. 2006; 12(13): 1645-80.
    • (2006) Curr Pharm Des , vol.12 , Issue.13 , pp. 1645-1680
    • Marklund, N.1    Bakshi, A.2    Castelbuono, D.J.3    Conte, V.4    McIntosh, T.K.5
  • 69
    • 0025242563 scopus 로고
    • Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
    • Katayama Y, Becker DP, Tamura T, Hovda DA. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg. 1990; 73(6): 889-900.
    • (1990) J Neurosurg , vol.73 , Issue.6 , pp. 889-900
    • Katayama, Y.1    Becker, D.P.2    Tamura, T.3    Hovda, D.A.4
  • 70
    • 0025182940 scopus 로고
    • Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
    • Nilsson P, Hillered L, Pontén U, Ungerstedt U. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J Cereb Blood Flow Metab. 1990; 10(5): 631-7.
    • (1990) J Cereb Blood Flow Metab , vol.10 , Issue.5 , pp. 631-637
    • Nilsson, P.1    Hillered, L.2    Pontén, U.3    Ungerstedt, U.4
  • 72
    • 0031046699 scopus 로고    scopus 로고
    • Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat
    • Koizumi H, Fujisawa H, Ito H, Maekawa T, Di X, Bullock R. Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat. Brain Res. 1997; 747(2): 304-12.
    • (1997) Brain Res , vol.747 , Issue.2 , pp. 304-312
    • Koizumi, H.1    Fujisawa, H.2    Ito, H.3    Maekawa, T.4    Di, X.5    Bullock, R.6
  • 73
    • 0141676771 scopus 로고    scopus 로고
    • Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    • Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol. 2002; 1(6): 383-6.
    • (2002) Lancet Neurol , vol.1 , Issue.6 , pp. 383-386
    • Ikonomidou, C.1    Turski, L.2
  • 74
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: review of properties, regulation, and physiological functions
    • Anderson CM, Swanson RA. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia. 2000; 32(1): 1-14.
    • (2000) Glia , vol.32 , Issue.1 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 75
    • 0028190755 scopus 로고
    • Massive astrocytic swelling in response to extracellular glutamate-a possible mechanism for post-traumatic brain swelling?
    • Maxwell WL, Bullock R, Landholt H, Fujisawa H. Massive astrocytic swelling in response to extracellular glutamate-a possible mechanism for post-traumatic brain swelling? Acta Neurochir Suppl (Wien). 1994; 60: 465-7.
    • (1994) Acta Neurochir Suppl (Wien). , vol.60 , pp. 465-467
    • Maxwell, W.L.1    Bullock, R.2    Landholt, H.3    Fujisawa, H.4
  • 76
    • 0037177827 scopus 로고    scopus 로고
    • Neutrophil-derived glutamate regulates vascular endothelial barrier function
    • Collard CD, Park KA, Montalto MC, Alapati S, Buras JA, Stahl GL, et al. Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem. 2002; 277(17): 14801-11.
    • (2002) J Biol Chem , vol.277 , Issue.17 , pp. 14801-14811
    • Collard, C.D.1    Park, K.A.2    Montalto, M.C.3    Alapati, S.4    Buras, J.A.5    Stahl, G.L.6
  • 77
    • 0344873159 scopus 로고    scopus 로고
    • Early neutrophilic expression of vascular endothelial growth factor after traumatic brain injury
    • Chodobski A, Chung I, Koźniewska E, Ivanenko T, Chang W, Harrington JF, et al. Early neutrophilic expression of vascular endothelial growth factor after traumatic brain injury. Neuroscience. 2003; 122(4): 853-67.
    • (2003) Neuroscience , vol.122 , Issue.4 , pp. 853-867
    • Chodobski, A.1    Chung, I.2    Koźniewska, E.3    Ivanenko, T.4    Chang, W.5    Harrington, J.F.6
  • 78
    • 77955570062 scopus 로고    scopus 로고
    • Glutamate receptors, neurotoxicity and neurodegeneration
    • Lau A, Tymianski M. Glutamate receptors, neurotoxicity and neurodegeneration. Pflügers Arch. 2010; 460(2): 525-42.
    • (2010) Pflügers Arch. , vol.460 , Issue.2 , pp. 525-542
    • Lau, A.1    Tymianski, M.2
  • 80
    • 0038102462 scopus 로고    scopus 로고
    • Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus
    • Gillard SE, Tzaferis J, Tsui HC, Kingston AE. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. J Comp Neurol. 2003; 461(3): 317-32.
    • (2003) J Comp Neurol , vol.461 , Issue.3 , pp. 317-332
    • Gillard, S.E.1    Tzaferis, J.2    Tsui, H.C.3    Kingston, A.E.4
  • 81
    • 0345303766 scopus 로고    scopus 로고
    • Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor
    • Sharp CD, Hines I, Houghton J, Warren A, Jackson THt, Jawahar A, et al. Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. Am J Physiol. 2003; 285(6): H2592-8.
    • (2003) Am J Physiol , vol.285 , Issue.6
    • Sharp, C.D.1    Hines, I.2    Houghton, J.3    Warren, A.4    Jackson, T.5    Jawahar, A.6
  • 82
    • 0002684715 scopus 로고    scopus 로고
    • Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells
    • Morley P, Small DL, Murray CL, Mealing GA, Poulter MO, Durkin JP, et al. Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells. J Cereb Blood Flow Metab. 1998; 18(4): 396-406.
    • (1998) J Cereb Blood Flow Metab , vol.18 , Issue.4 , pp. 396-406
    • Morley, P.1    Small, D.L.2    Murray, C.L.3    Mealing, G.A.4    Poulter, M.O.5    Durkin, J.P.6
  • 83
    • 15744362982 scopus 로고    scopus 로고
    • N-methyl-d-aspartate receptor activation in human cerebral endothelium promotes intracellular oxidant stress
    • Sharp CD, Houghton J, Elrod JW, Warren A, Jackson THt, Jawahar A, et al. N-methyl-d-aspartate receptor activation in human cerebral endothelium promotes intracellular oxidant stress. Am J Physiol. 2005; 288(4): H1893-9.
    • (2005) Am J Physiol , vol.288 , Issue.4
    • Sharp, C.D.1    Houghton, J.2    Elrod, J.W.3    Warren, A.4    Jackson, T.5    Jawahar, A.6
  • 84
    • 0034520063 scopus 로고    scopus 로고
    • Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-d-aspartate receptor antagonist, after experimental traumatic brain injury in rats
    • discussion 404-6
    • Dempsey RJ, Bas{comma below}kaya MK, Doǧan A. Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-d-aspartate receptor antagonist, after experimental traumatic brain injury in rats. Neurosurgery. 2000; 47(2): 399-404. discussion 404-6.
    • (2000) Neurosurgery , vol.47 , Issue.2 , pp. 399-404
    • Dempsey, R.J.1    Baskaya, M.K.2    Doǧan, A.3
  • 85
    • 33646436473 scopus 로고    scopus 로고
    • Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection
    • Parfenova H, Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, et al. Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. Am J Physiol. 2006; 290(5): C1399-410.
    • (2006) Am J Physiol , vol.290 , Issue.5
    • Parfenova, H.1    Basuroy, S.2    Bhattacharya, S.3    Tcheranova, D.4    Qu, Y.5    Regan, R.F.6
  • 86
    • 0037313972 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase
    • Parfenova H, Fedinec A, Leffler CW. Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase. J Cereb Blood Flow Metab. 2003; 23(2): 190-7.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.2 , pp. 190-197
    • Parfenova, H.1    Fedinec, A.2    Leffler, C.W.3
  • 87
    • 57349133682 scopus 로고    scopus 로고
    • Cerebromicrovascular endothelial cells are resistant to l-glutamate
    • Domoki F, Kis B, Gáspár T, Bari F, Busija DW. Cerebromicrovascular endothelial cells are resistant to l-glutamate. Am J Physiol. 2008; 295(4): R1099-108.
    • (2008) Am J Physiol , vol.295 , Issue.4
    • Domoki, F.1    Kis, B.2    Gáspár, T.3    Bari, F.4    Busija, D.W.5
  • 88
    • 72949115293 scopus 로고    scopus 로고
    • Antioxidant therapies for traumatic brain injury
    • Hall ED, Vaishnav RA, Mustafa AG. Antioxidant therapies for traumatic brain injury. Neurotherapeutics. 2010; 7(1): 51-61.
    • (2010) Neurotherapeutics , vol.7 , Issue.1 , pp. 51-61
    • Hall, E.D.1    Vaishnav, R.A.2    Mustafa, A.G.3
  • 89
    • 0027968141 scopus 로고
    • Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat
    • Smith SL, Andrus PK, Zhang JR, Hall ED. Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J Neurotrauma. 1994; 11(4): 393-404.
    • (1994) J Neurotrauma. , vol.11 , Issue.4 , pp. 393-404
    • Smith, S.L.1    Andrus, P.K.2    Zhang, J.R.3    Hall, E.D.4
  • 90
    • 0035900210 scopus 로고    scopus 로고
    • 4-Hydroxynonenal impairs the permeability of an in vitro rat blood-brain barrier
    • Mertsch K, Blasig I, Grune T. 4-Hydroxynonenal impairs the permeability of an in vitro rat blood-brain barrier. Neurosci Lett. 2001; 314(3): 135-8.
    • (2001) Neurosci Lett , vol.314 , Issue.3 , pp. 135-138
    • Mertsch, K.1    Blasig, I.2    Grune, T.3
  • 91
    • 0032752658 scopus 로고    scopus 로고
    • Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat
    • Agarwal R, Shukla GS. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. Neurochem Res. 1999; 24(12): 1507-14.
    • (1999) Neurochem Res , vol.24 , Issue.12 , pp. 1507-1514
    • Agarwal, R.1    Shukla, G.S.2
  • 92
    • 35948971753 scopus 로고    scopus 로고
    • Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling
    • Schreibelt G, Kooij G, Reijerkerk A, van Doorn R, Gringhuis SI, van der Pol S, et al. Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J. 2007; 21(13): 3666-76.
    • (2007) FASEB J , vol.21 , Issue.13 , pp. 3666-3676
    • Schreibelt, G.1    Kooij, G.2    Reijerkerk, A.3    van Doorn, R.4    Gringhuis, S.I.5    van der Pol, S.6
  • 93
    • 21444450963 scopus 로고    scopus 로고
    • 2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway
    • 2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway. Eur J Cell Biol. 2005; 84(7): 687-97.
    • (2005) Eur J Cell Biol. , vol.84 , Issue.7 , pp. 687-697
    • Fischer, S.1    Wiesnet, M.2    Renz, D.3    Schaper, W.4
  • 94
    • 34047114464 scopus 로고    scopus 로고
    • Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction
    • Haorah J, Ramirez SH, Schall K, Smith D, Pandya R, Persidsky Y. Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J Neurochem. 2007; 101(2): 566-76.
    • (2007) J Neurochem , vol.101 , Issue.2 , pp. 566-576
    • Haorah, J.1    Ramirez, S.H.2    Schall, K.3    Smith, D.4    Pandya, R.5    Persidsky, Y.6
  • 95
    • 0032513129 scopus 로고    scopus 로고
    • Nitric oxide protects blood-brain barrier in vitro from hypoxia/reoxygenation-mediated injury
    • Utepbergenov DI, Mertsch K, Sporbert A, Tenz K, Paul M, Haseloff RF, et al. Nitric oxide protects blood-brain barrier in vitro from hypoxia/reoxygenation-mediated injury. FEBS Lett. 1998; 424(3): 197-201.
    • (1998) FEBS Lett , vol.424 , Issue.3 , pp. 197-201
    • Utepbergenov, D.I.1    Mertsch, K.2    Sporbert, A.3    Tenz, K.4    Paul, M.5    Haseloff, R.F.6
  • 97
    • 0027742538 scopus 로고
    • Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I
    • Bradley JR, Johnson DR, Pober JS. Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. Am J Pathol. 1993; 142(5): 1598-609.
    • (1993) Am J Pathol , vol.142 , Issue.5 , pp. 1598-1609
    • Bradley, J.R.1    Johnson, D.R.2    Pober, J.S.3
  • 98
    • 31344458952 scopus 로고    scopus 로고
    • Structure and function of matrix metalloproteinases and TIMPs
    • Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 2006; 69(3): 562-73.
    • (2006) Cardiovasc Res , vol.69 , Issue.3 , pp. 562-573
    • Nagase, H.1    Visse, R.2    Murphy, G.3
  • 99
    • 20344373695 scopus 로고    scopus 로고
    • Multiple roles for MMPs and TIMPs in cerebral ischemia
    • Cunningham LA, Wetzel M, Rosenberg GA. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia. 2005; 50(4): 329-39.
    • (2005) Glia , vol.50 , Issue.4 , pp. 329-339
    • Cunningham, L.A.1    Wetzel, M.2    Rosenberg, G.A.3
  • 100
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2007; 27(4): 697-709.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.4 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 101
    • 34547793659 scopus 로고    scopus 로고
    • Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    • Rosenberg GA, Yang Y. Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus. 2007; 22(5): E4.
    • (2007) Neurosurg Focus , vol.22 , Issue.5
    • Rosenberg, G.A.1    Yang, Y.2
  • 102
    • 0035793934 scopus 로고    scopus 로고
    • Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures
    • Rosenberg GA, Cunningham LA, Wallace J, Alexander S, Estrada EY, Grossetete M, et al. Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res. 2001; 893(1-2): 104-12.
    • (2001) Brain Res. , vol.893 , Issue.1-2 , pp. 104-112
    • Rosenberg, G.A.1    Cunningham, L.A.2    Wallace, J.3    Alexander, S.4    Estrada, E.Y.5    Grossetete, M.6
  • 104
    • 57549112353 scopus 로고    scopus 로고
    • Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
    • Newby AC. Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol. 2008; 28(12): 2108-14.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.12 , pp. 2108-2114
    • Newby, A.C.1
  • 105
    • 27544505259 scopus 로고    scopus 로고
    • Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats
    • Truettner JS, Alonso OF, Dalton Dietrich W. Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats. J Cereb Blood Flow Metab. 2005; 25(11): 1505-16.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.11 , pp. 1505-1516
    • Truettner, J.S.1    Alonso, O.F.2    Dalton Dietrich, W.3
  • 107
    • 48149099095 scopus 로고    scopus 로고
    • Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases
    • Vilalta A, Sahuquillo J, Rosell A, Poca MA, Riveiro M, Montaner J. Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases. Intensive Care Med. 2008; 34(8): 1384-92.
    • (2008) Intensive Care Med , vol.34 , Issue.8 , pp. 1384-1392
    • Vilalta, A.1    Sahuquillo, J.2    Rosell, A.3    Poca, M.A.4    Riveiro, M.5    Montaner, J.6
  • 108
    • 0033638508 scopus 로고    scopus 로고
    • Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    • Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000; 20(12): 1681-9.
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.12 , pp. 1681-1689
    • Asahi, M.1    Asahi, K.2    Jung, J.C.3    Del Zoppo, G.J.4    Fini, M.E.5    Lo, E.H.6
  • 109
    • 0034666112 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury
    • Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, et al. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000; 20(18): 7037-42.
    • (2000) J Neurosci , vol.20 , Issue.18 , pp. 7037-7042
    • Wang, X.1    Jung, J.2    Asahi, M.3    Chwang, W.4    Russo, L.5    Moskowitz, M.A.6
  • 110
    • 52549107417 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia
    • Fujimoto M, Takagi Y, Aoki T, Hayase M, Marumo T, Gomi M, et al. Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab. 2008; 28(10): 1674-85.
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.10 , pp. 1674-1685
    • Fujimoto, M.1    Takagi, Y.2    Aoki, T.3    Hayase, M.4    Marumo, T.5    Gomi, M.6
  • 111
    • 75449117953 scopus 로고    scopus 로고
    • Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1
    • Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, et al. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009; 26(11): 1935-41.
    • (2009) J Neurotrauma. , vol.26 , Issue.11 , pp. 1935-1941
    • Tejima, E.1    Guo, S.2    Murata, Y.3    Arai, K.4    Lok, J.5    van Leyen, K.6
  • 112
    • 33645744014 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in delayed cortical responses after stroke
    • Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, et al. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006; 12(4): 441-5.
    • (2006) Nat Med. , vol.12 , Issue.4 , pp. 441-445
    • Zhao, B.Q.1    Wang, S.2    Kim, H.Y.3    Storrie, H.4    Rosen, B.R.5    Mooney, D.J.6
  • 113
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9(6): 669-76.
