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Volumn 190, Issue 1, 2004, Pages 192-203

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury

Author keywords

A plaque; Alzheimer's disease; Glial cell

Indexed keywords

ALPHA SYNUCLEIN; APOLIPOPROTEIN E; BETA SYNUCLEIN; BIOCHEMICAL MARKER; GAMMA SYNUCLEIN; PROTEIN PRECURSOR; TAU PROTEIN; UBIQUITIN;

EID: 5044237263     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.06.011     Document Type: Article
Times cited : (366)

References (71)
  • 2
    • 0003181187 scopus 로고    scopus 로고
    • National Institute on Aging and Reagan Institute working group on diagnosis criteria for the neuropathological assessment of Alzheimer's disease. Consensus recommendations for the postmortem diagnosis of AD
    • Anonymous National Institute on Aging and Reagan Institute working group on diagnosis criteria for the neuropathological assessment of Alzheimer's disease. Consensus recommendations for the postmortem diagnosis of AD. Neurobiol. Aging. 18:1997;S1-S3
    • (1997) Neurobiol. Aging , vol.18
    • Anonymous1
  • 3
    • 0033003126 scopus 로고    scopus 로고
    • A high incidence of apolipoprotein e epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits
    • Arai T., Ikeda K., Akiyama H., Haga C., Usami M., Sahara N., Iritani S., Mori H. A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits. Acta Neuropathol. 97:1999;82-84
    • (1999) Acta Neuropathol. , vol.97 , pp. 82-84
    • Arai, T.1    Ikeda, K.2    Akiyama, H.3    Haga, C.4    Usami, M.5    Sahara, N.6    Iritani, S.7    Mori, H.8
  • 4
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H., Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging. 18:1997;351-357
    • (1997) Neurobiol. Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 5
    • 0036592636 scopus 로고    scopus 로고
    • Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists
    • Butterfield D.A., Griffin S., Munch G., Pasinetti G.M. Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists. J. Alzheimer's Dis. 4:2002;193-201
    • (2002) J. Alzheimer's Dis. , vol.4 , pp. 193-201
    • Butterfield, D.A.1    Griffin, S.2    Munch, G.3    Pasinetti, G.M.4
  • 10
    • 0026022286 scopus 로고
    • Post-traumatic Alzheimer's disease: Preponderance of a single plaque type
    • Clinton J., Ambler M.W., Roberts G.W. Post-traumatic Alzheimer's disease: preponderance of a single plaque type. Neuropathol. Appl. Neurobiol. 17:1991;69-74
    • (1991) Neuropathol. Appl. Neurobiol. , vol.17 , pp. 69-74
    • Clinton, J.1    Ambler, M.W.2    Roberts, G.W.3
  • 12
    • 0014723027 scopus 로고
    • Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients
    • Dayan A.D. Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients. Acta Neuropathol. 16:1970;85-94
    • (1970) Acta Neuropathol. , vol.16 , pp. 85-94
    • Dayan, A.D.1
  • 14
    • 0025289562 scopus 로고
    • Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person
    • Delaere P., Duyckaerts C., Masters C., Beyreuther K., Piette F., Hauw J.J. Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci. Lett. 116:1990;87-93
    • (1990) Neurosci. Lett. , vol.116 , pp. 87-93
    • Delaere, P.1    Duyckaerts, C.2    Masters, C.3    Beyreuther, K.4    Piette, F.5    Hauw, J.J.6
  • 16
    • 0026452028 scopus 로고
    • Expression of amyloid precursor protein mRNAs in endothelial, neuronal, and glial cells: Modulation by interleukin-1
    • Forloni G., Demicheli F., Giorgi S., Bendotti C., Angeretti N. Expression of amyloid precursor protein mRNAs in endothelial, neuronal, and glial cells: modulation by interleukin-1. Brain Res., Mol. Brain Res. 16:1992;128-134
    • (1992) Brain Res., Mol. Brain Res. , vol.16 , pp. 128-134
    • Forloni, G.1    Demicheli, F.2    Giorgi, S.3    Bendotti, C.4    Angeretti, N.5
  • 17
    • 0032868750 scopus 로고    scopus 로고
    • Neuronal cytoskeletal changes are an early consequence of repetitive head injury
    • Geddes J.F., Vowles G.H., Nicoll J.A., Revesz T. Neuronal cytoskeletal changes are an early consequence of repetitive head injury. Acta Neuropathol. 98:1999;171-178
    • (1999) Acta Neuropathol. , vol.98 , pp. 171-178
    • Geddes, J.F.1    Vowles, G.H.2    Nicoll, J.A.3    Revesz, T.4
  • 18
    • 0027278450 scopus 로고
    • Molecular pathology of head trauma: Altered β APP metabolism and the aetiology of Alzheimer's disease
