The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus

Biochemical and Biophysical Research Communications

Volumn 384, Issue 2, 2009, Pages 149-154

  Pendergrass, Karl D ^a   Gwathmey, TanYa M ^a   Michalek, Ryan D ^a   Grayson, Jason M ^a   Chappell, Mark C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin II; Angiotensin type 1 receptor; Kidney; NOX4; Nuclei; Reactive oxygen species

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANTIBODY; BISINDOLYLMALEIMIDE; DIPHENYLIODONIUM SALT; LOSARTAN; NUCLEOPORIN; NUCLEOPORIN 62; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL LABELING; CELL NUCLEUS; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE; KIDNEY CORTEX; KIDNEY FUNCTION; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; CELL NUCLEUS; INDOLES; KIDNEY; LOSARTAN; MALE; MALEIMIDES; PROTEIN KINASE C; RATS; RATS, INBRED LEW; REACTIVE OXYGEN SPECIES; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 65549148254     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.126     Document Type: Article

References (37)

1. Gobeil F., Fortier A., Zhu T., Bossolasco M., Leduc M., Grandbois M., Heveker N., Bkaily G., Chemtob S., and Barbaz D. G-protein-coupled receptors signaling at the cell nucleus: an emerging paradigm. Can. J. Physiol. Pharmacol. 84 (2006) 287-297
2. Goetzl E.J. Diverse pathways for nuclear signaling by G protein-coupled receptors and their ligands. FASEB J. 21 (2007) 638-642
3. Boivin B., Vaniotis G., Allen B.G., and Hebert T.E. G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm?. J. Recept. Signal. Transduct. Res. 28 (2008) 15-28
4. Pendergrass K.D., Averill D.B., Ferrario C.M., Diz D.I., and Chappell M.C. Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat. Am. J. Physiol. Renal. Physiol. 290 (2006) F1497-F1506
5. T.M. Gwathmey, H.A. Shaltout, K.D. Pendergrass, N.T. Pirro, J.P. Figueroa, J.C. Rose, D.I. Diz, M.C. Chappell, Nuclear Angiotensin II-Type 2 (AT2) receptors are functionally liked to nitric oxide production, Am. J. Physiol. Renal Physiol. Epub Feb 25 (2009).
6. Li X.C., and Zhuo J.L. Intracellular angiotensin II induces in vitro transcription of TGF-β, MCP-1 and NHE3 mRNAs in rat renal cortical nuclei via activation of nuclear AT1 receptors. Am. J. Physiol. Cell Physiol. 294 (2008) C1034-1045
7. Garrido A.M., and Griendling K.K. NADPH oxidases and angiotensin II receptor signaling. Mol. Cell. Endocrinol. 302 (2008) 148-158
8. Kuroda J., Nakagawa K., Yamasaki T., Nakamura K., Takeya R., Kuribayashi F., Imajoh-Ohmi S., Igarashi K., Shibata Y., Sueishi K., and Sumimoto H. The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells 10 (2005) 1139-1151
9. Geiszt M., Kopp J.B., Varnal P., and Leto T.L. Identification of Renox, an NAD(P)H oxidase in kidney. PNAS 97 (2000) 8010-8014
10. Hilenski L.L., Clempus R.E., Quinn M.T., Lambeth J.D., and Griendling K.K. Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 677-683
11. Michalek R.D., Nelson K.J., Holbrook B.C., Yi J.S., Stridiron D., Daniel L.W., Fetrow J.S., King S.B., Poole L.B., and Grayson J.M. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J. Immunol. 179 (2007) 6456-6467
12. Sachse A., and Wolf G. Angiotensin II-induced reactive oxygen species and the kidney. J. Am. Soc. Neph. 18 (2007) 2439-2446
13. Shiose A., Kuroda J., Tsuruya K., Hirai M., Hirakata H., Naito S., Hattori M., Sakaki Y., and Sumimoto H. A novel superoxide-producing NAD(P)H oxidase in kidney. J. Biol. Chem. 276 (2001) 1417-1423
14. Sturrock A., Huecksteadt T.P., Norman K., Sanders K., Murphy T.M., Chitano P., Wilson K., Hoidal J.R., and Kennedy T.P. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 292 (2007) L1543-L1555