    • (2003) Nat Med. , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 114
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA
    • Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol. 1991; 5(12): 1806-14.
    • (1991) Mol Endocrinol , vol.5 , Issue.12 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3    Cachianes, G.4    Li, B.5    Leung, D.W.6
  • 115
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem. 1992; 267(36): 26031-7.
    • (1992) J Biol Chem , vol.267 , Issue.36 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 116
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell. 1993; 4(12): 1317-26.
    • (1993) Mol Biol Cell. , vol.4 , Issue.12 , pp. 1317-1326
    • Park, J.E.1    Keller, G.A.2    Ferrara, N.3
  • 117
    • 0030976894 scopus 로고    scopus 로고
    • Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect
    • Plouët J, Moro F, Bertagnolli S, Coldeboeuf N, Mazarguil H, Clamens S, et al. Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect. J Biol Chem. 1997; 272(20): 13390-6.
    • (1997) J Biol Chem , vol.272 , Issue.20 , pp. 13390-13396
    • Plouët, J.1    Moro, F.2    Bertagnolli, S.3    Coldeboeuf, N.4    Mazarguil, H.5    Clamens, S.6
  • 118
    • 22344437713 scopus 로고    scopus 로고
    • Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    • Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol. 2005; 169(4): 681-91.
    • (2005) J Cell Biol. , vol.169 , Issue.4 , pp. 681-691
    • Lee, S.1    Jilani, S.M.2    Nikolova, G.V.3    Carpizo, D.4    Iruela-Arispe, M.L.5
  • 120
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    • Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA. 1993; 90(22): 10705-9.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.22 , pp. 10705-10709
    • Kendall, R.L.1    Thomas, K.A.2
  • 121
    • 3543131382 scopus 로고    scopus 로고
    • A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma
    • Ebos JM, Bocci G, Man S, Thorpe PE, Hicklin DJ, Zhou D, et al. A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma. Mol Cancer Res. 2004; 2(6): 315-26.
    • (2004) Mol Cancer Res. , vol.2 , Issue.6 , pp. 315-326
    • Ebos, J.M.1    Bocci, G.2    Man, S.3    Thorpe, P.E.4    Hicklin, D.J.5    Zhou, D.6
  • 122
    • 34249318758 scopus 로고    scopus 로고
    • Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability
    • Kumai Y, Ooboshi H, Ibayashi S, Ishikawa E, Sugimori H, Kamouchi M, et al. Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability. J Cereb Blood Flow Metab. 2007; 27(6): 1152-60.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.6 , pp. 1152-1160
    • Kumai, Y.1    Ooboshi, H.2    Ibayashi, S.3    Ishikawa, E.4    Sugimori, H.5    Kamouchi, M.6
  • 124
    • 1442303839 scopus 로고    scopus 로고
    • Very early expression of vascular endothelial growth factor in brain oedema tissue associated with brain contusion
    • Suzuki R, Fukai N, Nagashijma G, Asai JI, Itokawa H, Nagai M, et al. Very early expression of vascular endothelial growth factor in brain oedema tissue associated with brain contusion. Acta Neurochir Suppl. 2003; 86: 277-9.
    • (2003) Acta Neurochir Suppl. , vol.86 , pp. 277-279
    • Suzuki, R.1    Fukai, N.2    Nagashijma, G.3    Asai, J.I.4    Itokawa, H.5    Nagai, M.6
  • 125
    • 0035021651 scopus 로고    scopus 로고
    • VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly
    • Wang W, Dentler WL, Borchardt RT. VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly. Am J Physiol. 2001; 280(1): H434-40.
    • (2001) Am J Physiol , vol.280 , Issue.1
    • Wang, W.1    Dentler, W.L.2    Borchardt, R.T.3
  • 126
    • 68949129005 scopus 로고    scopus 로고
    • Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
    • Murakami T, Felinski EA, Antonetti DA. Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem. 2009; 284(31): 21036-46.
    • (2009) J Biol Chem , vol.284 , Issue.31 , pp. 21036-21046
    • Murakami, T.1    Felinski, E.A.2    Antonetti, D.A.3
  • 127
    • 60649108674 scopus 로고    scopus 로고
    • VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
    • Argaw AT, Gurfein BT, Zhang Y, Zameer A, John GR. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci USA. 2009; 106(6): 1977-82.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.6 , pp. 1977-1982
    • Argaw, A.T.1    Gurfein, B.T.2    Zhang, Y.3    Zameer, A.4    John, G.R.5
  • 128
    • 34249865081 scopus 로고    scopus 로고
    • Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway
    • Vogel C, Bauer A, Wiesnet M, Preissner KT, Schaper W, Marti HH, et al. Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway. J Cell Physiol. 2007; 212(1): 236-43.
    • (2007) J Cell Physiol , vol.212 , Issue.1 , pp. 236-243
    • Vogel, C.1    Bauer, A.2    Wiesnet, M.3    Preissner, K.T.4    Schaper, W.5    Marti, H.H.6
  • 129
    • 0031825437 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells
    • Esser S, Lampugnani MG, Corada M, Dejana E, Risau W. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci. 1998; 111(13): 1853-65.
    • (1998) J Cell Sci. , vol.111 , Issue.13 , pp. 1853-1865
    • Esser, S.1    Lampugnani, M.G.2    Corada, M.3    Dejana, E.4    Risau, W.5
  • 130
    • 70350015332 scopus 로고    scopus 로고
    • The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species
    • Monaghan-Benson E, Burridge K. The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species. J Biol Chem. 2009; 284(38): 25602-11.
    • (2009) J Biol Chem , vol.284 , Issue.38 , pp. 25602-25611
    • Monaghan-Benson, E.1    Burridge, K.2
  • 131
    • 0029620361 scopus 로고
    • Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury
    • Soares HD, Hicks RR, Smith D, McIntosh TK. Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci. 1995; 15(12): 8223-33.
    • (1995) J Neurosci , vol.15 , Issue.12 , pp. 8223-8233
    • Soares, H.D.1    Hicks, R.R.2    Smith, D.3    McIntosh, T.K.4
  • 132
    • 0033606040 scopus 로고    scopus 로고
    • Kinetics of polymorphonuclear neutrophil infiltration after a traumatic brain injury in rat
    • Royo NC, Wahl F, Stutzmann JM. Kinetics of polymorphonuclear neutrophil infiltration after a traumatic brain injury in rat. NeuroReport. 1999; 10(6): 1363-7.
    • (1999) NeuroReport , vol.10 , Issue.6 , pp. 1363-1367
    • Royo, N.C.1    Wahl, F.2    Stutzmann, J.M.3
  • 133
    • 0344074656 scopus 로고    scopus 로고
    • Intracerebral inflammation after human brain contusion
    • discussion 298-9
    • Holmin S, Söderlund J, Biberfeld P, Mathiesen T. Intracerebral inflammation after human brain contusion. Neurosurgery. 1998; 42(2): 291-8. discussion 298-9.
    • (1998) Neurosurgery , vol.42 , Issue.2 , pp. 291-298
    • Holmin, S.1    Söderlund, J.2    Biberfeld, P.3    Mathiesen, T.4
  • 134
    • 0035479822 scopus 로고    scopus 로고
    • Leukocyte transendothelial migration: orchestrating the underlying molecular machinery
    • Worthylake RA, Burridge K. Leukocyte transendothelial migration: orchestrating the underlying molecular machinery. Curr Opin Cell Biol. 2001; 13(5): 569-77.
    • (2001) Curr Opin Cell Biol , vol.13 , Issue.5 , pp. 569-577
    • Worthylake, R.A.1    Burridge, K.2
  • 135
    • 0029759630 scopus 로고    scopus 로고
    • Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats
    • Clark RS, Carlos TM, Schiding JK, Bree M, Fireman LA, DeKosky ST, et al. Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats. J Neurotrauma. 1996; 13(6): 333-41.
