LOX-1 and angiotensin receptors, and their interplay

Cardiovascular Drugs and Therapy

Volumn 25, Issue 5, 2011, Pages 401-417

  Wang, Xianwei ^a,b   Phillips, M Ian ^c   Mehta, Jawahar L ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^c KECK GRADUATE INSTITUTE   (United States)

Author keywords

AT2 receptor (AT2R); Atherosclerosis; Hypertension; LOX 1 AT1 receptor (AT1R); Reactive oxygen species

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CELL GROWTH; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM INJURY; FIBROBLAST; FLUID BALANCE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; LIPID METABOLISM; MUSCLE HYPERTROPHY; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL HYPERTROPHY; WATER SALT BALANCE;

ANIMALS; DYSLIPIDEMIAS; HUMANS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM; SCAVENGER RECEPTORS, CLASS E;

EID: 83055194537     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-011-6331-7     Document Type: Article

References (211)

1. J Mikdashi B Handwerger P Langenberg, et al. 2007 Baseline disease activity, hyperlipidemia, and hypertension are predictive factors for ischemic stroke and stroke severity in systemic lupus erythematosus Stroke 38 281 285 17218611 10.1161/01.STR.0000254476.05620.14 (Pubitemid 46184295)
2. S Miura K Saku SS Karnik 2003 Molecular analysis of the structure and function of the angiotensin II Type 1 receptor Hypertens Res 26 937 943 14717335 1:CAS:528:DC%2BD2cXhvF2lu7o%3D 10.1291/hypres.26.937 (Pubitemid 38128765)
3. GE Foster PJ Hanlly SB Ahmed, et al. 2010 Intermittent hypoxia increases arterial blood pressure in humans through a renin-angiotensin system-dependent mechanism Hypertension 56 369 377 20625082 1:CAS:528:DC%2BC3cXhtVCntrvP 10.1161/HYPERTENSIONAHA.110.152108
4. JC Cruz-Márquez JC Cruz-Campos A Cruz-Campos, et al. 2011 Effect of altitude training on the renin-angiotensin-aldosterone system and blood pressure in women Br J Sports Med 45 533
5. S Saidi SG Mallat WY Almawi, et al. 2009 Association between renin-angiotensin-aldosterone system genotypes and haplotypes and risk of ischemic stroke of atherosclerotic etiology Acta Neurol Scand 119 356 363 19473121 1:CAS:528:DC%2BD1MXnvVWgtro%3D 10.1111/j.1600-0404.2008.01105.x
6. C Sekuri FS Cam E Ercan, et al. 2005 Renin-angiotensin system gene polymorphisms and premature coronary heart disease J Renin Angiotensin Aldosterone Syst 6 38 42 16088850 1:CAS:528:DC%2BD2MXlsFejt7w%3D 10.3317/jraas.2005.005 (Pubitemid 40796847)
7. SC Heffelfinger 2007 The renin angiotensin system in the regulation of angiogenesis Curr Pharm Des 13 1215 1229 17504231 1:CAS:528:DC%2BD2sXmsFehsrg%3D 10.2174/138161207780618858 (Pubitemid 46739330)
8. BM Singh JL Mehta 2003 Interactions between the renin-angiotensin system and dyslipidemia: relevance in the therapy of hypertension and coronary heart disease Arch Intern Med 163 1296 1304 12796065 1:CAS:528:DC%2BD3sXltVSntr0%3D 10.1001/archinte.163.11.1296 (Pubitemid 36676194)
9. J Chen D Li Schaefer, et al. 2006 Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan Atherosclerosis 184 295 301 16005008 1:CAS:528:DC%2BD28XhsFCluw%3D%3D 10.1016/j.atherosclerosis.2005.04. 016 (Pubitemid 43049713)
10. T Kizawa Y Nakamura S Takahashi, et al. 2009 Pathogenic role of angiotensin II and oxidised LDL in obstructive sleep apnoea Eur Respir J 34 1390 1398 19574336 1:CAS:528:DC%2BC3cXltVWrug%3D%3D 10.1183/09031936.00009709
11. DF Guo YL Sun P Hamet, et al. 2001 The angiotensin II type1 receptor and receptor-associated proteins Cell Res 11 165 180 11642401 1:STN:280: DC%2BD3Mrmt1yjug%3D%3D 10.1038/sj.cr.7290083 (Pubitemid 33677246)
12. RM Carey ZQ Wang HM Siragy 2000 Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function Hypertension 35 155 163 10642292 1:CAS:528:DC%2BD3cXpt1Wqug%3D%3D (Pubitemid 30054167)
13. C Wang S Jayadev JA Escobedo 1995 Identification of a domain in the angiotension II type 1 receptor determing Gq coupling by the use of receptor chimeras J Biol Chem 270 16677 16682 7622477 1:CAS:528:DyaK2MXmvFOktrk%3D 10.1074/jbc.270.28.16677
14. JL Mehta J Chen PL Hermonat, et al. 2006 Lectin-like, oxidized low-density lipoprotein receptor (LOX-1): a critical player in the development of atherosclerosis and related disorders Cardiovasc Res 69 36 45 16324688 1:CAS:528:DC%2BD2MXhtlGisb3O 10.1016/j.cardiores.2005.09.006 (Pubitemid 41814809)
15. J Ishiyama R Taguchi A Yamamoto, et al. 2010 Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells Atherosclerosis 209 118 124 19782984 1:CAS:528:DC%2BC3cXis1egur4%3D 10.1016/j.atherosclerosis.2009.09.004
16. D Li J Mehta 2000 Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells Circulation 101 2889 2895 10869259 1:CAS:528:DC%2BD3cXkvFWlsb8%3D (Pubitemid 30415877)
17. PE Westerweel MC Verhaar 2010 LOX-1: luring ox-LDL into the arterial wall J Hypertens 28 1127 1128 20467265 1:CAS:528:DC%2BC3cXmtVSmsrc%3D 10.1097/HJH.0b013e32833a35d3
18. BY Kang JA Khan S Ryu, et al. 2010 Curcumin reduces angiotension II-mediated cardiomyocyte growth via LOX-1 inhibition J Cardiovasc Pharmacol 55 176 183 19935077 1:CAS:528:DC%2BC3cXitFCrsbY%3D 10.1097/FJC.0b013e3181ca4ba1
19. BY Kang JL Mehta 2009 Rosuvastatin attenuates Ang-II mediated cardiomyocyte hypertrophy via inhibition of LOX-1 J Cardiovasc Pharmacol Ther 14 283 291 19724024 1:CAS:528:DC%2BD1MXhsFKjtLzF 10.1177/1074248409344329
20. D Li T Saldeen F Romeo, et al. 2000 Oxidized LDL upregulates angiotension II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB Circulation 102 1970 1976 11034947 1:CAS:528:DC%2BD3cXnvV2qtbo%3D
21. J Chen Y Liu H Liu, et al. 2006 Molecular dissection of angiotensin II-activated human LOX-1 promoter Arterioscler Thromb Vasc Biol 26 1163 1168 16484599 1:CAS:528:DC%2BD28XjsVersrc%3D 10.1161/01.ATV.0000209998.73303.b5 (Pubitemid 43732128)
22. H Morawietz U Rueckschloss B Niemann, et al. 1999 Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein Circulation 100 899 902 10468518 1:CAS:528:DyaK1MXmtVyksrY%3D (Pubitemid 29407168)
23. T Sawamura N Kume T Aoyama, et al. 1997 An endothelial receptor for oxidized low-density lipoprotein Nature 386 73 77 9052782 1:CAS:528: DyaK2sXhslCnsLg%3D 10.1038/386073a0 (Pubitemid 27130922)
24. JE Murphy PR Tedbury S Homer-Vanniasinkam JH Walker S Ponnambalam 2005 Biochemistry and cell biology of mammalian scavenger receptors Atherosclerosis 182 1 15 15904923 1:CAS:528:DC%2BD2MXpt1eqtrw%3D 10.1016/j.atherosclerosis.2005. 03.036 (Pubitemid 41188365)
25. M Nowicki K Müller H Serke, et al. 2010 Oxidized low-density lipoprotein (oxLDL)-induced cell death in dorsal root ganglion cell cultures depends not on the lectin-like oxLDL receptor-1 but on the toll-like receptor-4 J Neurosci Res 88 403 412 19705455 1:CAS:528:DC%2BD1MXhsFensbrM 10.1002/jnr.22205
26. T Aoyama T Sawamura Y Furutani, et al. 1999 Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene Biochem J 339 177 184 10085242 1:CAS:528:DyaK1MXisFWmu7w%3D 10.1042/0264-6021:3390177 (Pubitemid 29179305)
27. L Li T Sawamura G Renier, et al. 2003 Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium Diabetes 52 1843 1850 12829655 1:CAS:528:DC%2BD3sXltlWhurg%3D 10.2337/diabetes.52.7.1843 (Pubitemid 36792477)
28. T Hayek M Aviiram R Heinrich, et al. 2000 Losartan inhibits cellular uptake of oxidized LDL by monocyte-macrophages from hypercholesterolemic patients Biochem Biophys Res Commun 273 417 420 10873620 1:CAS:528: DC%2BD3cXkt1Kmt74%3D 10.1006/bbrc.2000.2963 (Pubitemid 30599000)
29. J Ge D Huang C Liang, et al. 2004 Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: modulation by losartan Atherosclerosis 177 263 268 15530898 1:CAS:528:DC%2BD2cXpsFeqs7w%3D 10.1016/j.atherosclerosis.2004.07.021 (Pubitemid 39505256)
30. H Morawietz N Duerrschmidt B Niemann, et al. 2001 Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells Biochem Biophys Res Commun 284 961 965 11409887 1:CAS:528:DC%2BD3MXktl2msbw%3D 10.1006/bbrc.2001. 5044 (Pubitemid 32924741)
31. N Kume T Murase H Moriwaki, et al. 1998 Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells Circ Res 83 322 327 9710125 1:CAS:528:DyaK1cXltlegtbw%3D (Pubitemid 28371322)
32. H Chen D Li T Sawamura, et al. 2000 Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: modulation by losartan Biochem Biophys Res Commun 276 1100 1104 11027596 1:CAS:528:DC%2BD3cXntFOrurg%3D 10.1006/bbrc.2000.3532
33. JL Mehta 2004 The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in atherosclerosis Can J Cardiol Suppl B 32B 36B
34. T Ueno S Kaname K Takaichi, et al. 2003 LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats Hypertens Res 26 117 122 12661921 1:CAS:528:DC%2BD3sXjtVelsrg%3D 10.1291/hypres.26.117 (Pubitemid 36193107)
35. XP Chen GH Du 2007 Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance Chin Med J 120 421 426 17376315 1:CAS:528:DC%2BD2sXktFeqtbg%3D
36. M Falconi S Biocca G Novelli, et al. 2007 Molecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant BMC Struct Biol 7 73 17988382 10.1186/1472-6807-7-73 1:CAS:528:DC%2BD1cXnslaktA%3D%3D
37. D Li JL Mehta 2009 Intracellular signaling of LOX-1 in endothelial cell apoptosis Circ Res 104 566 568 19286611 1:CAS:528:DC%2BD1MXkvVKmtrc%3D 10.1161/CIRCRESAHA.109.194209
38. A Dandapat C Hu L Sun, et al. 2007 Small concentrations of ox-LDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway Arterioscler Thromb Vasc Biol 27 2435 2442 17717293 1:CAS:528:DC%2BD2sXhtFKitbjE 10.1161/ATVBAHA.107.152272 (Pubitemid 350203961)
39. JL Mehta B Hu J Chen, et al. 2003 Pioglitazone inhibits Lox-1 expression in human coronary artery endothelial cells by reducing intracellular superoxide radical generation Arterioscler Thromb Vasc Biol 23 2203 2208 12958047 1:CAS:528:DC%2BD3sXpsVGht70%3D 10.1161/01.ATV.0000094411.98127.5F (Pubitemid 37532321)
40. R Hyde ME Corkins GA Somers, et al. 2011 PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabdotis elegans mechanosensory response Gene Brain Behav 10 286 298 1:CAS:528:DC%2BC3MXmt1GktrY%3D 10.1111/j.1601-183X. 2010.00667.x
41. L Li T Sawamura G Renier 2004 Glucose enhance human macrophage LOX-1 expression: role for LOX-1 in glucose-indced macrophage foam cell formation Circ Res 94 892 901 15001526 1:CAS:528:DC%2BD2cXivVKqsbs%3D 10.1161/01.RES. 0000124920.09738.26 (Pubitemid 38490066)
42. D Li L Liu H Chen, et al. 2003 LOX-1, an oxidized LDL endothelial receptor, induces CD/CD40L signaling in human coronary artery endothelial cells Arterioscler Thromb Vasc Biol 23 816 862 12637341 1:CAS:528:DC%2BD3sXjtlaktLc%3D 10.1161/01.ATV.0000066685.13434.FA (Pubitemid 36566171)
43. AA Anwar FY Li DS Leake, et al. 2005 Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2 Free Radic Bio Med 39 227 236 1:CAS:528:DC%2BD2MXlt1Witbo%3D 10.1016/j.freeradbiomed.2005.03.012 (Pubitemid 40814548)
44. WJ Lee HC Ou WC Hsu, et al. 2010 Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cell J Vasc Surg 52 1290 1300 20692795 10.1016/j.jvs.2010.04.085
45. Sun Y, Chen X. Ox-LDL-induced LOX-1 expression in vascular smooth muscle cells: role of reactive oxygen species. Fund Clin Pharmacol. 2010;Epub ahead of print.
46. RS Vohra JE Murphy JH Walker, et al. 2006 Atherosclerosis and the Lectin-like oxidized low-density lipoprotein scavenger receptor Trends Cardiovasc Med 16 60 64 16473764 1:CAS:528:DC%2BD28Xhtlaltbk%3D 10.1016/j.tcm.2005.12.001 (Pubitemid 43214528)
47. M Chen T Masaki T Sawamura 2002 LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis Pharmacol Ther 95 89 100 12163130 1:CAS:528:DC%2BD38XmtVWltrw%3D 10.1016/S0163-7258(02)00236-X
48. H Hattori A Sonoda H Sato, et al. 2006 G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke Brain Res 1121 246 249 17022953 1:CAS:528:DC%2BD28Xht1Shtb3N 10.1016/j.brainres.2006.08.091 (Pubitemid 44708883)
49. J Xu JH Zhu MJ Shi 2010 Value of serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and LOX-1 mRNA in peripheral mononuclear cells in early diagnosis of acute coronary syndrome] Nan Fang Yi Ke Da Xue Xue Bao 30 2749 2751 21177197 1:CAS:528:DC%2BC3MXhsFOnurc%3D
50. R Takanabe-Mori K Ono N Sowa, et al. 2010 Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice Biochem Biophys Res Commun 298 576 580 10.1016/j.bbrc.2010.06.123 1:CAS:528: DC%2BC3cXps1Chs7Y%3D
51. N Yamamoto M Toyoda M Abe, et al. 2009 Lectin-like oxidized LDL receptor-1 (LOX-1) expression in the tubulointerstitial area likely plays an important role in human diabetic nephropathy Intern Med 48 189 194 19218767 10.2169/internalmedicine.48.1251
52. K Oka T Sawamura K Kikuta, et al. 1998 Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells Proc Natl Acad Sci USA 95 9535 9540 9689115 1:CAS:528:DyaK1cXltlClsLs%3D 10.1073/pnas.95.16.9535 (Pubitemid 28506266)
53. P Zhang MC Liu L Cheng, et al. 2009 Blockade of LOX-1 prevents endotoxin-induced acute lung inflammation and injury in mice J Innate Immun 1 358 365 20375593 1:CAS:528:DC%2BD1MXmtlCjt78%3D 10.1159/000161070
54. T Kakinuma T Yasuda T Nakagawa, et al. 2004 Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage Arthritis Rheum 50 3495 3503 15529384 1:CAS:528:DC%2BD2cXhtVOqtrvE 10.1002/art.20581 (Pubitemid 39488674)
55. M Akagi S Kanata S Mori, et al. 2007 Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis Osteoarthritis Cartilage 15 281 290 16945559 1:STN:280:DC%2BD2s7gs1Wgsw%3D%3D 10.1016/j.joca.2006.07.010 (Pubitemid 46238241)
56. SK Calderwood SS Mambula PJ Gray Jr 2007 Extracellular heat shock proteins in cell signaling and immunity Ann N Y Acad Sci 1113 28 39 17978280 1:CAS:528:DC%2BD2sXhsVanurbP 10.1196/annals.1391.019
57. CM Godin SS Ferguson 2010 The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase Mol Pharmacol 77 903 911 20181817 1:CAS:528:DC%2BC3cXmslKnsbY%3D 10.1124/mol.110.063859
58. KM Curnow L Pascoe PC White 1992 Genetic analysis of the human type 1 angiotensin II receptor Mol Endocrinol 6 1113 1118 1508224 1:CAS:528: DyaK3sXisVOrsL8%3D 10.1210/me.6.7.1113
59. N Tanaka A Miyajima T Kosaka, et al. 2010 Cis-dichlorodiammineplatinum upregulates angiotensin II type 1 receptors through reactive oxygen species generation and enhances VEGF production in bladder cancer Mol Cancer Ther 9 2982 2992 20978160 1:CAS:528:DC%2BC3cXhtl2rtrfE 10.1158/1535-7163.MCT-10-0535
60. M de Gasparo KJ Catt T Inagami, et al. 2000 International union of pharmacology. XXIII. The angiotensin II receptors Pharmacol Rev 52 415 472 10977869
61. C Szpirer M Riviere J Szpirer, et al. 1993 Chromosomal assignment of human and rat hypertension candidate genes: type 1 angiotensin II receptor genes and SA gene J hypertens 11 919 925 8254174 1:CAS:528:DyaK2MXjvVKnsLs%3D 10.1097/00004872-199309000-00005 (Pubitemid 23277466)
62. JL Lewis T Serikawa DG Warnock 1993 Chromosomal localization of angiotensin II type 1 receptor isoforms in the rat Biochem Biophys Res Commun 194 667 682 10.1006/bbrc.1993.1875 (Pubitemid 23245189)
63. B Shen LM Harrison-Bernard AJ Fuller, et al. 2007 The bradykinin B2 receptor gene Is a target of angiotensin II type 1 receptor signaling J Am Soc Nephrol 18 1140 1149 17344422 1:CAS:528:DC%2BD2sXkslSrsLw%3D 10.1681/ASN.2006101127 (Pubitemid 46536900)
64. DF Guo H Furuta M Mizukoshi, et al. 1994 The genomic organization of human angiotensin II type 1 receptor Biochem Biophys Res Commun 200 313 319 8166699 1:CAS:528:DyaK2cXkslCrsLg%3D 10.1006/bbrc.1994.1450 (Pubitemid 24183609)
65. B Su MM Martin KB Beason, et al. 1994 The genomic organization and functional analysis of the promoter for the human angiotensin II type 1 receptor Biochem Biophys Res Commun 200 1039 1046 10.1006/bbrc.1994.2567 (Pubitemid 24367156)
66. K Takeuchi W Alexander Y Nakamura, et al. 1993 Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene Circ Res 73 612 621 8370119 1:CAS:528:DyaK2cXitVym (Pubitemid 23276983)
67. DF Guo T Inagami 1994 The genomic organization of the rat angiotensin II receptor AT1B Biochim Biophys Acta 1218 91 94 8193170 1:CAS:528: DyaK2cXkt1Okt7Y%3D
68. KM Vasudevan LA Garraway 2010 AKT signaling in physiology and disease Curr Top Microbiol Immunol 347 105 133 20549472 1:CAS:528:DC%2BC3MXmvVaisrs%3D 10.1007/82-2010-66
69. L Hunyady KJ Catt 2006 Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II Mol Endocrinol 20 953 970 16141358 1:CAS:528:DC%2BD28Xksleqs7w%3D 10.1210/me.2004-0536
70. M Ushio-Fukai KK Griendling M Akers, et al. 1998 Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits J Biol Chem. 273 19772 19777 9677408 1:CAS:528: DyaK1cXlt1Citbs%3D 10.1074/jbc.273.31.19772 (Pubitemid 28367037)
71. AE Cuadra Z Shan C Sumners, et al. 2010 A current view of brain renin-angiotensin system: Is the (pro)renin receptor the missing link? Pharmacol Ther 125 27 38 19723538 1:CAS:528:DC%2BD1MXhsFyiu7%2FM 10.1016/j.pharmthera. 2009.07.007
72. J Yu D Lubinsky N Tsomaia, et al. 2007 Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells J Cell Biochem 101 192 204 17212359 1:CAS:528:DC%2BD2sXkvFeku7g%3D 10.1002/jcb.21161 (Pubitemid 46652584)
73. Nishida M, Kitajima, Saiki S, et al. Regulation of angiotensin II receptor signaling by cysteine modification of NF-κB. Nitric Oxide. 2010;Epub ahead of print.
