Rac1 is a critical mediator of endothelium-derived neurotrophic activity

Science Signaling

Volumn 2, Issue 61, 2009, Pages

  Sawada, Naoki ^a   Kim, Hyung Hwan ^a   Moskowitz, Michael A ^b   Liao, James K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMIN; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; CHROMOSOME PROTEIN; COLLAGEN; CYCLINE; DNA TOPOISOMERASE (ATP HYDROLYSING); FIBRONECTIN; GELATINASE A; GLYCOPROTEIN; HEAT SHOCK PROTEIN; HEPARIN; HISTONE H1; HYDROGEN PEROXIDE; KINESIN; LIPID PEROXIDE; MOLECULAR MOTOR; NEUROTROPHIC FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROFILIN; PROTEIN; PROTEIN ECT2; PROTEIN FOS; PROTEIN MYB; PROTEOHEPARAN SULFATE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; TAU PROTEIN; THROMBOSPONDIN 1; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ARTN PROTEIN, MOUSE; LIPOCORTIN 5; NERVE GROWTH FACTOR; NERVE PROTEIN; NEUROPEPTIDE; RAC PROTEIN; RAC1 PROTEIN, MOUSE;

ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; BRAIN BLOOD VESSEL; BRAIN INJURY; BRAIN ISCHEMIA; CELL ADHESION; CELL DIVISION; CELL SURVIVAL; DRUG PENETRATION; ENDOTHELIUM; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMIZYGOSITY; HUMAN; HYPOXIA; MEMBRANE PERMEABILITY; MICROARRAY ANALYSIS; MITOSIS; NERVE CELL; NEUROPROTECTION; NEUROTROPISM; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN FUNCTION; STRESS; UPREGULATION; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; COMPARATIVE STUDY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANALYSIS OF VARIANCE; ANIMALS; ANNEXIN A5; BRAIN; BRAIN ISCHEMIA; CELL ADHESION; ENDOTHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; MICE, MUTANT STRAINS; MICROARRAY ANALYSIS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; RAC GTP-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 66149111387     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000162     Document Type: Article

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56. We thank D. J. Kwiatkowski for providing us with conditional Rac1 mice. This work was supported by grants from the NIH (HL052233, HL080187, and NS101828). N.S. was supported by the fellowships from the Uehara Memorial Foundation, the Cell Science Research Foundation, and Mochida Memorial Foundation for Medical and Pharmaceutical Research. There are no disclosures or conflicts of interest for all of the authors.