    • (1996) J Neurotrauma. , vol.13 , Issue.6 , pp. 333-341
    • Clark, R.S.1    Carlos, T.M.2    Schiding, J.K.3    Bree, M.4    Fireman, L.A.5    Dekosky, S.T.6
  • 136
    • 0033932664 scopus 로고    scopus 로고
    • Effect of leukocyte-endothelial adhesion antagonism on neutrophil migration and neurologic outcome after cortical trauma
    • Weaver KD, Branch CA, Hernandez L, Miller CH, Quattrocchi KB. Effect of leukocyte-endothelial adhesion antagonism on neutrophil migration and neurologic outcome after cortical trauma. J Trauma. 2000; 48(6): 1081-90.
    • (2000) J Trauma. , vol.48 , Issue.6 , pp. 1081-1090
    • Weaver, K.D.1    Branch, C.A.2    Hernandez, L.3    Miller, C.H.4    Quattrocchi, K.B.5
  • 137
    • 0036738821 scopus 로고    scopus 로고
    • Administration of either anti-intercellular adhesion molecule-1 or a nonspecific control antibody improves recovery after traumatic brain injury in the rat
    • Knoblach SM, Faden AI. Administration of either anti-intercellular adhesion molecule-1 or a nonspecific control antibody improves recovery after traumatic brain injury in the rat. J Neurotrauma. 2002; 19(9): 1039-50.
    • (2002) J Neurotrauma. , vol.19 , Issue.9 , pp. 1039-1050
    • Knoblach, S.M.1    Faden, A.I.2
  • 138
    • 41949101390 scopus 로고    scopus 로고
    • Transient blockage of the CD11d/CD18 integrin reduces contusion volume and macrophage infiltration after traumatic brain injury in rats
    • Utagawa A, Bramlett HM, Daniels L, Lotocki G, Dekaban GA, Weaver LC, et al. Transient blockage of the CD11d/CD18 integrin reduces contusion volume and macrophage infiltration after traumatic brain injury in rats. Brain Res. 2008; 1207: 155-63.
    • (2008) Brain Res. , vol.1207 , pp. 155-163
    • Utagawa, A.1    Bramlett, H.M.2    Daniels, L.3    Lotocki, G.4    Dekaban, G.A.5    Weaver, L.C.6
  • 139
    • 0032926263 scopus 로고    scopus 로고
    • Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome
    • Whalen MJ, Carlos TM, Dixon CE, Schiding JK, Clark RS, Baum E, et al. Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome. J Neurotrauma. 1999; 16(4): 299-309.
    • (1999) J Neurotrauma. , vol.16 , Issue.4 , pp. 299-309
    • Whalen, M.J.1    Carlos, T.M.2    Dixon, C.E.3    Schiding, J.K.4    Clark, R.S.5    Baum, E.6
  • 140
    • 0033795488 scopus 로고    scopus 로고
    • Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1
    • Whalen MJ, Carlos TM, Dixon CE, Robichaud P, Clark RS, Marion DW, et al. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J Leukoc Biol. 2000; 67(2): 160-8.
    • (2000) J Leukoc Biol , vol.67 , Issue.2 , pp. 160-168
    • Whalen, M.J.1    Carlos, T.M.2    Dixon, C.E.3    Robichaud, P.4    Clark, R.S.5    Marion, D.W.6
  • 141
    • 50049089619 scopus 로고    scopus 로고
    • Moving targets: cell migration inhibitors as new anti-inflammatory therapies
    • Mackay CR. Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol. 2008; 9(9): 988-98.
    • (2008) Nat Immunol , vol.9 , Issue.9 , pp. 988-998
    • Mackay, C.R.1
  • 142
    • 66249147220 scopus 로고    scopus 로고
    • Endogenous signals initiating inflammation in the injured nervous system
    • Pineau I, Lacroix S. Endogenous signals initiating inflammation in the injured nervous system. Glia. 2009; 57(4): 351-61.
    • (2009) Glia , vol.57 , Issue.4 , pp. 351-361
    • Pineau, I.1    Lacroix, S.2
  • 143
    • 77956225959 scopus 로고    scopus 로고
    • Expression and regulation of toll-like receptors in cerebral endothelial cells
    • Nagyo{double acute}szi P, Wilhelm I, Farkas AE, Fazakas C, Dung NT, Haskó J, et al. Expression and regulation of toll-like receptors in cerebral endothelial cells. Neurochem Int. 2010; 57(5): 556-64.
    • (2010) Neurochem Int , vol.57 , Issue.5 , pp. 556-564
    • Nagyoszi, P.1    Wilhelm, I.2    Farkas, A.E.3    Fazakas, C.4    Dung, N.T.5    Haskó, J.6
  • 144
    • 33847099936 scopus 로고    scopus 로고
    • Astrocytes are active players in cerebral innate immunity
    • Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol. 2007; 28(3): 138-45.
    • (2007) Trends Immunol. , vol.28 , Issue.3 , pp. 138-145
    • Farina, C.1    Aloisi, F.2    Meinl, E.3
  • 145
    • 0031242254 scopus 로고    scopus 로고
    • Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms
    • Barnard EA, Simon J, Webb TE. Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms. Mol Neurobiol. 1997; 15(2): 103-29.
    • (1997) Mol Neurobiol , vol.15 , Issue.2 , pp. 103-129
    • Barnard, E.A.1    Simon, J.2    Webb, T.E.3
  • 147
    • 33747412582 scopus 로고    scopus 로고
    • Pathophysiological roles of P2 receptors in glial cells
    • discussion 103-12, 275-81
    • Abbracchio MP, Verderio C. Pathophysiological roles of P2 receptors in glial cells. Novartis Found Symp. 2006; 276: 91-103. discussion 103-12, 275-81.
    • (2006) Novartis Found Symp , vol.276 , pp. 91-103
    • Abbracchio, M.P.1    Verderio, C.2
  • 149
    • 0033742535 scopus 로고    scopus 로고
    • Stretch-induced endothelin-1 production by astrocytes
    • Ostrow LW, Langan TJ, Sachs F. Stretch-induced endothelin-1 production by astrocytes. J Cardiovasc Pharmacol. 2000; 36 Suppl 1: S274-7.
    • (2000) J Cardiovasc Pharmacol , vol.36 , Issue.SUPPL. 1
    • Ostrow, L.W.1    Langan, T.J.2    Sachs, F.3
  • 150
    • 80054820481 scopus 로고    scopus 로고
    • Mild stretch-induced injury increases susceptibility to interleukin-1β-induced release of matrix metalloproteinase-9 from astrocytes
    • Ralay Ranaivo H, Zunich S, Choi N, Hodge J, Wainwright M. Mild stretch-induced injury increases susceptibility to interleukin-1β-induced release of matrix metalloproteinase-9 from astrocytes. J Neurotrauma. 2011; 28(9): 1757-66.
    • (2011) J Neurotrauma , vol.28 , Issue.9 , pp. 1757-1766
    • Ralay Ranaivo, H.1    Zunich, S.2    Choi, N.3    Hodge, J.4    Wainwright, M.5
  • 151
    • 0029960060 scopus 로고    scopus 로고
    • Experimental brain injury induces differential expression of tumor necrosis factor-α mRNA in the CNS
    • Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK. Experimental brain injury induces differential expression of tumor necrosis factor-α mRNA in the CNS. Mol Brain Res. 1996; 36(2): 287-91.
    • (1996) Mol Brain Res. , vol.36 , Issue.2 , pp. 287-291
    • Fan, L.1    Young, P.R.2    Barone, F.C.3    Feuerstein, G.Z.4    Smith, D.H.5    McIntosh, T.K.6
  • 153
    • 0036664602 scopus 로고    scopus 로고
    • Interleukin-1β messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature
    • discussion 203
    • Kinoshita K, Chatzipanteli K, Vitarbo E, Truettner JS, Alonso OF, Dietrich WD. Interleukin-1β messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature. Neurosurgery. 2002; 51(1): 195-203. discussion 203.
    • (2002) Neurosurgery , vol.51 , Issue.1 , pp. 195-203
    • Kinoshita, K.1    Chatzipanteli, K.2    Vitarbo, E.3    Truettner, J.S.4    Alonso, O.F.5    Dietrich, W.D.6
  • 154
    • 0027400847 scopus 로고
    • Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre-and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand
    • Taupin V, Toulmond S, Serrano A, Benavides J, Zavala F. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol. 1993; 42(2): 177-85.
    • (1993) J Neuroimmunol , vol.42 , Issue.2 , pp. 177-185
    • Taupin, V.1    Toulmond, S.2    Serrano, A.3    Benavides, J.4    Zavala, F.5
  • 156
    • 0033574558 scopus 로고    scopus 로고
    • Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-α exposure
    • Mark KS, Miller DW. Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-α exposure. Life Sci. 1999; 64(21): 1941-53.
    • (1999) Life Sci , vol.64 , Issue.21 , pp. 1941-1953
    • Mark, K.S.1    Miller, D.W.2
  • 157
    • 34548434392 scopus 로고    scopus 로고
    • Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration
    • Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK. Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci. 2007; 27(35): 9301-9.
    • (2007) J Neurosci , vol.27 , Issue.35 , pp. 9301-9309
    • Shaftel, S.S.1    Carlson, T.J.2    Olschowka, J.A.3    Kyrkanides, S.4    Matousek, S.B.5    O'Banion, M.K.6
  • 158
    • 2642615752 scopus 로고    scopus 로고
    • Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
    • Wójciak-Stothard B, Entwistle A, Garg R, Ridley AJ. Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J Cell Physiol. 1998; 176(1): 150-65.
    • (1998) J Cell Physiol , vol.176 , Issue.1 , pp. 150-165
    • Wójciak-Stothard, B.1    Entwistle, A.2    Garg, R.3    Ridley, A.J.4
  • 159
    • 0042525938 scopus 로고    scopus 로고
    • NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
    • Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, et al. NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003; 22(15): 3898-909.
    • (2003) EMBO J , vol.22 , Issue.15 , pp. 3898-3909
    • Sakon, S.1    Xue, X.2    Takekawa, M.3    Sasazuki, T.4    Okazaki, T.5    Kojima, Y.6
  • 160
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ
    • Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, et al. Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ. J Cell Sci. 2000; 113(11): 2085-90.
    • (2000) J Cell Sci. , vol.113 , Issue.11 , pp. 2085-2090
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3    Mankertz, A.4    Riecken, E.O.5    Fromm, M.6
  • 161
    • 0028353728 scopus 로고
    • ICAM-1 expression on human brain microvascular endothelial cells
    • Hess DC, Bhutwala T, Sheppard JC, Zhao W, Smith J. ICAM-1 expression on human brain microvascular endothelial cells. Neurosci Lett. 1994; 168(1-2): 201-4.
    • (1994) Neurosci Lett , vol.168 , Issue.1-2 , pp. 201-204
    • Hess, D.C.1    Bhutwala, T.2    Sheppard, J.C.3    Zhao, W.4    Smith, J.5
  • 162
    • 0029067723 scopus 로고
    • Expression of vascular cell adhesion molecule-1 (VCAM-1) by human brain microvessel endothelial cells in primary culture
    • Wong D, Dorovini-Zis K. Expression of vascular cell adhesion molecule-1 (VCAM-1) by human brain microvessel endothelial cells in primary culture. Microvasc Res. 1995; 49(3): 325-39.
    • (1995) Microvasc Res , vol.49 , Issue.3 , pp. 325-339
    • Wong, D.1    Dorovini-Zis, K.2
  • 163
    • 0029664486 scopus 로고    scopus 로고
    • Regualtion by cytokines and lipopolysaccharide of E-selectin expression by human brain microvessel endothelial cells in primary culture
    • Wong D, Dorovini-Zis K. Regualtion by cytokines and lipopolysaccharide of E-selectin expression by human brain microvessel endothelial cells in primary culture. J Neuropathol Exp Neurol. 1996; 55(2): 225-35.
    • (1996) J Neuropathol Exp Neurol , vol.55 , Issue.2 , pp. 225-235
    • Wong, D.1    Dorovini-Zis, K.2
  • 164
    • 0031298625 scopus 로고    scopus 로고
    • Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults
    • Stanimirovic DB, Wong J, Shapiro A, Durkin JP. Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults. Acta Neurochir Suppl. 1997; 70: 12-6.
    • (1997) Acta Neurochir Suppl. , vol.70 , pp. 12-16
    • Stanimirovic, D.B.1    Wong, J.2    Shapiro, A.3    Durkin, J.P.4
  • 165
    • 0033454739 scopus 로고    scopus 로고
    • Regulation of intercellular adhesion molecule-1 (CD54) gene expression
    • Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol. 1999; 66(6): 876-88.
    • (1999) J Leukoc Biol , vol.66 , Issue.6 , pp. 876-888
    • Roebuck, K.A.1    Finnegan, A.2
  • 166
    • 0030891491 scopus 로고    scopus 로고
    • Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats
    • Carlos TM, Clark RS, Franicola-Higgins D, Schiding JK, Kochanek PM. Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats. J Leukoc Biol. 1997; 61(3): 279-85.
    • (1997) J Leukoc Biol , vol.61 , Issue.3 , pp. 279-285
    • Carlos, T.M.1    Clark, R.S.2    Franicola-Higgins, D.3    Schiding, J.K.4    Kochanek, P.M.5
  • 167
    • 0035074345 scopus 로고    scopus 로고
    • Endothelial cell activation following moderate traumatic brain injury
    • Balabanov R, Goldman H, Murphy S, Pellizon G, Owen C, Rafols J, et al. Endothelial cell activation following moderate traumatic brain injury. Neurol Res. 2001; 23(2-3): 175-82.
    • (2001) Neurol Res , vol.23 , Issue.2-3 , pp. 175-182
    • Balabanov, R.1    Goldman, H.2    Murphy, S.3    Pellizon, G.4    Owen, C.5    Rafols, J.6
  • 168
    • 0031965653 scopus 로고    scopus 로고
    • The relationship of soluble adhesion molecule concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury
    • McKeating EG, Andrews PJ, Mascia L. The relationship of soluble adhesion molecule concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury. Anesth Analg. 1998; 86(4): 759-65.
    • (1998) Anesth Analg , vol.86 , Issue.4 , pp. 759-765
    • McKeating, E.G.1    Andrews, P.J.2    Mascia, L.3
  • 169
    • 0031776012 scopus 로고    scopus 로고
    • Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury
    • Pleines UE, Stover JF, Kossmann T, Trentz O, Morganti-Kossmann MC. Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury. J Neurotrauma. 1998; 15(6): 399-409.
    • (1998) J Neurotrauma. , vol.15 , Issue.6 , pp. 399-409
    • Pleines, U.E.1    Stover, J.F.2    Kossmann, T.3    Trentz, O.4    Morganti-Kossmann, M.C.5
  • 170
    • 0030851444 scopus 로고    scopus 로고
    • New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats
    • Yamasaki Y, Matsuo Y, Zagorski J, Matsuura N, Onodera H, Itoyama Y, et al. New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats. Brain Res. 1997; 759(1): 103-11.
    • (1997) Brain Res. , vol.759 , Issue.1 , pp. 103-111
    • Yamasaki, Y.1    Matsuo, Y.2    Zagorski, J.3    Matsuura, N.4    Onodera, H.5    Itoyama, Y.6
  • 171
    • 0034991284 scopus 로고    scopus 로고
    • Neuroprotection in ischemia-reperfusion injury: an antiinflammatory approach using a novel broad-spectrum chemokine inhibitor
    • Beech JS, Reckless J, Mosedale DE, Grainger DJ, Williams SC, Menon DK. Neuroprotection in ischemia-reperfusion injury: an antiinflammatory approach using a novel broad-spectrum chemokine inhibitor. J Cereb Blood Flow Metab. 2001; 21(6): 683-9.
    • (2001) J Cereb Blood Flow Metab , vol.21 , Issue.6 , pp. 683-689
    • Beech, J.S.1    Reckless, J.2    Mosedale, D.E.3    Grainger, D.J.4    Williams, S.C.5    Menon, D.K.6
  • 172
    • 34247874753 scopus 로고    scopus 로고
    • Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice
    • Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV. Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke. 2007; 38(4): 1345-53.
    • (2007) Stroke , vol.38 , Issue.4 , pp. 1345-1353
    • Dimitrijevic, O.B.1    Stamatovic, S.M.2    Keep, R.F.3    Andjelkovic, A.V.4
  • 173
    • 79953091772 scopus 로고    scopus 로고
    • Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury
    • Semple BD, Bye N, Ziebell JM, Morganti-Kossmann MC. Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury. Neurobiol Dis. 2010; 40(2): 394-403.
    • (2010) Neurobiol Dis , vol.40 , Issue.2 , pp. 394-403
    • Semple, B.D.1    Bye, N.2    Ziebell, J.M.3    Morganti-Kossmann, M.C.4
  • 174
    • 77950520442 scopus 로고    scopus 로고
    • Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice
    • Semple BD, Bye N, Rancan M, Ziebell JM, Morganti-Kossmann MC. Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice. J Cereb Blood Flow Metab. 2010; 30(4): 769-82.
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.4 , pp. 769-782
    • Semple, B.D.1    Bye, N.2    Rancan, M.3    Ziebell, J.M.4    Morganti-Kossmann, M.C.5
  • 175
    • 0029784344 scopus 로고    scopus 로고
    • Recombinant human adenovirus with rat MIP-2 gene insertion causes prolonged PMN recruitment to the murine brain
    • Bell MD, Taub DD, Kunkel SJ, Strieter RM, Foley R, Gauldie J, et al. Recombinant human adenovirus with rat MIP-2 gene insertion causes prolonged PMN recruitment to the murine brain. Eur J Neurosci. 1996; 8(9): 1803-11.
    • (1996) Eur J Neurosci , vol.8 , Issue.9 , pp. 1803-1811
    • Bell, M.D.1    Taub, D.D.2    Kunkel, S.J.3    Strieter, R.M.4    Foley, R.5    Gauldie, J.6
  • 176
    • 0028841168 scopus 로고
    • Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1
    • Fuentes ME, Durham SK, Swerdel MR, Lewin AC, Barton DS, Megill JR, et al. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. J Immunol. 1995; 155(12): 5769-76.
    • (1995) J Immunol , vol.155 , Issue.12 , pp. 5769-5776
    • Fuentes, M.E.1    Durham, S.K.2    Swerdel, M.R.3    Lewin, A.C.4    Barton, D.S.5    Megill, J.R.6
  • 177
    • 0038796526 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells
    • Chen Y, Hallenbeck JM, Ruetzler C, Bol D, Thomas K, Berman NE, et al. Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells. J Cereb Blood Flow Metab. 2003; 23(6): 748-55.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.6 , pp. 748-755
    • Chen, Y.1    Hallenbeck, J.M.2    Ruetzler, C.3    Bol, D.4    Thomas, K.5    Berman, N.E.6
  • 178
    • 77955893200 scopus 로고    scopus 로고
    • Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury
    • Szmydynger-Chodobska J, Fox LM, Lynch KM, Zink BJ, Chodobski A. Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury. J Neurotrauma. 2010; 27(8): 1449-61.
    • (2010) J Neurotrauma. , vol.27 , Issue.8 , pp. 1449-1461
    • Szmydynger-Chodobska, J.1    Fox, L.M.2    Lynch, K.M.3    Zink, B.J.4    Chodobski, A.5
  • 181
    • 0032743422 scopus 로고    scopus 로고
    • Increased expression of bioactive chemokines in human cerebromicrovascular endothelial cells and astrocytes subjected to simulated ischemia in vitro
    • Zhang W, Smith C, Shapiro A, Monette R, Hutchison J, Stanimirovic D. Increased expression of bioactive chemokines in human cerebromicrovascular endothelial cells and astrocytes subjected to simulated ischemia in vitro. J Neuroimmunol. 1999; 101(2): 148-60.
    • (1999) J Neuroimmunol , vol.101 , Issue.2 , pp. 148-160
    • Zhang, W.1    Smith, C.2    Shapiro, A.3    Monette, R.4    Hutchison, J.5    Stanimirovic, D.6
  • 182
    • 0036892646 scopus 로고    scopus 로고
    • Leukocyte extravasation: chemokine transport and presentation by the endothelium
    • Middleton J, Patterson AM, Gardner L, Schmutz C, Ashton BA. Leukocyte extravasation: chemokine transport and presentation by the endothelium. Blood. 2002; 100(12): 3853-60.
    • (2002) Blood , vol.100 , Issue.12 , pp. 3853-3860
    • Middleton, J.1    Patterson, A.M.2    Gardner, L.3    Schmutz, C.4    Ashton, B.A.5
  • 183
    • 39749175539 scopus 로고    scopus 로고
    • Transcellular transport of CCL2 across brain microvascular endothelial cells
    • Ge S, Song L, Serwanski DR, Kuziel WA, Pachter JS. Transcellular transport of CCL2 across brain microvascular endothelial cells. J Neurochem. 2008; 104(5): 1219-32.
    • (2008) J Neurochem , vol.104 , Issue.5 , pp. 1219-1232
    • Ge, S.1    Song, L.2    Serwanski, D.R.3    Kuziel, W.A.4    Pachter, J.S.5
  • 186
    • 0344465840 scopus 로고    scopus 로고
    • Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase
    • Stamatovic SM, Keep RF, Kunkel SL, Andjelkovic AV. Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci. 2003; 116(22): 4615-28.
    • (2003) J Cell Sci. , vol.116 , Issue.22 , pp. 4615-4628
    • Stamatovic, S.M.1    Keep, R.F.2    Kunkel, S.L.3    Andjelkovic, A.V.4
  • 187
    • 0025648347 scopus 로고
    • Early polymorphonuclear leukocyte accumulation correlates with the development of posttraumatic cerebral edema in rats
    • Schoettle RJ, Kochanek PM, Magargee MJ, Uhl MW, Nemoto EM. Early polymorphonuclear leukocyte accumulation correlates with the development of posttraumatic cerebral edema in rats. J Neurotrauma. 1990; 7(4): 207-17.
    • (1990) J Neurotrauma. , vol.7 , Issue.4 , pp. 207-217
    • Schoettle, R.J.1    Kochanek, P.M.2    Magargee, M.J.3    Uhl, M.W.4    Nemoto, E.M.5
  • 188
    • 0027931320 scopus 로고
    • Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats
    • Uhl MW, Biagas KV, Grundl PD, Barmada MA, Schiding JK, Nemoto EM, et al. Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats. J Neurotrauma. 1994; 11(3): 303-15.
    • (1994) J Neurotrauma. , vol.11 , Issue.3 , pp. 303-315
    • Uhl, M.W.1    Biagas, K.V.2    Grundl, P.D.3    Barmada, M.A.4    Schiding, J.K.5    Nemoto, E.M.6
  • 189
    • 0032792162 scopus 로고    scopus 로고
    • Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats
    • Whalen MJ, Carlos TM, Kochanek PM, Clark RS, Heineman S, Schiding JK, et al. Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats. J Neurotrauma. 1999; 16(7): 583-94.
    • (1999) J Neurotrauma. , vol.16 , Issue.7 , pp. 583-594
    • Whalen, M.J.1    Carlos, T.M.2    Kochanek, P.M.3    Clark, R.S.4    Heineman, S.5    Schiding, J.K.6
  • 190
    • 0029851730 scopus 로고    scopus 로고
    • 2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs
    • 2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J Biol Chem. 1996; 271(48): 30950-5.
    • (1996) J Biol Chem , vol.271 , Issue.48 , pp. 30950-30955
    • Osborn, M.T.1    Chambers, T.C.2
  • 191
    • 0346458629 scopus 로고    scopus 로고
    • Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures
    • Dinkel K, Dhabhar FS, Sapolsky RM. Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures. Proc Natl Acad Sci USA. 2004; 101(1): 331-6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.1 , pp. 331-336
    • Dinkel, K.1    Dhabhar, F.S.2    Sapolsky, R.M.3
  • 192
    • 44949248404 scopus 로고    scopus 로고
    • Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege
    • Neumann J, Sauerzweig S, Rönicke R, Gunzer F, Dinkel K, Ullrich O, et al. Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J Neurosci. 2008; 28(23): 5965-75.
    • (2008) J Neurosci , vol.28 , Issue.23 , pp. 5965-5975
    • Neumann, J.1    Sauerzweig, S.2    Rönicke, R.3    Gunzer, F.4    Dinkel, K.5    Ullrich, O.6
  • 193
    • 70350029795 scopus 로고    scopus 로고
    • Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability
    • DiStasi MR, Ley K. Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability. Trends Immunol. 2009; 30(11): 547-56.