74. J Heineke JD Molkentin 2006 Regulation of cardiac hypertrophy by introcelluar signaling pathway Nat Rev Mol Cell Biol 7 589 600 16936699 1:CAS:528:DC%2BD28Xot1Cqu78%3D 10.1038/nrm1983 (Pubitemid 44325350)
75. L Jin Z Ying RC Webb 2004 Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta Am J Physiol Heart Circ Physiol 287 H1495 H1500 15371261 1:CAS:528:DC%2BD2cXptFansLs%3D 10.1152/ajpheart.01006.2003 (Pubitemid 39313251)
76. M Nishida S Tanabe Y Maruyama, et al. 2005 G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes J Biol Chem 280 18434 18441 15743761 1:CAS:528:DC%2BD2MXjsl2htLY%3D 10.1074/jbc.M409710200 (Pubitemid 41389093)
77. B Liu J Yu L Taylor, et al. 2006 Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective tissue growth factor expression by angiotensin II 1a and bradykinin B2 receptors in Rat1 fibroblasts J Cell Biochem 97 1104 1120 16294326 1:CAS:528:DC%2BD28XjtVOnsbk%3D 10.1002/jcb.20709
78. C Vecchione E Patrucco G Marino, et al. 2005 Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3K{gamma} J Exp Med 201 1217 1228 15824082 1:CAS:528:DC%2BD2MXjs1CitLk%3D 10.1084/jem.20040995 (Pubitemid 40629066)
79. K Defea 2008 Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction Br J Pharmacol 153 S298 S309 18037927 1:CAS:528:DC%2BD1cXislSjtrc%3D 10.1038/sj.bjp.0707508 (Pubitemid 351340984)
80. B Li PY Cheung X Wang, et al. 2007 Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells Carcinogenesis 28 2313 2320 17638919 1:CAS:528:DC%2BD2sXht1yktbfI 10.1093/carcin/bgm152 (Pubitemid 350111589)
81. DP Brazil ZZ Yang BA Hemmings 2004 Advances in protein kinase B signalling: AKTion on multiple fronts Trends Biochem Sci 29 233 242 15130559 1:CAS:528:DC%2BD2cXjvVemtbY%3D 10.1016/j.tibs.2004.03.006 (Pubitemid 38591317)
82. Sbroqqió M, Carnevale D, Bertero A, et al. IQGAP1 regulates ERK1/2 and AKT signaling in the heart and sustains functional remodeling upon pressure overload. Cardiovasc Res. 2011;Epub head of print.
83. Z Chang Q Xiao Q Feng, et al. 2010 PKB/Akt signaling in heart development and disease Front Biosci (Elite Ed) 2 1485 1491 10.2741/E207
84. JM Gasc C Monnot E Causer, et al. 1993 Co-expression of type 1 angiotensin II receptor (AT1R) and renin mRNAs in juxtaglomerular cells of the rat kidney Endocrinology 132 2723 2725 8504772 1:CAS:528:DyaK3sXkvVOhsbc%3D 10.1210/en.132.6.2723 (Pubitemid 23156933)
85. LG Navar LM Harrison-Bernard A Nishiyama, et al. 2002 Regulation of intrarenal angiotensin II in hypertension Hypertension 39 316 322 11882566 1:CAS:528:DC%2BD38Xhs1Wls7k%3D 10.1161/hy0202.103821 (Pubitemid 34165142)
86. Y Takeda 2005 Role of cardiovascular aldosterone in hypertension Curr Med Chem Cardiovasc Hematol Agents 3 261 266 15974890 1:CAS:528: DC%2BD2MXmtlCjtbo%3D 10.2174/1568016054368151 (Pubitemid 40974786)
87. Schulz E, Gori T, Münzel T. Oxidative stress and endothelial dysfunction in hypertension. Hypertens Res. 2011;Epub ahead of print.
88. SR Datla KK Griendling 2010 Reactive oxygen species, NADPH oxidases, and hypertension Hypertension 56 325 330 20644010 1:CAS:528:DC%2BC3cXhtVCntrrO 10.1161/HYPERTENSIONAHA.109.142422
89. D Li B Yang MI Philips, et al. 1999 Proapoptotic effects of ANG II in human artery endothelial cells: role of AT1 receptor and PKC activation Am J Physiol 276 H786 H792 10070060 1:CAS:528:DyaK1MXit1anu78%3D (Pubitemid 29157449)
90. XP Wang R Zhang K Wu, et al. 2004 Angiotensin II mediates acinar cell poptosis during the development of rat pancreatic fibrosis by AT1R Pancreas 29 264 270 15502641 1:CAS:528:DC%2BD2cXhtVKnt7%2FK 10.1097/00006676-200411000-00004 (Pubitemid 40228271)
91. B Ding J Abe H Wei, et al. 2005 A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early receptor (ICER) leads to cardiomyocyte apoptosis Proc Natl Acad Sci USA 102 14771 14776 16186489 1:CAS:528:DC%2BD2MXhtFKjsbzM 10.1073/pnas.0506489102 (Pubitemid 41457131)
92. R Vivar C Soto M Copaja, et al. 2008 Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor J Cardiovasc Pharmacol 52 184 190 18670360 1:CAS:528:DC%2BD1cXhtVWnsrrI 10.1097/FJC.0b013e318181fadd
93. Y Zhao X Chen L Cai, et al. 2008 Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells Acta Biochim Biophys Sin (Shanghai) 40 304 310 1:CAS:528:DC%2BD1cXmt1als74%3D 10.1111/j.1745-7270.2008. 00402.x (Pubitemid 351572111)
94. Q Gong M Davis G Chipitsyna, et al. 2010 Blocking angiotensin II Type 1 receptor triggers apoptotic cell death in human pancreatic cancer cells Pancreas 39 581 594 20118823 1:CAS:528:DC%2BC3cXnslansrw%3D 10.1097/MPA.0b013e3181c314cd
95. J Wasa H Sugiura Kohyama, et al. 2011 The tumor suppressive effect of angiotensin II type 1 receptor antagonist in a murine osteosarcoma modle Anticancer Res 31 123 127 21273589 1:CAS:528:DC%2BC3MXisVanu7s%3D
96. S Carl-McGrath MP Ebert U Lendeckel, et al. 2007 Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread Cancer Biol Ther 6 1218 1226 18059164 1:CAS:528: DC%2BD1cXkvVaitA%3D%3D (Pubitemid 351590375)
97. M Kosuqi A Miyajima E Kikuchi, et al. 2007 Effect of angiotensin II type 1 receptor antagonist on tumor growth and angiogenesis in a xenograft model of human bladder cancer Hum Cell 20 1 9 10.1111/j.1749-0774.2007.00025.x (Pubitemid 46761472)
98. T Yin X Ma L Zhao, et al. 2008 Angiotensin II promotes NO production, inhibits apoptosis and enhances adhesion potential of bone marrow-derived endothelial progenitor cells Cell Res 18 792 799 18560380 1:CAS:528: DC%2BD1cXnvFyhsLc%3D 10.1038/cr.2008.69 (Pubitemid 351948226)
99. M Bahiense-Olivera AL Mattar, et al. 2010 Interstitial expression of angiotensin II and AT1 receptor are increased in patients with progressive glomerulopathies J Renin Angiotensin Aldosterone Syst 11 158 164 10.1177/1470320310367929
100. TV Lanz Z Ding PP Ho, et al. 2010 Angiotensin II sustains brain inflammation in mice via TGF-beta J Clin Invest 120 2782 2794 20628203 1:CAS:528:DC%2BC3cXhtVaiur7J 10.1172/JCI41709
101. N Zhu D Zhang S Chen, et al. 2011 Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration Atherosclerosis 215 286 293 21310411 1:CAS:528:DC%2BC3MXkt1egtr8%3D 10.1016/j.atherosclerosis. 2010.12.024