    • K. Kogure, K.-A. Hossmann, Siesjo B.K. New York: Elsevier Science Publishers B.V.
    • Gentleman S.M., Graham D.I., Roberts G.W. Molecular pathology of head trauma: altered β APP metabolism and the aetiology of Alzheimer's disease. Kogure K., Hossmann K.-A., Siesjo B.K. Progress in Brain Research. vol. 96:1993;237-246 Elsevier Science Publishers B.V., New York
    • (1993) Progress in Brain Research , vol.96 , pp. 237-246
    • Gentleman, S.M.1    Graham, D.I.2    Roberts, G.W.3
  • 23
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
    • Griffin W.S., Sheng J.G., Roberts G.W., Mrak R.E. Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54:1995;276-281
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 276-281
    • Griffin, W.S.1    Sheng, J.G.2    Roberts, G.W.3    Mrak, R.E.4
  • 25
    • 0026546599 scopus 로고
    • An "anatomical cascade hypothesis" for Alzheimer's disease
    • Hardy J. An "anatomical cascade hypothesis" for Alzheimer's disease. Trends Neurosci. 15:1992;200-201
    • (1992) Trends Neurosci. , vol.15 , pp. 200-201
    • Hardy, J.1
  • 26
    • 0036896994 scopus 로고    scopus 로고
    • Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease
    • Hartman R.E., Laurer H., Longhi L., Bales K.R., Paul S.M., McIntosh T.K., Holtzman D.M. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J. Neurosci. 22:2002;10083-10087
    • (2002) J. Neurosci. , vol.22 , pp. 10083-10087
    • Hartman, R.E.1    Laurer, H.2    Longhi, L.3    Bales, K.R.4    Paul, S.M.5    McIntosh, T.K.6    Holtzman, D.M.7
  • 28
    • 0030930206 scopus 로고    scopus 로고
    • The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains
    • Ikonomovic M.D., Mizukami K., Davies P., Sheffield R., Armstrong D.M. The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains. J. Neuropathol. Exp. Neurol. 56:1997;1018-1027
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 1018-1027
    • Ikonomovic, M.D.1    Mizukami, K.2    Davies, P.3    Sheffield, R.4    Armstrong, D.M.5
  • 29
    • 0028169925 scopus 로고
    • Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aß monoclonals: Evidence that an initially deposited species is Aβ42(43)
    • Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aß monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron. 13:1994;45-53
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 30
    • 0028919919 scopus 로고
    • Amyloid protein (A) deposition: A 42(43) precedes a 40 in Down syndrome
    • Iwatsubo T., Mann D., Odaka A., Suzuki N., Ihara Y. Amyloid protein (A) deposition: A 42(43) precedes A 40 in Down syndrome. Ann. Neurol. 37:1995;294-299
    • (1995) Ann. Neurol. , vol.37 , pp. 294-299
    • Iwatsubo, T.1    Mann, D.2    Odaka, A.3    Suzuki, N.4    Ihara, Y.5
  • 31
    • 0019520764 scopus 로고
    • Disability after severe head injury: Observations on the use of the Glasgow Outcome Scale
    • Jennett B., Snoek J., Bond M.R., Brooks N. Disability after severe head injury: observations on the use of the Glasgow Outcome Scale. J. Neurol., Neurosurg. Psychiatry. 44:1981;285-293
    • (1981) J. Neurol., Neurosurg. Psychiatry , vol.44 , pp. 285-293
    • Jennett, B.1    Snoek, J.2    Bond, M.R.3    Brooks, N.4
  • 32
    • 0023905906 scopus 로고
    • Clinical, pathological and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
    • Katzman R., Terry R., DeTeresa R., Brown T., Davies P., Fuld P., Renbing X., Peck A. Clinical, pathological and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann. Neurol. 23:1988;138-144
    • (1988) Ann. Neurol. , vol.23 , pp. 138-144
    • Katzman, R.1    Terry, R.2    Deteresa, R.3    Brown, T.4    Davies, P.5    Fuld, P.6    Renbing, X.7    Peck, A.8
  • 33
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian Z.S. Diagnosis of Alzheimer's disease. Arch. Neurol. 42:1985;1097-1105
    • (1985) Arch. Neurol. , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 35
    • 0033022354 scopus 로고    scopus 로고
    • Head injuries and cognitive decline among older adults: A population-based study
    • Luukinen H., Viramo P., Koski K., Laippala P., Kivela S.L. Head injuries and cognitive decline among older adults: a population-based study. Neurology. 55:1999;557-562
    • (1999) Neurology , vol.55 , pp. 557-562
    • Luukinen, H.1    Viramo, P.2    Koski, K.3    Laippala, P.4    Kivela, S.L.5
  • 36
    • 0028331648 scopus 로고
    • Senile plaques do not progressively accumulate with normal aging
    • Mackenzie I.R. Senile plaques do not progressively accumulate with normal aging. Acta Neuropathol. 87:1994;520-525
    • (1994) Acta Neuropathol. , vol.87 , pp. 520-525
    • MacKenzie, I.R.1
  • 39
    • 0034002073 scopus 로고    scopus 로고
    • Altered expression of amyloid precursors proteins after traumatic brain injury in rats: In situ hybridization and immunohistochemical study
    • Masumura M., Hata R., Uramoto H., Murayama N., Ohno T., Sawada T. Altered expression of amyloid precursors proteins after traumatic brain injury in rats: in situ hybridization and immunohistochemical study. J. Neurotrauma. 17:2000;123-134
    • (2000) J. Neurotrauma , vol.17 , pp. 123-134
    • Masumura, M.1    Hata, R.2    Uramoto, H.3    Murayama, N.4    Ohno, T.5    Sawada, T.6
  • 40
    • 0027945346 scopus 로고
    • Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
    • Matsuo E.S., Shin R.-W., Billingsley M.L., Van de Voorde A., O'Connor M., Trojanowski J.Q., Lee V.M.-Y. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron. 13:1994;989-1002
    • (1994) Neuron , vol.13 , pp. 989-1002
    • Matsuo, E.S.1    Shin, R.-W.2    Billingsley, M.L.3    Van De Voorde, A.4    O'Connor, M.5    Trojanowski, J.Q.6    Lee, V.M.-Y.7
  • 42
    • 0027235553 scopus 로고
    • Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their 1st-degree relatives
    • Mayeux R., Ottman R., Tang M.X., Noboabauza L., Marder K., Gurland B., Stern Y. Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their 1st-degree relatives. Ann. Neurol. 33:1993;494-501
    • (1993) Ann. Neurol. , vol.33 , pp. 494-501
    • Mayeux, R.1    Ottman, R.2    Tang, M.X.3    Noboabauza, L.4    Marder, K.5    Gurland, B.6    Stern, Y.7
  • 45
    • 0028670780 scopus 로고
    • Increased numbers of βaPP-immunoreactive neurones in the entorhinal cortex after head injury
    • McKenzie J.E., Gentleman S.M., Roberts G.W., Graham D.I., Royston M.C. Increased numbers of βAPP-immunoreactive neurones in the entorhinal cortex after head injury. NeuroReport. 6:1994;161-164
    • (1994) NeuroReport , vol.6 , pp. 161-164
    • McKenzie, J.E.1    Gentleman, S.M.2    Roberts, G.W.3    Graham, D.I.4    Royston, M.C.5
  • 46
    • 0031866674 scopus 로고    scopus 로고
    • Apolipoprotein e genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease
    • McNamara M.J., Gomez-Isla T., Hyman B.T. Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease. Arch. Neurol. 55:1998;1001-1004
    • (1998) Arch. Neurol. , vol.55 , pp. 1001-1004
    • McNamara, M.J.1    Gomez-Isla, T.2    Hyman, B.T.3
  • 47
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., van Belle G., Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 48
    • 0031770501 scopus 로고    scopus 로고
    • Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus
    • Murakami N., Yamaki T., Iwamoto Y., Sakakibara T., Kobori N., Fushiki S., Ueda S. Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus. J. Neurotrauma. 15:1998;993-1003
    • (1998) J. Neurotrauma , vol.15 , pp. 993-1003
    • Murakami, N.1    Yamaki, T.2    Iwamoto, Y.3    Sakakibara, T.4    Kobori, N.5    Fushiki, S.6    Ueda, S.7
  • 53
    • 0028986690 scopus 로고
    • Apolipoprotein e epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury
    • Nicoll J.A., Roberts G.W., Graham D.I. Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nat. Med. 1:1995;135-137
    • (1995) Nat. Med. , vol.1 , pp. 135-137
    • Nicoll, J.A.1    Roberts, G.W.2    Graham, D.I.3
  • 54
    • 0030006010 scopus 로고    scopus 로고
    • Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and B-amyloid peptide after experimental brain injury in the rat
    • Pierce J.E.S., Trojanowski J.Q.T., Graham D.I., Smith D.H., McIntosh T.K. Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and B-amyloid peptide after experimental brain injury in the rat. J. Neurosci. 16:1996;1083-1090
    • (1996) J. Neurosci. , vol.16 , pp. 1083-1090
    • Pierce, J.E.S.1    Trojanowski, J.Q.T.2    Graham, D.I.3    Smith, D.H.4    McIntosh, T.K.5
  • 56
    • 0024206272 scopus 로고
    • Immunocytochemistry of neurofibrillary tangles in dementia pugilistica and Alzheimer's disease: Evidence for common genesis
