Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells

Circulation

Volumn 101, Issue 25, 2000, Pages 2889-2895

  Li, Dayuan ^a   Mehta, Jawahar L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Cell adhesion molecules; Endothelium; Gene therapy; Lipoproteins; Receptors

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; LECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; FLUORESCENCE MICROSCOPY; GENE SEQUENCE; GENE THERAPY; HUMAN; HUMAN CELL; INCUBATION TIME; MONOCYTE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0034720846     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.25.2889     Document Type: Article

References (38)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;363:801-809.
2. Libby P, Hanson GK. Biology of disease: involvement of the immune system in atherosclerosis: current knowledge and unanswered questions. Lab Invest. 1991;64:5-13.
3. Gu L, Okada Y, Clinton SK, et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 1998;2:275-281.
4. Bevilacqua MP, Nelson RM, Mannori G, et al. Endothelial leukocyte adhesion molecules in human disease. Ann Rev Med. 1994;45:361-378.
5. Navab M, Imes SS, Hama SY, et al. Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemoattractant protein 1 synthesis and is abolished by high density lipoprotein. J Clin Invest. 1991;88: 2039-2046.
6. Randolph GJ, Furie MB. A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitro. J Immunol. 1995;155:3610-3618.
7. Marumo T, Schini-Kerth VB, Fisslthaler B, et al. Platelet-derived growth factor-stimulated superoxide anion production modulated activation of transcription factor NF-KB and expression of monocyte chemoattractant protein-1 in human aortic smooth muscle cells. Circulation. 1997;96: 2361-2367.
8. Chen XL, Tummala PE, Olbrych MT, et al. Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Circ Res. 1998;83:952-959.
9. Duff JL, Marrero MB, Paxton WG, et al. Angiotensin II signal transduction and the mitogen-activated protein kinase pathway. Cardiovasc Res. 1995;95:1353-1362.
10. Mehta JL, Li DY. Identification and autoregulation of receptor for ox-LDL in cultured human coronary artery endothelial cells. Biochem Biophys Res Commun. 1998;248:511-514.
11. Kume N, Murase T, Moriwaki H, et al. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res. 1998; 83:322-327.
12. Li DY, Zhang YC, Philips MI, et al. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation. Circ Res. 1999;84:1043-1049.
13. Nagas M, Hirose S, Fujita T. Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low density lipoproteins (LOX-1). Biochem J. 1998;330:1417-1422.
14. Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386:73-77.
15. Negus RPM, Stamp GWH, Relf MG, et al. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J Clin Invest. 1995;95:2391-2396.
16. Nandoskar M, Ferrante A, Bates EJ, et al. Inhibition of human monocyte respiratory burst, degranulation, phospholipid, methylation and bacterial activity by pneumolysin. Immunology. 1986;59:515-520.
17. Martin A, Foxall T, Blumberg JB, et al. Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro. Arterioscler Thromb Vasc Biol. 1997;17:429-436.
18. Spertini O, Luscinskas FW, Gimbrone MA Jr, et al. Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med. 1992;176:1789-1792.
19. Marcus-Sekura C. Techniques for using antisense oligodeoxyribonucleotides to study gene expression. Anal Biochem. 1988;172:289-295.
20. Wagner R. Gene inhibition using antisense oligodeoxyribonucleotides. Nature. 1994;372:333-335.
21. Stein CA, Cheng YC. Antisense oligonucleotides as therapeutic agents: is the bullet really magic? Science. 1993;261:1004-1012.
22. Gao WY, Han FS, Storm C, et al. Phosphorothioate oligonucleotides are inhibitors of human DNA polymerase and RNAse H: implications for antisense technology. Mol Pharmacol. 1992;41:223-229.
23. Bennett CF, Condon TP, Grimm S, et al. Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J Immunol. 1994;152:3530-3540.
24. Boiziau C, Moreau S, Toulme IJ. A phosphorothioate oligonucleotide blocks reverse transcription via an antisense mechanism. FEBS Lett. 1994;41:223-229.
25. Takahashi M, Masuyama J, Ikeda U, et al. Suppressive role of endogenous endothelial monocyte chemoattractant protein-1 on monocyte transendothelial migration in vitro. Arterioscler Thromb Vasc Biol. 1995;15:629-636.
26. Takahashi M, Masuyama J, Ikeda U, et al. Induction of monocyte chemoattractant protein-1 synthesis in human monocytes during transendothelial migration in vitro. Circ Res. 1995;76:750-757.
27. Shyy YJ, Whickham LL, Hagan JP, et al. Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers. J Clin Invest. 1993;92:1745-1751.
28. Han KH, Tangirala RK, Green SR, et al. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes: a regulatory role for plasma LDL. Arterioscler Thromb Vasc Biol. 1998;18:1983-1991.
29. Wang GP, Deng ZD, Nj J, et al. Oxidized low density lipoprotein and very low density lipoprotein enhance expression of monocyte chemoattractant protein-1 in rabbit peritoneal exudate macrophages. Atherosclerosis. 1997;133:31-36.
30. Takahara N, Kashiwagi A, Nishio Y, et al. Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells. Diabetologia. 1997;40:662-670.
31. Dicorleto PE, Chiston GM. Participation of the endothelium in the development of the atherosclerotic plaque. Prog Lipid Res. 1986;25:365-374.
32. Faruqi RM, DiCorleto PE. Mechanism of monocyte recruitment and accumulation. Br Heart J. 1993;69:s19-s29.
33. Faggiotto A, Ross R. Studies of hypercholesterolemia in the nonhuman primate, II: fatty streak conversion to fibrous plaque. Arteriosclerosis. 1984;4:341-356.
34. Gerrity RG. The role of monocyte in atherogenesis, I: transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol. 1981;103-181-190.
35. Li DY, Yang BC, Mehta JL. Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am J Physiol. 1999, 275: H568-H576.
36. Kusuhara M, Chait A, Cader A, et al. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol. 1997;17:141-148.
37. Ito A, Tsao PS, Adimoolam S, et al. Novel mechanism for endothelial dysfunction: dysfunction of dimethylarginine dimethylaminohydrolase. Circulation. 1999;99:3092-3095.
38. Sata M, Walsh K. Endothelial cells apoptosis induced by oxidized LDL is associated with the downregulation of the cellular caspase inhibitor FLIP. J Biol Chem. 1998;273:33103-33106.