102. T Sakurai M Kudo N Fukuta, et al. 2011 Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis Pancreatology 11 7 13 21464581 1:CAS:528:DC%2BC3MXkt1Kisro%3D 10.1159/000323478
103. S Chen Y Ge J Si, et al. 2008 Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade Kidney Int 74 1128 1138 18650791 1:CAS:528:DC%2BD1cXht1CmsbbJ 10.1038/ki.2008.380
104. Y Okunuki Y Usui N Nagai, et al. 2009 Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan Invest Ophthalmol 50 2255 2261 10.1167/iovs.08-2649
105. J Stegbauer DH Lee S Seubert, et al. 2009 Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system Proc Natl Acad Sci USA 106 14942 14947 19706425 1:CAS:528:DC%2BD1MXhtFGnur3L 10.1073/pnas.0903602106
106. M Platten S Youssef EM Hur, et al. 2009 Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity Proc Natl Acad Sci USA 106 14948 14953 19706421 1:CAS:528:DC%2BD1MXhtFGnur3E 10.1073/pnas.0903958106
107. BL Falcón SJ Veerasingham C Sumner MK Raizada 2005 Angiotension II type 2 receptor-mediated gene expression profiling in human coronary artery endothelial cells Hypertension 45 692 697 15710780 10.1161/01.HYP.0000154254. 89733.29 (Pubitemid 40418367)
108. M Hiraoka T Taniguchi H Nakai, et al. 2001 No evidence for AT2R gene derangement in human urinary tract anomalies Kidney Int 29 1244 1249 10.1046/j.1523-1755.2001.0590041244.x (Pubitemid 32281211)
109. T Watanabe TA Barker BC Berk 2005 Angiotensin II and the endothelium. Diverse signals and effects Hypertension 45 163 169 15630047 1:CAS:528:DC%2BD2MXmtVWnsA%3D%3D 10.1161/01.HYP.0000153321.13792.b9 (Pubitemid 40179951)
110. VT Karamyan J Arsenault E Escher, et al. 2010 Preliminary biochemical characterization of the novel, non-AT1, non-AT2 angiotensin binding site from the rat brain Endocrine 37 442 448 20960166 1:CAS:528:DC%2BC3cXksFKntrc%3D 10.1007/s12020-010-9328-2
111. T Naito LJ Ma H Yang, et al. 2010 Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis Am J Physiol Renal Physiol 298 F683 F691 20042458 1:CAS:528:DC%2BC3cXjsFGnurg%3D 10.1152/ajprenal.00503.2009
112. AM Allen J Zhou FA Mendelsohn 2000 Localization of angiotensin AT1 and AT2 receptor Am J Hypertens 13 31S 38S 10678286 1:CAS:528:DC%2BD3cXhs12htLc%3D 10.1016/S0895-7061(99)00249-6 (Pubitemid 30103853)
113. J Yatabe M Yoneda MS Yatable, et al. 2011 Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor Endocrinology 152 1582 1588 21303953 1:CAS:528:DC%2BC3MXkvVOkt7c%3D 10.1210/en.2010-1070
114. B Ulmasov Z Xu LH Tetri, et al. 2009 Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis Am J Physiol Gastrointest Liver Physiol 296 G284 G294 19033539 1:CAS:528:DC%2BD1MXitVaqt7Y%3D 10.1152/ajpgi.90409.2008
115. F Hu P Morrissey J Yao, et al. 2004 Development of AT(1) and AT(2) receptors in the ovine fetal brain Brain Res Dev Brain Res 150 51 61 15126038 1:CAS:528:DC%2BD2cXjs1aqt74%3D 10.1016/j.devbrainres.2004.02.007 (Pubitemid 39090083)
116. X Zhang M Lassila ME Cooper, et al. 2004 Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors Hypertension 43 276 281 14718351 1:CAS:528:DC%2BD2cXlvFegsQ%3D%3D 10.1161/01.HYP.0000113628.94574.0f (Pubitemid 38174187)
117. JC Santos S Jerez M Peral de Bruno, et al. 2000 Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin Braz J Med Biol Res 33 1099 1104 10973145 1:CAS:528:DC%2BD3cXntlShtrg%3D 10.1590/S0100- 879X2000000900018
118. Steckelings UM, Widdop RE, Paulis L, et al. The angiotensin AT2 receptor in left ventricular hypertrophy. J Hypertens. 2010;S50-S55.
119. S Busche S Gallinat RM Bohle, et al. 2000 Expression of angiotesion AT (1) and AT (2) receptors in adult rat cardiomyocytes after myocardial in farction. A single-cell reverse transcriptase-polymerase chain reaction study Am J Pathol 157 605 611 10934163 1:CAS:528:DC%2BD3cXlvFyqsb8%3D 10.1016/S0002-9440(10)64571-3 (Pubitemid 30626919)
120. WR Ford AS Clanachan BI Jugdutt 1996 Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts Circulation 94 3087 3089 8989113 1:CAS:528:DyaK2sXks12qsQ%3D%3D (Pubitemid 26427471)
121. D Tousoulis N Koumallos C Antoniades, et al. 2010 Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males Am J Hypertens 23 237 242 19959996 1:CAS:528:DC%2BC3cXhvFGhs74%3D 10.1038/ajh.2009.233
122. L Gao IH Zucker 2011 AT2 receptor signaling and sympathetic regulation Curr Opin Pharmacol 11 124 130 21159555 1:CAS:528:DC%2BC3MXksFyms7k%3D 10.1016/j.coph.2010.11.004
123. G Koike M Horiuchi T Yamada, et al. 1994 Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung Biochem Biophys Res Commun 203 1842 1850 7945336 1:CAS:528:DyaK2MXhtVSjurs%3D 10.1006/bbrc.1994.2402 (Pubitemid 24321580)
124. M Volpe Mussumeci P De Paolis, et al. 2003 Angiotensin II type 2 receptor subtype: an uprising frontier in cardiovascular disease? J Hypertens 21 1429 1443 12872031 1:CAS:528:DC%2BD3sXlvFarsLk%3D 10.1097/00004872-200308000-00001 (Pubitemid 36994116)
125. ES Jones A Vinh CA McCarthy, et al. 2008 AT2 receptors: functional relevance in cardiovascular disease Pharmacol Ther 120 292 316 18804122 1:CAS:528:DC%2BD1cXhsVWrsL7N 10.1016/j.pharmthera.2008.08.009
126. HM Siragy RM Carey 1996 The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′,5′-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats J Clin Invest 97 1978 1982 8621783 1:STN:280:DyaK287psVKquw%3D%3D 10.1172/JCI118630
127. HM Siragy RM Carey 1997 The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats J Clin Invest 100 264 269 9218502 1:CAS:528:DyaK2sXkslKgtb0%3D 10.1172/JCI119531 (Pubitemid 27349072)
128. PE Walters TA Gaspari RE Widdop 2005 Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats Hypertension 45 960 966 15767466 1:CAS:528:DC%2BD2MXjtlymurk%3D 10.1161/01.HYP.0000160325.59323.b8 (Pubitemid 40628944)
129. HM Siragy T Inagami RM Carey 2007 NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats Am J Physiol Regul Integr Com Physiol 293 R1461 R1467 1:CAS:528:DC%2BD2sXht1Wlu7zN 10.1152/ajpregu.00014. 2007 (Pubitemid 47535763)
130. S Kurisu R Ozono T Oshima, et al. 2003 Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis Hypertension 41 99
131. L Zhu OA Carretero TD Liao, et al. 2010 Role of prolycarboxypeptidase in angiotensin II type 2 receptor-mediated bradykinin release in mouse coronary artery endothelial cells Hypertension 56 384 390 20606103 1:CAS:528: DC%2BC3cXhtVCntrvJ 10.1161/HYPERTENSIONAHA.110.155051
132. AJ Lokuta C Cooper ST Gaa, et al. 1994 Angiotensin II stimulate the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells J Biol Chem 269 4832 4838 8106454 1:CAS:528: DyaK2cXhvVCjsrk%3D (Pubitemid 24239457)
133. R Kacimi AM Gerdes 2003 Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure Hypertension 41 968 977 12642504 1:CAS:528:DC%2BD3sXitlKgsrs%3D 10.1161/01.HYP.0000062465.60601.CC (Pubitemid 36418474)
134. S Gallinat S Busche S Schutze, et al. 1999 AT2 receptor stimulation induces generation of ceramides in PC12W cells FEBS Lett 443 75 79 9928956 1:CAS:528:DyaK1MXksFCruw%3D%3D 10.1016/S0014-5793(98)01675-5 (Pubitemid 29073398)
135. B Chertin U Rolle A Farkas, et al. 2002 The role of nitric oxide in reflux nephropathy Pediatr Surg Int 18 630 634 12471480 10.1007/s00383-002-0858- 4 (Pubitemid 36069920)
136. EI Ager WW Chong SW Wen, et al. 2010 Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases Cancer Cell Int 10 19 20584290 10.1186/1475-2867-10-19 1:CAS:528:DC%2BC3cXos1arsrk%3D
137. RE Widdop A Vinh D Henrion, et al. 2008 Vascular angiotensin AT2 receptors in hypertension and ageing Clin Exp Pharmacol Physiol 35 386 390 18307726 1:CAS:528:DC%2BD1cXjvFequrs%3D 10.1111/j.1440-1681.2008.04883.x (Pubitemid 351337334)
138. HM Siragy M de Gasparo RM Carey 2000 Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats Hypertension 35 1074 1077 10818067 1:CAS:528:DC%2BD3cXjvV2qsbc%3D (Pubitemid 30327260)
139. HM Siragy RM Carey 1999 Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model Hypertension 33 1237 1242 10334818 1:CAS:528:DyaK1MXjslSqurc%3D (Pubitemid 29230980)
140. RM Carey NL Howell XH Jin, et al. 2001 Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats Hypertension 38 1272 1277 11751702 1:CAS:528:DC%2BD38Xitl2jsw%3D%3D 10.1161/hy1201.096576 (Pubitemid 34033401)
141. RE Widdop K Matrougui BI Levy, et al. 2002 AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade Hypertension 40 516 520 12364356 1:CAS:528:DC%2BD38Xntlams78%3D 10.1161/01.HYP.0000033224.99806. 8A
142. RE Hannan EA Davis RE Widdop 2003 Functional role of angiotensin II AT2 receptor in modulation of AT1 receptor-mediated contraction in rat uterine artery: involvement of bradykinin and nitric oxide Br J Pharmacol 140 987 995 14530222 1:CAS:528:DC%2BD3sXps1eksL0%3D 10.1038/sj.bjp.0705484 (Pubitemid 37464083)
143. HM Siragy T Inagami T Ichiki, et al. 1999 Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor Proc Natl Acad Sci USA 96 6506 6510 10339618 1:CAS:528: DyaK1MXksFKktbs%3D 10.1073/pnas.96.11.6506 (Pubitemid 29256696)
144. MI Oliverio HS Kim M Ito, et al. 1999 Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II Proc Natl Acad Sci USA 95 15496 15501 10.1073/pnas.95.26.15496 (Pubitemid 29018727)
145. JH Lee S Xia L Ragolia 2008 Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats Am J Physiol Regul Integr Comp Physiol 295 R144 R154 18463192 1:CAS:528:DC%2BD1cXoslynsbo%3D 10.1152/ajpregu.00191.2008
146. J Kang C Sumners P Posner 1993 Angiotensin II type 2 receptor-modulated changes in potassium current in cultured neurons Am J Physiol 265 C607 C616 8214016 1:CAS:528:DyaK2cXhtlal
147. NY Tan JM Li R Stocker, et al. 2009 Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and Fasl-Fas engagement Circ Res 105 422 430 19628789 1:CAS:528:DC%2BD1MXhtVekt77E 10.1161/CIRCRESAHA.109.203323
148. H Li Y Qi C Li, et al. 2009 Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells Mol Cancer Ther 8 3255 3265 19996275 1:CAS:528:DC%2BD1MXhsFCitb3N 10.1158/1535-7163.MCT-09-0237
149. Y Qi H Li A Mecca V Shenoy, et al. 2008 Overexpression of angiotensin II type receptor (AT2R) in neonatal cardiomyocytes induces apoptosis FASEB J 22 1238.18
150. JY Kong SW Rabkin 2000 Angiotensin II does not induce apoptosis but rather prevents apoptosis in cardiomyocytes Peptides 21 1237 1247 11035211 1:CAS:528:DC%2BD3cXotFGqtrk%3D 10.1016/S0196-9781(00)00265-5
151. BI Jugdutt V Menon 2004 AT1 receptor blockade limits myocardial injury and upregulates AT2 receptors during reperfused myocardial infarction Mol Cell Biochem 260 111 118 15228092 1:CAS:528:DC%2BD2cXjsFSmtbc%3D 10.1023/B:MCBI. 0000026062.29029.d4 (Pubitemid 39127578)
152. XQ Jin N Fulkuda JZ Su, et al. 2002 AT2 receptor gene transfer downregulates AT1a receptor in vascular smooth muscle cells Hypertension 39 1021 1027 12019286 1:CAS:528:DC%2BD38Xkt1agt7g%3D 10.1161/01.HYP.0000016179.52601.B4 (Pubitemid 34547803)
153. JZ Su N Fulkuda XQ Jin, et al. 2002 Effect of AT2 receptor on expression of AT1 and TGF-beta receptors in VSMCs from SHR Hypertension 40 853 858 12468569 1:CAS:528:DC%2BD38XovFKntro%3D 10.1161/01.HYP.0000042096.17141.B1 (Pubitemid 35434906)
154. BL Metcalfe MJ Huentelman LD Parilak, et al. 2004 Prevention of cardiac hypertrophy by angiotension II type-2 receptor gene transfer Hypertension 43 1233 1238 15166182 1:CAS:528:DC%2BD2cXktFSks7g%3D 10.1161/01.HYP.0000127563. 14064.FD (Pubitemid 38691745)
155. C Hu A Dandapat J Chen, et al. 2008 Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression Atherosclerosis 199 288 294 18096165 1:CAS:528:DC%2BD1cXptVWktr4%3D 10.1016/j.atherosclerosis.2007.11. 006
156. LC Matavelli J Huang HM Siragy 2011 Angiotensin AT2R receptor stimulation inhibits early renal inflammation in renovascular hypertension Hypertension 57 308 313 21189405 1:CAS:528:DC%2BC3MXnvVWmuw%3D%3D 10.1161/HYPERTENSIONAHA.110. 164202
157. M Ruiz-Ortega M Rupérez V Esteban, et al. 2006 Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases Nephrol Dial Transplant 21 16 20 16280370 1:CAS:528:DC%2BD28XisFKhtQ%3D%3D 10.1093/ndt/gfi265 (Pubitemid 43057101)
158. S Voros Z Yang CM Bove, et al. 2006 Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling Am J Physiol Heart Circ Physiol 290 H1004 H1010 16214839 1:CAS:528:DC%2BD28XjtFCgtrw%3D 10.1152/ajpheart.00886.2005
159. YM Zuo Y Wang JP Liu 2010 Recent advances and findings of angiotensin type 2 receptor: a review Chin Med J 123 3462 3466 1:CAS:528: DC%2BC3MXltl2lsA%3D%3D
160. YH Liu XP Yang VG Sharov, et al. 1997 Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors J Clin Invest 99 1926 1935 9109437 1:CAS:528:DyaK2sXisF2qu7g%3D 10.1172/JCI119360 (Pubitemid 27175940)
161. S Mankad T d' Amato N Reichek, et al. 2001 Combining angiotensin II receptor antagonism and angiotensin converting enzyme inhibition further attenuates post-infarction left ventricular remodeling Circulation 103 2845 2850 11401943 1:CAS:528:DC%2BD3MXltlyitL0%3D (Pubitemid 32550075)
162. R Munoz-Garcia R Maeso E Rodrigo, et al. 1995 Acute renal exretory acions of losartan in spontaneously hypertensive rats: role of AT2 receptors, prostaglandins, kinins and nitric oxide J Hypertens 13 1779 1784 8903651 1:CAS:528:DyaK28XhtFGqtbY%3D (Pubitemid 26015816)
163. BI Jugdutt M Balghith 2001 Enhanced regional AT(2)-receptor and PKC (epsilon) expression during cardioprotection induced by AT(1)-receptor blockade after reperfused myocardial infarction J Renin Angiotensin Aldosterone Syst 2 134 140 11881113 1:CAS:528:DC%2BD3MXlslart7g%3D 10.1177/14703203010020012801
164. A Jalowy R Schulz H Dörge, et al. 1998 Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs J Am Coll Cardiol 32 1787 1796 9822110 1:CAS:528:DyaK1cXnvVymtrw%3D 10.1016/S0735-1097(98)00441-0 (Pubitemid 28545220)
165. RE Widdop ES Jones RE Hannan, et al. 2003 Angiotensin AT2 receptors: cardiovascular hope or hype? Br J Pharmacol 140 809 824 14530223 1:CAS:528:DC%2BD3sXps1eksrw%3D 10.1038/sj.bjp.0705448 (Pubitemid 37464062)
166. B Gigante O Piras P De Paolis, et al. 1998 Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats J Hypertens 16 2039 2043 9886894 1:CAS:528: DyaK1MXmtVekuw%3D%3D 10.1097/00004872-199816121-00027 (Pubitemid 29002385)
167. E Maquigussa CP Arnoni PC Cristovam, et al. 2010 Escherichia coli lipopolysaccharide impairs the calcium signaling pathway in mesangial cells: role of angiotensin II receptors Exp Biol Med (Maywood) 235 761 767 1:CAS:528:DC%2BC3cXpsVOjtrw%3D 10.1258/ebm.2010.010006
168. S AbdAlla H Lother AM Abdel-tawab, et al. 2001 The angiotensin II AT2 receptor is an AT1 receptor antagonist J Biol Chem 276 39721 39726 11507095 1:CAS:528:DC%2BD3MXotFGit7s%3D 10.1074/jbc.M105253200
169. YD Lang CL Huang TY Wu, et al. 2010 The renin-angiotensin system mediates hyperoxia-induced collagen production in human lung fibroblasts Free Radic Biol Med 49 88 95 20353822 1:CAS:528:DC%2BC3cXmsVGgsL4%3D 10.1016/j.freeradbiomed. 2010.03.022
170. R Zhu L Yang L Shen, et al. 2009 ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene J Huazhong Univ Sci Technolog Med Sci 29 177 181 19399400 10.1007/s11596-009-0208-z 1:CAS:528:DC%2BD1MXltVylsbw%3D
171. CF Spurney A Sali AD Guerron, et al. 2011 Losartan decreases cardiac muscle fibrosis and improves cardia function in dystrophin-deficient mdx mice J Cardiovasc Pharmacol Ther 16 87 95 21304057 1:CAS:528:DC%2BC3MXjtVOkurc%3D 10.1177/1074248410381757
172. Y Tsutsumi H Matsubara N Ohkubo, et al. 1998 Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression Circ Res 83 1035 1046 9815151 1:CAS:528:DyaK1cXnsVykurc%3D (Pubitemid 28520933)
173. N Ohkubo H Matsubara Y Nozawa, et al. 1997 Angiotensintype 2 receptor are reexpression by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism Circulation 96 3954 3962 9403620 1:CAS:528:DyaK2sXnvV2itLw%3D
174. J Varagic D Susic ED Frohlich 2001 Coronary hemodynamic and ventricular responses to angiotensin type 1 receptor inhibition in SHR: interaction with angiotensin type 2 receptors Hypertension 37 1399 1403 11408384 1:CAS:528:DC%2BD3MXksFOlsLs%3D (Pubitemid 34225381)
175. LY Chan JC Leung SC Tang, et al. 2005 Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy J Am Soc Nephrol 16 2306 2317 15930094 1:CAS:528:DC%2BD2MXovVOkur0%3D 10.1681/ASN.2004121117 (Pubitemid 41725048)
176. H Okada Y Watanable T Kobayasshi, et al. 2004 Angiotensin II type 1 and type 2 receptors reciprocally modulate pro-inflammatory/ pro-fibrotic reactions in activated splenic lymphocytes Am J Nephrol 24 322 329 15148459 1:CAS:528:DC%2BD2cXlsVyqtbc%3D 10.1159/000078496 (Pubitemid 39070116)
177. M Ruiz-Orteqa M Rupérez V Esteban, et al. 2006 Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney disease Nephrol Dial Transplant 21 16 20 10.1093/ndt/gfi265 (Pubitemid 43057101)
178. SC Clayton KK Haack IH Zucker 2011 Renal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure Am J Physiol Renal Physiol 300 F31 F39 20962112 1:CAS:528:DC%2BC3MXhslWnsbc%3D 10.1152/ajprenal.00088.2010
179. SS Landgraf M Wengert JS Silva, et al. 2011 Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats Am J Physiol Renal Renal Physiol 300 F499 F510 1:CAS:528:DC%2BC3MXisFOiurY%3D 10.1152/ajprenal.00384.2010
180. H Okada T Inoue T Kikuta, et al. 2006 A possible anti-inflammatory role of angiotensin II type 2 receptor in immune-mediated glomerulonephritis during type 1 receptor blockade Am J Pathol 169 1577 1589 17071582 1:CAS:528: DC%2BD28Xht12isr%2FO 10.2353/ajpath.2006.060178 (Pubitemid 351181990)
181. ND Vaziri Y Bai Z Ni, et al. 2007 Intra-renal angiotensin II/AT1 receptor, oxidative stress, inflammation, and progressive injury in renal mass reduction J Pharmacol Exp Ther 323 85 93 17636006 1:CAS:528:DC%2BD2sXhtFahsLbO 10.1124/jpet.107.123638 (Pubitemid 47443257)
182. JA Sullivan HL Rupnow JM Cale, et al. 2005 Pregnancy and ovarian steroid regulation of angiotensin II type 1 and type 2 receptor expression in ovine uterine endothelium and vascular smooth muscle Endothelium 12 41 56 16036315 1:CAS:528:DC%2BD2MXks1Ontrg%3D 10.1080/10623320590933752 (Pubitemid 40861886)
183. S Keidar J Attias 1997 Angiotensin II injection into mice increases the uptake of oxidized LDL by their mcrophages via a proteoglycan-mediated pathway Biochem Biophys Res Commun 239 63 67 9345270 1:CAS:528:DyaK2sXmvVKms70%3D 10.1006/bbrc.1997.7428 (Pubitemid 27480316)