    • (2009) Trends Immunol. , vol.30 , Issue.11 , pp. 547-556
    • Distasi, M.R.1    Ley, K.2
  • 196
    • 23744437416 scopus 로고    scopus 로고
    • Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia
    • Gidday JM, Gasche YG, Copin JC, Shah AR, Perez RS, Shapiro SD, et al. Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol. 2005; 289(2): H558-68.
    • (2005) Am J Physiol , vol.289 , Issue.2
    • Gidday, J.M.1    Gasche, Y.G.2    Copin, J.C.3    Shah, A.R.4    Perez, R.S.5    Shapiro, S.D.6
  • 197
    • 0028242968 scopus 로고
    • Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-α in vivo
    • Gotsch U, Jäger U, Dominis M, Vestweber D. Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-α in vivo. Cell Adhes Commun. 1994; 2(1): 7-14.
    • (1994) Cell Adhes Commun. , vol.2 , Issue.1 , pp. 7-14
    • Gotsch, U.1    Jäger, U.2    Dominis, M.3    Vestweber, D.4
  • 198
    • 0026643572 scopus 로고
    • Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system
    • Andersson PB, Perry VH, Gordon S. Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system. J Exp Med. 1992; 176(1): 255-9.
    • (1992) J Exp Med. , vol.176 , Issue.1 , pp. 255-259
    • Andersson, P.B.1    Perry, V.H.2    Gordon, S.3
  • 199
    • 0030848142 scopus 로고    scopus 로고
    • Is the pial microvessel a good model for blood-brain barrier studies?
    • Allt G, Lawrenson JG. Is the pial microvessel a good model for blood-brain barrier studies? Brain Res Rev. 1997; 24(1): 67-76.
    • (1997) Brain Res Rev , vol.24 , Issue.1 , pp. 67-76
    • Allt, G.1    Lawrenson, J.G.2
  • 200
    • 70449106029 scopus 로고    scopus 로고
    • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    • Bartholomäus I, Kawakami N, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature. 2009; 462(7269): 94-8.
    • (2009) Nature , vol.462 , Issue.7269 , pp. 94-98
    • Bartholomäus, I.1    Kawakami, N.2    Odoardi, F.3    Schläger, C.4    Miljkovic, D.5    Ellwart, J.W.6
  • 201
    • 65649096159 scopus 로고    scopus 로고
    • Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
    • Kivisäkk P, Imitola J, Rasmussen S, Elyaman W, Zhu B, Ransohoff RM, et al. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann Neurol. 2009; 65(4): 457-69.
    • (2009) Ann Neurol , vol.65 , Issue.4 , pp. 457-469
    • Kivisäkk, P.1    Imitola, J.2    Rasmussen, S.3    Elyaman, W.4    Zhu, B.5    Ransohoff, R.M.6
  • 203
    • 0033948974 scopus 로고    scopus 로고
    • Choroid plexus in the central nervous system: biology and physiopathology
    • Strazielle N, Ghersi-Egea JF. Choroid plexus in the central nervous system: biology and physiopathology. J Neuropathol Exp Neurol. 2000; 59(7): 561-74.
    • (2000) J Neuropathol Exp Neurol , vol.59 , Issue.7 , pp. 561-574
    • Strazielle, N.1    Ghersi-Egea, J.F.2
  • 204
    • 4544382301 scopus 로고    scopus 로고
    • Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke
    • O'Donnell ME, Tran L, Lam TI, Liu XB, Anderson SE. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab. 2004; 24(9): 1046-56.
    • (2004) J Cereb Blood Flow Metab , vol.24 , Issue.9 , pp. 1046-1056
    • O'Donnell, M.E.1    Tran, L.2    Lam, T.I.3    Liu, X.B.4    Anderson, S.E.5
  • 205
    • 68849124098 scopus 로고    scopus 로고
    • Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin
    • Lam TI, Wise PM, O'Donnell ME. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. Am J Physiol. 2009; 297(2): C278-89.
    • (2009) Am J Physiol , vol.297 , Issue.2
    • Lam, T.I.1    Wise, P.M.2    O'Donnell, M.E.3
  • 207
    • 44449168771 scopus 로고    scopus 로고
    • NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade
    • Lu KT, Cheng NC, Wu CY, Yang YL. NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade. Crit Care Med. 2008; 36(3): 917-22.
    • (2008) Crit Care Med , vol.36 , Issue.3 , pp. 917-922
    • Lu, K.T.1    Cheng, N.C.2    Wu, C.Y.3    Yang, Y.L.4
  • 208
    • 0037008460 scopus 로고    scopus 로고
    • + exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model
    • + exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res. 2002; 945(2): 242-8.
    • (2002) Brain Res. , vol.945 , Issue.2 , pp. 242-248
    • Suzuki, Y.1    Matsumoto, Y.2    Ikeda, Y.3    Kondo, K.4    Ohashi, N.5    Umemura, K.6
  • 214
    • 0141456728 scopus 로고    scopus 로고
    • Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain
    • Chen M, Dong Y, Simard JM. Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain. J Neurosci. 2003; 23(24): 8568-77.
    • (2003) J Neurosci , vol.23 , Issue.24 , pp. 8568-8577
    • Chen, M.1    Dong, Y.2    Simard, J.M.3
  • 215
    • 34547401505 scopus 로고    scopus 로고
    • Non-selective cation channels, transient receptor potential channels and ischemic stroke
    • Simard JM, Tarasov KV, Gerzanich V. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta. 2007; 1772(8): 947-57.
    • (2007) Biochim Biophys Acta , vol.1772 , Issue.8 , pp. 947-957
    • Simard, J.M.1    Tarasov, K.V.2    Gerzanich, V.3
  • 216
    • 59649105028 scopus 로고    scopus 로고
    • De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
    • Gerzanich V, Woo SK, Vennekens R, Tsymbalyuk O, Ivanova S, Ivanov A, et al. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med. 2009; 15(2): 185-91.
    • (2009) Nat Med , vol.15 , Issue.2 , pp. 185-191
    • Gerzanich, V.1    Woo, S.K.2    Vennekens, R.3    Tsymbalyuk, O.4    Ivanova, S.5    Ivanov, A.6
  • 219
    • 59149087488 scopus 로고    scopus 로고
    • Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage
    • Simard JM, Geng Z, Woo SK, Ivanova S, Tosun C, Melnichenko L, et al. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2009; 29(2): 317-30.
    • (2009) J Cereb Blood Flow Metab , vol.29 , Issue.2 , pp. 317-330
    • Simard, J.M.1    Geng, Z.2    Woo, S.K.3    Ivanova, S.4    Tosun, C.5    Melnichenko, L.6
  • 220
    • 77956921028 scopus 로고    scopus 로고
    • Molecular mechanisms of microvascular failure in central nervous system injury-synergistic roles of NKCC1 and SUR1/TRPM4
    • Simard JM, Kahle KT, Gerzanich V. Molecular mechanisms of microvascular failure in central nervous system injury-synergistic roles of NKCC1 and SUR1/TRPM4. J Neurosurg. 2010; 113(3): 622-9.
    • (2010) J Neurosurg , vol.113 , Issue.3 , pp. 622-629
    • Simard, J.M.1    Kahle, K.T.2    Gerzanich, V.3
  • 221
    • 60549106649 scopus 로고    scopus 로고
    • Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke
    • Simard JM, Yurovsky V, Tsymbalyuk N, Melnichenko L, Ivanova S, Gerzanich V. Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke. Stroke. 2009; 40(2): 604-9.
    • (2009) Stroke , vol.40 , Issue.2 , pp. 604-609
    • Simard, J.M.1    Yurovsky, V.2    Tsymbalyuk, N.3    Melnichenko, L.4    Ivanova, S.5    Gerzanich, V.6
  • 222
    • 78650178829 scopus 로고    scopus 로고
    • Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury
    • Patel AD, Gerzanich V, Geng Z, Simard JM. Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury. J Neuropathol Exp Neurol. 2010; 69(12): 1177-90.
    • (2010) J Neuropathol Exp Neurol , vol.69 , Issue.12 , pp. 1177-1190
    • Patel, A.D.1    Gerzanich, V.2    Geng, Z.3    Simard, J.M.4
  • 224
    • 0028174629 scopus 로고
    • β amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease
    • Roberts GW, Gentleman SM, Lynch A, Murray L, Landon M, Graham DI. β amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1994; 57(4): 419-25.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , Issue.4 , pp. 419-425
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3    Murray, L.4    Landon, M.5    Graham, D.I.6
  • 225
  • 226
    • 64149105502 scopus 로고    scopus 로고
    • Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
    • Loane DJ, Pocivavsek A, Moussa CE, Thompson R, Matsuoka Y, Faden AI, et al. Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med. 2009; 15(4): 377-9.
