Vascular angiotensin AT2 receptors in hypertension and ageing

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 4, 2008, Pages 386-390

  Widdop, Robert E ^a   Vinh, Antony ^a   Henrion, Daniel ^b   Jones, Emma S ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITÉ D'ANGERS   (France)

Author keywords

Ageing; AT1 receptor; AT2 receptor; Blood pressure; Hypertension; Remodelling; Vascular; Vasodilatation

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANTIHYPERTENSIVE AGENT; ATENOLOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; RECEPTOR SUBTYPE; VALSARTAN; ANGIOTENSIN II;

AGING; ANTIHYPERTENSIVE THERAPY; CONFERENCE PAPER; HEART HYPERTROPHY; HUMAN; HYPERTENSION; IN VIVO STUDY; MESENTERIC ARTERY; NONHUMAN; PHENOTYPE; RAT; RECEPTOR UPREGULATION; SPONTANEOUSLY HYPERTENSIVE HEART FAILURE RAT; VASOCONSTRICTION; VASODILATATION; BLOOD VESSEL; GENETICS; METABOLISM; REVIEW;

AGING; ANGIOTENSIN II; BLOOD VESSELS; HUMANS; HYPERTENSION; RECEPTOR, ANGIOTENSIN, TYPE 2;

EID: 40349103781     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.04883.x     Document Type: Conference Paper

References (39)

1. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 2000 52 : 415 72.
2. Griendling KK, Lassegue B, Alexander RW. Angiotensin receptors and their therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 1996 36 : 281 306.
3. Timmermans PB, Carini DJ, Chiu AT et al. Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. Hypertension 1991 18 (5 Suppl III136 42.
4. Shibouta Y, Inada Y, Ojima M et al. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1- [[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7- carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)- ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116). J. Pharmacol. Exp. Ther. 1993 266 : 114 20.
5. Morsing P. Candesartan: A new-generation angiotensin II AT1 receptor blocker: Pharmacology, antihypertensive efficacy, renal function, and renoprotection. J. Am. Soc. Nephrol. 1999 10 (Suppl. 11 S248 54.
6. Whitebread S, Mele M, Kamber B, de Gasparo M. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem. Biophys. Res. Commun 1989 163 : 284 91.
7. Steckelings UM, Kaschina E, Unger T. The AT2 receptor - A matter of love and hate. Peptides 2005 26 : 1401 9.
8. Carey RM. Cardiovascular and renal regulation by the angiotensin type 2 receptor: The AT2 receptor comes of age. Hypertension 2005 45 : 840 4.
9. Widdop RE, Jones ES, Hannan RE, Gaspari TA. Angiotensin AT2 receptors: Cardiovascular hope or hype? Br. J. Pharmacol. 2003 140 : 809 24.
10. Widdop RE, Matrougui K, Levy BI, Henrion D. AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension 2002 40 : 516 20.
11. Savoia C, Ebrahimian T, He Y, Gratton JP, Schiffrin EL, Touyz RM. Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. J. Hypertens. 2006 24 : 2417 22.
12. Henrion D, Kubis N, Levy BI. Physiological and pathophysiological functions of the AT subtype receptor of angiotensin II. From large arteries to the microcirculation. Hypertension 2001 38 : 1150 7.
13. Hannan RE, Widdop RE. Vascular angiotensin II actions mediated by angiotensin II type 2 receptors. Curr. Hypertens. Rep. 2004 6 : 117 23.
14. Matrougui K, Levy BI, Henrion D. Tissue angiotensin II and endothelin-1 modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats. Br. J. Pharmacol. 2000 130 : 521 6.
15. Matrougui K, Loufrani L, Heymes C, Levy BI, Henrion D. Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. Hypertension 1999 34 : 659 65.
16. Touyz RM, Endemann D, He G, Li JS, Schiffrin EL. Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension 1999 33 : 366 72.
17. You D, Loufrani L, Baron C, Levy BI, Widdop RE, Henrion D. High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats. Circulation 2005 111 : 1006 11.
18. Gohlke P, Pees C, Unger T. AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 1998 31 : 349 55.
19. Otsuka S, Sugano M, Makino N, Sawada S, Hata T, Niho Y. Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats. Hypertension 1998 32 : 467 72.
20. Barber MN, Sampey DB, Widdop RE. AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats. Hypertension 1999 34 : 1112 16.
21. Carey RM, Howell NL, Jin XH, Siragy HM. Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats. Hypertension 2001 38 : 1272 7.
22. Li XC, Widdop RE. AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR. Br. J. Pharmacol. 2004 142 : 821 30.
23. Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995 377 : 744 7.
24. Ichiki T, Labosky PA, Shiota C et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 1995 377 : 748 50.
25. Tsutsumi Y, Matsubara H, Masaki H et al. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J. Clin. Invest. 1999 104 : 925 35.
26. Jones ES, Black MJ, Widdop RE. Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade. J. Mol. Cell. Cardiol. 2004 37 : 1023 30.
27. Savoia C, Touyz RM, Volpe M, Schiffrin EL. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic Hypertensive Patients. Hypertension 2006.
28. Batenburg WW, Garrelds IM, Bernasconi CC et al. Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. Circulation 2004 109 : 2296 301.
29. Tea BS, Der Sarkissian S, Touyz RM, Hamet P, deBlois D. Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension 2000 35 : 1069 73.
30. Lakatta EG, Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part II. The aging heart in health: Links to heart disease. Circulation 2003 107 : 346 54.
31. Wang M, Takagi G, Asai K et al. Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates. Hypertension 2003 41 : 1308 16.
32. Heymes C, Silvestre JS, Llorens-Cortes C et al. Cardiac senescence is associated with enhanced expression of angiotensin II receptor subtypes. Endocrinology 1998 139 : 2579 87.
33. Burrell LM, Johnston CI. Angiotensin II receptor antagonists. Potential in elderly patients with cardiovascular disease. Drugs Aging 1997 10 : 421 34.
34. Basso N, Paglia N, Stella I et al. Protective effect of the inhibition of the renin-angiotensin system on aging. Regul. Pept. 2005 128 : 247 52.
35. Booz GW. Cardiac angiotensin AT2 receptor: What exactly does it do? Hypertension 2004 43 : 1162 3.
36. Zwart AS, Davis EA, Widdop RE. Modulation of AT1 receptor-mediated contraction of rat uterine artery by AT2 receptors. Br. J. Pharmacol. 1998 125 : 1429 36.
37. Hannan RE, Davis EA, Widdop RE. Functional role of angiotensin II AT2 receptor in modulation of AT1 receptor-mediated contraction in rat uterine artery: Involvement of bradykinin and nitric oxide. Br. J. Pharmacol. 2003 140 : 987 95.
38. Phoon S, Howes LG. Forearm vasodilator response to angiotensin II in elderly women receiving candesartan: Role of AT(2)-receptors. J. Renin Angiotensin Aldosterone Syst. 2002 3 : 36 9.
39. Pinaud F, Bocquet A, Dumont O et al. Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats. Hypertension 2007 50 : 96 102.