184. S Keidar M Kaplan A Hoffman, et al. 1995 Angiotnsin II stimulates macrophages mediated oxidation of low density lipoproteins Atherosclerosis 115 201 215 7661879 1:CAS:528:DyaK2MXls12jtrg%3D 10.1016/0021-9150(94)05514-J
185. D Li YC Zhang MI Philips, et al. 1999 Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation Circ Res 84 1043 1049 10325241 1:CAS:528:DyaK1MXjtFCjtrY%3D (Pubitemid 29227683)
186. G Nickenig S Wassmann M Böhm 2000 Regulation of the angiotensin AT1 receptor by hypercholesterolaemia Diabetes Obes Metab 2 223 228 11225655 1:CAS:528:DC%2BD3cXlvFyltLs%3D 10.1046/j.1463-1326.2000.00060.x (Pubitemid 33072190)
187. G Nickenig A Sachinidis F Michaelsen, et al. 1997 Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells Circulation 95 473 478 9008466 1:CAS:528: DyaK2sXpt1eiuw%3D%3D (Pubitemid 27056216)
188. BC Yang MI Phillips D Mohuczy, et al. 1998 Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits Arterioscler Thromb Vasc Biol 18 1433 1439 9743232 1:CAS:528:DyaK1cXmtlyiur4%3D 10.1161/01.ATV.18.9.1433 (Pubitemid 28421881)
189. M Maczerwski J Maczewska M Duda 2008 Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptors Br J Pharmacol 154 1640 1648 10.1038/bjp.2008.218 1:CAS:528:DC%2BD1cXps1GrurY%3D
190. C Hu A Dandapat JL Mehta 2007 Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway Hypertension 50 952 957 17893372 1:CAS:528:DC%2BD2sXhtFGjur7I 10.1161/HYPERTENSIONAHA.107.096446 (Pubitemid 350287540)
191. N Sakamoto T Ishibashi K Sugimoto, et al. 2009 Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells J Cell Physiol 220 706 715 19452449 1:CAS:528:DC%2BD1MXpsV2ntbw%3D 10.1002/jcp.21818
192. KD Pendergrass TM Gwathmey RD Michalek, et al. 2009 The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus Biochem Biophys Res Commun 384 149 154 19409874 1:CAS:528:DC%2BD1MXmtFSit7Y%3D 10.1016/j.bbrc.2009.04.126
193. M Nagase K Ando T Nagase, et al. 2001 Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium Biochem Biophys Res Commun 281 720 725 11237717 1:CAS:528:DC%2BD3MXhsFOgtrY%3D 10.1006/bbrc.2001.4374 (Pubitemid 32917860)
194. T Ichiki K Takeda T Tokunou, et al. 2001 Reactive oxygen species-mediated homologous downregulation of angiotensin II type 1 receptor mRNA by angiotensin II Hypertension 37 535 540 11230331 1:CAS:528:DC%2BD3MXhvVSnu7g%3D (Pubitemid 32199024)
195. C Zhang YX Zhao YH Zhang, et al. 2010 Angiotensin-coverting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells Proc Natl Acad Sci USA 107 15886 15891 20798044 1:CAS:528:DC%2BC3cXhtFOqtLbP 10.1073/pnas.1001253107
196. Lu J, Mitra S, Wang X, et al. Contribution of oxidative stress and lectin-like oxLDL-receptor LOX-1 in atherogenesis and tumorigenesis. Antioxid Redox Signal. 2011;Epub ahead of print.
197. T Petnehazy KY Stokes KC Wood, et al. 2006 Role of blood cell-associated AT1 receptor in the microvascular responses to hypercholesterolemia Arterioscer Thromb Vasc Biol 26 313 318 1:CAS:528:DC%2BD28XksFKqsQ%3D%3D 10.1161/01.ATV.0000193625.32499.71 (Pubitemid 43732193)
198. C Hu A Dandapat L Sun, et al. 2008 Regulation of TGFbeta1-mediated collagen formation by LOX-1: studies based on forced overexpression of TGFbeta1 in wild-type and lox-1 knock-out mouse cardiac fibroblasts J Biol Chem 283 10226 10231 18182394 1:CAS:528:DC%2BD1cXksFagsrc%3D 10.1074/jbc.M708820200
199. A Koïtka Z Cao P Koh, et al. 2010 Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes Diabetologia 53 584 592 19957160 10.1007/s00125-009-1619-x 1:CAS:528:DC%2BC3cXhsVygsbs%3D
200. VL Sales GK Sukhova MA Lopez-llasaca, et al. 2005 Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution Circulation 112 3328 3336 16286588 1:CAS:528:DC%2BD2MXht1arsrnO 10.1161/CIRCULATIONAHA.105.541714 (Pubitemid 43739379)
201. A Dandapat CP Hu J Chen, et al. 2008 Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque Biochem Biophys Res Commun 366 871 877 18037370 1:CAS:528: DC%2BD1cXislynuw%3D%3D 10.1016/j.bbrc.2007.11.061
202. MD Rekhter 1999 Collagen synthesis in atherosclerosis: too much and not enough Cardiovasc Res 41 376 384 10341837 1:CAS:528:DyaK1MXht12ru7o%3D 10.1016/S0008-6363(98)00321-6 (Pubitemid 29087334)
203. S Katsuda Y Okada T Minamoto, et al. 1992 Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies Arterioscler Thromb 12 494 502 1373075 1:STN:280:DyaK383hsFOlug%3D%3D 10.1161/01.ATV.12.4.494
204. R Kittelberger PF Davis WE Stehbens 1990 Type VI collagen in experimental atherosclerosis Experientia 46 264 267 2178953 1:CAS:528:DyaK3cXktVCjsrk%3D 10.1007/BF01951760
205. SG Velleman RJ McCormick D Ely, et al. 2001 Collagen characteristics and organization during the progression of cholesterol-induced atherosclerosis in Japanese quail Exp Bio Med (Maywood) 226 328 333 1:CAS:528:DC%2BD3MXjtlGgsLk%3D
206. C Hu A Dandapat L Sun, et al. 2008 LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet Cardiovasc Res 79 287 293 18453637 1:CAS:528:DC%2BD1cXot1Wisrg%3D 10.1093/cvr/cvn110 (Pubitemid 351951615)
207. S Kitamoto K Egashira C Kataoka, et al. 2000 Chronic inhibition of nitric oxide synthesis in rats increases aortic superoxide anion production via the action of angiotensin II J Hypertens 18 1795 1800 11132603 1:CAS:528: DC%2BD3MXhtlChsg%3D%3D 10.1097/00004872-200018120-00013
208. P Libby PM Ridker A Maseri 2002 Inflammation and atherosclerosis Circulation 105 1135 1143 11877368 1:CAS:528:DC%2BD38XislWhu7k%3D 10.1161/hc0902.104353 (Pubitemid 34212626)
209. W Hollander 1976 Role of hypertension in atherosclerosis and cardiovascular disease Am J Cardiol 38 786 800 136891 1:CAS:528: DyaE2sXktFWisQ%3D%3D 10.1016/0002-9149(76)90357-X (Pubitemid 8005693)
210. C Savoia M D'Agostino F Lauri, et al. 2011 Angiotensin type 2 receptor in hypertensive cardiovascular disease Curr Opin Nephrol Hypertens 20 125 132 21245762 1:CAS:528:DC%2BC3MXhslynsrk%3D 10.1097/MNH.0b013e3283437fcd
211. JH Dominguez JL Mehta D Li, et al. 2008 Anti-LOX-1 therapy in rats with diabetes and dyslipidemia: ablation of renal vascular and epithelial manifestations Am J Physiol Renal Physiol 294 F110 F119 17989113 1:CAS:528:DC%2BD1cXhtVKnsbg%3D 10.1152/ajprenal.00013.2007