Interstitial expression of angiotensin II and AT1 receptor are increased in patients with progressive glomerulopathies

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 11, Issue 3, 2010, Pages 158-164

  Bahiense Oliveira, Marília ^a   Mattar, Ana Lúcia ^a   Avancini Malheiros, Denise Maria ^a   Woronik, Viktoria ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

angiotensin II; AT1 receptor; glomerulonephritis; glomerulopathy; proteinuria

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; CREATININE; SERUM ALBUMIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE COURSE; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULOPATHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY FIBROSIS; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MEMBRANOUS GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; PROGRESSIVE GLOMERULOPATHY; PROTEIN EXPRESSION; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 77956309144     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.1177/1470320310367929     Document Type: Article

References (27)

1. Warnock DG Prevention, protection, and the intrarenal renin-angiotensin systems. Semin Nephrol 2001 ; 21: 593-602.
2. Zatz R. Haemodynamically mediated glomerular injury: the end of a 15-year-old controversy? Curr Opin Nephrol Hypertens 1996 ; 5: 468-470.
3. Bttinger EP, Bitzer M. TGF-2 signaling in renal disease. J Am Soc Nephrol 2002 ; 13 2600-2610.
4. Abbate M., Zoja C., Rottoli D., Corna D., Tomasoni S., Remuzzi G. Proximal tubular cells promote fibrogenesis by TGF-21-mediated induction of peritubular myofibroblasts. Kidney Int 2002 ; 61: 2066-2077.
5. Velez JC The importance of the intrarenal renin-angiotensin system. Nat Clin Pract Nephrol 2009 ; 5: 89-100.
6. Agarwal R., Siva S., Dunn S., Sharma K. Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-2 levels. Am J Kidney Dis 2002 ; 39: 486-492.
7. Suzuki Y., Ruiz-Ortega M., Gomez-Guerrero C., Tomino Y., Egido J. Angiotensin II, the immune system and renal diseases: another road for RAS? Nephrol Dial Transplant 2003 ; 18: 1423-1426.
8. Ardaillou R. Angiotensin II-complexities beyond AT1 and AT2 receptors. Nephrol Dial Transplant 1998 ; 13: 2988-2990.
9. Maschio G., Alberti D., Janin G., Locatelli F., Mann JFE, Matolese M., et al. Effect of angiotensin-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N Engl J Med 1996 ; 334: 939-945.
10. Ruggenenti P., Perna A., Gherardi G., Gaspari F., Benini T., Remuzzi G. Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). Ramipril Efficacy in Nephropathy Lancet 1998 ; 352: 1252-1256.
11. Kshirsagar AV, Joy MS, Hogan SL, Falk RJ, Colindres RE Effect of ACE inhibitors in diabetic and nondiabetic chronic renal disease: a systematic overview of randomized placebo-controlled trials. Am J Kidney Dis 2000 ; 35: 695-707.
12. Gonalves AR, Fujihara CK, Mattar AL, Malheiros DMA, Noronha IL, de Nucci G., et al. Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal antiinflammatory. Am J Physiol Renal Physiol 2004 ; 286: F945 - F954.
13. Graciano ML, Cavaglieri RC, Dellê H., Dominguez WV, Casarini DE, Malheiros DMA, et al. Intrarenal renin-angiotensin system is unregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. J Am Soc Nephrol 2004 ; 15: 1805-1815.
14. Franco M., Martínez F., Quiroz Y., Galicia O., Bautista R., Johnson RJ, Rodríguez-Iturbe B. Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol 2007 ; 293: R251 - R256.
15. Arima S., Ito S. New insights into actions of the renin- angiotensin system in the kidney: concentrating on the ang II receptors and the newly described ang-(1-7) and its receptor. Semin Nephrol 2001 ; 21: 535-543.
16. Matsubara H., Sugaya T., Murasawa S., Nozawa Y., Mori Y., Masaki H., et al. Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridization. Nephron 1998 ; 80: 25-34.
17. Fujihara C., Noronha IL, Malheiros DMA, Antunes GR, Oliveira IB, Zatz R. Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney. J Am Soc Nephrol 2000 ; 11: 283-290.
18. Benigni A., Gagliardini E., Remuzzi G. Changes in glomerular perm-selectivity induced by angiotensin II imply podocyte dysfunction and slit diaphragm protein rearrangement. Semin Nephrol 2004 ; 24: 131-140.
19. Navar G., Lewis L., Hymel A., Braam B., Mitchell KD Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol 1994 ; 5: 1153-1158.
20. Navar LG, Harrison-Bernard LM, Nishiyama A., Koburi H. Regulation of intrarenal angiotensin II in hypertension. Hypertension 2002 ; 39: 316-322.
21. Nishiyama A., Seth DM, Navar G. Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension 2002 ; 39: 129-134.
22. Price D., Porter L., Gordon M., Fisher NDL, De'Oliveira JMF, Laffel LMB, et al. The paradox of the low-renin state in diabetic nephropathy. J Am Soc Nephrol 1999 ; 10: 2382-2391.
23. Campbell DJ, Lawrence AC, Towrie A., Kladis A., Valentijn AJ Differential regulation of angiotensin peptide levels in plasma and kidney of the rat. Hypertension 1991 ; 18: 763-773.
24. Zatz, R. Fujihara CK Mechanisms of progressive renal disease: role of angiotensin II, cyclooxygenase products and nitric oxide. J Hypertens 2002 ; 20 (Suppl 3). S37 - S44.
25. Mezzano S., Aros CA, Droguett A., Burgos ME, Ardiles LG, Flores CA, et al. Renal angiotensin II up-regulation and myofibroblast activation in human membranous nephropathy. Kidney Int 2003 ; 64 (Suppl 86). S39 - S45.
26. Mifune M., Sasamura H., Nakazato Y., Yamaji Y., Ashima N., Sakita T. Examination of angiotensin II type 1 and type 2 receptor expression in human kidneys by immunohistochemistry. Clin Exp Hypertens 2001 ; 23: 257-266.
27. Wagner J., Gehlen F., Ciecnhanowicz A., Ritz E. Angiotensin II receptor type 1 gene expression in human glomerulonephritis and Diabetes Mellitus. J Am Soc Nephrol 1999 ; 10: 545-551.