15. Hu T., Ramachandrarao S.P., Siva S., Valancius C., Zhu Y., Mahadev K., Toh I., Goldstein B.J., Woolkalis M., and Sharma K. Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells. Am. J. Physiol. Renal Physiol. 289 (2005) F816-F825
16. Natarajan V., Pendyala S., Gorshkova I.A., Usatyuk P., He D., Pennathur A., Lambeth J.D., and Thannickal V.J. Role of NOX4 and NOX2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells. Antioxid. Redox Signal. 11 (2009) 747-764
17. Martyn K.D., Frederick L.M., von L.K., Dinauer M.C., and Knaus U.G. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal. 18 (2006) 69-82
18. 2 and plays an integral role in insulin signal transduction. Mol. Cell. Biol. 24 (2004) 1844-1854
19. Cheng G., Cao Z., Xu X., van Meir E.G., and Lambeth J.D. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269 (2001) 131-140
20. Gorin Y., Ricono J.M., Kim N.H., Bhandari B., Choudhury G.G., and Abboud H.E. Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am. J. Physiol. Renal Physiol. 285 (2003) F219-F229
21. Block K., Eid A., Griendling K.K., Lee D.Y., Wittrant Y., and Gorin Y. Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J. Biol. Chem. 283 (2008) 24061-24076
22. Perisic O., Wilson M.I., Karathanassis D., Bravo J., Pacold M.E., Ellson C.D., Hawkins P.T., Stephens L., and Williams R.L. The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase. Adv. Enzyme Regul. 44 (2004) 279-298
23. Oliva J.L., Griner E.M., and Kazanietz M.G. PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors 23 (2005) 245-252
24. Parekh D.B., Ziegler W., and Parker P.J. Multiple pathways control protein kinase C phosphorylation. EMBO J. 19 (2000) 496-503
25. Deleris P., Gayral S., and Breton-Douillon M. Nuclear Ptdlns(3, 4, 5)P3 signaling: an ongoing story. J. Cell. Biochem. 98 (2006) 469-485
26. Irvine R.F. Nuclear lipid signaling. Nat. Rev. Mol. Cell Biol. 4 (2003) 349-360
27. Choi H., Leto T.L., Hunyady L., Catt K.J., Bae Y.S., and Rhee S.G. Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase. J. Biol. Chem. 283 (2008) 255-267
28. Seshiah P.N., Weber D.S., Rocic P., Valppu L., Taniyama Y., and Griendling K.K. Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators. Circ. Res. 91 (2002) 406-413
29. Robertson Jr. A.L., and Khairallah P.A. Angiotensin II: rapid localization in nuclei of smooth and cardiac muscle. Science 172 (1971) 1138-1139
30. Lu D., Yang H., Shaw G., and Raizada M.K. Angiotensin II-induced nuclear targeting of the angiotensin type 1 (AT1) receptor in brain neurons. Endocrinology 139 (1998) 365-375
31. Booz G.W., Conrad K.M., Hess A.L., Singer H.A., and Baker K.M. Angiotensin-II-binding sites on hepatocyte nuclei. Endocrinology 130 (1992) 3641-3649
32. Lee D.K., Lanca A.J., Cheng R., Nguyen T., Ji X.D., Gobeil Jr. F., Chemtob S., George S.R., and O'Dowd B.F. Agonist-independent nuclear localization of the apelin, angiotensin AT1, and bradykinin B2 receptors. J. Biol. Chem. 279 (2004) 7901-7908
33. Re R. Implications of intracrine hormone action for physiology and medicine. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H751-H757
34. Kumar R., Singh V.P., and Baker K.M. The intracellular renin-angiotensin system: implications in cardiovascular remodeling. Curr. Opin. Nephrol. Hypertens. 17 (2008) 168-173
35. Baker K.M., Chernin M.I., Schreiber T., Sanghi S., Haiderzaidi S., Booz G.W., Dostal D.E., and Kumar R. Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regul. Pept. 120 (2004) 5-13
36. van Kats J.P., Methot D., Paradis P., Silversides D.W., and Reudelhuber T.L. Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart. J. Biol. Chem. 276 (2001) 44012-44017
37. Yu C., Gong R., Tolbert E.M., and Dworkin L.D. Long-term, high dosage candesartan suppresses inflammation and injury in chronic kidney disease: non-hemodynamic renal protection. J. Am. Soc. Nephrol. 18 (2007) 750-759