Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model

Hypertension

Volumn 33, Issue 5, 1999, Pages 1237-1242

  Siragy, Helmy M ^a   Carey, Robert M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Angiotensin II; Bradykinin; Cyclic GMP; Hypertension, renovascular; Receptors, angiotensin II

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BRADYKININ; CYCLIC GMP; LOSARTAN; NITRIC OXIDE;

ADOLESCENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; INTERSTITIAL FLUID; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RENOVASCULAR HYPERTENSION; SODIUM EXCRETION; SYSTOLIC BLOOD PRESSURE;

EID: 0032930191     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.33.5.1237     Document Type: Article

References (18)

1. 2 receptor ligands CGP 42112 B and PD 123319 in the sodium-depleted rat. Eur J Pharmacol 1993;249: 85-93.
2. 2) receptor protein in rat kidney. Hypertension. 1997;30:1238-1246.
3. Zhuo J, Alcorn D, Harris PJ, Mendelsohn FAO. Localization and properties of angiotensin II receptors in rat kidney. Kidney Int. 1993;44(suppl 42):S40-S46.
4. 2 production in conscious rats J Clin Invest. 1996;97:1978-1982.
5. 2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest. 1997;100:264-269.
6. Tomanek RJ, Aydelotte MR. Late onset renal hypertension in old rats alters left ventricular structure and function. Am J Physiol. 1992;262: H531-H538.
7. Grollman A. A simplified procedure for inducing chronic renal hypertension in the mammal. Proc Soc Exp Biol Med. 1944;57:102-104.
8. Siragy HM, Howell NL, Ragsdale NV, Carey RM. Renal interstitial fluid angiotensin: modulation by anesthesia, epinephrine, sodium depletion, and renin inhibition. Hypertension. 1995;25:1021-1024.
9. 2 and nitric oxide. Hypertension. 1997;29:757-762.
10. Sealey JE, Laragh JH. How to do a plasma renin assay. Cardiovasc Med. 1977;2:1079-1092.
11. Nolly H, Miatello R, Damiani MT, Abate CD. Possible protective effects of kinins and convening enzyme inhibitors in cardiovascular tissues. Immunopharmacology. 1997;36:185-191.
12. Nims RW, Cook JC, Krishna MC, Christodoulou D, Poore CM, Miles AM, Grisham MB, Wink DA. Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds. Methods Enzymol. 1996;268:93-105.
13. Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, Henke ST, Breipohl G, König W, Knolle J, Schölkens BA. HOE 140, a new potent and long acting bradykinin-antagonist: in vivo studies. Br J Pharmacol. 1991;102:774-777.
14. Zou LX, Imig JD, Von Thun AM, Hymel A, Ono H, Navar LG. Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. Hypertension. 1996;28:669-677.
15. 1 receptor. Am J Hypertens. 1998;11:570-578.
16. 2 receptor protein in rats with angiotensin-dependent hypertension. Hypertension. 1999;33:96-101.
17. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by kinin-dependent mechanisms. Hypertension. 1998;31:349-355.
18. Siragy HM. Evidence that intrarenal bradykinin plays a role in regulation of renal function. Am J Physiol. 1993;265:E648-E654.