Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells

Atherosclerosis

Volumn 209, Issue 1, 2010, Pages 118-124

  Ishiyama, Junichi ^a   Taguchi, Ryoko ^a   Yamamoto, Akiko ^a   Murakami, Koji ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

LOX 1; Macrophage; NEFA; p38 MAPK; Palmitic acid; Scavenger receptor

Indexed keywords

CD36 ANTIGEN; CD68 ANTIGEN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; SCAVENGER RECEPTOR; SCAVENGER RECEPTOR AI; SCAVENGER RECEPTOR BI; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPID TRANSPORT; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ATHEROSCLEROSIS; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPROTEINS, LDL; MACROPHAGES; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITIC ACID; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SCAVENGER RECEPTORS, CLASS E; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 77049090228     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.09.004     Document Type: Article

References (36)

1. Pilz S., Scharnagl H., Tiran B., et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J Clin Endocrinol Metab 91 (2006) 2542-2547
2. Steinberg H.O., Tarshoby M., Monestel R., et al. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100 (1997) 1230-1239
3. Wang X.L., Zhang L., Youker K., et al. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes 55 (2006) 2301-2310
4. Zhang W.Y., Schwartz E., Wang Y., et al. Elevated concentrations of nonesterified fatty acids increase monocyte expression of CD11b and adhesion to endothelial cells. Arterioscler Thromb Vasc Biol 26 (2006) 514-519
5. Shi H., Kokoeva M.V., Inouye K., et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116 (2006) 3015-3025
6. Murphy J.E., Tedbury P.R., Homer-Vanniasinkam S., et al. Biochemistry and cell biology of mammalian scavenger receptors. Atherosclerosis 182 (2005) 1-15
7. Febbraio M., Abumrad N.A., Hajjar D.P., et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274 (1999) 19055-19062
8. Moriwaki H., Kume N., Sawamura T., et al. Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein. Arterioscler Thromb Vasc Biol 18 (1998) 1541-1547
9. Daviet L., and McGregor J.L. Vascular biology of CD36: roles of this new adhesion molecule family in different disease states. Thromb Haemost 78 (1997) 65-69
10. Febbraio M., Podrez E.A., Smith J.D., et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest 105 (2000) 1049-1056
11. Kataoka H., Kume N., Miyamoto S., et al. Expression of lectin like oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation 99 (1999) 3110-3117
12. Mehta J.L., Sanada N., Hu C.P., et al. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res 100 (2007) 1634-1642
13. Li L., Sawamura T., and Renier G. Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation. Circ Res 94 (2004) 892-901
14. Smirnova I.V., Kajstura M., Sawamura T., et al. Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation. Am J Physiol Heart Circ Physiol 287 (2004) H782-H790
15. Coll T., Jove M., Rodriguez-Calvo R., et al. Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes 55 (2006) 2779-2787
16. Haversen L., Danielsson K.N., Fogelstrand L., et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202 (2009) 382-393
17. Moriwaki H., Kume N., Kataoka H., et al. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha. FEBS Lett 440 (1998) 29-32
18. Ciapaite J., Bakker S.J., Diamant M., et al. Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects. Implications for a mechanism linking obesity and type 2 diabetes. JFEBS J 273 (2006) 5288-5302
19. Staiger H., Staiger K., Stefan N., et al. Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes 53 (2004) 3209-3216
20. van Wijk J.P., de Koning E.J., Castro Cabezas M., et al. Rosiglitazone improves postprandial triglyceride and free fatty acid metabolism in type 2 diabetes. Diabetes Care 28 (2005) 844-849
21. Maingrette F., and Renier G. Linoleic acid increases lectin-like oxidized LDL receptor-1 (LOX-1) expression in human aortic endothelial cells. Diabetes 54 (2005) 1506-1513
22. Brinkley T.E., Kume N., Mitsuoka H., et al. Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women. Obesity (Silver Spring) 16 (2008) 1454-1456
23. Shiu S.W., Tan K.C., Wong Y., et al. Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus. Atherosclerosis 203 (2009) 522-527
24. Dominguez J.H., Mehta J.L., Li D., et al. Anti-LOX-1 therapy in rats with diabetes and dyslipidemia: ablation of renal vascular and epithelial manifestations. Am J Physiol Renal Physiol 294 (2008) F110-F119
25. Chen M., Masaki T., and Sawamura T. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 95 (2002) 89-100
26. Kunjathoor V.V., Febbraio M., Podrez E.A., et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 277 (2002) 49982-49988
27. Chen M., Kakutani M., Minami M., et al. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 20 (2000) 1107-1115
28. Fisker Hag A.M., Pedersen S.F., and Kjaer A. Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice. Biochem Biophys Res Commun 377 (2008) 689-693
29. Mehta J.L., Chen J., Hermonat P.L., et al. Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc Res 69 (2006) 36-45
30. Li D., Liu L., Chen H., et al. LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation 107 (2003) 612-617
31. Cominacini L., Pasini A.F., Garbin U., et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 275 (2000) 12633-12638
32. Schaeffer D.F., Riazy M., Parhar K.S., et al. LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma. J Lipid Res 50 (2009) 1676-1684
33. Mukai E., Kume N., Hayashida K., et al. Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells. Atherosclerosis 176 (2004) 289-296
34. Lee J.G., Lim E.J., Park D.W., et al. A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation. Cell Signal 20 (2008) 2266-2275
35. McCubrey J.A., Lahair M.M., and Franklin RA. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 8 (2006) 1775-1789
36. Lambertucci R.H., Hirabara S.M., Silveira Ldos R., et al. Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells. J Cell Physiol 216 (2008) 796-804