    • (2009) Nat Med. , vol.15 , Issue.4 , pp. 377-379
    • Loane, D.J.1    Pocivavsek, A.2    Moussa, C.E.3    Thompson, R.4    Matsuoka, Y.5    Faden, A.I.6
  • 227
    • 79951690872 scopus 로고    scopus 로고
    • Modulation of ABCA1 by an LXR agonist reduces beta-amyloid levels and improves outcome after traumatic brain injury
    • Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, et al. Modulation of ABCA1 by an LXR agonist reduces beta-amyloid levels and improves outcome after traumatic brain injury. J Neurotrauma. 2011; 28(2): 225-36.
    • (2011) J Neurotrauma. , vol.28 , Issue.2 , pp. 225-236
    • Loane, D.J.1    Washington, P.M.2    Vardanian, L.3    Pocivavsek, A.4    Hoe, H.S.5    Duff, K.E.6
  • 228
    • 33745054649 scopus 로고    scopus 로고
    • Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells
    • Kim WS, Guillemin GJ, Glaros EN, Lim CK, Garner B. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. NeuroReport. 2006; 17(9): 891-6.
    • (2006) NeuroReport , vol.17 , Issue.9 , pp. 891-896
    • Kim, W.S.1    Guillemin, G.J.2    Glaros, E.N.3    Lim, C.K.4    Garner, B.5
  • 229
    • 33646205692 scopus 로고    scopus 로고
    • Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells
    • Panzenboeck U, Kratzer I, Sovic A, Wintersperger A, Bernhart E, Hammer A, et al. Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells. Int J Biochem Cell Biol. 2006; 38(8): 1314-29.
    • (2006) Int J Biochem Cell Biol , vol.38 , Issue.8 , pp. 1314-1329
    • Panzenboeck, U.1    Kratzer, I.2    Sovic, A.3    Wintersperger, A.4    Bernhart, E.5    Hammer, A.6
  • 230
    • 84857412491 scopus 로고    scopus 로고
    • Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood-brain barrier
    • Do TM, Ouellet M, Calon F, Chimini G, Chacun H, Farinotti R, et al. Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood-brain barrier. Mol Cell Biochem. 2011; 357(1-2): 397-404.
    • (2011) Mol Cell Biochem , vol.357 , Issue.1-2 , pp. 397-404
    • Do, T.M.1    Ouellet, M.2    Calon, F.3    Chimini, G.4    Chacun, H.5    Farinotti, R.6
  • 231
    • 4043061467 scopus 로고    scopus 로고
    • LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
    • Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, et al. LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms. Neuron. 2004; 43(3): 333-44.
    • (2004) Neuron , vol.43 , Issue.3 , pp. 333-344
    • Deane, R.1    Wu, Z.2    Sagare, A.3    Davis, J.4    du Yan, S.5    Hamm, K.6
  • 232
    • 40949149021 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier
    • Akanuma S, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, et al. ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier. Neurochem Int. 2008; 52(6): 956-61.
    • (2008) Neurochem Int , vol.52 , Issue.6 , pp. 956-961
    • Akanuma, S.1    Ohtsuki, S.2    Doi, Y.3    Tachikawa, M.4    Ito, S.5    Hori, S.6
  • 233
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • Löscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol. 2005; 76(1): 22-76.
    • (2005) Prog Neurobiol , vol.76 , Issue.1 , pp. 22-76
    • Löscher, W.1    Potschka, H.2
  • 234
    • 46949098349 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
    • Miller DS, Bauer B, Hartz AM. Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy. Pharmacol Rev. 2008; 60(2): 196-209.
    • (2008) Pharmacol Rev , vol.60 , Issue.2 , pp. 196-209
    • Miller, D.S.1    Bauer, B.2    Hartz, A.M.3
  • 235
    • 72049119592 scopus 로고    scopus 로고
    • Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach
    • Potschka H. Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach. Pharmacol Ther. 2010; 125(1): 118-27.
    • (2010) Pharmacol Ther , vol.125 , Issue.1 , pp. 118-127
    • Potschka, H.1
  • 236
    • 33645340038 scopus 로고    scopus 로고
    • Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia
    • Spudich A, Kilic E, Xing H, Kilic U, Rentsch KM, Wunderli-Allenspach H, et al. Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nat Neurosci. 2006; 9(4): 487-8.
    • (2006) Nat Neurosci , vol.9 , Issue.4 , pp. 487-488
    • Spudich, A.1    Kilic, E.2    Xing, H.3    Kilic, U.4    Rentsch, K.M.5    Wunderli-Allenspach, H.6
  • 237
    • 0032878575 scopus 로고    scopus 로고
    • Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents
    • Scheff SW, Sullivan PG. Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents. J Neurotrauma. 1999; 16(9): 783-92.
    • (1999) J Neurotrauma , vol.16 , Issue.9 , pp. 783-792
    • Scheff, S.W.1    Sullivan, P.G.2
  • 238
    • 0034057187 scopus 로고    scopus 로고
    • Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury
    • Sullivan PG, Thompson M, Scheff SW. Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury. Exp Neurol. 2000; 161(2): 631-7.
    • (2000) Exp Neurol , vol.161 , Issue.2 , pp. 631-637
    • Sullivan, P.G.1    Thompson, M.2    Scheff, S.W.3
  • 240
    • 0037449449 scopus 로고    scopus 로고
    • Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria
    • Hansson MJ, Persson T, Friberg H, Keep MF, Rees A, Wieloch T, et al. Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria. Brain Res. 2003; 960(1-2): 99-111.
    • (2003) Brain Res , vol.960 , Issue.1-2 , pp. 99-111
    • Hansson, M.J.1    Persson, T.2    Friberg, H.3    Keep, M.F.4    Rees, A.5    Wieloch, T.6
  • 241
    • 33645319458 scopus 로고    scopus 로고
    • Clinical treatments for mitochondrial dysfunctions after brain injury
    • Merenda A, Bullock R. Clinical treatments for mitochondrial dysfunctions after brain injury. Curr Opin Crit Care. 2006; 12(2): 90-6.
    • (2006) Curr Opin Crit Care , vol.12 , Issue.2 , pp. 90-96
    • Merenda, A.1    Bullock, R.2
  • 242
    • 67849135779 scopus 로고    scopus 로고
    • Combination therapies for traumatic brain injury: prospective considerations
    • The Combination Therapies for Traumatic Brain Injury Workshop Leaders
    • Margulies S, Hicks R, The Combination Therapies for Traumatic Brain Injury Workshop Leaders. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma. 2009; 26(6): 925-39.
    • (2009) J Neurotrauma. , vol.26 , Issue.6 , pp. 925-939
    • Margulies, S.1    Hicks, R.2
  • 243
    • 33645502138 scopus 로고    scopus 로고
    • Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses
    • Work LM, Büning H, Hunt E, Nicklin SA, Denby L, Britton N, et al. Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Mol Ther. 2006; 13(4): 683-93.
    • (2006) Mol Ther , vol.13 , Issue.4 , pp. 683-693
    • Work, L.M.1    Büning, H.2    Hunt, E.3    Nicklin, S.A.4    Denby, L.5    Britton, N.6
  • 244
    • 44949103395 scopus 로고    scopus 로고
    • Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons
    • Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, et al. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci USA. 2008; 105(21): 7582-7.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.21 , pp. 7582-7587
    • Guo, S.1    Kim, W.J.2    Lok, J.3    Lee, S.R.4    Besancon, E.5    Luo, B.H.6
  • 245
    • 66149111387 scopus 로고    scopus 로고
    • Rac1 is a critical mediator of endothelium-derived neurotrophic activity
    • Sawada N, Kim HH, Moskowitz MA, Liao JK. Rac1 is a critical mediator of endothelium-derived neurotrophic activity. Sci Signal. 2009; 2(61): 10.
    • (2009) Sci Signal , vol.2 , Issue.61 , pp. 10
    • Sawada, N.1    Kim, H.H.2    Moskowitz, M.A.3    Liao, J.K.4


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