    • Roberts G.W. Immunocytochemistry of neurofibrillary tangles in dementia pugilistica and Alzheimer's disease: evidence for common genesis. Lancet. 2:1988;1456-1458
    • (1988) Lancet , vol.2 , pp. 1456-1458
    • Roberts, G.W.1
  • 57
    • 0025840201 scopus 로고
    • βa4 amyloid protein deposition in brain after head trauma
    • Roberts G.W., Gentleman S.M., Lynch A., Graham D.I. βA4 amyloid protein deposition in brain after head trauma. Lancet. 338:1991;1422-1423
    • (1991) Lancet , vol.338 , pp. 1422-1423
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3    Graham, D.I.4
  • 59
    • 0028174629 scopus 로고
    • β amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer's disease
    • Roberts G.W., Gentleman S.M., Lynch A., Murray L., Landon M., Graham D.I. β amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. J. Neurol., Neurosurg. Psychiatry. 57:1994;419-425
    • (1994) J. Neurol., Neurosurg. Psychiatry , vol.57 , pp. 419-425
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3    Murray, L.4    Landon, M.5    Graham, D.I.6
  • 60
    • 0031438499 scopus 로고    scopus 로고
    • The role of interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications
    • Rothwell N., Allan S., Toulmond S. The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. J. Clin. Invest. 100:1997;2648-2652
    • (1997) J. Clin. Invest. , vol.100 , pp. 2648-2652
    • Rothwell, N.1    Allan, S.2    Toulmond, S.3
  • 62
    • 0034963745 scopus 로고    scopus 로고
    • Tau isofom profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease
    • Schmidt M.L., Zhukareva V., Newell K.L., Lee V.M.-Y., Trojanowski J.Q. Tau isofom profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease. Acta Neuropathol. 101:2001;518-524
    • (2001) Acta Neuropathol. , vol.101 , pp. 518-524
    • Schmidt, M.L.1    Zhukareva, V.2    Newell, K.L.3    Lee, V.M.-Y.4    Trojanowski, J.Q.5
  • 66
    • 0034698233 scopus 로고    scopus 로고
    • Antibodies to the C-terminus of the beta-amyloid precursor protein (APP): A site specific marker for the detection of traumatic axonal injury
    • Stone J.R., Singleton R.H., Povlishock J.T. Antibodies to the C-terminus of the beta-amyloid precursor protein (APP): a site specific marker for the detection of traumatic axonal injury. Brain Res. 871:2000;288-302
    • (2000) Brain Res. , vol.871 , pp. 288-302
    • Stone, J.R.1    Singleton, R.H.2    Povlishock, J.T.3
  • 67
    • 0033857342 scopus 로고    scopus 로고
    • X-34, a fluorescent derivative of Congo red: A novel histochemical stain for Alzheimer's disease pathology
    • Styren S.D., Hamilton R.L., Styren G.C., Klunk W.E. X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J. Histochem. Cytochem. 48:2000;1223-1232
    • (2000) J. Histochem. Cytochem. , vol.48 , pp. 1223-1232
    • Styren, S.D.1    Hamilton, R.L.2    Styren, G.C.3    Klunk, W.E.4
  • 68
    • 0016391336 scopus 로고
    • Assessment of coma and impaired consciousness. A practical scale
    • Teasdale G., Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 2:1974;81-84
    • (1974) Lancet , vol.2 , pp. 81-84
    • Teasdale, G.1    Jennett, B.2
  • 69
    • 0036777211 scopus 로고    scopus 로고
    • Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses
    • Trojanowski J.Q., Lee V.M.-Y. Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses. Neurotoxicology. 23:2002;457-460
    • (2002) Neurotoxicology , vol.23 , pp. 457-460
    • Trojanowski, J.Q.1    Lee, V.M.-Y.2
  • 70
    • 0037080159 scopus 로고    scopus 로고
    • Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis
    • Uryu K., Laurer H., McIntosh T., Pratico D., Martinez D., Leight S., Lee V.M., Trojanowski J.Q. Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J. Neurosci. 22:2002;446-454
    • (2002) J. Neurosci. , vol.22 , pp. 446-454
    • Uryu, K.1    Laurer, H.2    McIntosh, T.3    Pratico, D.4    Martinez, D.5    Leight, S.6    Lee, V.M.7    Trojanowski, J.Q.8
  • 71
    • 0032800818 scopus 로고    scopus 로고
    • Intracellular APP processing and a beta production in Alzheimer disease
    • Wilson C.A., Doms R.W., Lee V.M. Intracellular APP processing and A beta production in Alzheimer disease. J. Neuropathol. Exp. Neurol. 58:1999;787-794
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 787-794
    • Wilson, C.A.1    Doms, R.W.2    Lee, V.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.