Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: Modulation by losartan

Biochemical and Biophysical Research Communications

Volumn 276, Issue 3, 2000, Pages 1100-1104

  Chen, Hongjiang ^a,b   Li, Dayuan ^a,b   Sawamura, Tatsuya ^c   Inoue, Kazuhiko ^c   Mehta, Jawahar L ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Angiotensin II; AT1 receptor; Intimal proliferation; Losartan; LOX 1

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; LOSARTAN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; CHOLESTEROL DIET; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; INTIMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RECEPTOR UPREGULATION;

EID: 0034610008     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3532     Document Type: Article

References (22)

1. Oxidative modification of LDL and atherogenesis
2. Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells
3. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation
4. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: Upregulated expression by TNF-alpha
5. LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells
6. Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
7. Increased uptake of LDL by oxidized macrophages is the result of an initial enhanced LDL receptor activity and of a further progressive oxidation of LDL
8. Angiotensin II injection into mice increases the uptake of oxidized LDL by their macrophages via a proteoglycan-mediated pathway
9. Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein
10. Increased angiotensin II type I receptor expression in hypercholesterolemic atherosclerosis in rabbits
11. Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression
12. Single step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extration
13. Angiotensin II atherogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis
14. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
15. Angiotensin, LDL peroxidation and atherosclerosis
16. Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells
17. Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin, and amlodipine
18. Ox-LDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas
19. The angiotensin-II receptor antagonist, losartan, inhibits LDL lipid peroxidation and atherosclerosis in apolipoprotein E-deficient mice
20. Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia
21. Modulation of arterial thrombosis by angiotensin-converting enzyme inhibition and angiotensin II type 1-receptor blockade
22. Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia